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WO2009131698A3 - PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF - Google Patents

PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF Download PDF

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Publication number
WO2009131698A3
WO2009131698A3 PCT/US2009/002529 US2009002529W WO2009131698A3 WO 2009131698 A3 WO2009131698 A3 WO 2009131698A3 US 2009002529 W US2009002529 W US 2009002529W WO 2009131698 A3 WO2009131698 A3 WO 2009131698A3
Authority
WO
WIPO (PCT)
Prior art keywords
naglu
glucosaminidase
acetyl
alpha
phosphorylated recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/002529
Other languages
French (fr)
Other versions
WO2009131698A2 (en
Inventor
Norman Matthew Ellinwood
Rafi Simon Awedikian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iowa State University Research Foundation Inc ISURF
Original Assignee
Iowa State University Research Foundation Inc ISURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iowa State University Research Foundation Inc ISURF filed Critical Iowa State University Research Foundation Inc ISURF
Publication of WO2009131698A2 publication Critical patent/WO2009131698A2/en
Publication of WO2009131698A3 publication Critical patent/WO2009131698A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04045—N-Acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (3.1.4.45)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates generally to phosphorylated recombinant NaGIu fusion proteins, the production of phosphorylated recombinant NaGIu fusion proteins and uses thereof.
PCT/US2009/002529 2008-04-23 2009-04-23 PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF Ceased WO2009131698A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4736208P 2008-04-23 2008-04-23
US61/047,362 2008-04-23

Publications (2)

Publication Number Publication Date
WO2009131698A2 WO2009131698A2 (en) 2009-10-29
WO2009131698A3 true WO2009131698A3 (en) 2010-05-27

Family

ID=41217336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/002529 Ceased WO2009131698A2 (en) 2008-04-23 2009-04-23 PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF

Country Status (1)

Country Link
WO (1) WO2009131698A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA129740C2 (en) 2010-06-25 2025-07-23 Такеда Фармасьютікал Компані Лімітед USE OF A COMPOSITION CONTAINING ARYLSULPHATASE A (ASA) PROTEIN
EP2975134A3 (en) * 2010-07-22 2016-02-24 Shire Human Genetic Therapies, Inc. Crystal structure of human alpha-n-acetylglucosaminidase
RU2014117291A (en) * 2011-10-12 2015-11-20 Синаджева Биофарма Корп. NAGLU RECOMBINANT HUMAN PROTEIN AND ITS APPLICATION
WO2015035239A2 (en) * 2013-09-05 2015-03-12 University Of Washington Through Its Center For Commercialization Reagents and methods for screening mps i, ii, iiia, iiib, iva, vi, and vii
EP3160494B1 (en) * 2014-06-25 2019-11-20 Shire Human Genetic Therapies, Inc. Generation of mannose-6-phosphate containing recombinant alpha-n-acetyl glucosaminidase
KR20200104864A (en) * 2017-11-30 2020-09-04 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Gene therapy for mucopolysaccharide type IIIB
CA3169548A1 (en) * 2020-03-23 2021-09-30 Haiyan Fu Aav-naglu vectors for treatment of mucopolysaccharidosis iiib

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020019040A1 (en) * 2000-03-27 2002-02-14 Noteborn Mathieu Hubertus M. Apoptin-associating protein
US20030039643A1 (en) * 1995-11-23 2003-02-27 Hopwood John Joseph Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same
US20060198833A1 (en) * 2003-06-05 2006-09-07 The Salk Institute For Biological Studies Compositions and methods for targeting a polypeptide to the central nervous system
US20080014188A1 (en) * 2004-02-06 2008-01-17 Zankel Todd C Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039643A1 (en) * 1995-11-23 2003-02-27 Hopwood John Joseph Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same
US20020019040A1 (en) * 2000-03-27 2002-02-14 Noteborn Mathieu Hubertus M. Apoptin-associating protein
US20060198833A1 (en) * 2003-06-05 2006-09-07 The Salk Institute For Biological Studies Compositions and methods for targeting a polypeptide to the central nervous system
US20080014188A1 (en) * 2004-02-06 2008-01-17 Zankel Todd C Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof

Also Published As

Publication number Publication date
WO2009131698A2 (en) 2009-10-29

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