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WO2009137270A3 - Azetidine derivatives - Google Patents

Azetidine derivatives Download PDF

Info

Publication number
WO2009137270A3
WO2009137270A3 PCT/US2009/041343 US2009041343W WO2009137270A3 WO 2009137270 A3 WO2009137270 A3 WO 2009137270A3 US 2009041343 W US2009041343 W US 2009041343W WO 2009137270 A3 WO2009137270 A3 WO 2009137270A3
Authority
WO
WIPO (PCT)
Prior art keywords
azetidine derivatives
disorders
mch
metabolic
bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/041343
Other languages
French (fr)
Other versions
WO2009137270A2 (en
Inventor
Yu Jiang
Gil Ma
Kai Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of WO2009137270A2 publication Critical patent/WO2009137270A2/en
Publication of WO2009137270A3 publication Critical patent/WO2009137270A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to azetidine derivatives which bind to the MCH l receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of metabolic and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.
PCT/US2009/041343 2008-05-09 2009-04-22 Azetidine derivatives Ceased WO2009137270A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5183908P 2008-05-09 2008-05-09
US61/051,839 2008-05-09

Publications (2)

Publication Number Publication Date
WO2009137270A2 WO2009137270A2 (en) 2009-11-12
WO2009137270A3 true WO2009137270A3 (en) 2009-12-30

Family

ID=41265293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/041343 Ceased WO2009137270A2 (en) 2008-05-09 2009-04-22 Azetidine derivatives

Country Status (1)

Country Link
WO (1) WO2009137270A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013105676A1 (en) * 2012-01-12 2013-07-18 Takeda Pharmaceutical Company Limited Benzimidazole derivatives as mch receptor antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006010446A2 (en) * 2004-07-27 2006-02-02 7Tm Pharma A/S Medicinal use of receptor ligands
WO2006015279A1 (en) * 2004-07-28 2006-02-09 Neurogen Corporation Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders
WO2006044174A2 (en) * 2004-10-13 2006-04-27 Neurogen Corporation Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006010446A2 (en) * 2004-07-27 2006-02-02 7Tm Pharma A/S Medicinal use of receptor ligands
WO2006015279A1 (en) * 2004-07-28 2006-02-09 Neurogen Corporation Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders
WO2006044174A2 (en) * 2004-10-13 2006-04-27 Neurogen Corporation Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor

Also Published As

Publication number Publication date
WO2009137270A2 (en) 2009-11-12

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