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WO2009119971A3 - 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한 바이오칩 - Google Patents

생리활성물질을 전기적으로 검출하는 방법 및 이를 위한 바이오칩 Download PDF

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Publication number
WO2009119971A3
WO2009119971A3 PCT/KR2009/000285 KR2009000285W WO2009119971A3 WO 2009119971 A3 WO2009119971 A3 WO 2009119971A3 KR 2009000285 W KR2009000285 W KR 2009000285W WO 2009119971 A3 WO2009119971 A3 WO 2009119971A3
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reaction
active materials
physiologically active
biochip
same
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French (fr)
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WO2009119971A2 (ko
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이재훈
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Digital Genomics Inc
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Digital Genomics Inc
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Priority to JP2010549557A priority Critical patent/JP5371061B2/ja
Priority to EP09724909A priority patent/EP2273263B1/en
Priority to US12/922,934 priority patent/US8354307B2/en
Priority to CN2009801108754A priority patent/CN101981445B/zh
Publication of WO2009119971A2 publication Critical patent/WO2009119971A2/ko
Publication of WO2009119971A3 publication Critical patent/WO2009119971A3/ko
Anticipated expiration legal-status Critical
Priority to US13/708,236 priority patent/US9005545B2/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

본 발명은 생리활성물질의 생물학적, 생화학적 또는 화학적 반응에 따른 전기적 특성 변화를 정밀하게 검출하여 생리활성물질의 존재여부 및/또는 반응여부를 검출하는 방법 및 이를 위해 제공되는 바이오칩에 관한 것이다. 본 발명에서는 검출대상 시료의 반응은 일반적인 반응용액 하에서 수행하되, 반응 전에 반응 챔버 내에 물과 같은 유전상수가 큰 레퍼런스 유체를 채워 임피던스값 또는 커패시턴스값을 측정하고, 반응 완료 후에는 반응용액을 제거하고 상기 유전상수가 큰 레퍼런스 유체를 다시 채워 임피던스값 또는 커패시턴스값을 측정한 후, 반응 전후의 임피던스값 또는 커패시턴스값을 비교함으로써 검출대상 시료 내에 생리활성물질의 존재여부 및/또는 반응여부를 확인하는 방식을 채택한다.
PCT/KR2009/000285 2008-03-24 2009-01-20 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한 바이오칩 Ceased WO2009119971A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2010549557A JP5371061B2 (ja) 2008-03-24 2009-01-20 生理活性物質を電気的に検出する方法およびこれのためのバイオチップ
EP09724909A EP2273263B1 (en) 2008-03-24 2009-01-20 Method for electrically detecting physiologically active materials and biochip for the same
US12/922,934 US8354307B2 (en) 2008-03-24 2009-01-20 Method for detecting biomolecules electrically and biochip therefor
CN2009801108754A CN101981445B (zh) 2008-03-24 2009-01-20 电学地检测生理活性物质的方法和用于该方法的生物芯片
US13/708,236 US9005545B2 (en) 2008-03-24 2012-12-07 Method for detecting biomolecules electrically and biochip therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080027099A KR100969667B1 (ko) 2008-03-24 2008-03-24 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
KR10-2008-0027099 2008-03-24

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/922,934 A-371-Of-International US8354307B2 (en) 2008-03-24 2009-01-20 Method for detecting biomolecules electrically and biochip therefor
US13/708,236 Division US9005545B2 (en) 2008-03-24 2012-12-07 Method for detecting biomolecules electrically and biochip therefor

Publications (2)

Publication Number Publication Date
WO2009119971A2 WO2009119971A2 (ko) 2009-10-01
WO2009119971A3 true WO2009119971A3 (ko) 2009-11-19

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PCT/KR2009/000285 Ceased WO2009119971A2 (ko) 2008-03-24 2009-01-20 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한 바이오칩

Country Status (6)

Country Link
US (2) US8354307B2 (ko)
EP (1) EP2273263B1 (ko)
JP (1) JP5371061B2 (ko)
KR (1) KR100969667B1 (ko)
CN (1) CN101981445B (ko)
WO (1) WO2009119971A2 (ko)

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Publication number Publication date
EP2273263A4 (en) 2011-05-11
US9005545B2 (en) 2015-04-14
EP2273263B1 (en) 2013-03-20
US20130143775A1 (en) 2013-06-06
CN101981445A (zh) 2011-02-23
KR20090101764A (ko) 2009-09-29
US20110024309A1 (en) 2011-02-03
CN101981445B (zh) 2013-09-04
WO2009119971A2 (ko) 2009-10-01
EP2273263A2 (en) 2011-01-12
JP2011517769A (ja) 2011-06-16
JP5371061B2 (ja) 2013-12-18
KR100969667B1 (ko) 2010-07-14
US8354307B2 (en) 2013-01-15

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