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WO2009115429A1 - Préparation alimentaire et composition pharmaceutique contenant un extrait embryonnaire - Google Patents

Préparation alimentaire et composition pharmaceutique contenant un extrait embryonnaire Download PDF

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Publication number
WO2009115429A1
WO2009115429A1 PCT/EP2009/052764 EP2009052764W WO2009115429A1 WO 2009115429 A1 WO2009115429 A1 WO 2009115429A1 EP 2009052764 W EP2009052764 W EP 2009052764W WO 2009115429 A1 WO2009115429 A1 WO 2009115429A1
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
embryonic
egg
preparation according
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/052764
Other languages
English (en)
Inventor
Joan Cunill Aixela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2009115429A1 publication Critical patent/WO2009115429A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/08—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from eggs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L15/00—Egg products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/982—Reproductive organs; Embryos, Eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the applicant has been able to verify that the administration of embryo extracts taken in a stage before the extraction stages used up until now, and very specific of embryonic development, has surprisingly revitalizing effects that are0 most likely related to a significant effect on the cell division rate.
  • the embryonic germ must be obtained before the formation of segmented mesodermal tissue masses, or somites, in the embryonic development, but once the blastula phase has been completed.
  • the embryonic germ is obtained in the food preparation of the invention when the three embryonic ectoblast-mesoblast-entoblast layers have been developed in a fertilized and incubated egg for a specific period, whereby the food preparation comprises at least one embryonic germ in the final gastrula phase.
  • the embryonic germ is extracted from a hen egg during the period comprised between 18 and 30 hours after its incubation.
  • the preparation further comprises part of the yolk of the egg sucked during the extraction of the germ by suction.
  • the preparation is preferably frozen for its conservation and subsequent oral administration.
  • the administration of the preparation in humans is indicated as a regenerating agent in the event of skin dryness or hair loss.
  • the administration of the preparation in animals is indicated as a revitalizing agent and stimulant of the defences in the event of suffering from infectious or parasitic diseases such as Leishmaniasis in dogs or viral immunodeficiencies in cats.
  • a pharmaceutical composition containing as an active substance at least one embryonic extract in the final gastrula embryonic development stage extracted from a fertilized and incubated egg is disclosed.
  • composition is intended for its use in antidegenerative treatments, for treating arthrosis, cirrhosis, nephritis or neurodegenerative processes.
  • composition is also intended for its use in regenerative treatments in mammals.
  • composition is intended for its use as a coadjuvant of treatments against cancer, such as radiotherapy and chemotherapy.
  • a fertilized hen egg is removed from an incubator after a period comprised between 18 and 36 hours after its incubation.
  • An embryonic germ in the final gastrula phase, before the formation of somites, is thus achieved.
  • the content obtained after the breaking of the shell, formed by the yolk and the white, is subsequently deposited on a sterile tray.
  • the yolk is shaken by rocking the tray until the embryonic germ is located in a dorsal and centred position.
  • the suction of said embryonic germ is then carried out, which germ is contained together with the surrounding yolk in an amount of volume approximately between 0.5 and 2 ml, according to the suction carried out.
  • a sterile syringe, plunger or pipette is used for the mentioned suction, in a way which is known in itself.
  • a treatment based on the preparation according to the invention was started.
  • a dose of 2 ml was administered three times a day, follicle growth, normalization of prostatic symptoms, normalization of the cardiac rhythm and the blood pressure starting to be observed six months after the start of the treatment. After 5 years it can be verified that the quality of life of said patient has been improved.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur une préparation alimentaire et sur une composition pharmaceutique contenant un extrait embryonnaire et sur leurs utilisations respectives. La préparation alimentaire comprend un germe embryonnaire dans la phase gastrula finale extrait d'un œuf fertilisé et incubé. De plus, la composition pharmaceutique contient en tant que substance active un extrait embryonnaire dans le stade de développement embryonnaire de gastrula finale extrait d'un œuf fertilisé et incubé. Ladite préparation est utilisée en tant que complément alimentaire pour la prévention de la chute des cheveux. De plus, ladite composition pharmaceutique peut être utilisée en tant que médicament pour des traitements antidégénératifs.
PCT/EP2009/052764 2008-03-19 2009-03-10 Préparation alimentaire et composition pharmaceutique contenant un extrait embryonnaire Ceased WO2009115429A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200800802 2008-03-19
ES200800802A ES2337537B8 (es) 2008-03-19 2008-03-19 Preparado alimenticio y composicion farmaceutica que contiene un extracto embrionario y sus respectivos usos.

Publications (1)

Publication Number Publication Date
WO2009115429A1 true WO2009115429A1 (fr) 2009-09-24

Family

ID=40833510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052764 Ceased WO2009115429A1 (fr) 2008-03-19 2009-03-10 Préparation alimentaire et composition pharmaceutique contenant un extrait embryonnaire

Country Status (2)

Country Link
ES (1) ES2337537B8 (fr)
WO (1) WO2009115429A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053503A1 (fr) 2011-10-13 2013-04-18 Cunill Aixela Juan Préparation à base d'œufs à propriétés régénérantes, analgésiques et/ou anti-inflammatoires
ITMI20120008A1 (it) * 2012-01-04 2013-07-05 Biava Maura Composizioni ad attività anti-neurodegenerativa
WO2018134460A1 (fr) * 2017-01-19 2018-07-26 Liofilizados Girona, Sl Préparation à base d'oeuf à propriétés anti-inflammatoires et antioxydantes

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4400640A1 (de) * 1994-01-12 1995-07-13 Eftag Entstaubung Foerdertech Verwendung von, Mittel mit und Verfahren zur Herstellung eines Arzneimittels mit Embryonalgewebe
WO1998011905A1 (fr) * 1996-09-20 1998-03-26 Adriana Carluccio Composition pharmaceutique contenant un extrait embryonnaire ou d'uterus gravide, utilise comme substance active et procede de preparation de ladite composition
CA2197050A1 (fr) * 1997-02-07 1998-08-07 Morton P. Shulman Agents anticancereux issus d'oeufs en coquille fecondes incubes
FR2778850A1 (fr) * 1998-05-22 1999-11-26 Jacques Vincent Cavaille Composition pharmaceutique ralentissant le vieillisement de l'organisme des mammiferes
EP1374703A1 (fr) * 2002-06-20 2004-01-02 Pier Mario Biava Utilisation d'un extrait embryonnaire d'origine animale - non humaine - pour la préparation d'une substance nutritive et d'un complément alimentaire diététique-nutraceutique
US20070275036A1 (en) * 2006-05-18 2007-11-29 Celldyne Biopharma, Llc Avian follistatin product

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888172A (en) * 1982-09-23 1989-12-19 Alfaceu Corporation Pharmaceutical for treating tumors and methods for making it
ITMI20051572A1 (it) * 2005-08-12 2007-02-13 Alberto Astaldi Composizione farmaceutica contenente come sostanza attiva una frazione proteica estratta da embrioni di ovipari nel periodo del differenziamento cellulare e relativo processo di preparazione

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4400640A1 (de) * 1994-01-12 1995-07-13 Eftag Entstaubung Foerdertech Verwendung von, Mittel mit und Verfahren zur Herstellung eines Arzneimittels mit Embryonalgewebe
WO1998011905A1 (fr) * 1996-09-20 1998-03-26 Adriana Carluccio Composition pharmaceutique contenant un extrait embryonnaire ou d'uterus gravide, utilise comme substance active et procede de preparation de ladite composition
CA2197050A1 (fr) * 1997-02-07 1998-08-07 Morton P. Shulman Agents anticancereux issus d'oeufs en coquille fecondes incubes
FR2778850A1 (fr) * 1998-05-22 1999-11-26 Jacques Vincent Cavaille Composition pharmaceutique ralentissant le vieillisement de l'organisme des mammiferes
EP1374703A1 (fr) * 2002-06-20 2004-01-02 Pier Mario Biava Utilisation d'un extrait embryonnaire d'origine animale - non humaine - pour la préparation d'une substance nutritive et d'un complément alimentaire diététique-nutraceutique
US20070275036A1 (en) * 2006-05-18 2007-11-29 Celldyne Biopharma, Llc Avian follistatin product

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053503A1 (fr) 2011-10-13 2013-04-18 Cunill Aixela Juan Préparation à base d'œufs à propriétés régénérantes, analgésiques et/ou anti-inflammatoires
JP2014530223A (ja) * 2011-10-13 2014-11-17 オヴィヴィティ グループ，エス． エル． 再生性、鎮痛性および／または抗炎症性を有する卵調製物
RU2585049C2 (ru) * 2011-10-13 2016-05-27 Овивити Груп, С.Л. Препарат из яиц с регенерирующими, анальгезирующими и противовоспалительными свойствами
US9717764B2 (en) 2011-10-13 2017-08-01 Ovivity Group, S.L. Egg preparation with regenerating, analgesic and/or anti-inflammatory properties
ITMI20120008A1 (it) * 2012-01-04 2013-07-05 Biava Maura Composizioni ad attività anti-neurodegenerativa
WO2018134460A1 (fr) * 2017-01-19 2018-07-26 Liofilizados Girona, Sl Préparation à base d'oeuf à propriétés anti-inflammatoires et antioxydantes

Also Published As

Publication number Publication date
ES2337537A1 (es) 2010-04-26
ES2337537B2 (es) 2011-02-02
ES2337537B8 (es) 2011-08-01

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