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WO2009115790A2 - Articulations osseuses de remplacement - Google Patents

Articulations osseuses de remplacement Download PDF

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Publication number
WO2009115790A2
WO2009115790A2 PCT/GB2009/000715 GB2009000715W WO2009115790A2 WO 2009115790 A2 WO2009115790 A2 WO 2009115790A2 GB 2009000715 W GB2009000715 W GB 2009000715W WO 2009115790 A2 WO2009115790 A2 WO 2009115790A2
Authority
WO
WIPO (PCT)
Prior art keywords
cross
linked
bone joint
joint according
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/000715
Other languages
English (en)
Other versions
WO2009115790A3 (fr
Inventor
Peter White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2009115790A2 publication Critical patent/WO2009115790A2/fr
Publication of WO2009115790A3 publication Critical patent/WO2009115790A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30065—Properties of materials and coating materials thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
    • A61F2002/30067—Coating or prosthesis-covering structure made of thermoplastic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A61F2002/30973—Two joined adjacent layers having complementary interlocking protrusions and recesses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00574—Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
    • A61F2310/0058—Coating made of diamond or of diamond-like carbon DLC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00856—Coating or prosthesis-covering structure made of compounds based on metal nitrides
    • A61F2310/00862—Coating made of boron nitride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Definitions

  • This invention relates to replacement bone joints and is particularly although not exclusively concerned with replacement hip joints.
  • Replacement hip joints have a femoral component such as tapered titanium implant which is fixed within the femur bone, a ball at the upper end of the femoral component, and an acetabular component fitted within the acetabulum socket of the pelvis.
  • the acetabular component may comprise a lined shell and the femoral ball fits movably within this.
  • the contacting surfaces of the ball and the acetabular component should be large and strong enough to be capable of withstanding the impact and movement stresses which occur in use.
  • the surfaces of the ball and socket should be such as to permit easy articulation movement, i.e. such as to have a low coefficient of friction, whilst being hard-wearing.
  • Metal-on-metal contact surfaces are known, typically stainless steel and cobalt chrome. They are strong and hard-wearing. However there is growing concern over the effects of metal wear debris and the possibility of dispersed metal ions being taken up by the immune system both locally and distant with the potential to cause swelling of the lymph nodes and genetoxicity. Allergy is another possible side effect, for instance, nickel and chromium ions can act as allergens in some individuals.
  • Ceramic-on-ceramic joint surfaces are also known, made from aluminium oxide. These can be very hard-wearing. However, there can be practical size limitations, particularly due to the inherent brittleness of the material, although newer formulations are less brittle. In addition, the effect of aluminium oxide particles resulting from wear on the joint surfaces is as yet unknown.
  • Ceramic-on-metal joints may also be used. However, it has been found that ceramic linings, where thin wall thicknesses are employed, are liable to fracture as the ceramic is generally too brittle to offer a robust contact surface.
  • Metal-on-polyethylene and ceramic-on-polyethylene joint surfaces are also known and are widely used. These give excellent articulation.
  • the use of plastics material advantageously gives an impact cushioning or damping effect.
  • Early systems utilised non-cross-linked polyethylene but were found to be too soft with poor wear characteristics.
  • Current systems utilise high molecular weight, highly cross-linked polyethylenes which are better than lower molecular weight and non-cross-linked grades.
  • cross-linked systems currently in common use remain insufficiently hard-wearing.
  • cross-linked polyethylene systems are prone to fragment with prolonged use producing debris in the joint, and this is a known cause of osteolysis and a major source of revision operations.
  • the sterilisation and cross-linking processes are carried out by irradiating the polyethylene with gamma radiation in an inert atmosphere.
  • Low dosages of radiation are required for sterilisation but much larger multiple doses are utilised to obtain the degree of hardness required.
  • the short and long-term durability can be compromised both by a failure to fully cross-link the system and also in a system where the dosage of radiation has been excessive. Degradation of the polymer, embrirtlement and environmental stress cracking can also occur during the moulding/extrusion process used to produce the joint component.
  • a further problem arising from the use of artificial bone joints is that the synovial fluid is less efficient as a lubricant in an artificial bone joint, such as a hip joint. Ceramic-on-ceramic joints appear to have the best fluid film lubrication whilst other combinations show mixed results. It has been found that the hydrophobic nature of polyethylene appears to neutralise the effectiveness of the synovial fluid as a lubricant.
  • an object of the present invention is to provide strong, hard-wearing replacement bone joints and components for bone joint replacement that have some or all of the following properties.
  • the replacement bone joints are intended to give excellent articulation, maintain their properties during the life time of the product, have good tolerance to processing, sterilization, provide improved cushioning and damping characteristics when compared to metals and ceramics, be inert, biocompatible, non toxic, have anti microbial properties, and surface hydrophilicity to promote improved synovial lubrication.
  • a replacement bone joint having structural joint members with respective contact surfaces, said surfaces being movable relative to each other wherein at least one surface is formed separately to the respective structural member from a hard-wearing plastics material, characterised in that the plastics material is a non-cross-linked thermoplastic material.
  • a durable, long lasting joint which has good impact resistance, cushioning and damping properties, and low friction can be achieved together with the additional benefits of surface hydrophilicity, increased surface hardness, microbial resistance and improved tensile strength.
  • thermoplastics material removes dependence upon the degree of cross-linking as a control of the physical properties of the material.
  • the surface hardness of the material will typically be at a level which minimises the internal shearing which is common in polyethylene joints.
  • the amount of debris formed in the joint can be significantly reduced.
  • the replacement bone joint will comprise two contact surfaces formed from the hard-wearing non-cross-linked thermoplastic material.
  • the non-cross-linked thermoplastic surface may be a lining or coating. Preferably it is a coating adhered to the respective joint member.
  • the joint member may be treated to increase the effective surface area of the substrate and promote secure firm adhesion of the non-cross-linked thermoplastic material of the coating or lining to the member. Such treatment may include the provision of holes, perforations, or convolutions in the surface of the member.
  • the surface of the member may be etched, grit-blasted or chemically treated. In one embodiment a recess e.g.
  • the invention can be applied to a range of replacement bone joints including hip joints; joints for knees, elbows, fingers, or toes; bone plates for use as replacements of articulating surfaces such as the knee; bone plates and for use in splinting fractures; and bone plates used for bone bridging as in major resections of the mandible in the case of trauma or cancer surgery.
  • the replacement bone joint will be a hip joint.
  • the non-cross-linked thermoplastic material is Nylon 11.
  • Nylon 11 is often made from linseed oil.
  • Other polyamides (Nylon 11, 12, 66, 6) may be also be used, as may other non-cross-linked thermoplastic materials including acrylonitrile butadiene styrene, ethylene vinyl alcohol, polyacetal, polyacrylates, polyamide-imide, polybutylene terephthalate, polycarbonate, polyester, polytetrafluoroethylene, polyetheretherketone, polyimide, polyphthalamide, and polysulfone.
  • the non-cross-linked thermoplastic materials may be used either alone or in combination. Where used in combination, one of the materials used will often be a polyamide so that the resulting material benefits from the high tensile strength found in polyamides.
  • the term "in combination” applies to the combination of polymers by intimate mixing to form a single surface, or the combination of polymers as separate contact surfaces where more than one surface is formed from a non-cross-linked thermoplastic material.
  • Body-compatible additives may be incorporated within the polymer matrix of the non-cross-linked thermoplastic material. Examples of body-compatible additives include lubricants, reinforcing products, and anti-bacterial products.
  • Lubricants for use in the invention include silicone, hydrogels, molybdenum sulphide, polyvinyl pyrollidone, glycerine, mineral oil grease, and/or graphite. Lubricants selected from silicone, hydrogel, molybdenum sulphide and graphite lubricants are commonly used.
  • Reinforcing products may be selected from glass, stainless steel, and/or carbon fibre.
  • the thermoplastic material contains no, or substantially no, fibrous reinforcing material, and preferably contains no, or substantially no, reinforcing material of any kind.
  • At least one anti-bacterial substance such as anti-bacterial products that allow the slow release of silver ions either onto the surface or the zone above the surface of the non-cross-linked thermoplastic material so making it hostile to bacteria such as e- coli, staphylococcus, aureus pneumophilia, salmonella typhimurium, Iegionella &
  • MRSA may also be used.
  • Non-cross-linked thermoplastic material such as ultra thin surface treatments, can be employed to increase hydrophilicity where necessary, for instance, if the surface of the non-cross-linked thermoplastic material is not already inherently hydrophilic to the extent required to promote production of the synovial fluid.
  • Other surface treatments can be used for any other suitable purpose e.g. to increase the hardness or wear resistance, for instance, inorganic coatings such as tungsten disulphide, molybdenum disulphide, boron nitride, and diamond like carbon may be used.
  • inorganic coatings such as tungsten disulphide, molybdenum disulphide, boron nitride, and diamond like carbon may be used.
  • non-cross-linked thermoplastic material is to be interpreted as including non-cross-linked thermoplastic material in combination with other materials and substances or modified as mentioned above.
  • the surface of the joint member to which the non-cross-linked thermoplastics material of the lining or coating is applied may be formed from any suitable substrate material known in the art.
  • substrate materials may include metals, such as stainless steel, cobalt, chrome, titanium and its alloys; ceramics, such as aluminium oxide; composite materials reinforced with fibres such as carbon or stainless steel; and combinations of these substrate materials.
  • Use of the non-cross-linked thermoplastic material as a coating over another substrate can result in the properties of the combination being greater than the individual parts e.g. a Nylon 11 coated cobalt chrome femoral head can retain all the strength of the metal substrate and impart the beneficial properties of the coating but negate the undesirable properties of the metal such as nickel allergies and release of potentially toxic metal ions.
  • the substrate material may also be formed from the same said non-cross-linked thermoplastic material as that which is used to form the aforesaid coating or lining.
  • the substrate material may be composed primarily or entirely or substantially entirely of the non-cross-linked thermoplastic material.
  • the coating or lining may be of a typical but not exclusive mean depth or thickness in the range 0.025mm - 11.00mm, particularly dependent on the coating or lining technique used.
  • the range may be 0.025mm - 0.50mm.
  • electrostatic coating a range of 0.025mm - 0.1mm may be used.
  • fluid bed coating the range may be 0.25mm - 0.50mm.
  • the thickness may be 3mm - 11.00mm.
  • each coating or lining may be selected independently. Such depth selection and tolerance would consider, for instance, the radial gap required between the femoral head and the acetabulum cup, the nature of the substrate to be coated or lined, the physical abrasion to which the coating or lining will be subjected and the tensile strength of the non-cross-linked thermoplastic material of each surface.
  • bone replacement joint at least one substance which inhibits, controls, or promotes the growth of tissue or bone cells over the surface of the joint.
  • the joint is a replacement hip joint
  • the joint is a bone bridging plate
  • tissue re-growth across the treated area may be desirable.
  • Such substance or substances may be incorporated in or applied to the surface of the non-cross-linked thermoplastic material.
  • Growth inhibitory substances include polytetrafluoroethylene, polyethylene glycol and biomaterial matrices which impart growth inhibitory properties to the coating.
  • Growth promoting substances include tissue sealants, such as fibrin glue; growth factors, such as platelet-derived growth factor (PDGF), insulin-binding growth factor- 1 (IGF-I), insulin-binding growth factor-2 (IGF-2), epidermal growth factor (EGF), transforming growth factor- ⁇ (TGF- ⁇ ), transforming growth factor-jS (TGF- jS), platelet factor 4 (PF-4), osteogenin and other bone growth factors, collagen growth factors, heparin binding growth factor- 1 (HBGF-I), heparin binding growth factor-2 (HBGF-2) and biologically active derivatives of any of said growth factors; and potentiating compounds, such as heparin.
  • PDGF platelet-derived growth factor
  • IGF-I insulin-binding growth factor- 1
  • IGF-2 insulin-binding growth factor-2
  • EGF epidermal growth factor
  • Figure 1 shows a schematic cross-sectional view of an artificial hip joint including a femoral prosthesis and an acetabulum prostheses.
  • Figure 2 shows a side elevational view of the femoral prosthesis of Figure 1;
  • Figure 3 shows a rear elevational view of the femoral prosthesis of Figure 2;
  • Figure 4 shows a perspective view of the acetabulum prosthesis of Figure 1 from above.
  • one embodiment of the invention comprises a bone replacement hip joint 10 composed of a femoral component (a femoral prosthesis 15) and an acetabular component (an acetabulum prosthesis 20).
  • the femoral prosthesis 15 is further illustrated in Figures 2 and 3, and comprises a femur head 25, having a neck 30 and shoulder 35 with a tapering stem 40 extending therefrom. As shown in figure 3, the head 25 may be a separate component to the remainder of the femoral prosthesis 15 being connected by way of a spigot 65 forming part of the femoral stem 40.
  • the head 25 which is made of stainless steel has been machined 250 microns undersize.
  • the Nylon 11 coating is machined and polished according to ISO 7206-2 1996 whereby the spherical articulating surface of the Nylon 11 femoral head has a finish, when measured in accordance with the principles given in ISO 468, with an Ra value not greater than 0.05micron, using a cut off value of 0.08mm. When examined by normal corrected vision, the articulating surface shall be free from embedded particles and from scratches and score marks other than those arising from the finishing process.
  • the remainder of the femoral prosthesis 15, specifically the neck 30, the shoulder 35 and the stem 40, is made of titanium.
  • the stem 40 is of a length such that it will extend a substantial distance into the medulary canal of a femur to be treated and adhere thereto using friction.
  • the femoral prosthesis 15 may be cemented into place. Pins (not shown) may also be used to retain the femoral prosthesis 15 in position until bone in-growth and adhesion to the prosthesis 15 has occurred. There may be a notch beneath the head 25 into which the Nylon coating flows to key the coating in position.
  • the acetabulum prosthesis 20 is further illustrated in Figure 4 and comprises a hemispherical cup 45 into which the head 25 of the femoral prosthesis 15 is placed and an angular flange forming a lip 50 around the cup 45.
  • the acetabulum prosthesis 20 is composed of machined titanium lined at the contact surface 55 with femoral prosthesis 15, with moulded non-cross-linked Nylon 66.
  • the lining 60 may have a thickness in the range 5-1 lmm.
  • the acetabulum prosthesis 20 can be retained in the pelvis using medical grade cement (not shown). Where necessary the acetabulum prosthesis 20 may be temporarily retained in place using pins (not shown), until such time as bone in-growth has sufficiently adhered the acetabulum prosthesis 20 to the pelvis.
  • Figure 1 shows the placement and interaction of the femoral 15 and acetabulum 20 prostheses, the stem 40 of the femoral prosthesis 15 being inserted into the medulary canal of a femur with the prosthetic shoulder 35 being supported on the shoulder thereof.
  • the acetabulum prosthesis 20 is placed in a cup shaped depression formed by scraping out the damaged socket in the pelvis. Except where otherwise explicitly indicated, all numbers in this description are to be understood as modified by the word "about.” All amounts are by weight of the final composition, unless otherwise specified.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une articulation osseuse de remplacement possédant des éléments d'articulation tels qu'une prothèse fémorale (15) et une prothèse cotyloïdienne (20), définissant une articulation de type rotule entre une tête (25) et une cupule (45). La cupule possède une garniture (60) et la tête est pourvue d'un revêtement collé. Le revêtement et/ou la garniture (60) sont formés d'un matériau thermoplastique non réticulé tel que le nylon. En particulier, le revêtement collé peut être constitué de nylon 11.
PCT/GB2009/000715 2008-03-19 2009-03-18 Articulations osseuses de remplacement Ceased WO2009115790A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0805122A GB0805122D0 (en) 2008-03-19 2008-03-19 Replacement bone joints
GB0805122.9 2008-03-19

Publications (2)

Publication Number Publication Date
WO2009115790A2 true WO2009115790A2 (fr) 2009-09-24
WO2009115790A3 WO2009115790A3 (fr) 2009-11-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000715 Ceased WO2009115790A2 (fr) 2008-03-19 2009-03-18 Articulations osseuses de remplacement

Country Status (2)

Country Link
GB (1) GB0805122D0 (fr)
WO (1) WO2009115790A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012155591A1 (fr) * 2011-05-17 2012-11-22 Zhao Dezheng Dispositif d'articulation bionique à lubrification fermée
US9579205B2 (en) 2013-09-12 2017-02-28 Ronen Shavit Liners for medical joint implants with improved wear-resistance

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012155591A1 (fr) * 2011-05-17 2012-11-22 Zhao Dezheng Dispositif d'articulation bionique à lubrification fermée
US9579205B2 (en) 2013-09-12 2017-02-28 Ronen Shavit Liners for medical joint implants with improved wear-resistance

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