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WO2009116081A3 - Procédé amélioré de préparation daprépitant - Google Patents

Procédé amélioré de préparation daprépitant Download PDF

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Publication number
WO2009116081A3
WO2009116081A3 PCT/IN2009/000134 IN2009000134W WO2009116081A3 WO 2009116081 A3 WO2009116081 A3 WO 2009116081A3 IN 2009000134 W IN2009000134 W IN 2009000134W WO 2009116081 A3 WO2009116081 A3 WO 2009116081A3
Authority
WO
WIPO (PCT)
Prior art keywords
aprepitant
preparation
improved process
intermediates
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000134
Other languages
English (en)
Other versions
WO2009116081A2 (fr
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Mummadi Venkatesh
Mummadi Venkazesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2009116081A2 publication Critical patent/WO2009116081A2/fr
Anticipated expiration legal-status Critical
Publication of WO2009116081A3 publication Critical patent/WO2009116081A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation d'un composé daprépitant de formule I ainsi que de nouveaux polymorphes de ses intermédiaires.
PCT/IN2009/000134 2008-03-03 2009-03-02 Procédé amélioré de préparation daprépitant Ceased WO2009116081A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN526CH2008 2008-03-03
IN526/CHE/2008 2008-03-03

Publications (2)

Publication Number Publication Date
WO2009116081A2 WO2009116081A2 (fr) 2009-09-24
WO2009116081A3 true WO2009116081A3 (fr) 2011-01-06

Family

ID=41091341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000134 Ceased WO2009116081A2 (fr) 2008-03-03 2009-03-02 Procédé amélioré de préparation daprépitant

Country Status (1)

Country Link
WO (1) WO2009116081A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939285B (zh) * 2010-05-24 2014-12-24 成都地奥制药集团有限公司 5-[[2(r)-[1(r)-[3,5-双(三氟甲基)苯基]乙氧基]-3(s)-4-(氟苯基)-4-吗啉基]甲基]-1,2-二氢-3h-1,2,4-三唑-3-酮的制备方法
WO2013124823A1 (fr) * 2012-02-23 2013-08-29 Piramal Enterprises Limited Procédé perfectionné pour la préparation d'aprépitant
CZ304770B6 (cs) * 2012-03-13 2014-10-08 Zentiva, K.S. Způsob výroby 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluormethyl)fenyl)ethoxy)-3-(4-fluorfenyl)morfolino)methyl)-1H-1,2,4-triazol-5(4H)-onu (Aprepitantu) v polymorfní formě II
CN111943904B (zh) * 2019-05-15 2023-05-05 南京正大天晴制药有限公司 一种神经激肽1受体拮抗剂关键中间体的精制方法
CN110746371B (zh) * 2019-11-20 2022-07-15 山东鲁抗医药股份有限公司 制备阿瑞匹坦的中间体及其制备方法与应用
CN112939885A (zh) * 2021-02-05 2021-06-11 海南鑫开源医药科技有限公司 一种阿瑞吡坦关键中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096742A (en) * 1997-07-02 2000-08-01 Merck & Co., Inc. Polymorphic form of a tachykinin receptor antagonist
US6395898B1 (en) * 2000-06-09 2002-05-28 Merck & Co. Inc. Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
US20040214746A1 (en) * 2001-12-10 2004-10-28 Bosch H. William Pharmaceutical composition of a tachykinin receptor antagonist
WO2007039883A2 (fr) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Procede permettant de preparer de l'aprepitant
WO2008026216A2 (fr) * 2006-08-28 2008-03-06 Hetero Drugs Limited Procédé de purification d'aprépitant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096742A (en) * 1997-07-02 2000-08-01 Merck & Co., Inc. Polymorphic form of a tachykinin receptor antagonist
US6395898B1 (en) * 2000-06-09 2002-05-28 Merck & Co. Inc. Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
US20040214746A1 (en) * 2001-12-10 2004-10-28 Bosch H. William Pharmaceutical composition of a tachykinin receptor antagonist
WO2007039883A2 (fr) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Procede permettant de preparer de l'aprepitant
WO2008026216A2 (fr) * 2006-08-28 2008-03-06 Hetero Drugs Limited Procédé de purification d'aprépitant

Also Published As

Publication number Publication date
WO2009116081A2 (fr) 2009-09-24

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