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WO2009132928A3 - Marqueurs moléculaires pour le pronostic d'un cancer - Google Patents

Marqueurs moléculaires pour le pronostic d'un cancer Download PDF

Info

Publication number
WO2009132928A3
WO2009132928A3 PCT/EP2009/054034 EP2009054034W WO2009132928A3 WO 2009132928 A3 WO2009132928 A3 WO 2009132928A3 EP 2009054034 W EP2009054034 W EP 2009054034W WO 2009132928 A3 WO2009132928 A3 WO 2009132928A3
Authority
WO
WIPO (PCT)
Prior art keywords
high risk
risk
low risk
outcome
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/054034
Other languages
English (en)
Other versions
WO2009132928A2 (fr
Inventor
Udo Stropp
Christian VON TÖRNE
Mathias Gehrmann
Ralf Kronenwett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics GmbH Germany
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics GmbH Germany, Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics GmbH Germany
Publication of WO2009132928A2 publication Critical patent/WO2009132928A2/fr
Publication of WO2009132928A3 publication Critical patent/WO2009132928A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention porte sur un procédé d'identification d'un ensemble de gènes donnant des informations sur l'issue d'une maladie qui peuvent être combinées en un algorithme pour un test pronostique ou prédictif. L'algorithme fait usage de données d'expression génique provenant d'échantillons biologiques et définit si les patients ont un risque élevé ou un risque faible, par exemple chez des patients cancéreux, un groupe à issue favorable ou à issue défavorable de métastase. Des profils de référence d'expression génique sont obtenus pour les groupes à risque élevé et à faible risque, respectivement. Un échantillon d'un patient inconnu est analysé et classé comme appartenant au groupe à risque élevé ou à risque faible, respectivement, en fonction de la corrélation avec le profil de référence de risque élevé ou au profil de référence de risque faible.
PCT/EP2009/054034 2008-05-02 2009-04-03 Marqueurs moléculaires pour le pronostic d'un cancer Ceased WO2009132928A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08008371.0 2008-05-02
EP08008371 2008-05-02

Publications (2)

Publication Number Publication Date
WO2009132928A2 WO2009132928A2 (fr) 2009-11-05
WO2009132928A3 true WO2009132928A3 (fr) 2009-12-23

Family

ID=40875041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/054034 Ceased WO2009132928A2 (fr) 2008-05-02 2009-04-03 Marqueurs moléculaires pour le pronostic d'un cancer

Country Status (1)

Country Link
WO (1) WO2009132928A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2776751C (fr) * 2009-11-23 2019-07-02 Genomic Health, Inc. Procedes destines a predire l'issue clinique d'un cancer
FI20105252A0 (fi) 2010-03-12 2010-03-12 Medisapiens Oy Menetelmä, järjestely ja tietokoneohjelmatuote biologisen tai lääketieteellisen näytteen analysoimiseen
PT2553118E (pt) 2010-03-31 2014-12-17 Sividon Diagnostics Gmbh Método para previsão da recorrência de cancro da mama em tratamento endócrino
US9777334B2 (en) 2012-04-30 2017-10-03 The Research Foundation for State University of New York Cancer blood test using BC200 RNA isolated from peripheral blood for diagnosis and treatment of invasive breast cancer
EP2951317B1 (fr) 2013-02-01 2017-10-11 Sividon Diagnostics GmbH Procédé pour prédire le bénéfice de l'inclusion de taxane dans un régime de chimiothérapie chez des patients atteints d'un cancer du sein
EP3679160A4 (fr) 2017-09-08 2021-05-19 Myriad Genetics, Inc. Procédé d'utilisation de biomarqueurs et de variables cliniques pour prédire l'intérêt d'une chimiothérapie

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030158399A1 (en) * 1995-03-03 2003-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
WO2005033699A2 (fr) * 2003-10-03 2005-04-14 Ncc Technology Ventures Pte Limited Dispositifs et methodes destines a la classification du cancer du sein
WO2006136314A1 (fr) * 2005-06-23 2006-12-28 Siemens Medical Solutions Diagnostics Gmbh Particules magnetiques comportant une couche de silice fermee ultrafine, leur procede de production, et leur utilisation
WO2007030611A2 (fr) * 2005-09-09 2007-03-15 The Board Of Regents Of The University Of Texas System Indice calcule d'expression genomique de recepteurs des oestrogenes (er) et genes associes aux er

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030158399A1 (en) * 1995-03-03 2003-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
WO2005033699A2 (fr) * 2003-10-03 2005-04-14 Ncc Technology Ventures Pte Limited Dispositifs et methodes destines a la classification du cancer du sein
WO2006136314A1 (fr) * 2005-06-23 2006-12-28 Siemens Medical Solutions Diagnostics Gmbh Particules magnetiques comportant une couche de silice fermee ultrafine, leur procede de production, et leur utilisation
WO2007030611A2 (fr) * 2005-09-09 2007-03-15 The Board Of Regents Of The University Of Texas System Indice calcule d'expression genomique de recepteurs des oestrogenes (er) et genes associes aux er

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GLINSKY G V ET AL: "Classification of human breast cancer using gene expression profiling as a component of the survival predictor algorithm", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 7, 1 April 2004 (2004-04-01), pages 2272 - 2283, XP002309961, ISSN: 1078-0432 *
SORLIE T ET AL: "Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 19, 11 September 2001 (2001-09-11), pages 10869 - 10874, XP002215483, ISSN: 0027-8424 *
VEER VAN 'T L J ET AL: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 415, no. 6871, 31 January 2002 (2002-01-31), pages 530 - 536, XP002259781, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2009132928A2 (fr) 2009-11-05

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