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WO2009110523A3 - Dendrimer particle, mri contrast medium, and method of manufacturing a dendrimer particle - Google Patents

Dendrimer particle, mri contrast medium, and method of manufacturing a dendrimer particle Download PDF

Info

Publication number
WO2009110523A3
WO2009110523A3 PCT/JP2009/054107 JP2009054107W WO2009110523A3 WO 2009110523 A3 WO2009110523 A3 WO 2009110523A3 JP 2009054107 W JP2009054107 W JP 2009054107W WO 2009110523 A3 WO2009110523 A3 WO 2009110523A3
Authority
WO
WIPO (PCT)
Prior art keywords
dendrimer
dendrimer particle
particle
manufacturing
contrast medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/054107
Other languages
French (fr)
Other versions
WO2009110523A2 (en
Inventor
Kimihiro Yoshimura
Hidetoshi Tsuzuki
Tetsuya Yano
Yoshinori Tomida
Shinzaburo Ito
Satoshi Nitahara
Hiroyuki Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Canon Inc
Kyoto University NUC
Original Assignee
Canon Inc
Kyoto University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canon Inc, Kyoto University NUC filed Critical Canon Inc
Publication of WO2009110523A2 publication Critical patent/WO2009110523A2/en
Publication of WO2009110523A3 publication Critical patent/WO2009110523A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/02—Compositions of unspecified macromolecular compounds characterised by the presence of specified groups, e.g. terminal or pendant functional groups
    • C08L101/04—Compositions of unspecified macromolecular compounds characterised by the presence of specified groups, e.g. terminal or pendant functional groups containing halogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerization Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Provided is a dendrimer particle having a unit that contains a fluorine atom at a plurality of branch ends of an aliphatic branched polymer (dendrimer). Further, the dendrimer particle is produced using an atom transfer radical polymerization method or the like. Thus, an F-MRI contrast medium, dendrimer particles with high contrast sensitivity and a rigorously controlled size and a method of manufacturing the same are provided.
PCT/JP2009/054107 2008-03-03 2009-02-26 Dendrimer particle, mri contrast medium, and method of manufacturing a dendrimer particle Ceased WO2009110523A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2008-052408 2008-03-03
JP2008052408 2008-03-03
JP2008-230241 2008-09-08
JP2008230241A JP5578776B2 (en) 2008-03-03 2008-09-08 Dendrimer particles, contrast agent for MRI, and method for producing dendrimer particles

Publications (2)

Publication Number Publication Date
WO2009110523A2 WO2009110523A2 (en) 2009-09-11
WO2009110523A3 true WO2009110523A3 (en) 2009-12-10

Family

ID=40933650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/054107 Ceased WO2009110523A2 (en) 2008-03-03 2009-02-26 Dendrimer particle, mri contrast medium, and method of manufacturing a dendrimer particle

Country Status (2)

Country Link
JP (1) JP5578776B2 (en)
WO (1) WO2009110523A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153729B2 (en) * 2008-05-29 2012-04-10 The Regents Of The University Of California Highly efficient agents for dispersion of nanoparticles in matrix materials
JP5802680B2 (en) * 2010-11-26 2015-10-28 国立大学法人九州大学 Water-soluble hyperbranched polymer with paramagnetism
WO2012074051A1 (en) * 2010-12-01 2012-06-07 国立大学法人九州大学 Fluorinated hyperbranched polymer and process for production thereof
WO2012142670A1 (en) * 2011-04-20 2012-10-26 The University Of Queensland Nuclear magnetic resonance agent
GB2521655A (en) * 2013-12-27 2015-07-01 Nipsea Technologies Pte Ltd Water dispersible dendritic polymers
CN107189075B (en) * 2017-06-06 2018-03-02 东北石油大学 A kind of dendrimer compound and its preparation method and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002220468A (en) * 2000-11-24 2002-08-09 Communication Research Laboratory New thioether derivative, production method thereof and usage thereof
WO2007112100A2 (en) * 2006-03-24 2007-10-04 The University Of Utah Research Foundation Highly fluorinated oils and surfactants and methods of making and using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445016B2 (en) * 2006-04-14 2013-05-21 Interface Biologics, Inc. Grafted polymers and uses thereof
US7842390B2 (en) * 2006-10-03 2010-11-30 The Penn State Research Foundation Chain end functionalized fluoropolymers having good electrical properties and good chemical reactivity
JP2008163056A (en) * 2006-12-26 2008-07-17 Lion Corp Method for synthesizing hyperbranched polymer, hyperbranched polymer, resist composition, semiconductor integrated circuit, and method for manufacturing semiconductor integrated circuit
JP2007231292A (en) * 2007-05-09 2007-09-13 Kaneka Corp Method for producing star-shaped polymer
JP5631005B2 (en) * 2007-12-25 2014-11-26 日本曹達株式会社 Onium salt-containing polymer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002220468A (en) * 2000-11-24 2002-08-09 Communication Research Laboratory New thioether derivative, production method thereof and usage thereof
WO2007112100A2 (en) * 2006-03-24 2007-10-04 The University Of Utah Research Foundation Highly fluorinated oils and surfactants and methods of making and using same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JEONG S. W. ET AL.: "Encapsulation and diffusion of Water-Soluble Dendrimers in a Bicontinuous Cubic Phase", LANGMUIR, vol. 18, 2002, pages 1073 - 1076, XP002550214 *
LONGMAID H. E. ET AL.: "In vivo 19F NMR Imaging of Liver, Tumor and Abscess in Rats", INVESTIGATIVE RADIOLOGY, 1985, pages 141 - 145, XP008113211 *
MARTIN-RAPUN R ET AL: "LIQUID CRYSTALLINE SEMIFLUROINATED IONIC DENDRIMERS", LIQUID CRYSTALS, TAYLOR AND FRANCIS, ABINGDON, GB, vol. 34, no. 3, 1 March 2007 (2007-03-01), pages 395 - 400, XP001540571, ISSN: 0267-8292 *
TAI-SHUNG ET AL.: "PAMAM Dendrimer-Induced Cross-Linking Modification of Polyimide Membranes", LANGMUIR, vol. 20, 2004, pages 2966 - 2969, XP007910126 *
WANG J-S ET AL: "CONTROLLED/LIVING RADICAL POLYMERIZATION ATOM TRANSFER RADICAL POLYMERIZATION IN THE PRESENCE OF TRANSITION-METAL COMPLEXES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC. US, vol. 117, 1 January 1995 (1995-01-01), pages 5614/5615, XP000907306, ISSN: 0002-7863 *
XIAO ET AL.: "Surface characterization, modification chemistry, and Separation Performance of polyimide and Polyamidoamine Dendrimer Composite films", LANGMUIR, vol. 20, 2004, pages 8230 - 8238, XP007910127 *

Also Published As

Publication number Publication date
JP5578776B2 (en) 2014-08-27
JP2009235372A (en) 2009-10-15
WO2009110523A2 (en) 2009-09-11

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