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WO2009128265A1 - Seringue - Google Patents

Seringue Download PDF

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Publication number
WO2009128265A1
WO2009128265A1 PCT/JP2009/001746 JP2009001746W WO2009128265A1 WO 2009128265 A1 WO2009128265 A1 WO 2009128265A1 JP 2009001746 W JP2009001746 W JP 2009001746W WO 2009128265 A1 WO2009128265 A1 WO 2009128265A1
Authority
WO
WIPO (PCT)
Prior art keywords
gasket
barrel
plunger
peripheral surface
annular protrusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/001746
Other languages
English (en)
Japanese (ja)
Inventor
村松康宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP2010508115A priority Critical patent/JP5459204B2/ja
Publication of WO2009128265A1 publication Critical patent/WO2009128265A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3106—Plugs for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod

Definitions

  • the present invention relates to a syringe provided with a barrel for injecting liquid, a plunger for pushing out the liquid injected into the barrel, and a gasket attached to the tip of the plunger.
  • Syringes are used to inject liquids such as chemicals into the body.
  • the syringe includes a barrel that injects liquid, a plunger that pushes out the liquid injected into the barrel, and a gasket that is attached to the tip of the plunger. Further, a male screw part for attaching the gasket is formed at the tip part of the plunger, and a female screw part screwed with the male screw part is engraved on the inner peripheral surface of the gasket.
  • the gasket is a member that is in sliding contact with the inner peripheral surface of the barrel, and is a member that requires smooth slidability and excellent liquid tightness or air tightness.
  • the sliding property of the gasket and the liquid-tightness or airtightness are closely related to the structure of the inner space in the first annular projection near the top surface of the gasket as a factor to increase or decrease the repulsive force of the gasket. .
  • Patent Document 1 a hard resin material used as a barrel material is applied to the gasket material, and a desired slidability is applied to the gasket by adjusting the outer diameter of the gasket and the thickness of the collar portion. In addition to liquid tightness or air tightness, chemical resistance is imparted.
  • Patent Document 2 discloses a configuration of a gasket in which a coating containing a slidability-imparting component and a flexibility-imparting component is formed on the outer peripheral surface of the gasket, and fine particles are provided on the surface of the coating to form a rough surface. Has been. And it is described that according to the gasket of such a structure, stable slidability can be obtained without applying a lubricant to the sliding surface of the gasket.
  • the conventional syringe has the following problems. For example, if the inner side of the first annular projection near the top surface of the gasket is formed of a solid body, the rubber repulsive force of the gasket becomes too large, and the sliding resistance increases and the desired slidability of the gasket is obtained. It will disappear. On the other hand, when a large space is formed by punching the inside of the first annular projection near the top surface of the gasket, the amount of deformation at the first annular projection of the gasket increases, and the desired liquid-tightness of the gasket is increased. Sex or airtightness cannot be obtained.
  • the present invention has been made on the basis of these points, and the object of the present invention is to achieve a smoother gasket than the current product by an extremely simple configuration in which the shape of the gasket and the shape of the tip of the plunger are partially modified.
  • An object of the present invention is to provide a syringe capable of obtaining excellent slidability and excellent liquid tightness or air tightness.
  • a syringe according to claim 1 of the present invention is a syringe provided with a barrel for injecting liquid, a plunger for pushing out the liquid injected into the barrel, and a gasket attached to the tip of the plunger.
  • the plunger has a male screw portion for attaching the gasket to the tip portion of the plunger, and a diameter that is the same as or smaller than the valley diameter of the male screw portion that contacts the inner wall surface of the top surface portion of the gasket and supports the gasket.
  • a female screw part that engages with the male screw part on the inner peripheral surface of the gasket, and the female screw that receives the support convex part on the top surface part.
  • a receiving recess having a diameter equal to or smaller than the inner diameter of the portion is provided, and the outer peripheral surface of the gasket is in sliding contact with the inner peripheral surface of the barrel at a position near the top surface portion. It is characterized in that the first annular projection is provided that.
  • the syringe according to claim 2 is characterized in that, in the syringe according to claim 1, the receiving recess is provided in an inner space of the gasket corresponding to a portion where the first annular protrusion is provided. It is what.
  • the syringe according to claim 3 is the syringe according to claim 1 or 2, wherein the outer peripheral surface of the gasket has a third annular protrusion that is in sliding contact with the inner peripheral surface of the barrel at a position on the hem side that is open.
  • a second annular protrusion is provided in an intermediate space between the third annular protrusion and the first annular protrusion so as to be in sliding contact with the inner peripheral surface of the barrel.
  • the syringe according to claim 4 is the syringe according to any one of claims 1 to 3, wherein the sliding contact surface of the first annular protrusion that is in sliding contact with the inner peripheral surface of the barrel has a width in the height direction of the gasket. It is characterized by being comprised by the curved-surface part which does not have.
  • the syringe according to claim 5 is the syringe according to any one of claims 1 to 3, wherein the sliding contact surface of the first annular protrusion that is in sliding contact with the inner peripheral surface of the barrel has a width in the height direction of the gasket. It is comprised by the straight body part which has this.
  • the syringe according to claim 6 is the syringe according to any one of claims 1 to 5, wherein a fitting portion is formed on a support convex portion of the plunger, and a protrusion is formed on an inner peripheral surface of the fitting portion. And a convex portion is formed in the receiving concave portion of the gasket, and a groove portion that engages with the protruding portion is provided in the convex portion.
  • the following actions are obtained by the above means.
  • the receiving concave portion having the same diameter as or smaller than the inner diameter of the female screw portion is provided on the top surface portion of the gasket, the desired gasket without increasing the rubber repulsion force of the gasket. Slidability can be secured.
  • the support convex portion provided at the distal end portion of the plunger is fitted in the receiving concave portion, the amount of deformation at the first annular projection of the gasket can be reduced, and the desired liquid tightness of the gasket. Moreover, airtightness can be obtained.
  • the receiving recess is provided in the inner space of the gasket corresponding to the portion where the first annular protrusion is provided, the amount of deformation in the reduced diameter direction of the first annular protrusion is effective. Therefore, the liquid-tightness or gas-tightness of the gasket can be improved. Further, in addition to the first annular protrusion, when the second annular protrusion and the third annular protrusion that are in sliding contact with the inner peripheral surface of the barrel are provided, the liquid-tightness or airtightness of the gasket is further improved. To do.
  • the sliding contact surface of the first annular protrusion is constituted by a curved surface portion having no width in the height direction of the gasket, the slidability of the gasket is improved. Further, when the sliding contact surface of the first annular protrusion is constituted by a straight body portion having a width in the height direction of the gasket, the liquid tightness or air tightness of the gasket is improved.
  • a fitting portion is formed on the support convex portion of the plunger, a protrusion is provided on the inner peripheral surface of the fitting portion, and a convex portion is formed in the receiving concave portion of the gasket,
  • the protrusion is provided with a groove that engages with the protrusion
  • the support convex portion receives the recessed portion.
  • the protrusion on the inner peripheral surface of the fitting portion gets over the flexible convex portion and is engaged with the groove to be in a fixed state. Therefore, loosening between the gasket and the plunger can be effectively prevented.
  • the gasket has a very simple configuration that only partially modifies the shape of the gasket and the tip of the plunger. Obtainable.
  • FIG. 1 is a side view showing a syringe of the present invention
  • FIG. 2 is a side view showing an enlarged gasket
  • FIG. 3 is a bottom view showing the gasket enlarged
  • FIG. 4 is the same as above
  • FIG. It is a sectional side view which expands and shows a part.
  • the syringe 1 of the present invention is used as an example by being attached to a continuous infusion device (not shown).
  • a continuous infusion device not shown
  • the liquid L takes about 5 hours. It is designed to be continuously injected into the body automatically.
  • the syringe 1 includes a barrel 3 that injects a liquid L, a plunger 5 that pushes out the liquid L injected into the barrel 3, and a gasket 9 that is attached to the tip 7 of the plunger 5.
  • the barrel 3 is a transparent cylindrical container member whose one end is closed, and is formed of a hard plastic material such as polypropylene or cyclic polyolefin as an example. On the other end of the barrel 3 that is opened, a finger hook 11 that protrudes outward in a flange shape is formed.
  • the finger-hanging part 11 is formed so as to protrude a lot in the vertical direction, and is configured so that a finger is hung on the protruding part.
  • a nozzle portion 15 having a diameter smaller than that of the peripheral body portion 13 of the barrel 3 is formed on one end face of the barrel 3 that is closed. Further, a plug 17 is attached to the nozzle portion 15 when not in use as shown in FIG. 1, and the opening 19 of the nozzle portion 15 is sealed.
  • the plunger 5 is formed of a rigid body such as a hard plastic material similar to the barrel 3.
  • the plunger 5 includes a rod 21 to be inserted into the peripheral body portion 13 of the barrel 3 and a disc-shaped pressing plate 25 as an example formed at the base end portion 23 of the rod 21.
  • the distal end portion 7 of the plunger 5 is provided with a male screw portion 27 for attaching the gasket 9 and a support convex portion 33 that contacts the inner wall surface 31 of the top surface portion 29 of the gasket 9 and supports the gasket 9. It has been.
  • the outer diameter D1 of the support protrusion 33 is smaller than the root diameter D2 of the male screw portion 27.
  • the gasket 9 is made of a flexible elastic material such as synthetic rubber.
  • the gasket 9 is a cap-shaped member with the top surface portion 29 closed, and the top surface portion 29 has an umbrella shape with a raised center.
  • a body 35 extending toward the plunger 5 is integrally formed on the periphery of the top surface 29.
  • a first annular protrusion 39 that is in sliding contact with the inner peripheral surface 14 of the peripheral barrel portion 13 of the barrel 3 is provided on the outer peripheral surface 37 of the barrel portion 35 at a position near the top surface portion 29.
  • the sliding contact surface of the first annular protrusion 39 is formed by a curved surface portion having no width B in the height direction H of the gasket 9.
  • the outer peripheral surface 37 of the barrel portion 35 is provided with a third annular protrusion 43 that is slidably in contact with the inner peripheral surface 14 of the peripheral barrel portion 13 of the barrel 3 at a position on the opened skirt portion 41 side.
  • a second annular protrusion 45 is provided at an intermediate position between the third annular protrusion 43 and the first annular protrusion 39 so as to be in sliding contact with the inner peripheral surface 14 of the peripheral body 13 of the barrel 3.
  • the sliding contact surface of the second annular protrusion 45 is formed by a curved surface portion having no width B in the height direction H of the gasket 9, similar to the sliding contact surface of the first annular protrusion 39.
  • the slidable contact surface of the annular protrusion 43 is constituted by a straight body portion having a width B in the height direction H of the gasket 9.
  • the top portions (peaks) of the first annular protrusion 39, the second annular protrusion 45, and the third annular protrusion 43 are defined as a first peak P1, a second peak P2, and a third peak P3.
  • the diameter of each peak is set to 20.6 mm.
  • drum 35 is set to 19.8 mm as an example, and the thickness of the trunk
  • a female screw portion 47 that is screwed with the male screw portion 27 provided at the distal end portion 7 of the plunger 5 is engraved on the inner peripheral surface of the trunk portion 35, and the top surface portion. 29 is provided with a receiving recess 49 having an inner diameter D5 that is smaller than the inner diameter D4 of the female thread portion 47 that receives the support convex portion 33.
  • the inner diameter D4 of the female screw portion 47 is set to 11.6 mm
  • the inner diameter D5 of the receiving recess 49 is set to 9.6 mm.
  • projections 51 having an oval shape in a bottom view are provided on the end surface of the body portion 35 on the skirt portion 41 side as an example at intervals of 90 °.
  • FIG. 6 is an enlarged side sectional view showing the current gasket and the tip of the plunger
  • FIG. 7 shows the pushing amount and sliding resistance value of the plungers of the current product, the invention product, and the comparative product in a state where no internal pressure is applied.
  • FIG. 8 is a graph showing the sliding resistance value for each peak
  • FIG. 9 is the plunger push-in amount and sliding resistance of the current product, the invention product, and the comparative product, with the internal pressure applied.
  • FIG. 10 is a comparison table showing the overall sliding resistance value and the sliding resistance value by peak.
  • Comparative test 1 (see FIGS. 7 and 8) In Comparative Test 1, the relationship between the plunger push-in amount and the sliding resistance value and the sliding resistance value for each peak were analyzed for three samples of the current product, the invention product, and the comparative product, and the analysis results were compared. Further, the syringe 100 according to the current product and the comparative product are both in the shape shown in FIG. 6, the diameter of the first peak P1 is 20.55 mm, the diameter of the second peak P2 is 20.35 mm, and the diameter of the third peak P3 is 20. 6 mm and the diameter D3 of the outer peripheral surface 37 of the body portion 35 is 19.4 mm.
  • the comparative product uses the barrel 3 made of the material a
  • the current product uses the barrel 3 made of the material b.
  • the barrel 3 made of material a is made of polypropylene and has an elastic modulus of 1350 MPa, a wall thickness of 0.95 mm, the inner diameter of the peripheral barrel 13 is 20.1 mm, and the barrel 3 of material b is made of cyclic polyolefin and has an elastic modulus of 3200 MPa and a wall thickness. 1.1 mm and the inner diameter of the circumferential barrel 13 is 20.1 mm.
  • a comparative test was conducted between the current product using the barrel 3 of the present invention, the invention according to the present embodiment shown in FIGS. 1 to 4 to which the barrel 3 of the material b was applied, and the comparative product using the barrel 3 of the material a. Carried out.
  • the relationship between the pushing amount of the plunger 5 and the sliding resistance value is as shown in FIG. 7, and there is a large difference between the current product using the barrel 3 made of the material b and the comparative product using the barrel 3 made of the material a. Although not seen, a significant improvement (decrease) in the sliding resistance value was confirmed in the invention using the barrel 3 of the material b.
  • the sliding resistance value of the current product using the barrel 3 of the material b is 25.1N
  • the sliding resistance value of the comparative product using the barrel 3 of the material a is 24.4N
  • the barrel 3 of the material b is used.
  • the sliding resistance value of the product of the invention was 17.4N.
  • the sliding resistance value for each peak of the first peak P1, the second peak P2, and the third peak P3 is as shown in FIG. 8, and the sliding resistance value for each peak is the same result as described above. was gotten. Accordingly, the sliding resistance of the gasket 9 is less influenced by the difference in the material of the barrel 3 and greatly changes depending on the difference in the shape of the gasket 9 and the tip 7 of the plunger 5, and the gasket 9 is devised by devising these shapes. It was found that the sliding resistance was reduced.
  • the sliding resistance value of the product according to the present embodiment is 17.4N as described above, clears the target value of 20N, and can contribute to further improvement of the slidability of the gasket 9. Was confirmed.
  • Comparative test 2 (see FIGS. 9 and 10)
  • the relationship between the pushing amount of the plunger 5 and the sliding resistance value is as shown in FIG. 9, and the current product using the barrel 3 made of the material b and the barrel 3 made of the material a are used as in the comparative test 1. Although no significant difference was observed in the comparative product, significant improvement (decrease) in the sliding resistance value was confirmed in the invention using the barrel 3 made of the material b.
  • the sliding resistance value of the current product using the barrel 3 of the material b is 29.8N
  • the sliding resistance value of the comparative product using the barrel 3 of the material a is 29.5N
  • the barrel 3 of the material b is used.
  • the sliding resistance value of the product of the invention was 25.3N.
  • the peak-specific sliding resistance values of the first peak P1, the second peak P2, and the third peak P3 are as shown in FIG. 10, and the peak-specific sliding resistance values are the same as described above.
  • a significant decrease in the sliding resistance value was confirmed particularly at the first peak P1 and the second peak P2. Therefore, as in the comparative test 1, the sliding resistance of the gasket 9 is less affected by the difference in the material of the barrel 3 and greatly changes depending on the difference in the shapes of the gasket 9 and the tip portion 7 of the plunger 5. It was confirmed that the invention according to the embodiment can contribute to further improvement of the slidability of the gasket 9.
  • Comparative test 3 (see FIG. 11) In the comparative test 3, the relationship between the displacement of the plunger 5 and the sliding resistance value when the two samples of the current product and the invention product were used for continuous injection by a pump was analyzed, and the analysis results were compared.
  • the relationship between the displacement of the plunger 5 and the sliding resistance value is as shown in FIG. 11, and since the current product is jagged (sawtooth change) with a large amplitude, the deformation of the peak of the sliding resistance value is large. On the other hand, it was confirmed that the deformation of the peak of the sliding resistance value was small because the invention product was jagged (sawtooth change) with a small amplitude.
  • the invention according to the present embodiment can obtain a smoother sliding characteristic due to the difference in slidability with respect to the awkward movement of the current product, and the gasket 9 can be made smoother. It has been confirmed that it can contribute to the improvement of slidability.
  • the gasket 9 is smoother than the current product and the comparative product with a very simple configuration that only partially changes the shape of the gasket 9 and the shape of the tip portion 7 of the plunger 5. Slidability and excellent liquid tightness or air tightness can be obtained.
  • the syringe 1 of this invention is not limited to the thing of the said embodiment, The design change within the summary of the invention is possible.
  • the gasket 9 may not necessarily include the first annular protrusion 39, the second annular protrusion 45, and the third annular protrusion 43. Accordingly, only the first annular protrusion 39 is provided, or two annular protrusions of the first annular protrusion 39 and the second annular protrusion 45 to the third annular protrusion 43 are provided, or The gasket 9 may be provided with four or more annular protrusions.
  • the inner diameter D5 of the receiving recess 49 is not limited to that of the above embodiment, and various changes can be made. An example is shown in FIG.
  • FIG. 5 is a side sectional view showing another embodiment in which the shape of the first annular protrusion of the gasket is different from the diameter of the second annular protrusion. That is, in the embodiment shown in FIG. 5, the first annular projection 39 of the gasket 9 is different from the embodiment shown in FIGS. 1 to 4, and the sliding contact surface of the first annular projection 39 is different from that of the gasket 9. It is constituted by a straight body portion having a width B in the height direction H. In the embodiment shown in FIG. 5, the diameter of the second annular protrusion 45 of the gasket 9 is set to 20.3 mm, which is smaller than the diameter 20.6 mm of the first annular protrusion 39.
  • the syringe 1A using the gasket 9 having such a configuration also has the desired slidability, liquid-tightness or air-tightness of the gasket 9 as in the syringe 1 shown in FIGS. Due to the presence of the straight body portion provided on the first annular protrusion 39, the structure is more excellent in liquid tightness or air tightness than the syringe 1 shown in FIGS.
  • the outer diameter of the support convex portion may be the same as the valley diameter of the male screw portion, and a receiving concave portion having the same inner diameter as the inner diameter of the female screw portion may be formed.
  • Other configurations are the same as those in the above embodiment, and the description thereof is omitted. According to the said structure, since the receiving recessed part same as the internal diameter of an internal thread part is provided in the top
  • the support convex portion provided at the tip of the plunger is fitted into the receiving concave portion, the amount of deformation at the first annular projection of the gasket can be reduced, and the desired liquid tightness of the gasket can be achieved. Moreover, airtightness can be obtained. Therefore, as in the case of the above-described embodiment, the smooth slidability of the gasket that exceeds the current product and the comparative product by an extremely simple configuration that only modifies the shape of the gasket and the shape of the tip of the plunger, Excellent liquid tightness or air tightness can be obtained.
  • a fitting portion 53 is formed on the support convex portion 33 of the plunger 5
  • a projection 55 is provided on the inner peripheral surface of the fitting portion 53
  • a convex portion 57 is formed at 49, and a groove portion 59 that engages with the protruding portion 55 is provided at the convex portion 57.
  • Other configurations are the same as those in the above embodiment, and the description thereof is omitted.
  • the syringe 1B using the gasket 9 having such a configuration also has the desired slidability, liquid-tightness or air-tightness of the gasket 9 in the same manner as the syringe 1 shown in FIGS.
  • the function of preventing loosening between the gasket 9 and the plunger 5 due to vibration during production or transportation can be exhibited.
  • the present invention can be used in the manufacture and field of use of a syringe including a barrel for injecting liquid, a plunger for pushing out the liquid injected into the barrel, and a gasket attached to the tip of the plunger. It has applicability when it is desired to improve the mobility and improve the liquid tightness or air tightness.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Sealing Devices (AREA)

Abstract

L'invention concerne une seringue présentant une structure extrêmement simple permettant à un joint de coulisser doucement, ainsi que d'excellentes étanchéité et herméticité. Cette seringue (1) comprend un cylindre (3) dans lequel est placé un liquide (L), un piston (5) servant à évacuer le liquide (L) placé dans le cylindre (3) et un joint (9) monté sur l'extrémité avant (7) du piston (5). Cette extrémité avant (7) du piston (5) comporte un filet mâle (27) sur lequel est monté le joint (9) et un élément saillant de support (33) présentant un diamètre inférieur au diamètre à fond de filet (D2) du filet mâle (27) en contact avec une surface de paroi interne (31) de la partie surface supérieure (29) du joint (9) pour soutenir ce dernier (9). Un filet femelle (47) venant en contact avec le filet mâle (27) est formé dans la surface périphérique interne du joint (9). Un renfoncement de réception (49) présentant un diamètre inférieur au diamètre interne (D4) du filet femelle (47) et recevant l'élément saillant de support (33) est formé dans la partie surface supérieure (29). Un premier élément saillant annulaire (39) en contact coulissant avec la surface périphérique interne (14) du cylindre (3) est disposé à l'emplacement de la surface périphérique externe (37) du joint (9) qui se trouve à proximité de la partie surface supérieure (29).
PCT/JP2009/001746 2008-04-16 2009-04-15 Seringue Ceased WO2009128265A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010508115A JP5459204B2 (ja) 2008-04-16 2009-04-15 シリンジ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008-106952 2008-04-16
JP2008106952 2008-04-16

Publications (1)

Publication Number Publication Date
WO2009128265A1 true WO2009128265A1 (fr) 2009-10-22

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PCT/JP2009/001746 Ceased WO2009128265A1 (fr) 2008-04-16 2009-04-15 Seringue

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WO (1) WO2009128265A1 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011115446A (ja) * 2009-12-04 2011-06-16 Jms Co Ltd プランジャーロッドとガスケットとの結合構造
USD665904S1 (en) 2010-05-14 2012-08-21 Taisei Kako Co., Ltd. Plunger rod for a medical syringe
WO2012134430A1 (fr) * 2011-03-25 2012-10-04 West Pharmaceutical Services, Inc. Tige de piston de seringue pharmaceutique
WO2014163645A1 (fr) * 2013-04-05 2014-10-09 West Pharmaceutical Services, Inc. Piston de seringue pharmaceutique
WO2014196056A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Seringue et seringue pré-remplie
WO2014194918A1 (fr) * 2013-06-05 2014-12-11 Mediject Aps Piston destiné à être utilisé dans une seringue de rapport dimensionnel spécifique d'une structure d'étanchéité
WO2014196057A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Instrument pour injection, et ampoule-seringue
WO2015012206A1 (fr) * 2013-07-22 2015-01-29 ニプロ株式会社 Joint, et piston plongeur, seringue, et seringue préremplie les utilisant
EP2957310A1 (fr) * 2014-06-18 2015-12-23 Sumitomo Rubber Industries, Ltd. Joint destiné à être utilisé pour une seringue médicale et une telle seringue
EP2980458A1 (fr) * 2014-07-31 2016-02-03 Sumitomo Rubber Industries, Ltd. Joint
EP3006069A1 (fr) * 2014-10-10 2016-04-13 Sumitomo Rubber Industries, Ltd. Joint d'étanchéité pour seringue préremplie
US20170296752A1 (en) * 2016-04-15 2017-10-19 Sumitomo Rubber Industries, Ltd. Gasket, and medical syringe
EP3281661A1 (fr) * 2016-08-08 2018-02-14 Sumitomo Rubber Industries, Ltd. Joint
CN108245743A (zh) * 2016-12-28 2018-07-06 住友橡胶工业株式会社 医疗用注射器
JP2018158179A (ja) * 2018-07-12 2018-10-11 テルモ株式会社 注射器およびプレフィルドシリンジ
JP2020108858A (ja) * 2018-07-12 2020-07-16 テルモ株式会社 注射器およびプレフィルドシリンジ
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
US11577326B2 (en) * 2019-06-25 2023-02-14 Kennametal Inc. Sealing piston for a hydraulic expansion chucking device and expansion chucking device
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000300670A (ja) * 1999-04-26 2000-10-31 Fukoku Co Ltd ディスポーサブル注射器用シリンジガスケットおよびその製造方法
JP2006167110A (ja) * 2004-12-15 2006-06-29 Terumo Corp 医療用具
JP2007289677A (ja) * 2006-03-28 2007-11-08 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000300670A (ja) * 1999-04-26 2000-10-31 Fukoku Co Ltd ディスポーサブル注射器用シリンジガスケットおよびその製造方法
JP2006167110A (ja) * 2004-12-15 2006-06-29 Terumo Corp 医療用具
JP2007289677A (ja) * 2006-03-28 2007-11-08 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011115446A (ja) * 2009-12-04 2011-06-16 Jms Co Ltd プランジャーロッドとガスケットとの結合構造
USD665904S1 (en) 2010-05-14 2012-08-21 Taisei Kako Co., Ltd. Plunger rod for a medical syringe
WO2012134430A1 (fr) * 2011-03-25 2012-10-04 West Pharmaceutical Services, Inc. Tige de piston de seringue pharmaceutique
US10258744B2 (en) 2013-04-05 2019-04-16 West Pharmaceutical Services, Inc. Pharmaceutical syringe piston
US11607498B2 (en) 2013-04-05 2023-03-21 West Pharmaceutical Services, Inc. Pharmaceutical syringe piston
US11369742B2 (en) 2013-04-05 2022-06-28 West Pharmaceutical Services, Inc. Pharmaceutical syringe piston
WO2014163645A1 (fr) * 2013-04-05 2014-10-09 West Pharmaceutical Services, Inc. Piston de seringue pharmaceutique
US11951289B2 (en) 2013-04-05 2024-04-09 West Pharmaceutical Services, Inc. Pharmaceutical syringe piston
AU2014277300B2 (en) * 2013-06-05 2018-12-13 Injecto Group A/S Piston for use a syringe with specific dimensional ratio of a sealing structure
WO2014194918A1 (fr) * 2013-06-05 2014-12-11 Mediject Aps Piston destiné à être utilisé dans une seringue de rapport dimensionnel spécifique d'une structure d'étanchéité
US10569030B2 (en) 2013-06-05 2020-02-25 Injecto A/S Piston for use as a syringe with specific dimensional ratio of a sealing structure
CN105324143B (zh) * 2013-06-05 2020-05-15 因杰科托集团公司 用于注射筒的具有密封结构的特定尺寸比例的活塞
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US9675764B2 (en) 2013-06-05 2017-06-13 Injecto A/S Piston for use a syringe with specific dimensional ratio of a sealing structure
CN105324143A (zh) * 2013-06-05 2016-02-10 因杰科托公司 用于注射筒的具有密封结构的特定尺寸比例的活塞
US11045606B2 (en) 2013-06-06 2021-06-29 Terumo Kabushikikaisha Syringe and prefilled syringe
US10279115B2 (en) 2013-06-06 2019-05-07 Terumo Kabushiki Kaisha Syringe and prefilled syringe
EP3006066A4 (fr) * 2013-06-06 2016-12-14 Terumo Corp Instrument pour injection, et ampoule-seringue
JPWO2014196057A1 (ja) * 2013-06-06 2017-02-23 テルモ株式会社 注射器およびプレフィルドシリンジ
JPWO2014196056A1 (ja) * 2013-06-06 2017-02-23 テルモ株式会社 注射器およびプレフィルドシリンジ
WO2014196056A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Seringue et seringue pré-remplie
US10137250B2 (en) 2013-06-06 2018-11-27 Terumo Kabushiki Kaisha Syringe and prefilled syringe
WO2014196057A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Instrument pour injection, et ampoule-seringue
WO2015012206A1 (fr) * 2013-07-22 2015-01-29 ニプロ株式会社 Joint, et piston plongeur, seringue, et seringue préremplie les utilisant
EP2957310A1 (fr) * 2014-06-18 2015-12-23 Sumitomo Rubber Industries, Ltd. Joint destiné à être utilisé pour une seringue médicale et une telle seringue
JP2016033401A (ja) * 2014-07-31 2016-03-10 住友ゴム工業株式会社 ガスケット
EP2980458A1 (fr) * 2014-07-31 2016-02-03 Sumitomo Rubber Industries, Ltd. Joint
US10088050B2 (en) 2014-07-31 2018-10-02 Sumitomo Rubber Industries, Ltd. Gasket
US20160033042A1 (en) * 2014-07-31 2016-02-04 Sumitomo Rubber Industries, Ltd. Gasket
EP3006069A1 (fr) * 2014-10-10 2016-04-13 Sumitomo Rubber Industries, Ltd. Joint d'étanchéité pour seringue préremplie
JP2016077354A (ja) * 2014-10-10 2016-05-16 住友ゴム工業株式会社 プレフィルドシリンジ用ガスケット
US20160101239A1 (en) * 2014-10-10 2016-04-14 Sumitomo Rubber Industries, Ltd. Gasket for prefilled syringe
CN105500561A (zh) * 2014-10-10 2016-04-20 住友橡胶工业株式会社 预装注射器用垫片
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
JP2021102171A (ja) * 2016-04-15 2021-07-15 住友ゴム工業株式会社 ガスケットおよび医療用注射器
US20170296752A1 (en) * 2016-04-15 2017-10-19 Sumitomo Rubber Industries, Ltd. Gasket, and medical syringe
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US10751473B2 (en) * 2016-04-15 2020-08-25 Sumitomo Rubber Industries, Ltd. Gasket, and medical syringe
CN107297002A (zh) * 2016-04-15 2017-10-27 住友橡胶工业株式会社 垫片以及医疗用注射器
CN107698712B (zh) * 2016-08-08 2022-01-21 住友橡胶工业株式会社 密封垫
EP3281661A1 (fr) * 2016-08-08 2018-02-14 Sumitomo Rubber Industries, Ltd. Joint
JP2018023467A (ja) * 2016-08-08 2018-02-15 住友ゴム工業株式会社 ガスケット
CN107698712A (zh) * 2016-08-08 2018-02-16 住友橡胶工业株式会社 密封垫
US10232120B2 (en) * 2016-08-08 2019-03-19 Sumitomo Rubber Industries, Ltd. Gasket
CN108245743B (zh) * 2016-12-28 2021-12-21 住友橡胶工业株式会社 医疗用注射器
CN108245743A (zh) * 2016-12-28 2018-07-06 住友橡胶工业株式会社 医疗用注射器
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
US12226613B2 (en) 2017-05-05 2025-02-18 Regeneron Pharmaceuticals, Inc. Auto-injector and related methods of use
JP2018158179A (ja) * 2018-07-12 2018-10-11 テルモ株式会社 注射器およびプレフィルドシリンジ
JP2020108858A (ja) * 2018-07-12 2020-07-16 テルモ株式会社 注射器およびプレフィルドシリンジ
US11577326B2 (en) * 2019-06-25 2023-02-14 Kennametal Inc. Sealing piston for a hydraulic expansion chucking device and expansion chucking device
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

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