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WO2009126866A3 - Delta-tocotrienol as a radioprotective countermeasure agent - Google Patents

Delta-tocotrienol as a radioprotective countermeasure agent Download PDF

Info

Publication number
WO2009126866A3
WO2009126866A3 PCT/US2009/040173 US2009040173W WO2009126866A3 WO 2009126866 A3 WO2009126866 A3 WO 2009126866A3 US 2009040173 W US2009040173 W US 2009040173W WO 2009126866 A3 WO2009126866 A3 WO 2009126866A3
Authority
WO
WIPO (PCT)
Prior art keywords
tocotrienol
delta
radioprotective
radiation
countermeasure agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/040173
Other languages
French (fr)
Other versions
WO2009126866A2 (en
Inventor
Venkataraman Srinivasan
John A. Hyatt
Andreas Papas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YASOO Health Inc
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
YASOO Health Inc
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YASOO Health Inc, Henry M Jackson Foundation for Advancedment of Military Medicine Inc filed Critical YASOO Health Inc
Publication of WO2009126866A2 publication Critical patent/WO2009126866A2/en
Publication of WO2009126866A3 publication Critical patent/WO2009126866A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides compositions comprising delta-tocotrienol, and derivatives thereof, that are effective for protection against radiation-induced injury and radiation-induced mortality. Also provided are methods of using these compositions for protecting the body from radiation-induced injury and radiation-induced mortality.
PCT/US2009/040173 2008-04-10 2009-04-10 Delta-tocotrienol as a radioprotective countermeasure agent Ceased WO2009126866A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4397208P 2008-04-10 2008-04-10
US61/043,972 2008-04-10

Publications (2)

Publication Number Publication Date
WO2009126866A2 WO2009126866A2 (en) 2009-10-15
WO2009126866A3 true WO2009126866A3 (en) 2010-01-14

Family

ID=41162635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/040173 Ceased WO2009126866A2 (en) 2008-04-10 2009-04-10 Delta-tocotrienol as a radioprotective countermeasure agent

Country Status (1)

Country Link
WO (1) WO2009126866A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10039722B2 (en) 2008-10-14 2018-08-07 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013344817B2 (en) * 2012-11-13 2015-09-17 Invictus Biotechnology Pty Ltd Transmucosal delivery of tocotrienol
CA2924126C (en) 2013-09-13 2023-05-02 The Board Of Trustees Of The University Of Arkansas Preparation and use of a composition for prevention and mitigation of the effects of radiation
US20160324914A1 (en) 2015-05-05 2016-11-10 Tocol Pharmaceuticals, Llc Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
CN113521030B (en) * 2020-04-13 2023-03-28 中国医学科学院放射医学研究所 ROS (reactive oxygen species) -sensitive polyethylene glycol-polyester copolymer nano drug delivery system and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452507A1 (en) * 1989-11-08 1991-10-23 Nippon Hypox Laboratories Incorporated Medicine comprising tocopheryl glycoside as active ingredient
US20060247306A1 (en) * 2003-02-14 2006-11-02 Kumar K S Radiation protection by gamma-tocotrienol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0452507A1 (en) * 1989-11-08 1991-10-23 Nippon Hypox Laboratories Incorporated Medicine comprising tocopheryl glycoside as active ingredient
US20060247306A1 (en) * 2003-02-14 2006-11-02 Kumar K S Radiation protection by gamma-tocotrienol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AKAHO ET AL.: "Preparation and In Vivo Evaluation of a Water-Soluble Prodrug for 2R-gamma- Tocotrienol and as a Two-Step Prodrug for 2,7,8-Trimethyl-2S- (beta-carboxyethyl) -6- hydroxychroman (S-gamma-CEHC) in Rat.", DRUG METABOLISM AND DISPOSITION., vol. 35, no. 9, September 2007 (2007-09-01), pages 1503 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10039722B2 (en) 2008-10-14 2018-08-07 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells

Also Published As

Publication number Publication date
WO2009126866A2 (en) 2009-10-15

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