[go: up one dir, main page]

WO2009114535A3 - Composition de pâte osseuse - Google Patents

Composition de pâte osseuse Download PDF

Info

Publication number
WO2009114535A3
WO2009114535A3 PCT/US2009/036673 US2009036673W WO2009114535A3 WO 2009114535 A3 WO2009114535 A3 WO 2009114535A3 US 2009036673 W US2009036673 W US 2009036673W WO 2009114535 A3 WO2009114535 A3 WO 2009114535A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
paste composition
bone paste
agents
remodeling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/036673
Other languages
English (en)
Other versions
WO2009114535A2 (fr
Inventor
J. Alexander Marchosky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marfly 2 LP
Original Assignee
Marfly 2 LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marfly 2 LP filed Critical Marfly 2 LP
Priority to JP2010550818A priority Critical patent/JP2011513034A/ja
Priority to EP09719893A priority patent/EP2257163A4/fr
Publication of WO2009114535A2 publication Critical patent/WO2009114535A2/fr
Publication of WO2009114535A3 publication Critical patent/WO2009114535A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des compositions de pâte osseuse qui favorisent la cicatrisation et le remodelage d'un os en stimulant des éléments de la moelle osseuse à l’aide d’une combinaison d'agents hémopoïétiques, d'agents angiogéniques, et d’un matériau de signalisation moléculaire de l’os.
PCT/US2009/036673 2008-03-10 2009-03-10 Composition de pâte osseuse Ceased WO2009114535A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2010550818A JP2011513034A (ja) 2008-03-10 2009-03-10 骨セメント組成物
EP09719893A EP2257163A4 (fr) 2008-03-10 2009-03-10 Composition de pâte osseuse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3514108P 2008-03-10 2008-03-10
US61/035,141 2008-03-10

Publications (2)

Publication Number Publication Date
WO2009114535A2 WO2009114535A2 (fr) 2009-09-17
WO2009114535A3 true WO2009114535A3 (fr) 2010-03-04

Family

ID=41053827

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/036673 Ceased WO2009114535A2 (fr) 2008-03-10 2009-03-10 Composition de pâte osseuse

Country Status (4)

Country Link
US (3) US8470369B2 (fr)
EP (1) EP2257163A4 (fr)
JP (1) JP2011513034A (fr)
WO (1) WO2009114535A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12377189B2 (en) 2008-12-13 2025-08-05 Bioventus Llc Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor
PT2389205T (pt) * 2008-12-13 2021-03-29 Bioventus Llc Método de fabrico de implante ósseo osteoindutor
US20110118850A1 (en) * 2008-12-13 2011-05-19 Amit Prakash Govil Bioactive Grafts and Composites
AU2010328427B2 (en) * 2009-12-13 2014-06-05 Advanced Biologics, Inc. Bioactive grafts and composites
CA2787208C (fr) 2010-01-15 2017-06-06 University Of Medicine And Dentistry Of New Jersey Utilisation de composes de vanadium pour accelerer la guerison osseuse
WO2013006798A1 (fr) 2011-07-06 2013-01-10 University Of Medicine And Dentistry Of New Jersey Composés de vanadium en tant que compléments thérapeutiques pour une régénération et une réparation de cartilage
US20140322292A1 (en) 2010-12-10 2014-10-30 Rutgers, The State University Of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration
JP6214548B2 (ja) * 2011-11-29 2017-10-18 ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー 骨再生のための治療補助薬としてのインスリン−疑似剤
AU2013334111A1 (en) * 2012-10-25 2015-05-28 Rutgers, The State University Of New Jersey Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
AU2014235352B2 (en) 2013-03-15 2017-04-27 Arteriocyte Medical Systems, Inc. Compositions of and methods for cancellous bone matrix
CN105636598B (zh) * 2013-09-02 2021-07-23 玛芬股份有限公司 包含胞外基质组织材料和成骨蛋白的产品
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
WO2016187413A1 (fr) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Fibres osseuses corticales déminéralisées modifiées
WO2019097885A1 (fr) * 2017-11-16 2019-05-23 三菱電機株式会社 Élément d'échange de chaleur totale et échangeur de chaleur totale
CN108144047A (zh) * 2017-12-30 2018-06-12 广州润虹医药科技股份有限公司 一种增加骨密度的含壳聚糖的保健组合物及其用途
CN110644076B (zh) * 2019-09-17 2021-10-26 南通大学 一种表面接枝重组表皮生长因子纳米纤维的制备方法
CN116643054B (zh) * 2023-06-02 2025-04-29 中国医科大学附属盛京医院 一种非综合征型唇腭裂产前无创诊断分子标志物c3蛋白及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US20040142465A1 (en) * 1998-12-21 2004-07-22 Fidia Advanced Biopolymers, S.R.L. Injectable hyaluronic acid derivative with pharmaceuticals/cells
US20050142163A1 (en) * 2003-11-10 2005-06-30 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050255545A1 (en) * 2002-02-01 2005-11-17 Smith Timothy J Regulation of human hematopoietin receptor-like protein
US20070254040A1 (en) * 2006-05-01 2007-11-01 James Scaffidi Nutritional supplement and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2215209B (en) * 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
EP0503583A1 (fr) * 1991-03-12 1992-09-16 Takeda Chemical Industries, Ltd. Composition à libération prolongée à base d'erythropoiètine
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5837258A (en) * 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
FR2706768B1 (fr) * 1993-05-13 1995-12-01 Inoteb
TW369414B (en) * 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
US6372257B1 (en) * 1999-06-29 2002-04-16 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
EP2233150B1 (fr) * 2003-12-30 2016-09-07 Augustinus Bader Erythropoietin pour utilisation dans la guérison de blessures ou la transplantation de cellules
US7691105B2 (en) * 2005-09-26 2010-04-06 Depuy Spine, Inc. Tissue augmentation, stabilization and regeneration technique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142465A1 (en) * 1998-12-21 2004-07-22 Fidia Advanced Biopolymers, S.R.L. Injectable hyaluronic acid derivative with pharmaceuticals/cells
US20050255545A1 (en) * 2002-02-01 2005-11-17 Smith Timothy J Regulation of human hematopoietin receptor-like protein
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US20050142163A1 (en) * 2003-11-10 2005-06-30 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20070254040A1 (en) * 2006-05-01 2007-11-01 James Scaffidi Nutritional supplement and use thereof

Also Published As

Publication number Publication date
WO2009114535A2 (fr) 2009-09-17
US9610304B2 (en) 2017-04-04
JP2011513034A (ja) 2011-04-28
EP2257163A2 (fr) 2010-12-08
US20170333485A1 (en) 2017-11-23
US20140072638A1 (en) 2014-03-13
US20090226534A1 (en) 2009-09-10
EP2257163A4 (fr) 2012-01-18
US8470369B2 (en) 2013-06-25

Similar Documents

Publication Publication Date Title
WO2009114535A3 (fr) Composition de pâte osseuse
EP2314323A3 (fr) Composition chirurgicale bioabsorbable
WO2009124971A3 (fr) Nouvelles compositions et leur utilisation
IL183083A (en) Implantable collagen compositions
PT2291174E (pt) Composição fluida compreendendo composições de oligómeropolímero biocompatíveis
ZA200809010B (en) Bone graft composition
EP3284772B8 (fr) Thioéthers, procédés pour les préparer et compositions comprenant ces thioéthers
EP1968483A4 (fr) Composition chirurgicale bioabsorbable
IL244812A0 (en) 6-ethyl, 23-methyl-cholic acid, its conjugates with glycine and taurine and pharmaceutical preparations containing them
WO2010065784A3 (fr) Procédés, dispositifs et compositions pour un remplissage dermique
WO2008060622A3 (fr) Méthodes et compositions améliorées pour la cicatrisation des plaies
TW200806280A (en) Pharmaceutical compositions
EP4534115A3 (fr) Biomatériaux injectables
IL201425A0 (en) Wound healing compositions containing keratin biomaterials
PH12012502150A1 (en) Conjugated blood coagulation factor viii
PT2358373E (pt) Composição injetável de polidesoxirribonucleotídeos para o tratamento de doenças osteoarticulares
EP2249888B8 (fr) Composite d'implant osseux
WO2011005510A3 (fr) Conjugués peptidiques et leurs utilisations
EP2001489A4 (fr) Compositions pharmaceutiques pour favoriser la cicatrisation
IL212152B (en) Peptides derived from the integrase protein of HIV-1 and preparations containing them
BRPI0719885A2 (pt) Pht alquilados como moduladores de receptores de pth e usos dos mesmos27
EP1960446A4 (fr) Compositions chirurgicales biocompatibles
AP2628A (en) Pharmaceutical compositions containining bradykinin antagonists and hyaluronic acid, and uses thereof
PL2219555T3 (pl) Biokompatybilne kompozycje białkowe ulegające przemianie fazowej
WO2008099198A3 (fr) Composés ostéogéniques

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09719893

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2009719893

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2010550818

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE