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WO2009117127A3 - Réparation de nerf avec un hydrogel et éventuellement un adhésif - Google Patents

Réparation de nerf avec un hydrogel et éventuellement un adhésif Download PDF

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Publication number
WO2009117127A3
WO2009117127A3 PCT/US2009/001739 US2009001739W WO2009117127A3 WO 2009117127 A3 WO2009117127 A3 WO 2009117127A3 US 2009001739 W US2009001739 W US 2009001739W WO 2009117127 A3 WO2009117127 A3 WO 2009117127A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
nerve repair
nerve
optional adhesive
subject invention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/001739
Other languages
English (en)
Other versions
WO2009117127A2 (fr
Inventor
David F. Muir
James B. Graham
Debbie Neubauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Priority to US12/922,725 priority Critical patent/US9386990B2/en
Priority to CA2718715A priority patent/CA2718715C/fr
Priority to EP09722994.2A priority patent/EP2271312A4/fr
Publication of WO2009117127A2 publication Critical patent/WO2009117127A2/fr
Publication of WO2009117127A3 publication Critical patent/WO2009117127A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A61B17/1128—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis of nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)

Abstract

Cette invention se rapporte à des matériaux et à des procédés destinés à réparer de manière efficace un nerf. Dans un mode de réalisation préféré, l'invention se rapporte à des procédés de réparation de nerf qui comprennent l'utilisation d'une colle de fibrine et d'un hydrogel de glycol polyéthylénique (PEG) de manière à coapter des greffons de nerf ou des tronçons de nerf coupés.
PCT/US2009/001739 2008-03-19 2009-03-19 Réparation de nerf avec un hydrogel et éventuellement un adhésif Ceased WO2009117127A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/922,725 US9386990B2 (en) 2008-03-19 2009-03-19 Nerve repair with a hydrogel and adhesive
CA2718715A CA2718715C (fr) 2008-03-19 2009-03-19 Reparation de nerf avec un hydrogel et eventuellement un adhesif
EP09722994.2A EP2271312A4 (fr) 2008-03-19 2009-03-19 Réparation de nerf avec un hydrogel et éventuellement un adhésif

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7013008P 2008-03-19 2008-03-19
US61/070,130 2008-03-19

Publications (2)

Publication Number Publication Date
WO2009117127A2 WO2009117127A2 (fr) 2009-09-24
WO2009117127A3 true WO2009117127A3 (fr) 2010-01-21

Family

ID=41091451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/001739 Ceased WO2009117127A2 (fr) 2008-03-19 2009-03-19 Réparation de nerf avec un hydrogel et éventuellement un adhésif

Country Status (4)

Country Link
US (1) US9386990B2 (fr)
EP (1) EP2271312A4 (fr)
CA (1) CA2718715C (fr)
WO (1) WO2009117127A2 (fr)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
US10842494B2 (en) 2011-10-17 2020-11-24 University Of Utah Research Foundation Methods and devices for connecting nerves
WO2013066619A1 (fr) 2011-10-17 2013-05-10 University Of Utah Research Foundation Procédés et dispositifs de liaison de nerfs
US20130142781A1 (en) * 2011-12-02 2013-06-06 Invivo Therapeutics Corporation Peg based hydrogel for peripheral nerve injury applications and compositions and method of use of synthetic hydrogel sealants
AU2013230776B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
EP2938367B1 (fr) * 2012-12-28 2020-12-16 Boston Scientific Scimed, Inc. Procédés, compositions et kits destinés à une réparation chirurgicale
AU2015358385B2 (en) 2014-12-03 2020-09-03 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue
WO2016176333A1 (fr) 2015-04-27 2016-11-03 Reflex Medical, Inc. Systèmes et procédés pour la neuromodulation cardio-pulmonaire sympathique
US9690975B2 (en) 2015-05-28 2017-06-27 Axogen Corporation Quantitative structural assay of a nerve graft
US11246879B2 (en) 2016-02-09 2022-02-15 Tulai Therapeutics, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
WO2017181068A1 (fr) 2016-04-14 2017-10-19 The Trustees Of The University Of Pennsylvania Électrodes vivantes implantables et leurs procédés d'utilisation
EP3478287A4 (fr) 2016-06-29 2020-04-08 Tulavi Therapeutics, Inc. Traitement de la septicémie et des états inflammatoires associés par neuromodulation locale du système nerveux autonome
EP3522941A4 (fr) * 2016-10-05 2020-06-17 3M Innovative Properties Company Composition de fibrinogène, procédé et articles pour plaies
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN117598837A (zh) * 2018-07-02 2024-02-27 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
WO2023212531A1 (fr) * 2022-04-27 2023-11-02 Board Of Regents, The University Of Texas System Fusion à l'aide de polyéthylène glycol dans une réparation nerveuse
CN119326935B (zh) * 2024-09-20 2025-10-21 上海市第六人民医院 一种用于截肢术后神经残端的生物胶带及其制备方法

Citations (4)

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US20010031974A1 (en) * 2000-01-31 2001-10-18 Hadlock Theresa A. Neural regeneration conduit
US7057019B2 (en) * 1996-09-23 2006-06-06 Incept Llc Crosslinked albumin hydrogels
US20070100358A2 (en) * 2002-08-01 2007-05-03 Texas Scottish Rite Hospital For Children A Biomimetic Synthetic Nerve Implant

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US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
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US7057019B2 (en) * 1996-09-23 2006-06-06 Incept Llc Crosslinked albumin hydrogels
US20010031974A1 (en) * 2000-01-31 2001-10-18 Hadlock Theresa A. Neural regeneration conduit
US20070100358A2 (en) * 2002-08-01 2007-05-03 Texas Scottish Rite Hospital For Children A Biomimetic Synthetic Nerve Implant

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Also Published As

Publication number Publication date
EP2271312A2 (fr) 2011-01-12
WO2009117127A2 (fr) 2009-09-24
CA2718715C (fr) 2014-11-18
CA2718715A1 (fr) 2009-09-24
US20110137328A1 (en) 2011-06-09
EP2271312A4 (fr) 2013-12-11
US9386990B2 (en) 2016-07-12

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