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WO2009138999A3 - Process for the preparation of paroxetine hydrochloride - Google Patents

Process for the preparation of paroxetine hydrochloride Download PDF

Info

Publication number
WO2009138999A3
WO2009138999A3 PCT/IN2009/000269 IN2009000269W WO2009138999A3 WO 2009138999 A3 WO2009138999 A3 WO 2009138999A3 IN 2009000269 W IN2009000269 W IN 2009000269W WO 2009138999 A3 WO2009138999 A3 WO 2009138999A3
Authority
WO
WIPO (PCT)
Prior art keywords
paroxetine
paroxetine hydrochloride
preparation
hydrolysis
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000269
Other languages
French (fr)
Other versions
WO2009138999A2 (en
Inventor
Babu Rao Konudula
Saswata Lahiri
Govind Singh Rawat
Veera Narayana Bandlamudi
V. G. Phani Sharma
Debashish Datta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2009138999A2 publication Critical patent/WO2009138999A2/en
Anticipated expiration legal-status Critical
Publication of WO2009138999A3 publication Critical patent/WO2009138999A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to process for the preparation of Paroxetine hydrochloride, wherein Paroxetine-N-phenyl carbamate is isolated as a crystalline solid and further subjected to hydrolysis and converted into Paroxetine hydrochloride. According to our present invention N-methyl paroxetine is reacted with phenylchloroformate in the presence of base, solvent or optionally crystallizing in a solvent to give pure Paroxetine-N-phenyl carbamate. It is subjected to hydrolysis in the presence of base to give pharmaceutically acceptable paroxetine hydrochloride salt.
PCT/IN2009/000269 2008-05-06 2009-05-05 Process for the preparation of paroxetine hydrochloride Ceased WO2009138999A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1113CH2008 2008-05-06
IN1113/CHE/2008 2008-05-06

Publications (2)

Publication Number Publication Date
WO2009138999A2 WO2009138999A2 (en) 2009-11-19
WO2009138999A3 true WO2009138999A3 (en) 2011-05-26

Family

ID=41319135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000269 Ceased WO2009138999A2 (en) 2008-05-06 2009-05-05 Process for the preparation of paroxetine hydrochloride

Country Status (1)

Country Link
WO (1) WO2009138999A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015262A2 (en) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015262A2 (en) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine

Also Published As

Publication number Publication date
WO2009138999A2 (en) 2009-11-19

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