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WO2009111676A8 - Boron-containing small molecules as anti-inflammatory agents - Google Patents

Boron-containing small molecules as anti-inflammatory agents Download PDF

Info

Publication number
WO2009111676A8
WO2009111676A8 PCT/US2009/036250 US2009036250W WO2009111676A8 WO 2009111676 A8 WO2009111676 A8 WO 2009111676A8 US 2009036250 W US2009036250 W US 2009036250W WO 2009111676 A8 WO2009111676 A8 WO 2009111676A8
Authority
WO
WIPO (PCT)
Prior art keywords
boron
small molecules
inflammatory agents
containing small
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/036250
Other languages
French (fr)
Other versions
WO2009111676A3 (en
WO2009111676A2 (en
Inventor
Tsutomu Akama
Yong-Kang Zhang
Charles Z. Ding
Jacob J. Plattner
Kirk R. Maples
Yvonne Freund
Virginia Sanders
Yi Xia
Stephen J. Baker
James A Niemann
Xiaosong Lu
Marcelo Sales
Rashmi Sharma
Rajeshwar Singh
Robert Jacobs
Daitao Chen
Michael Richard Kevin Alley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anacor Pharmaceuticals LLC
Original Assignee
Anacor Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RU2010140803/04A priority Critical patent/RU2547441C2/en
Priority to AU2009221793A priority patent/AU2009221793B2/en
Priority to JP2010549900A priority patent/JP5745279B2/en
Priority to KR1020107022132A priority patent/KR101672511B1/en
Priority to BRPI0908565A priority patent/BRPI0908565A2/en
Priority to KR1020157014083A priority patent/KR20150065941A/en
Priority to CN2009801162797A priority patent/CN102014927A/en
Priority to CA 2718170 priority patent/CA2718170A1/en
Priority to EP09700012A priority patent/EP2187893A4/en
Application filed by Anacor Pharmaceuticals LLC filed Critical Anacor Pharmaceuticals LLC
Priority to NZ58795509A priority patent/NZ587955A/en
Priority to MX2010009765A priority patent/MX2010009765A/en
Publication of WO2009111676A2 publication Critical patent/WO2009111676A2/en
Publication of WO2009111676A3 publication Critical patent/WO2009111676A3/en
Priority to IL207955A priority patent/IL207955A/en
Anticipated expiration legal-status Critical
Publication of WO2009111676A8 publication Critical patent/WO2009111676A8/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds and methods of treating anti-inflammatory conditions are disclosed.
PCT/US2009/036250 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents Ceased WO2009111676A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP09700012A EP2187893A4 (en) 2008-03-06 2009-03-05 SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES
JP2010549900A JP5745279B2 (en) 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
KR1020107022132A KR101672511B1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
BRPI0908565A BRPI0908565A2 (en) 2008-03-06 2009-03-05 compound, pharmaceutical formulation, methods for reducing the release of a cytokine or chemokine, treating a condition in an animal and inhibiting a phosphodiesterase
KR1020157014083A KR20150065941A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
CN2009801162797A CN102014927A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
CA 2718170 CA2718170A1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
RU2010140803/04A RU2547441C2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
NZ58795509A NZ587955A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
AU2009221793A AU2009221793B2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
MX2010009765A MX2010009765A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents.
IL207955A IL207955A (en) 2008-03-06 2010-09-02 Boron-containing small molecules as anti-inflammatory agents

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US3437108P 2008-03-06 2008-03-06
US61/034,371 2008-03-06
US5263708P 2008-05-12 2008-05-12
US61/052,637 2008-05-12
US9440608P 2008-09-04 2008-09-04
US61/094,406 2008-09-04
US10599008P 2008-10-16 2008-10-16
US61/105,990 2008-10-16
US11090308P 2008-11-03 2008-11-03
US61/110,903 2008-11-03
US14370009P 2009-01-09 2009-01-09
US61/143,700 2009-01-09
US14873109P 2009-01-30 2009-01-30
US61/148,731 2009-01-30

Publications (3)

Publication Number Publication Date
WO2009111676A2 WO2009111676A2 (en) 2009-09-11
WO2009111676A3 WO2009111676A3 (en) 2010-04-01
WO2009111676A8 true WO2009111676A8 (en) 2010-09-30

Family

ID=41056660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/036250 Ceased WO2009111676A2 (en) 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Country Status (2)

Country Link
EP (1) EP2187893A4 (en)
WO (1) WO2009111676A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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SI3424932T1 (en) 2005-02-16 2021-08-31 Anacor Pharmaceuticals, Inc. Boronophthalides for therapeutic use
CA2635680A1 (en) 2005-12-30 2007-07-12 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
EP1988779B1 (en) 2006-02-16 2015-06-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
RU2547441C2 (en) 2008-03-06 2015-04-10 Анакор Фармасьютикалз, Инк. Boron-containing small molecules as anti-inflammatory agents
EP2348863A4 (en) 2008-09-04 2012-03-07 Anacor Pharmaceuticals Inc SMALL MOLECULES CONTAINING BORON
WO2010028005A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
CA2744231A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
MX2012001156A (en) 2009-07-28 2012-05-08 Anacor Pharmaceuticals Inc Trisubstituted boron-containing molecules.
AP4039A (en) 2009-08-14 2017-02-28 Daitao Chen Boron-containing small molecules as antiprotozoal agents
WO2011022337A1 (en) 2009-08-19 2011-02-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011049971A1 (en) 2009-10-20 2011-04-28 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US8461134B2 (en) 2009-11-11 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011063293A1 (en) * 2009-11-20 2011-05-26 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antihelminth agents
US8716478B2 (en) * 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8623911B2 (en) 2010-03-19 2014-01-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
PL3251678T3 (en) 2010-09-07 2022-01-10 Anacor Pharmaceuticals, Inc. Benzoxaborole derivatives for treating bacterial infections
MX354676B (en) 2011-08-19 2018-03-15 Glaxo Group Ltd Benzofuran compounds for the treatment of hepatitis c virus infections.
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
KR101666331B1 (en) 2013-01-30 2016-10-13 다우 아그로사이언시즈 엘엘씨 Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
TW201625649A (en) 2014-07-01 2016-07-16 第一三共股份有限公司 Tricyclic compounds as antibacterial agents
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
PT3383363T (en) 2015-11-30 2021-03-03 Anacor Pharmaceuticals Inc TOPICAL PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF INFLAMMATION-RELATED AFFECTIONS
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US11447506B2 (en) 2016-05-09 2022-09-20 Anacor Pharmaceuticals, Inc. Crystal forms of crisaborole in free form and preparation method and use thereof
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor
EP3609504A4 (en) 2017-03-01 2021-03-03 Anacor Pharmaceuticals, Inc. NOVEL OXABOROL ANALOGA AND USES THEREOF
WO2018207216A1 (en) * 2017-05-12 2018-11-15 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (crisaborole)
US10865217B2 (en) 2017-05-23 2020-12-15 Msn Laboratories Private Limited, R & D Center Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
US11834466B2 (en) 2017-11-30 2023-12-05 5Metis, Inc. Benzoxaborole compounds and formulations thereof
JP2021534247A (en) 2018-08-18 2021-12-09 ボラゲン，インコーポレーテッド Solid form of substituted benzoxabolol and its composition
CN113166177B (en) 2018-10-05 2024-09-03 辉瑞公司 Boron-containing PDE4 inhibitors
JP7413346B2 (en) 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative
CN112174989B (en) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 A kind of preparation method of crisborole
US20230340530A1 (en) 2020-08-31 2023-10-26 Pfizer Inc. Methods of Protecting RNA
EP4572765A1 (en) * 2022-08-18 2025-06-25 Mitodicure GmbH Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
CN116239498B (en) * 2023-05-11 2023-07-21 北京元延医药科技股份有限公司 The method for preparing crisborole intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596985B2 (en) * 2000-02-22 2003-07-22 Rioch Company, Ltd. Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
SI3424932T1 (en) * 2005-02-16 2021-08-31 Anacor Pharmaceuticals, Inc. Boronophthalides for therapeutic use
US20060251689A1 (en) * 2005-03-30 2006-11-09 Astion Development A/S Treatment or prevention of pruritus
EP1988779B1 (en) * 2006-02-16 2015-06-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents

Also Published As

Publication number Publication date
WO2009111676A3 (en) 2010-04-01
EP2187893A2 (en) 2010-05-26
EP2187893A4 (en) 2012-02-22
WO2009111676A2 (en) 2009-09-11

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