[go: up one dir, main page]

WO2009130708A3 - Préparation de duloxétine et de ses sels - Google Patents

Préparation de duloxétine et de ses sels Download PDF

Info

Publication number
WO2009130708A3
WO2009130708A3 PCT/IN2009/000028 IN2009000028W WO2009130708A3 WO 2009130708 A3 WO2009130708 A3 WO 2009130708A3 IN 2009000028 W IN2009000028 W IN 2009000028W WO 2009130708 A3 WO2009130708 A3 WO 2009130708A3
Authority
WO
WIPO (PCT)
Prior art keywords
duloxetine
salts
preparation
salt
fluoronapthalene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000028
Other languages
English (en)
Other versions
WO2009130708A2 (fr
Inventor
Thota Giridhar
Gudipati Srinivasulu
Kotaru Srinivasa Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHODHANA LABORATORIES Ltd
Original Assignee
SHODHANA LABORATORIES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHODHANA LABORATORIES Ltd filed Critical SHODHANA LABORATORIES Ltd
Publication of WO2009130708A2 publication Critical patent/WO2009130708A2/fr
Anticipated expiration legal-status Critical
Publication of WO2009130708A3 publication Critical patent/WO2009130708A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

La présente invention concerne un procédé de préparation de duloxétine et de ses sels comprenant la réaction de (S)-(+)-N,N-diméthyl-3-(2- thiényl)-3-hydroxypropanamine ou d'un de ses sels avec du 1-fluoronapthalène en présence d'hydrure de sodium et de 4-méthylbenzoate de potassium, la N-déméthylation par formation de phénylcarbamate pour obtenir la duloxétine, qui peut ensuite être convertie en un sel pharmaceutiquement acceptable.
PCT/IN2009/000028 2008-04-22 2009-01-09 Préparation de duloxétine et de ses sels Ceased WO2009130708A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN993CH2008 2008-04-22
IN993/CHE/2008 2008-04-22

Publications (2)

Publication Number Publication Date
WO2009130708A2 WO2009130708A2 (fr) 2009-10-29
WO2009130708A3 true WO2009130708A3 (fr) 2012-10-04

Family

ID=41217217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000028 Ceased WO2009130708A2 (fr) 2008-04-22 2009-01-09 Préparation de duloxétine et de ses sels

Country Status (1)

Country Link
WO (1) WO2009130708A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6182183B2 (ja) * 2015-07-07 2017-08-16 東和薬品株式会社 デュロキセチン塩基及びデュロキセチン塩酸塩の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
WO2004056795A1 (fr) * 2002-12-19 2004-07-08 Cipla Ltd Procede de preparation de la duloxetine et intermediaires destines a etre utilises dans ledit procede

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
WO2004056795A1 (fr) * 2002-12-19 2004-07-08 Cipla Ltd Procede de preparation de la duloxetine et intermediaires destines a etre utilises dans ledit procede

Also Published As

Publication number Publication date
WO2009130708A2 (fr) 2009-10-29

Similar Documents

Publication Publication Date Title
IL184189A0 (en) Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
IL259296B (en) Sodium salt of (r1,s2,r5)-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
MX2010005889A (es) Derivados de tiofeno como agonistas de s1p1/edg1.
PL2086354T3 (pl) Sposób wytwarzania kompozycji soli o niskiej zawartości sodu
WO2006122828A3 (fr) Solution d'injection d'arn
MX342440B (es) Derivados fluorados de aminotriazol.
WO2009117150A3 (fr) Méthode de traitement d’un lupus avec des dérivés de céramide
GEP20115343B (en) New method for preparing functionalised benzocyclo-butenes and its application to the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid
WO2009153461A3 (fr) Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro-2h-3- benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011009938A3 (fr) Stambomycine et dérivés, leur production et leur utilisation comme médicaments
IN2012DN00765A (fr)
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
PL2234595T3 (pl) Sposób zmniejszania tendencji soli glikopironiowej do agregacji podczas składowania
WO2007095200A3 (fr) nouveau processus pour la preparation de (S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE, un intermediaire de la duloxetine
WO2011119785A3 (fr) Procédé et composition pour une récupération améliorée du pétrole
WO2009130708A3 (fr) Préparation de duloxétine et de ses sels
WO2008077939A3 (fr) Composition à base de duloxétine
WO2010129406A3 (fr) Procédés de promotion de la croissance musculaire
WO2007123900A3 (fr) Procédé de préparation de (s)-(+)-n,n-diméthyl-3-(1-naphtalényloxy)-3-(2-thiényl)propanamine optiquement active
MX2008014606A (es) Confites congelados.
WO2012150607A3 (fr) Composition orale liquide comprenant du divalproex de sodium, et son procédé de préparation
IL191525A0 (en) Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)- 3-hydroxypropanamine, a duloxetine intermediate
WO2013062294A3 (fr) Procédé amélioré de préparation de calcium de mitiglinide
WO2011048612A3 (fr) Procédé d'élaboration d'aminoindanes propargylés y compris un sel pharmaceutiquement acceptable correspondant
HUP0600198A3 (en) Duloxetine salts for producing pharmaceutical compositions, their preparation, use and impurirites

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09733836

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09733836

Country of ref document: EP

Kind code of ref document: A2