WO2009128867A3 - Recombinant biologically contained filovirus - Google Patents
Recombinant biologically contained filovirus Download PDFInfo
- Publication number
- WO2009128867A3 WO2009128867A3 PCT/US2009/000056 US2009000056W WO2009128867A3 WO 2009128867 A3 WO2009128867 A3 WO 2009128867A3 US 2009000056 W US2009000056 W US 2009000056W WO 2009128867 A3 WO2009128867 A3 WO 2009128867A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- filovirus
- recombinant biologically
- biologically contained
- contained
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14151—Methods of production or purification of viral material
- C12N2760/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention provides recombinant biologically contained filovirus and methods of making and using those viruses.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1953208P | 2008-01-07 | 2008-01-07 | |
| US61/019,532 | 2008-01-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009128867A2 WO2009128867A2 (en) | 2009-10-22 |
| WO2009128867A3 true WO2009128867A3 (en) | 2010-03-25 |
Family
ID=41199612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2009/000056 Ceased WO2009128867A2 (en) | 2008-01-07 | 2009-01-07 | Recombinant biologically contained filovirus |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2009128867A2 (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11802273B2 (en) | 2014-06-20 | 2023-10-31 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US12076387B2 (en) | 2010-03-23 | 2024-09-03 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US12122807B2 (en) | 2019-05-01 | 2024-10-22 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US12144857B2 (en) | 2018-08-20 | 2024-11-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| US12251436B2 (en) | 2017-10-25 | 2025-03-18 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US12365880B2 (en) | 2020-01-24 | 2025-07-22 | The University Of Tokyo | Recombinant influenza viruses with stabilized NA |
| US12364748B2 (en) | 2016-02-19 | 2025-07-22 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| US12410409B2 (en) | 2011-08-26 | 2025-09-09 | Wisconsin Alumni Research Foundation (Warf) | Influenza viruses with mutant PB2 gene segment as live attenuated vaccines |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7211378B2 (en) * | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
| WO2010048615A2 (en) * | 2008-10-24 | 2010-04-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services, Center For Disease Control And Prevention | Human ebola virus species and compositions and methods thereof |
| CN106636014A (en) * | 2015-10-28 | 2017-05-10 | 中国科学院上海巴斯德研究所 | Novel in-vitro and in-vivo infection model based on Ebola virus-like particles |
| WO2017087550A1 (en) * | 2015-11-16 | 2017-05-26 | Georgia State University Research Foundation, Inc. | Tunable vaccine platform against pathogens of the paramyxovirus family |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030215794A1 (en) * | 2002-01-31 | 2003-11-20 | Yoshihiro Kawaoka | Filovirus vectors and noninfectious Filovirus-based particles |
-
2009
- 2009-01-07 WO PCT/US2009/000056 patent/WO2009128867A2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030215794A1 (en) * | 2002-01-31 | 2003-11-20 | Yoshihiro Kawaoka | Filovirus vectors and noninfectious Filovirus-based particles |
Non-Patent Citations (6)
| Title |
|---|
| ANONYMOUS: "Index of GLRCE: documents from 2007", GREAT LAKES REGIONAL CENTER OF EXCELLENCE INDEX, 2007, XP002563469, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/docs/2007/> [retrieved on 20100114] * |
| ENTERLEIN , SVEN: "Untersuchungen zur Replikation und Transkription von Marburg- und Ebolavirus", 2005, PHILIPPS-UNIVERSITÄT MARBURG, XP002563470 * |
| HALFMANN PETER ET AL: "Generation of biologically contained Ebola viruses.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 29 JAN 2008, vol. 105, no. 4, 29 January 2008 (2008-01-29), pages 1129 - 1133, XP002563467, ISSN: 1091-6490 * |
| HALFMANN PETER ET AL: "Replication-deficient ebolavirus as a vaccine candidate.", JOURNAL OF VIROLOGY APR 2009, vol. 83, no. 8, April 2009 (2009-04-01), pages 3810 - 3815, XP002563468, ISSN: 1098-5514 * |
| KAWAOKA Y.: "Prevention and Control of Ebola Virus Infection (Ongoing Research Support)", 2007 GREAT LAKES REGIONAL CENTER OF EXCELLENCE (GLRCE) ANNUAL MEETING SCHEDULE, 29 November 2007 (2007-11-29), XP002563466, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/annualmeeting/2007Agenda.pdf> [retrieved on 20100114] * |
| KAWAOKA Y: "Identification by siRNA of host proteins involved in Ebolavirus replication", GREAT LAKES REGIONAL CENTER OF EXCELLENCE FOR BIODEFENSE AND EMERGING INFECTIOUS DISEASES RESEARCH, 2007, pages 1 - 19, XP002563465, Retrieved from the Internet <URL:http://www.rcebiodefense.org/glrce/docs/2007/Kawaoka.pdf> [retrieved on 20100113] * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12076387B2 (en) | 2010-03-23 | 2024-09-03 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US12410409B2 (en) | 2011-08-26 | 2025-09-09 | Wisconsin Alumni Research Foundation (Warf) | Influenza viruses with mutant PB2 gene segment as live attenuated vaccines |
| US11802273B2 (en) | 2014-06-20 | 2023-10-31 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US12364748B2 (en) | 2016-02-19 | 2025-07-22 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| US12251436B2 (en) | 2017-10-25 | 2025-03-18 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US12144857B2 (en) | 2018-08-20 | 2024-11-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| US12258557B2 (en) | 2019-02-08 | 2025-03-25 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US12122807B2 (en) | 2019-05-01 | 2024-10-22 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US12365880B2 (en) | 2020-01-24 | 2025-07-22 | The University Of Tokyo | Recombinant influenza viruses with stabilized NA |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009128867A2 (en) | 2009-10-22 |
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