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WO2009111565A3 - Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution - Google Patents

Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution Download PDF

Info

Publication number
WO2009111565A3
WO2009111565A3 PCT/US2009/036034 US2009036034W WO2009111565A3 WO 2009111565 A3 WO2009111565 A3 WO 2009111565A3 US 2009036034 W US2009036034 W US 2009036034W WO 2009111565 A3 WO2009111565 A3 WO 2009111565A3
Authority
WO
WIPO (PCT)
Prior art keywords
anesthetic
lipoxins
resolution
counteract
impact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/036034
Other languages
French (fr)
Other versions
WO2009111565A2 (en
Inventor
Charles N. Serhan
Nan Chiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of WO2009111565A2 publication Critical patent/WO2009111565A2/en
Publication of WO2009111565A3 publication Critical patent/WO2009111565A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Use of lipoxin compounds for the resolution of tissues treated with a anesthetic is described. Lipoxins help facilitate the resolution phase of healing post treatment with an anesthetic. Pretreatment of the anesthetized site with a lipoxin helps to promote resolution of the tissue relative to untreated tissue.
PCT/US2009/036034 2008-03-04 2009-03-04 Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution Ceased WO2009111565A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3365608P 2008-03-04 2008-03-04
US61/033,656 2008-03-04

Publications (2)

Publication Number Publication Date
WO2009111565A2 WO2009111565A2 (en) 2009-09-11
WO2009111565A3 true WO2009111565A3 (en) 2009-11-05

Family

ID=41056622

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2009/035974 Ceased WO2009111530A2 (en) 2008-03-04 2009-03-04 Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution
PCT/US2009/036034 Ceased WO2009111565A2 (en) 2008-03-04 2009-03-04 Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2009/035974 Ceased WO2009111530A2 (en) 2008-03-04 2009-03-04 Use of lipoxins to counteract the impact of anesthetic on inflammatory resolution

Country Status (1)

Country Link
WO (2) WO2009111530A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US6329425B1 (en) * 1991-04-01 2001-12-11 Brigham And Women's Hospital Modulation of inflammation related to Columnar epithelia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329425B1 (en) * 1991-04-01 2001-12-11 Brigham And Women's Hospital Modulation of inflammation related to Columnar epithelia
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BLAITHIN MCMAHON ET AL.: "Lipoxins: revelations on resolution.", TRENDS IN PHARMACOLOGICAL SCIENCES., vol. 22, no. 8, August 2001 (2001-08-01), pages 391 - 395 *
CAMILLA 1. SVENSSON ET AL.: "Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing.", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 204, no. 2, 19 February 2007 (2007-02-19), pages 245 - 252 *
I.M. FIERRO ET AL.: "Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH., vol. 34, no. 5, 2001, pages 555 - 566 *
JAN M. SCHWAB ET AL.: "Resolvin El and Protectin D1 activate inflammation-resolution programmes.", NATURE., vol. 447, 14 June 2007 (2007-06-14), pages 869 - 874 *
R. TYTHER ET AL.: "The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro.", IRISH JOURNAL OF MEDICINAL SCIENCE., vol. 170, no. 1, January 2001 (2001-01-01), pages 41 - 44 *
SHENG-WEI JIN ET AL.: "Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1.", ANESTHESIA & ANALGESIA., vol. 104, no. 2, February 2007 (2007-02-01), pages 369 - 377 *

Also Published As

Publication number Publication date
WO2009111530A3 (en) 2009-11-12
WO2009111565A2 (en) 2009-09-11
WO2009111530A2 (en) 2009-09-11

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