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WO2009121567A2 - Dispositif et procédé de dosage exact de liquides - Google Patents

Dispositif et procédé de dosage exact de liquides Download PDF

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Publication number
WO2009121567A2
WO2009121567A2 PCT/EP2009/002350 EP2009002350W WO2009121567A2 WO 2009121567 A2 WO2009121567 A2 WO 2009121567A2 EP 2009002350 W EP2009002350 W EP 2009002350W WO 2009121567 A2 WO2009121567 A2 WO 2009121567A2
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WO
WIPO (PCT)
Prior art keywords
liquid
metering tube
metered
read
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/002350
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German (de)
English (en)
Other versions
WO2009121567A3 (fr
Inventor
Frank Bartels
Markus Rawert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bartels Mikrotechnik GmbH
Original Assignee
Bartels Mikrotechnik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bartels Mikrotechnik GmbH filed Critical Bartels Mikrotechnik GmbH
Publication of WO2009121567A2 publication Critical patent/WO2009121567A2/fr
Publication of WO2009121567A3 publication Critical patent/WO2009121567A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems

Definitions

  • the present invention relates to an apparatus and method for precise metering, and more particularly to the removal and subsequent release of a predetermined amount of a fluid.
  • the present invention also relates to an apparatus and method for accurately metering liquids, which liquids may have different viscosities, temperatures, densities and the like, without adversely affecting the dosage accuracy achievable with the invention.
  • the dosing of liquids plays a decisive role in a large number of technical fields. For example, when joining components, it is important to apply a precisely metered amount of adhesive since the strength of the bond will be optimal in the case of too little or too much applied adhesive. This problem is compounded in the case of multicomponent adhesives, in which the mixing ratio of the individual components is precisely determined and must therefore be observed.
  • Another field of application in which the exact dosing of liquids is of the utmost importance is represented by the life sciences (English: “Lifesciences"). Since it is often necessary to handle small and very small amounts of liquid, this results in particularly low tolerated tolerances in the application, mixing, or extracting liquids or liquid mixtures.
  • a first example of an automated microdosing device is disclosed, for example, in the patent DE 101 53 708 B4.
  • This microdosing device comprises a nozzle body with a cavity in which a fluid to be dosed is present.
  • the dosing operation is carried out by means of a displacement body which is attached to an actuator.
  • This displacement body reduces the volume in the interior of the cavity, so that the fluid to be metered displaced from this and discharged from a nozzle.
  • the accuracy with which the fluid to be dispensed is dispensed from the nozzle depends largely on the accuracy with which the corresponding actuator can be controlled.
  • a device of the type shown is not suitable for the continuous dispensing of larger or any desired quantities of liquids to be dispensed.
  • the invention proposes first of all to estimate the liquid temperature and thus to determine a correction with which the control signal given on a metering pump is supplemented, so that the metering pump generates identical quantities of liquid on the basis of identical setting value input signals independently of the metering pump
  • Liquid temperature supplies require always to have information about the liquid temperature available. It also disregards that in a dosage of different liquids also each have different correction factors must be present, which are incidentally previously, for example by means of appropriate experiments, to determine.
  • a particular difficulty is to be able to meter a plurality of liquids by means of one and the same device or using one and the same method in succession, if these liquids with respect to important parameters (temperature, density, viscosity, surface tension) from each other differ.
  • One way to address this problem is to accurately analyze all liquids to be dosed with a particular device in advance and to place the doses that can be achieved under certain standard conditions into a corresponding (electronic) table. During the actual dosing process, these standard values can then be taken from the corresponding table and fed to a control device.
  • this approach only leads to success if every one of the possible liquids to be pumped is properly detected in advance.
  • the devices shown above are also only partially suitable for integration into corresponding, very low volumes available systems, since the space occupied by them is sometimes considerable.
  • the invention should be suitable for precisely metering liquids which may have different viscosities, temperatures, densities and the like, without adversely affecting the accuracy of the dosage achievable with the invention.
  • the invention should provide reliable and reproducible results as independent as possible of the liquid to be dispensed, its parameters, as well as the amount to be dispensed.
  • the effort for calibration of the device according to the invention when dosing a new liquid should be kept to a minimum.
  • the device according to the invention and the method according to the invention should also be independent of environmental parameters, such as pressure or temperature, insofar as a corresponding readjustment with the least possible effort and in an automated manner is possible.
  • the possibility should be given, quasi-continuously a virtually unlimited amount of liquid high Promote precisely dosed.
  • the measurement of the delivery rate of the liquid to be dispensed should be done without contact, but at the same time with the simplest possible and thus cost-effective means and without loss of time.
  • the device according to the invention should offer good possibilities for space-saving integration, in particular in miniaturized metering systems.
  • the device according to the invention serves the exact dosing of liquids, in particular a sequential plurality of liquids, which differ by their liquid parameters.
  • the device according to the invention comprises at least the following essential elements:
  • a pumping device a metering tube of known geometry; a detector for determining the fluid level.
  • the pumping device is arranged so that the liquid to be metered can be conveyed through the metering tube.
  • the pumping device may preferably be a micropump, and more preferably a piezo-driven micromembrane pump.
  • the micropump may be constructed so as to allow unidirectional or bidirectional conveyance, for example by means of a diaphragm and corresponding valves.
  • the metering tube is designed such that its geometry is known very precisely. This means that in particular the inner cross section or the inner diameter of the metering tube is exactly predetermined. According to the invention is also the distance between at least two predetermined positions exactly determinable along the longitudinal extent of the metering tube. Particularly preferably, the metering tube has the same cross section in its interior over its entire longitudinal extent. It advantageously has a cylindrical cross-section, but it can also be designed differently, for example, square.
  • the detector is arranged such that the position of a liquid front of the liquid to be metered can be detected at at least one read-out point of the metering tube.
  • the detector makes it possible to determine a position of the liquid front in the interior of the detector tube.
  • the detector merely enables the detection of the presence of the liquid front at one or more predetermined locations located along the length of the metering tube.
  • this further comprises at least one valve, wherein at least one valve is arranged so that the flow of liquid flowing through the metering tube is interrupted so that when closing the valve, the existing liquid volume in the metering tube not by adding further liquid can be increased. Accordingly, and because the volume of the metering tube is known in particular between the valve and the at least one read-out location, there is thus a precisely determined volume of liquid in the relevant part of the metering tube, which can then be metered.
  • an external connection can be added, which is preferably connected to a gas and more preferably to the ambient air.
  • the pumping device is arranged downstream of the valve, so that it can be conveyed with it optionally to metered liquid or an external medium.
  • the medium flowing through the external connection which may be advantageous, in particular, gas
  • the pumping device is arranged downstream of the valve, since the volume of the pumping device is not variable and, accordingly, can easily be added to the volume of the metering tube or of the section between the valve and the at least one read-out point.
  • the first embodiment of the device according to the invention described so far is based on the exact determinability of a volume, which is first completely filled with a liquid to be metered and then also completely emptied.
  • a suitable mechanism may be provided which allows to move the detector of the determination of the liquid front at least one and advantageously two or more predetermined locations axially to the metering tube, so that a device for adjustment and calibration of the predetermined volume of the liquid to be dispensed is provided.
  • a device is described according to an advantageous second embodiment of the present invention, which is designed such that in addition the time is determined, which requires the liquid front of the liquid to be metered when passing through the metering tube to cover a precisely known distance.
  • the inventively provided known geometry is therefore also given in the following examples.
  • this further comprises a time measuring device.
  • the time is determined, which requires the liquid front of a funded through the metering, to be metered liquid to a predetermined
  • this optical detector comprises a light source, which is preferably a white light emitter. It further comprises at least one illumination fiber for transmitting the light to the metering tube and a detector fiber for returning the light from the metering tube, as well as means for collecting the light.
  • the light source according to the invention is arranged so that the light can be introduced into a first end of the illumination fiber.
  • the illumination fiber in turn is arranged so that a second end thereof is in optical communication with a first end of the detector fiber.
  • Optical connection in this context means that a change in the light which emerges from the second end of the illumination fiber simultaneously leads to a change in the light which is radiated into the first end of the detector fiber
  • bonding may preferably be accomplished by aligning the fiber axes of the second end of the illumination fiber and the first end of the detector fiber substantially coaxially.
  • the metering tube is inventively arranged so that this optical connection can be influenced depending on the filling of the metering tube. According to a particularly preferred embodiment, therefore, the metering tube is arranged in the beam path of the optical connection, so that a change in the transparency of the metering tube leads to a change in the optical connection.
  • the optical connection is influenced without the dosing tube being arranged in the beam path.
  • Such influencing can be effected in particular by electrical and / or electronic aids, such as conductivity sensors on the inner wall of the metering tube in connection with, for example, electrically adjustable mirrors, which are located in the optical path of the optical connection.
  • a point at which the metering tube interacts with an optical connection is also referred to below as the readout point.
  • the metering tube particularly preferably has the same cross-section in its interior over its entire longitudinal extent, it may also be particularly preferred if the metering tube interacts with the respective optical connection at precisely those points where it generally interacts with a read-out point is arranged, has a cross-section, which further improves the accuracy of a detection of the liquid front. This can be done, for example, by reducing the cross-section at the corresponding points in comparison to the rest of the metering tube, so that the liquid flowing through the metering tube passes the corresponding read-out point faster.
  • the means for collecting the light is arranged so that the light from a second end of the detector fiber in the means for collecting the colored light can be irradiated.
  • the means for collecting the light is therefore the light, which is passed from the light source through the illumination fiber on the readout point (s) and the detector fiber, for example, in its intensity and / or wavelength detectable.
  • the optical detector also comprises color filters for the decomposition of, for example, white light into colored components, which are then separately detectable by the means for capturing the light.
  • This embodiment is advantageous if the position of the liquid front is to be detectable at two (or more) spaced locations (readout points) of the metering tube. Such a detection would initially mean that in each case two illumination fibers and two detector fibers would have to be present, each of which a combination of the same would be assigned to a corresponding readout.
  • the arrangement according to the invention of different color filters, which are assigned to the corresponding read-out points and influence the corresponding optical connection, can be used to precisely determine which read-out location supplies a specific signal to the detector, even when the individual detector fibers are brought together behind the dosing tube a single detector fiber can pass a plurality of different wavelengths side by side without interfering with each other.
  • the illumination fiber and / or the detector fiber of the optical detector each consist of a main fiber, which in parts can be divided into several individual fibers, and the areas of divided Einzelfasem are each arranged on the metering tube that the optical Connection of the individual fibers of both main fibers can be influenced by the filling of the metering tube, and possibly existing color filters are arranged so that they are in the region of the divided individual fibers.
  • the number of leading away from the lighting or to the detector leading individual fibers can be advantageously minimized, resulting in particular advantages in terms of the volume and / or the manufacturing cost and complexity of the device.
  • this comprises a plurality of read-out points and associated detector fibers, wherein at least the detector fiber and particularly preferably the illumination fiber, as described above, is divided into individual fibers in the region of the dosing tube.
  • the device does not have color filters or similar aids that allow discrimination of the signals generated by the individual readout sites.
  • the device for capturing the light "knows" that the liquid front passes through a read-out point, but not which of the read-out points has been passed, such an arrangement can also be used for exact dispensing by means of a variation of the method according to the invention, as described below.
  • the above-described detector according to the invention of the second embodiment of the present invention can also be provided in the first embodiment of the present invention, wherein also in the first and in the second embodiment, a suitable mechanism may be provided which allows to displace the detector of liquid front detection at least one and advantageously two or more predetermined locations axially to the metering tube so as to provide a means for adjusting and calibrating the predetermined volume of liquid to be dispensed.
  • the pumping device is present as a bidirectionally conveying pumping device and consists of two counter-rotating, unidirectionally conveying pumps. These individual, each unidirectionally conveying pumps can be arranged in series or parallel in the fluid flow, each allowing an oppositely directed promotion of the liquid to be dispensed.
  • the provision of two unidirectional pumps has the advantage that the failure of one of the two pumps can be more cost effectively remedied since a single unidirectional pump is usually less expensive than a more complex bidirectional pump.
  • unidirectionally conveying pumps are arranged in series.
  • the detector is arranged so that the position of the liquid front of the liquid to be metered at three readout points of the dosing tube is detectable.
  • the measurement method it becomes possible to have the measurement method to be described later not only on one route, namely, between the first and second readout points, but also on a second one Comparative route, namely between the second and the third readout to perform.
  • a comparison value can be obtained, which must be approximately identical to the first value during normal operation of the device. A deviation of the two values from each other, however, indicates a malfunction.
  • the liquid flow is interrupted by a valve and instead replaced by an external fluid to provide several separate metering volumes, for example by spaced differently spaced readout points, and / or by different Internal cross sections of the dosing tube between the individual readout points.
  • a different metering volume determined by the geometric boundary conditions can be selected.
  • the closing level of the valve can also be regarded as a first read-out point, between which a precisely determinable volume is provided according to the invention in conjunction with at least one further read-out point.
  • this also comprises a drive unit.
  • This drive unit includes inputs for signals of the time measuring device (if present) and the detector, and an input device for setting the desired dosage, for example by an operator, and also an output unit for controlling the pumping device, and a computing device for determining the driving time for the pumping device.
  • Preferred as such a drive unit is a commercially available
  • Personal computer which is equipped with the appropriate interfaces used. However, the corresponding functions are particularly preferably combined in a housing of small construction volume.
  • the device comprises a reservoir and / or a metering vessel, wherein the reservoir holds the liquid to be metered ready, which is then discharged by means of the device according to the invention in the metering vessel.
  • the metering vessel also be placed on a weighing device, so that the mass of the amount of liquid delivered into the dosing can be controlled.
  • the invention also provides a method for the exact dosing of liquids, which is particularly preferably carried out using the abovementioned devices according to the invention.
  • the inventive method is based on the fact that the direct determination of a variable volume or a flow rate may be complicated, the determination of a fixed volume and possibly the time required for a liquid front to go through a predetermined distance, however, very simple and exactly possible.
  • both variants of the method according to the invention are described, namely both a first embodiment, according to which only an exactly determinable volume must be present, and a second embodiment, according to which additionally a time measurement must be carried out.
  • the method according to the invention accordingly comprises the following steps:
  • the metered (metered) volume of liquid is pushed out of the metering tube. If the external fluid and the liquid to be metered are immiscible, an exact metering of the liquid can take place in this way.
  • external fluid in particular gas, such as particularly preferably air or inert gas
  • FIG. 3 The above-described first embodiment of the method according to the invention is shown schematically in FIG. 3, which will be understood by those skilled in the art in conjunction with FIG. 1 and the foregoing without further description, it being understood that the steps of the above process Any number of times are repeatable, so that a known amount of liquid can be delivered
  • a suitable mechanism can be provided, which allows the detector of the determination of the liquid front at least one and advantageously two or more predetermined locations to move axially to the metering tube, so that a method for adjustment and calibration of the predetermined volume of the liquid to be dispensed is feasible.
  • the method according to the invention therefore comprises the following steps, the pump device preferably being a bidirectionally conveying pump device:
  • the predetermining of the amount of a liquid to be metered, which is specified in step (a), can be carried out, for example, by means of an input device which can be assigned to a drive unit. In case of a continuous
  • step (h) in which the delivery rate of the liquid is determined very accurately. Since the geometry of the metering tube is known exactly, and also the distance between the first and the second
  • Reading point is known exactly, the corresponding volume between the two readout points can also be determined exactly.
  • the delivery rate can be determined from the time and the volume. The determination of the delivery rate is very easy and fast in this way.
  • the delivery rate can, in principle, be repeated before each metering operation.
  • step (i), (j) it is very easy according to the invention to precisely determine the appropriate time required for conveying the liquid to be metered through the remainder of the metering tube (step (i), (j)). Likewise, with the new delivery rate from reaching the output of the metering tube exactly that amount can be output that was also desired and specified.
  • Liquid front during the steps (b) to (f) from the end facing away from the exit is conveyed to the end at which the output is and never arrive two signals simultaneously, since the read-out points are spaced from each other first signal to be uniquely assigned to the first read-out station, etc.
  • the liquid front is placed at or before the first read-out point before starting a new dosing or calibration process (see below). This can be done, for example, by conveying the liquid for a sufficiently long time until it can safely be assumed that it has passed the first read-out point.
  • the counter can also be used in a return feed, in order to correctly assign the corresponding signals or the disappearance of the same when emptying the metering tube at the corresponding readout point.
  • the method according to the invention can be supplemented with particular preference by the following steps, which counteract dripping of the liquid to be metered, which is frequently encountered in the prior art, from the outlet of a metering tube:
  • the liquid is withdrawn into the metering tube, for which purpose the bidirectionally conveying Pumping device is used in the return.
  • the process of remindfördems stops just in the moment in which the liquid front of the withdrawn to be dosed liquid passes the second read-out. This ensures that the exact position of the liquid front is known, so that the following dosing process can begin with a defined initial state.
  • liquid front is located in the region between the first and the second read-out location, and if its position changes due to a temperature or other change in the volume of the liquid (for example due to unintentional pumping of the pumping device), it is ensured in any case before the next dosing process Liquid front is first promoted to the second readout point and thus to a defined location. It should be noted, however, that with a change in the volume of the fluid, the delivery rate may also change, and therefore, depending on the specific reason for the volume change, it is advantageous to repeat a complete calibration procedure as described below.
  • the liquid to be metered is returned in the direction away from the exit for calibration until the liquid front reaches or slightly exceeds the first read-out point, and then the steps (b ) to (h) so as to obtain the current delivery rate.
  • This sequence of steps thus serves a repetition of the time measurement, which requires the liquid to be metered during its promotion by means of the pumping device to from the first to the second Reading point to be promoted forward. Since the remaining parameters necessary for calculating the delivery rate (geometry of the metering tube) have not changed, the delivery rate can be recalculated based on the renewed time measurement and, if necessary, compared with the old, already calculated delivery rate. In the event of a deviation then the corresponding new value for the delivery rate must be used for further dosing.
  • this offers the possibility, during the calibration of the not only one, but two paths, which are respectively limited by the corresponding read-out points, to the time and thus to
  • the liquid level or the position of the liquid front can be detected at three readout points of the metering tube. It is also necessary that after first performing steps (b) to (h) they are repeated, but the steps are not performed between the first read-out location and the second read-out location, but between the second read-out location and the third read-out location that a second delivery rate can be calculated.
  • liquids can be used independently of their parameters, such as viscosity, density or temperature, as well as the amount to be metered Quantity be reliably and reproducibly dosed. Due to the simple calibration of the device according to the invention, the metering process is virtually independent of ambient parameters such as pressure or temperature. The device also allows quasi-continuously metering a virtually unlimited amount of liquid with high precision or with a very precisely adjusted delivery rate. Since the device comprises no moving parts for measuring the delivery rate except for the pumping device, this results in a special robustness of the entire device. Due to the good miniaturization of the detector principle, the device according to the invention is particularly suitable for use in correspondingly miniaturized systems, as used for example in the life sciences.
  • Figure 1 shows a first embodiment of the inventive device 1 for exact dosing in a schematic view.
  • Figure 2 shows a second embodiment of the inventive device 1 for exact dosing in a schematic view.
  • Figure 3 shows a first embodiment of the method according to the invention for exact dosing in a view as a flow chart.
  • Figure 4 shows a second embodiment of the method according to the invention for exact dosing in a view as a flow chart.
  • FIG. 1 shows a schematic representation of a first embodiment of the inventive device 1 for exact dosing in a schematic view.
  • a pumping device 2 conveys a liquid F to be dispensed from a reservoir 20.
  • the pumping device 2 consists in the illustrated example of a unidirectionally conveying pump 2 * .
  • the liquid to be metered F is replaced by a unspecified tubular device promoted in a metering tube 3.
  • the geometry of the metering tube 3 is exactly predetermined. In particular, the inner cross section or inner diameter and the length of the metering tube 3 is exactly known so that the corresponding volume in the interior of the metering tube 3 can be calculated.
  • the liquid F is limited during its passage through the metering tube at its front end by a corresponding liquid front 7, which is located in the illustrated example just before the first read-8. In a (not shown) Rothiquen the liquid F leaves this outlet 3 1 of the metering tube 3 and drips into a metering vessel 21 into it.
  • Fig. 1 also shows a schematic representation of a first embodiment of a detector 4 according to the invention, which is designed as an electrical detector.
  • This consists essentially of two projecting into the interior of the metering electrical conductors, which are shown in Fig. 1 by small arrows. At the same time, these arrows indicate the only read-out point 8 present in FIG. 1.
  • a voltage source U is connected to one of the electrical conductors, and the other is connected to a drive unit 19. As soon as the liquid front 7 passes the read-out point 8, the electrical resistance changes there and thus the voltage applied there. This change can be detected by means of the drive unit 19 and thus serves to determine the position of the liquid front 7 according to the invention.
  • the drive unit 19 also comprises an input device 19 ', which is used to specify the device 1 according to the invention the desired amount of the liquid F to be metered.
  • the drive unit 19 is connected to the pump device 2 by means of a further signal line (dash-dotted thin line).
  • Fig. 2 shows a schematic representation of a second further embodiment of the inventive device 1 for exact dosing.
  • a bi-directionally conveying pumping device 2 conveys a liquid F to be dispensed from a reservoir 20.
  • the bidirectionally conveying pumping device 2 is in the illustrated example composed of two unidirectionally conveying pumps 2 '. These can be particularly advantageous in a common Enclosed housing, which is indicated by the framed dashed line.
  • the liquid to be metered F is conveyed through a pipe-type device, not specified, into a metering tube 3.
  • the geometry of the metering tube 3 is exactly predetermined. In particular, the inner cross section or inner diameter and the length of the metering tube 3, as well as the distance between the different readout points 8, 8 ', 8 "exactly predetermined so that the corresponding part volume can be calculated in the interior of the metering tube 3.
  • the liquid F is limited during its passage through the metering tube at its front end by a corresponding liquid front 7, which in the example shown between the second read-out 8 1 and the third
  • Fig. 2 also shows another embodiment of a detector 4 according to the invention, which is designed as an optical detector 4 '.
  • the optical detector 4 ' initially comprises a light source 9. This emits, for example, white light in an illumination fiber 10, the first end 10A of the light source 9 faces.
  • the illumination fiber 10 is divided into three individual fibers 15. Each of these three individual fibers 15 is in each case brought with its second end 10B to the metering tube 3, but each at a different point thereof, so that three spaced readout points 8, 8 ', 8 "result. (For reasons of clarity, only one the three existing second ends 10B of the individual fibers 15 of the illumination fiber 10 provided with the corresponding reference numeral.)
  • the metering tube 3 On the opposite side of the metering tube 3 are also three individual fibers 15, which can each receive the light emerging from the metering tube 3 with a first end 11A. The individual fibers 15 are then combined to form a common main fiber 14. Since this fiber composite serves to transmit the light in the direction of a device for collecting the light 13, it is also referred to as detector fiber 11. The light from the detector fiber 11 leaves it from its second end 11 B.
  • the embodiment of the present embodiment of the device according to the invention shown in Figure 2 also shows three color filters 12, which are arranged between the respective second end of the illumination fiber 10B and the respective first end of the detector fiber 11A.
  • these three color filters 12 each filter different wavelengths from the irradiated light, so that the originally white light, which is irradiated into the illumination fiber 10, is divided into three beams of different frequencies. These three different frequencies are collected beyond the metering tube 3 by the detector fiber 11 and summarized in the main fiber 14.
  • FIG. 2 also shows that the individual fibers 15 of the illumination fiber 10 and the detector fiber 11 are aligned so as to form an optical path 18 which can be influenced both by the color filters 12 and the metering tube 3.
  • This optical path 18 is symbolized by a bold dotted line in the area of the three readout points 8, 8 ', 8 "shown in Figure 2.
  • the means 13 for collecting the light has the capability of detecting the three from a second end 11A the detector fiber 11 emerging light beams of different frequencies to detect separately.
  • the means for collecting the light 13 is connected by a signal line, which is shown in the figure 2 by means of a thin dotted line, with a time measuring device 5, so this came in particular provide a start or stop signal.
  • the time measuring device 5 is in turn linked to a drive unit 19.
  • the drive unit 19 also comprises an input device 19 ', which is used to specify the device 1 according to the invention the desired amount of the liquid F to be metered.
  • the drive unit 19 is connected by means of a further signal line to the bidirectionally conveying pump device 2.
  • a computing device with which the arithmetic operations necessary for carrying out the method according to the invention can be carried out.
  • the detector 4,4 ' according to the second embodiment of the present invention may also be advantageously provided in the first embodiment of the present invention. It will also be understood that in the first and second embodiments of the present invention, an appropriate mechanism for displacing and positioning the detector 4, 4 'described in the drawings for clarity may be provided for adjusting the predetermined metering volume.
  • Fig. 3 shows a first embodiment of the method according to the invention for exact dosing in a view as a flow chart which will become clear to the person skilled in the art from the above description.
  • Fig. 4 shows a schematic representation of the particularly advantageous second embodiment of the method according to the invention for exact dosing in a view as a flow chart.
  • the bidirectionally conveying pump device is switched on, and the delivery of the liquid to be metered from a reservoir begins.
  • a detector detects the presence of the liquid front of the liquid to be metered and transported at a first read-out location. As soon as the detector has detected the liquid front, it starts a time measuring device. Meanwhile, the pumping device remains switched on, and the liquid to be dispensed is conveyed further in the direction of the outlet of the metering tube. The detector now detects the presence of the liquid front at a second read-out location. As soon as the detector has detected the liquid front at the second read-out location, it stops the time-measuring device and the pump device.
  • the delivery rate can now be determined in conjunction with the delivery time, which was measured by the time measuring device.

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  • Chemical Kinetics & Catalysis (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne le dosage exact de liquides pouvant présenter différentes viscosités, températures, densités etc., sans que la précision du dosage n'en soit affectée. Le dispositif selon l'invention comporte au moins les éléments essentiels suivants: un dispositif de pompage (2) à effet bidirectionnel; un tube de dosage (3) de géométrie connue; et un détecteur optique (4) pour déterminer le niveau de liquide. Le dispositif de pompage (2) est disposé de telle manière que le liquide à doser (F) peut être transporté à travers le tube de dosage (3), et le détecteur optique (4) est disposé de telle manière que la position du front (7) de liquide à doser (F) peut être détectée sur au moins deux points de détection (8, 8') du tube de dosage (3). L'invention concerne également un procédé de dosage exact de liquides, de préférence mis en oeuvre au moyen du dispositif selon l'invention.
PCT/EP2009/002350 2008-03-31 2009-03-31 Dispositif et procédé de dosage exact de liquides Ceased WO2009121567A2 (fr)

Applications Claiming Priority (2)

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DE200810016513 DE102008016513B4 (de) 2008-03-31 2008-03-31 Vorrichtung und Verfahren zum exakten Dosieren von Flüssigkeiten
DE102008016513.1 2008-03-31

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WO2009121567A2 true WO2009121567A2 (fr) 2009-10-08
WO2009121567A3 WO2009121567A3 (fr) 2010-02-18

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US9034634B2 (en) 2010-12-03 2015-05-19 Abbott Point Of Care Inc. Sample metering device and assay device with integrated sample dilution
US9050595B2 (en) 2010-12-03 2015-06-09 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
US9052309B2 (en) 2010-12-03 2015-06-09 Abbott Point Of Care Inc. Ratiometric immunoassay method and blood testing device
CN105716680A (zh) * 2014-12-17 2016-06-29 恩德莱斯和豪瑟尔测量及调节技术分析仪表两合公司 用于确定表示液体量的值的设备以及其应用

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US9052309B2 (en) 2010-12-03 2015-06-09 Abbott Point Of Care Inc. Ratiometric immunoassay method and blood testing device
US9061283B2 (en) 2010-12-03 2015-06-23 Abbott Point Of Care Inc. Sample metering device and assay device with integrated sample dilution
US10058867B2 (en) 2010-12-03 2018-08-28 Abbott Point Of Care Inc. Sample metering device and assay device with integrated sample dilution
US9034634B2 (en) 2010-12-03 2015-05-19 Abbott Point Of Care Inc. Sample metering device and assay device with integrated sample dilution
US9766232B2 (en) 2010-12-03 2017-09-19 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
WO2012075256A3 (fr) * 2010-12-03 2012-07-19 Abbott Point Of Care Inc. Dispositif doseur d'échantillon et dispositif d'analyse comportant la dilution intégrée de l'échantillon
US9778271B2 (en) 2010-12-03 2017-10-03 Abbott Point Of Care Inc. Ratiometric immunoassay method and blood testing device
US9841396B2 (en) 2010-12-03 2017-12-12 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
US9846152B2 (en) 2010-12-03 2017-12-19 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
US9903875B2 (en) 2010-12-03 2018-02-27 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
US9933422B2 (en) 2010-12-03 2018-04-03 Abbott Point Of Care Inc. Assay devices with integrated sample dilution and dilution verification and methods of using same
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CN105716680A (zh) * 2014-12-17 2016-06-29 恩德莱斯和豪瑟尔测量及调节技术分析仪表两合公司 用于确定表示液体量的值的设备以及其应用

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Publication number Publication date
DE102008016513B4 (de) 2012-12-20
DE102008016513A1 (de) 2009-10-15
WO2009121567A3 (fr) 2010-02-18

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