WO2010051607A1

WO2010051607A1 - Water dispersible agrochemical formulations

Info

Publication number: WO2010051607A1
Application number: PCT/BR2009/000345
Authority: WO
Inventors: André Luis Conde DA SILVA; Carolina Coimbra Nunes; Nathalia Carlos Da Silva; Rafael Di Falco Cossiello; Ubiratan Ferreira Sousa
Original assignee: Oxiteno Sa Industria e Comercio
Current assignee: Oxiteno Sa Industria e Comercio
Priority date: 2008-11-06
Filing date: 2009-10-21
Publication date: 2010-05-14
Anticipated expiration: 2011-05-06
Also published as: BRPI0804820A2

Abstract

The present invention relates to the preparation of concentrates of biologically active substances that are dispersible in water for application thereof. Mores specifically, the invention refers to a process of provision, in nanometric scale, of particles of water insoluble or almost water insoluble active ingredients, that are applicable as active ingredients of agricultural defensives.

Description

"WATER DISPERSIBLE AGROCHEMICAL FORMULATIONS"

Field of the invention

The present invention relates to the preparation of concentrates of biologically active substances that may be dispersed in water for purposes of application thereof. More specifically, the invention refers to a method for the provision in nanometric scale of particles of water insoluble or almost water insoluble active ingredients that may be applied as active ingredients of agricultural defensives.

Description of the prior art

The substances used in agriculture as biocides, comprising among others, herbicides, fungicides and insecticides, are generally applied in the form of an aqueous solution or dispersion, by means of spraying or pulverization. However, the majority of the active ingredients used as biocides are insoluble or poorly soluble in water, such fact hindering the preparation of stable formulations which upon the dilution thereof in water might result in a product both economic and effective.

The insoluble active ingredients can be formulated in various forms, such as: concentrated suspensions (dispersion of solids in liquids, that are diluted with water to be applied); emulsionable concentrates (concentrated solutions that upon being diluted for application, form an emulsion), wettables (powders easily dispersible in water), water dispersible granules, among other forms. For purposes of obtainment of stability, either in the concentrate formulation, or in diluted form, there are used solvents and surfactants, which account for the solubilization of the active ingredient in the concentrates and for the stabilization of the dispersions and ease of application thereof. As a rale, these formulations, when in the condition intended for application thereof to dilution in water, exhibit particle sizes in the micrometric scale (10-6m), such dimension scale limiting the effectiveness of the product.

The preparation of these formulations usually entails the difficulty of associating the necessary stability of the biocide concentrates with the improved stability of their emulsions or dispersions, and therefore the technologies capable of prolonging the useful life of the emulsions or dispersions while simultaneously allowing the obtainment of stable concentrates represent a challenge in this particular field of development.

The stability of the concentrates is related to the obtainment of formulations without turbidity, crystallization, phase separation or decomposition of the active ingredient, and the stability of the aqueous dispersions is related to the time during which the same can be used for crop spraying without visually noticeable separation of the phases or decomposition of the active ingredient.

Among the various biocide actives, there is presently a great difficulty to prepare fungicide actives of the family of the triazoles and benzimidazoles, due to the strong tendency thereof to form crystals and lumps in the concentrated product and even in the water preparation liquor. Patent application No. BR PI 06028919-5 discusses this difficulty and describes emulsionable concentrates both stable and capable of providing emulsions upon proper water dilution for application, however exhibiting particles of nanometric scale upon the dispersion in water.

I. Ishaaya, et al. in "Nanosuspensions: Emerging Novel Agrochemical Formulations Insecticides Design Using Advanced

Technologies", 1-39, 2007 discusses the great potential for improvement of effectiveness of agrochemical formulations capable of generating dispersions of nanometric scale for application. The relatively large dimensions of the droplets of conventional dispersions (10-6m) causes as a result a loss of effectiveness in the application of the biocide, usually requiring the application of larger amounts of product per unit of area.

In order to achieve formulations with nanometric scale dispersions, some approaches are described in the scientific literature. In patent No. CN 1389109, nano-emulsions of pesticides are prepared in a process of emulsifϊcation and homogenization with hydrophilic or lipophilic photodegradable materials. However, this technique is limited to the use of pesticides in their liquid form, thereby imposing restrictions upon the family of solid organic biocides.

Patent application No. WO 92/10937 describes a concentrate comprising a solid water-insoluble active which is solubilized in a dispersing medium comprised of water miscible solvents and surfactants, however this composition is different from that of the present invention in terms of the absence of need to use miscible solvents, the different nature of the surfactants, and in the fact that the present invention allows the use of water in the composition, as will be described in the invention. Additionally, the results of the formulations discussed in patent application No. WO 92/10937 are described to have a particle size of less than 1 micron, while the results achieved based on the instant patent application reach values of less than 400 nm, a situation in which the benefits of the nano-dispersion become fully available.

In patent application No. US 2001/0051175 there is described a formulation wherein are used anionic, cationic and non-ionic surfactants, individually or in combination. The process of preparation comprises the obtainment of a premix by means of dispersion of particles of biocide using the technique of wet milling in an aqueous surfactant solution. The milling step using beads or spheres requires power consumption during the process, which according to what is mentioned in the examples, may require many hours until achieving the intended sizes of the nanometric scale particles. The milling technique also entails the disadvantage of generating localized heat due to attrition which might cause the degradation of the active ingredient or even of the surfactants systems. Moreover, the mechanical milling is only applicable to solid biocides at ambient temperature.

In patent application No. BR PI 9001572-0 and in patents Nos. BR

PI 9101691-6, and BR PI 9404456-2 there are disclosed formulations for various pesticides, among which the triazoles, using di-styryl-phenyl-tri-glycol ethers, fatty acid amides and phosphoric acid alkyl ether derivatives, for the purpose of warranting the stability of the formulations and inhibiting the formation of crystals. These formulations also generate micrometric-sized dispersions, and use fatty acid amides as solvents to formulate emulsionable concentrates. These products exhibit disadvantages related to the corrosion of rubber elements present in the spraying system; associated with the volatility of this type of solvent, which might cause problems to individuals that handle the same; and related to the possibility of bringing about phytotoxicity in the crops, which might entail loss of productivity.

The existing agrochemical formulations have particle sizes varying between 4 and 12 microns, and the typical particle size distribution thereof can be seen in Figure 1. The agronomical performance may be improved with the reduction of the effective size of these particles. They further entail problems associated to the clogging of filters and application nozzles arising fro the formation of crystals and/or lumps. One other aspect begging improvement is the reduction of phytotoxicity, a problem that is frequently correlated with a decrease in productivity of the crop.

The physical-chemical characteristics of the nanometric materials might provide a significant contribution towards improving the application performance. At nanometric sizes it is possible to increase the solubility of the active ingredient in water, consequently enhancing the effectiveness of the biocide used, in addition to the benefits of increased stability and longer useful life of these dispersions.

Objects of the invention

In light of what has been set forth above, a first object of the present invention consists in the provision of a solubilizing medium for biocide actives, capable of providing stable concentrates, and upon the dilution thereof in water, achieving a dispersion with a particle size distribution of less than 400 nm, and more specifically, with a mean particle size of the order of 180 nm.

According to the literature, the reduction of the particle size of the dispersion enhances the effect of the active ingredient, rendering possible a decrease of the application dosage, a lesser number of applications or an improved agronomical effectiveness.

One other object of the invention consists in the provision of a method for the preparation of these concentrates and their dispersions that may be able to afford an economy of the amount of power used in comparison with the processes known from the prior art.

One other object of the invention consists in the provision of a method able to be applied to biocides either in solid form or in liquid for at ambient temperature.

Description of the figures

The additional advantages and characteristics of the invention will become apparent from the description of the preferred embodiments thereof, given by way of example and not in any limitative sense, and of the figures to which such embodiments refer, wherein:

Fig. 1 is a graphic representation of the particle size distribution of dispersions of the tebuconazole prepared from formulations of emulsionable concentrates. Fig. 2 is a graphic representation of the particle size distribution of composition A, showing nanometric particles of approximately 180 nanometers using Tebuconazole as the active ingredient.

Fig. 3 is a graphic representation of the particle size distribution of the dispersion of composition B, showing nanometric particles of approximately 190 nanometers using Tebuconazole as the active ingredient.

Fig. 4 is a graphic representation of the particle size distribution of the dispersion of composition C, showing nanometric particles of approximately 190 nanometers using Tebuconazole as the active ingredient.

Fig. 5 is a graphic representation of the particle size distribution of the dispersion of composition D, showing nanometric particles of approximately 190 nanometers using Tebuconazole as the active ingredient.

Fig. 6 is a graphic representation of the particle size distribution of the dispersion of composition E, showing nanometric particles of approximately 190 nanometers using Flutriafol as the active ingredient.

Fig. 7 is a graphic comparison of the X-Ray Diffraction pattern of a solid sample of Tebuconazole (peaks 11, 12, 13 and 14) with that of Concentrate A of the set of examples (amorphous halo - curve 15).

Detailed description of the invention

The above listed objects, as well as others, are achieved by the invention by means of the provision of a solubilizing medium for the active ingredient, which enables the preparation of stable concentrates from simple mixing processes, with the optional use of heating to facilitate the process, which spontaneously generate the nanodispersions by simple dilution thereof in water for the preparation of agricultural defensive liquors in the field.

According to another characteristic of the invention, the solubilizing medium comprises at least one surfactant, optionally a water- soluble organic substance used as a carrier, and optionally water.

According to another characteristic of the invention, the concentration of the water soluble organic compound is comprehended within a range of concentration from zero to 80% w/w of the formulation, the total concentration of surfactants is comprised in a range of from 10 to 95% w/w of the formulation, the concentration of the active ingredient may be of up to 40% w/w of the total formulation. The use of water is also optional, and the same can be used up to the limit of 20% w/w of the formulation.

According to another characteristic of the invention, the water soluble organic substance or carrier, with optional presence in the solubilizing medium, comprises one or more of the compounds listed in the following: alkylene glycols, ethylene oxide and/or propylene oxide derivatives; polyethylene glycols and/or polypropylene glycols; glycol ethers, ethylene oxide and/or propylene oxide derivatives; glycerol; polyglycerol; alcohols comprising 3 to 14 carbon atoms, and their isomers, other polyhydroxylated compounds such as pentaerythritol, trimethylolpropane, neopentyl glycol, and dimethylformamide, among other possible compounds.

In a preferred embodiment, there is made use of the alkylene glycols, ethylene oxide and/or propylene oxide derivatives, the glycol ethers, ethylene oxide and/or propylene oxide derivatives, glycerin, or alcohols comprising from 3 to 14 carbon atoms and isomers thereof.

According to another characteristic of the invention, the surfactant present in the solubilizing medium may be comprised by one or more surfactants of the classes of anionic, cationic, non ionic, or amphoteric surfactants, or yet by polymeric surfactants.

The anionic surfactants for use in the present inventions may comprise: Dodecylbenzene sulfonic acid, in linear form or with branching in the hydrocarbon chain, either in acid form or in the form of its alkaline metal salts (sodium, potassium, etc.), alkali earth metals (calcium, magnesium, etc.), nitrogenated compounds (ammonium, monoethanolamine, diethanolamine, triethanolamine, etc.), among others; alkyl ether sulfate salts of alkaline metals (sodium, potassium, etc.), alkali earth metals (calcium, magnesium, etc.), nitrogenated compounds (ammonium, monoethanolamine, diethanolamine, triethanolamine, etc.), among others; sulfoccinates in the form of salts, carboxylated surfactants, for example soaps, also in the form of salts, phosphated surfactants, also in the form of salts; among others.

In the case of use of the alkyl ether sulfates or some salts of the dodecylbenzene sulfonic acid derivatives, it may be necessary to decrease the viscosity of the resulting concentrate, by means of addition of soluble ionic salts thereto, such as alkaline metal halides (NaCl, KCl, etc.). or yet, alkaline metal sulfates or permanganates.

In a preferred embodiment, there is used the dodecylbenzene sulfonic acid, in its linear form or with branching in the hydrocarbon chain, in acid form or in the form of its salts of sodium, ammonium, monoethanolamine, diethanolamine, triethanolamme, calcium, among others.

The non-ionic surfactants described in the present invention may be: alkoxylated, such as alkoxylated sorbitan esters, alkoxylated alcohols, alkoxylated vegetable oils, alkoxylated fatty acids, among others; fatty esters, such as polyethylene glycol esters, glycerol and/or polyglycerol esters, sorbitan esters; amides, such as fatty amides of ethanolamines or ethylene amines, fatty imidazolines, among others.

In a preferred embodiment, there are used: alkoxylated alcohols, such as 2-ethylhexanoic acid, capric, caprylic, isodecyl, isotridecyl, undecyl, lauryl, cetyl, stearyl, isostearyl, hydroxystearyl, oleyl, alkoxylated to an alkoxylation level of between 1 and 12 moles of ethylene and/or propylene oxides; alkoxylated vegetable oils, such as alkoxylated castor oil with degrees of alkoxylation of between 1 and 60 moles of ethylene oxide and/or propylene oxide; alkoxylated sorbitan esters, with degrees of alkoxylation of between 5 and 80 moles of ethylene oxide and/or propylene oxide.

The cationic surfactants of the present invention comprise, in a non- limitative list, the following substances: alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, alkyl hydroxyethyl dimethyl ammonium chloride, cetyl trimethyl ammonium chloride, esterquats, diestearyl dimethyl ammonium chloride, among others.

The pesticides of the composition according to the present invention are chemical, synthetic or natural extraction products that evidence fungicidal activity, herbicidal activity, activity as insecticides, nematicides and/or acaricides, or mixtures thereof, and are used in the control and/or prevention of weeds, diseases, pests and other vectors that compete with agricultural production.

In a preferred mode, the said pesticide is a fungicide, particularly a compound of the group of triazoles, more particularly tebuconazole, propiconazole, epoxyconazole, tetraconazole, metconazole, ciproconazole, amitrole, azaconazole, bitertanole, bromoconazole, difenoconazole, diniconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, paclobutrazole, penconazole, prothioconazole, simeconazole, triadimefon, triadimenol, triazamatoe and/or triticonazole.

Other classes of fungicides useful in the present invention are the benzoimidazoles, such as benomyl, carbendazim, Albendazole, thiabendazole, thiophanate-methyl and the strobirulines such as azoxystrobin, kresoxim-methyl, picoxystrobin, pyraclostrobin. According to the present invention, the active ingredient may be formulated in concentrations of up to 40% w/w in the concentrated product.

According to another characteristic of the present invention, the nanodispersions of the active substances comprised in the formulation are applicable in agricultural defensives, and in other applications such as for treatment of wood, treatment of seeds, pharmaceutical applications, paints, treatment of leathers and fabrics, among other possible applications.

The solubilizing medium of the present invention may comprise water in an amount of up to 20% of the concentrate.

According to another characteristic of the invention, the formation of the concentrate occurs spontaneously by the solubilization of the biocide under gentle stirring, which may be provided by simple mechanical stirring means, by recirculation systems, or by any other means used in industrial practice, and it is possible, although unnecessary, to use means of high-energy or shearing such as grinding mills, dispersing devices, sonification systems, etc.

For the preparation of the concentrate, there may be optionally used antifoaming additives, should there occur any excessive formation of foam.

According to another characteristic of the present invention, the function of the surfactants consists in: solubilizing the biocide in the concentrate, reducing the particle crystallization kinetics and avoiding the formation of crystals during the shelf storage time of the product; stabilizing the nanodispersion of the active ingredient upon dilution in water, further avoiding the crystallization and the remaining mechanisms of loss of stability such as formation of aggregates, flocculation, etc. The stabilization of the dispersion is essential for the homogeneity of the liquor during the application thereof and to avoid clogging the injection nozzles on spraying type application.

The main advantages evidenced by the dispersible concentrate and its aqueous nanodispersion are the following:

Greater stability of the biocide concentrate formulation, with no occurrence of crystallization, phase separation or degradation of the active ingredient, such characteristic implying a longer shelf time of the product;

Easy preparation of the concentrate, without requiring the use of expensive means and high consumption of energy;

Preparation of the nanodispersions at the time of application of the product in the field, by simple dilution of the biocide concentrate with water, without the need of resources of high energy and/or shear;

Potential improvement of agronomical effectiveness, due to increased bioavailability, resulting from the small dimensions of the particles obtained in the application liquor (simple dilution of the biocide concentrate in water);

Reduction of crystallization in the liquor, diminishing the problems of clogging and difficulty of application in the field;

Easier preparation of formulations combining different active ingredients, a difficulty usually noted in the conventional approaches used for obtainment of micro-dispersions, whereby the stability of the liquor is not easily achieved due to the difference of solubility and stability between the active ingredients.

Examples

For better understanding of the invention and in order to evidence the influence of the various components used, there are presented in the following, in table 1, several specific formulations intended for exemplary and not limitative purposes of obtainment of the dispersible concentrate.

Table 1 - Exemplary formulations of the dispersible concentrates.

Formulations A, B, C, D and E were prepared by adding the active ingredient to the dispersant mixture under gentle stirring and heating between 50° C and 100° C, with subsequent stirring for 20 minutes and cooling to ambient temperature. From the concentrates, the nanodispersions were prepared by means of the dilution thereof in water with hardnesses of 20 to 342 ppm of alkali earth metals, in concentrations of between 0.25 and 1.25% weight/volume.

The results observed for the concentrates A, B, C, D and E, and for the dispersions thereof, are described in Table 2 below, and the particle size distributions are in Figures 2 to 6, respectively.

Table 2 - Evaluation of the formulations of dispersible Concentrates and their aqueous dispersions.

(1) There is no precipitation, phase separation or appearance changes during the test.

(2) Presents a slightly bluish aspect, which is characteristic of the spreading of light of dispersions with particles smaller than 400 nm (wavelength limit of the visible spectrum). (3) Aspect identical to that of the immediate preparation, without any significant change of the particle size distribution.

The same experiments were conducted with regard to nanodispersions in water with hardness of 342 ppm, and the observations were identical with regard to aspect and particle size distribution.

The results evidence the feasibility of obtainment of the dispersible concentrates, and of the capacity thereof to generate stable nanodispersions with particle sizes of less than 400 nm.

The results of the tests having been conducted in respect of the stability of the concentrates and their nanodispersions validate the advantages described in connection with the obtainment of compositions exhibiting improved stability, longer shelf life (term of validity for use/consumption) for the concentrate, and a longer time for application of the nanodispersion liquor in the field.

The particle size distributions of examples A and C evidence the obtainment of nanodispersions with monomodal distribution, thereby evidencing the effectiveness of the invention to promote the reduction of the particle size of all active ingredient. This fact contributes to improve the stability of the nanodispersion.

The particle size distributions of examples B and D show the majority of the sample (-85%) in a peak with particle size of the order of 180 nm, and a small amount of the sample with a larger particle size, of micrometric scale. This fact, however, did not influence the stability of the nanodispersion within a period of 13 days.

The occurrence of solubilization of the active ingredient due to the combined action of the carriers and the surfactants may be noted in Figure 7, wherein are shown the results obtained by means of X-Ray Diffractometry

(XRD) for the solid tebuconazole and for the concentrate of the formulation A, obtained by means of the process according to the present invention.

Peaks 11, 12, 13, 14 are characteristic of a crystalline solid, in the present case, the tebuconazole. Curve 15 shows the existence of a great amorphous halo, indicating that the active ingredient is solubilized, without any presence of crystalline particles dispersed in the liquid.

Claims

1. Water dispersible agrochemical formulations which spontaneously generate nanodispersions by simple dilution thereof in water, under usual conditions for preparation of agricultural defensives in the field, characterized in that its preparation occurs from the solubilization of an active ingredient in a solubilizing medium which enables the preparation of stable concentrates of biocides from simple mixing processes, such processes being facilitated by the use of heating of from 50° C to 100° C during the solubilization and subsequent return to ambient temperature.

2. Water dispersible agrochemical formulations, as claimed in claim 1, characterized in that the solubilizing medium comprises at least 1 surfactant, and optionally the use of a water soluble organic compound and/or water.

3. Water dispersible agrochemical formulations, as claimed in claim 1, characterized in that the concentration ranges of the components in the final formulation of active ingredient concentrate are the following: total surfactants: 10 to 95% w/w of the composition water soluble organic compound: zero to 80% w/w of the composition • water: zero to 20% w/w of the composition active ingredient: up to 40% w/w of the composition

4. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2 or 3, characterized in that the water soluble organic compound comprises at least one of the following compounds: alkylene glycols, ethylene oxide and/or propylene oxide derivatives; polyethylene glycols and/or polypropylene glycols with molecular weight of up to 1500 Da; glycol ethers, ethylene oxide and/or propylene oxide derivatives; glycerol; polyglycerol; alcohols comprising 3 to 14 carbon atoms, in the form of any one of the isomers thereof; pentaerythritol; trimethylol propane; neopentyl glycol; and dimethyl formamide.

5. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2 or 3, characterized in that the water soluble organic compound comprises alkylene glycols, ethylene oxide and/or propylene oxide derivatives; glycol ethers, ethylene oxide and/or propylene oxide derivatives; glycerin, or alcohols comprising 3 to 14 carbon atoms and their isomers.

6. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2 or 3, characterized in that the water soluble organic compound comprises alkylene glycols, ethylene oxide derivatives, preferably monoethylene glycol, diethylene glycol, or triethylene glycol; and/or polyethylene glycols with molecular weight of up to 1500 Da.

7. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2 or 3, characterized in that the surfactants present in the solubilizing medium are selected from one or more surfactants of the anionic, cationic, non-ionic, or amphoteric surfactant classes.

8. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3 or 7, characterized in that the anionic surfactant present in the solubilizing medium is selected from: dodecylbenzene sulfonic acid, in its linear form or with branching in the hydrocarbon chain, in acid form or in the form of its salts of alkaline metals (sodium, potassium, etc.), alkali earth metals (calcium, magnesium, etc.), nitrogenated compounds (ammonium, monoethanolamine, diethanolamine, triethanolamine, etc.), sulfoccinates in the form of any of the various salts thereof; carboxylated surfactants, also in the form of the various salts thereof; and phosphated surfactants, also in the form of the various salts thereof.

9. Water dispersible agrochemical formulations, as claimed in any^¬ one of claims 1, 2, 3 or 7, characterized in that the anionic surfactant present in the solubilizing medium comprises: dodecylbenzene sulfonic acid, in its linear form or with branching in the hydrocarbon chain, in acid form or in the form of its salts of sodium, ammonium, monoethanolamine, diethanolamine, triethanolamine, and calcium.

10. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3 or 7, characterized in that the anionic surfactant present in the solubilizing medium comprises dodecylbenzene sulfonic acid, in its linear form, in acid form.

11. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3 or 7, characterized in that the non-ionic surfactant present in the solubilizing medium is selected from among: alkoxylated substances, such as alkoxylated sorbitan esters, alkoxylated alcohols, alkoxylated vegetable oils, alkoxylated fatty acids, among others; fatty esters, such as polyethylene glycol esters, glycerol and/or polyglycerol esters, sorbitan esters; amides, such as fatty amides of ethanolamines or ethylene amines, fatty imidazolines.

12. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3 or 7, characterized in that the non-ionic surfactant present in the solubilizing medium is selected from among: alkoxylated alcohols, such as 2-ethylhexanoic alcohol, capric alcohol, caprylic alcohol, isodecyl alcohol, isotridecyl alcohol, undecyl cetyl alcohol, stearyl alcohol, alkoxylated at alkoxylation degrees of between 1 and 12 moles of ethylene oxide and/or propylene oxide; alkoxylated vegetable oils, such as alkoxylated castor oils with alkoxylation degrees of between 1 and 60 moles of ethylene oxide and/or propylene oxide; alkoxylated sorbitan esters with alkoxylation degrees of between 5 and 80 moles of ethylene oxide and/or propylene oxide; and polyethylene glycol esters.

13. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3 or 7, characterized in that the non-ionic surfactant present in the solubilizing medium comprises: isodecyl alcohol with 3 moles of ethylene oxide, or sorbitan monooleate with 20 moles of ethylene oxide, or sorbitan monooleate with 80 moles of ethylene oxide, or ethoxylated castor oil with 54 moles of ethylene oxide, or polyethylene glycol diesterate with molecular weight between 4000 and 10000.

14. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, or 3, characterized in that the cationic surfactant present in the solubilizing medium is selected from among: alkyl trimethyl ammonium chloride, alkyl hydroxyethyl dimethyl ammonium chloride; cetyl trimethyl ammonium chloride, esterquats, diestearyl dimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, among others.

15. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, or 3, characterized in that the active ingredients are chemical, synthetic or natural extracted products that exhibit fungicidal, herbicidal, insecticidal, nematicidal and/or acaricidal activity, or mixtures thereof, used in the control and/or prevention of weeds, diseases, pests and other vectors that compete with agricultural production.

16. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, or 3, characterized in that the active ingredients are fungicides of the group of triazoles, more particularly tebuconazole, propiconazole, epoxyconazole, tetraconazole, metconazole, ciproconazole, amitrole, azaconazole, bitertanole, bromoconazole, difenoconazole, diniconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, paclobutrazole, penconazole, prothioconazole, simeconazole, triadimefon, triadimenol, triazamatoe and/or triticonazole.

17. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, or 3, characterized in that the active ingredients are fungicides of the group of benzimidazoles, more particularly benomyl, carbendazim, fuberidazole, thiabendazole and thiophanate-methyl

18. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, or 3, characterized in that the active ingredients are fungicides of the group of strobirulines, such as azoxystrobin, kresoxim-methyl, picoxystrobin or pyraclostrobin.

19. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3, 16, 17 or 18, characterized in that the active ingredients are used in the form of combinations between fungicides of the same family or of different families, whereby the agronomical effectiveness is enhanced by the synergistic effect of the combination of the various active ingredients.

20. Water dispersible agrochemical formulations, as claimed in any one of claims 1, 2, 3, 16, 17 or 18, characterized in that the formulations thereof with the active ingredients are applicable in agricultural defensives, and other fungicidal applications, such as wood treatment, seed treatment, pharmaceutical applications, paints, treatment of leathers and fabrics, among other possible applications.