[go: up one dir, main page]

WO2009105597A1 - Génération de bol de concentrateur d'oxygène pulsé - Google Patents

Génération de bol de concentrateur d'oxygène pulsé Download PDF

Info

Publication number
WO2009105597A1
WO2009105597A1 PCT/US2009/034610 US2009034610W WO2009105597A1 WO 2009105597 A1 WO2009105597 A1 WO 2009105597A1 US 2009034610 W US2009034610 W US 2009034610W WO 2009105597 A1 WO2009105597 A1 WO 2009105597A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient time
mass
bolus
predetermined
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/034610
Other languages
English (en)
Inventor
Andrew M. Voto
Michael P. Chekal
Michael S. Mcclain
Dana G. Pelletier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delphi Technologies Inc
Original Assignee
Delphi Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delphi Technologies Inc filed Critical Delphi Technologies Inc
Publication of WO2009105597A1 publication Critical patent/WO2009105597A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A61M16/0672—Nasal cannula assemblies for oxygen therapy
    • A61M16/0677—Gas-saving devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • B01D53/04—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
    • B01D53/047—Pressure swing adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/106—Silica or silicates
    • B01D2253/108—Zeolites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2256/00—Main component in the product gas stream after treatment
    • B01D2256/12—Oxygen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/10—Single element gases other than halogens
    • B01D2257/102—Nitrogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/40—Further details for adsorption processes and devices
    • B01D2259/40007—Controlling pressure or temperature swing adsorption
    • B01D2259/40009—Controlling pressure or temperature swing adsorption using sensors or gas analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/40—Further details for adsorption processes and devices
    • B01D2259/402—Further details for adsorption processes and devices using two beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/45—Gas separation or purification devices adapted for specific applications
    • B01D2259/4533—Gas separation or purification devices adapted for specific applications for medical purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2259/00—Type of treatment
    • B01D2259/45—Gas separation or purification devices adapted for specific applications
    • B01D2259/4541—Gas separation or purification devices adapted for specific applications for portable use, e.g. gas masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • B01D53/04—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
    • B01D53/047—Pressure swing adsorption
    • B01D53/0476—Vacuum pressure swing adsorption

Definitions

  • a portable oxygen concentrating or generating system presents unique problems. It is intended to be easily moveable so that it can be easily carried about by a user, since the portability aspect of the invention improves the lifestyle of a person who requires oxygen.
  • the device if the device is to be portable, it must be able to successfully function in significantly diverse environments, including temperature extremes and differing altitudes. This is significantly different than typical non-portable oxygen concentrating systems, such as those used to fill oxygen tanks - where the only portable aspect is the tank itself.
  • a portable oxygen generating device must be capable of function in diverse environments and be relatively lightweight.
  • a portable oxygen generating device must also be in a small package suitable for portability and it should control noise, since it will be contiguous with the patient or user of the device.
  • a pulsed oxygen concentrator provides a specific bolus mass of gas once every time the patient breathes. It is desirable for the bolus to be tightly controlled regardless of environmental and system conditions.
  • Typical pulsed oxygen concentrators use a valve to control the amount of gas that flows for each bolus, and a flow meter to provide feedback to control the duration that the valve is open, thereby delivering the desired bolus.
  • a pulsed oxygen concentrator comprises a selector for determining the desired (or predetermined) mass of a gas bolus delivered to a user and at least one sieve bed having an internal gas and an internal gas pressure within a volume defined by the at least one sieve bed.
  • At least one pressure sensor is operatively connected to the at least one sieve bed to measure the internal gas pressure of the sieve bed.
  • At least one sensor operatively connected to the oxygen concentrator to measure at least one ambient atmospheric parameter is also provided and at least one temperature sensor is connected to the at least one sieve bed.
  • At least one valve is in selective fluid communication with the at least one sieve bed and configured to regulate delivery of said internal gas to a user.
  • a feedforward control system has input parameters of the at least one pressure sensor, the at least one ambient atmospheric sensor or the at least one temperature sensor and the selector. At least one controlled output parameter is configured to control the at least one valve for delivering a bolus mass to the user.
  • a method of providing a predetermined gas bolus mass to a user comprises sensing a gas pressure within at least one sieve bed operatively disposed in a pulsed oxygen concentrator, sensing at least one ambient atmospheric parameter and sensing at least one temperature adjacent the at least one sieve bed.
  • the gas pressure, the at least one ambient atmospheric parameter and the at least one temperature are input into a feed forward controller. With the inputs, a gas bolus mass is released to substantially equal the predetermined gas bolus mass by feed-forward control.
  • the invention accurately estimates bolus flow using input from sensors that monitor both the environmental conditions and oxygen concentrator system conditions. As such, the invention eliminates the need for a flow sensor and/or flow meter.
  • FIG. 1 is a schematic diagram of an oxygen generating system in accordance with the invention.
  • FIG. 2 is a functional schematic diagram of the invention
  • FIG. 3 is a block diagram showing one aspect of the invention.
  • FIG. 4 is a graph showing another aspect of the invention.
  • the invention uses the fact that bolus flow can be considered in three segments that can be mathematically modeled.
  • the three segments are increasing flow, steady flow, and decreasing flow.
  • the increasing flow segment is associated with the opening of the valve.
  • the steady state segment occurs if the valve is open long enough for flow to reach steady state.
  • the decreasing flow segment is associated with closing the valve.
  • FIG. 1 an oxygen generating system or device 10, suitable for use with embodiments of the invention, is shown in FIG. 1.
  • any oxygen generating system may be suitable for use with the invention exemplified in FIGS. 2-4, various examples of which (not shown) are oxygen generating system(s) having fill valves (any suitable combination of 2-way, 3-way, 4-way valves, etc.), vent valves (any suitable combination of 2-way, 3-way, 4-way valves, etc.), a product tank(s), bleed orifice(s) and patient valving.
  • a nitrogen-adsorption process employed by the oxygen generating system may be a pressure swing adsorption (PSA) process or a vacuum pressure swing adsorption (VPSA) process, and such processes operate in repeating adsorption/desorption cycles.
  • PSA pressure swing adsorption
  • VPSA vacuum pressure swing adsorption
  • the oxygen generating device of the present invention includes a housing 11 having an inlet 13 formed therein.
  • the oxygen generating device 10 is portable so that it can be easily carried about by a user.
  • the present invention is suitable for any oxygen generating device, regardless of portability, where the features of the present invention are useful or desired.
  • the inlet is configured to receive a feed gas from the ambient atmosphere, the feed gas including at least oxygen and nitrogen.
  • the oxygen generating device also includes at least one sieve bed.
  • the oxygen generating device 10 includes a first sieve bed 12 and a second sieve bed 14, each in selective fluid communication with the feed gas.
  • each of the first and second sieve beds 12, 14 are configured to selectively receive the feed gas during a predetermined supply period.
  • the first and second sieve beds 12, 14 receives the feed gas via first and second supply conduits 16, 18, respectively.
  • the first and second supply conduits 16, 18 are generally operatively connected to respective first and second supply valves (or inlet valves) 20, 22.
  • the first and second supply valves 20, 22 are two-way valves.
  • the nitrogen-adsorption process employed by the oxygen generating device 10 operates via cycles, where one of the first or second sieve beds 12, 14 vents purge gas (i.e. nitrogen-enriched gas), while the other of the first or second sieve beds 12, 14 delivers oxygen-enriched gas to the user.
  • the functions of the respective sieve beds 12, 14 switch so that venting occurs from the sieve bed that previously was delivering oxygen-enriched gas, while oxygen enriched gas is delivered from the sieve bed that in the prior cycle was venting.
  • Switching is accomplished by opening the respective feed gas supply valve 20, 22 while the other of the feed gas supply valves 20, 22 is closed. More specifically, when one of the first or second sieve beds 12, 14 is receiving the feed gas, the respective one of the first or second supply valves 20, 22 is in an open position. In this case, the feed gas is prevented from flowing to the other of the first or second sieve beds 12, 14.
  • the opening and/or closing of the first and second supply valves 20, 22 may be controlled with respect to timing of opening and/or closing and/or with respect to the sequence in which the first and second supply valves 20, 22 are opened and/or closed.
  • the feed gas is compressed via a compressor 24 prior to entering the first or second supply conduits 16, 18.
  • the compressor 24 is a scroll compressor. As shown in FIGS. 1 and 2, the compressor 24 includes a suction port 52 configured to draw in a stream of the feed gas from the inlet 13.
  • the first and second sieve beds 12, 14 are each configured to separate at least most of the oxygen from the feed gas to produce the oxygen-enriched gas.
  • the first and second sieve beds 12, 14 each include the nitrogen-adsorption material (e.g., zeolite, other similar suitable materials, and/or the like) configured to adsorb at least nitrogen from the feed gas.
  • the sieve beds 12, 14 are operatively disposed in a housing 11 that includes sieve module 26.
  • the oxygen-enriched gas generated via either the PSA or VPSA processes includes a gas product having an oxygen content ranging from about 70 vo 1% to about 100 vol% of the total gas product.
  • the oxygen-enriched gas has an oxygen content of at least 87 vol% of the total gas product.
  • a user conduit 28 having a user outlet 30 is an alternate selective fluid communication with the first and second sieve beds 12, 14.
  • the user conduit 28 may be formed from any suitable material, e.g., at least partially from flexible plastic tubing.
  • the user conduit 28 is configured substantially in a "Y" shape.
  • the user conduit 28 may have a first conduit portion 28a and a second conduit portion 28b, which are in communication with the first sieve bed 12 and the second sieve bed 14, respectively, and merge together before reaching the user outlet 30.
  • the user outlet 30 is an opening in the user conduit 28 configured to output the substantially oxygen-enriched gas for use by the patient.
  • the user outlet 30 may additionally be configured with a nasal cannula, a respiratory mask, or any other suitable device (not shown), as desired.
  • the oxygen delivery device 10 also includes a sieve bed pressure sensor 37, 39 for the sieve beds 12, 14, respectively, and a sieve bed temperature sensor 44 configured to measure the pressure and temperature, respectively, of the first and second sieve beds 12, 14 during the PSA process. It will be appreciated that a single pressure sensor may also be used to measure the pressure of each of the sieve beds 12, 14.
  • the device 10 further includes an ambient pressure sensor 45 and an ambient temperature sensor 47 to measure the pressure and temperature, respectively, of the ambient environment.
  • At least the compressor 24, the first and second supply valves 20, 22, and the first and second patient (or user) delivery valves 32, 34 are controlled by a controller 54.
  • the sieve bed pressure sensors 37, 39, the sieve bed temperature sensor 44, the ambient pressure sensor 45, and the ambient temperature sensor 47 measure parameters that are inputs to the controller 54.
  • the controller 54 is a microprocessor including a memory.
  • a motor 56 drives the components of the oxygen generating system 10 including the compressor 24, the sieve beds 12, 14, the controller 54, the valves 20, 22, 32, 34, 40, 42, and the sensors 37, 39, 44, 45, 47.
  • the motor 56 is powered by a battery (not shown) located on the exterior of the housing 11.
  • motor 56 is a DC brushless, three-phase motor.
  • the system 10 includes a fan 58 configured to cool the compressor 24 and the motor 56.
  • the first conduit portion 28a and the second conduit portion 28b may be configured with a first patient (or user) delivery valve 32 and a second patient (or user) delivery valve 34, respectively.
  • the first and the second user valves 32, 34 are configured as two-way valves.
  • the respective one of the first or second user valves 32, 34 is open.
  • the respective one of the first or second feed gas supply valves 20, 22 is closed.
  • the nitrogen-adsorption process selectively adsorbs at least nitrogen from the feed gas.
  • the compressed feed gas is introduced into one of the first or the second sieve beds 12, 14, thereby pressurizing the respective first or second sieve bed 12, 14.
  • Nitrogen and possibly other components present in the feed gas are adsorbed by the nitrogen-adsorption material disposed in the respective first or second sieve bed 12, 14 during an appropriate PSA/VPSA cycle.
  • the pressure of respective first or second sieve beds 12, 14 is released based by opening one of valve 32 or 34 for a time to deliver a bolus mass of oxygen enriched gas to a patient or user, upon a suitable trigger.
  • the trigger may simply be a predetermined amount of time, or detection upon reaching a predetermined target pressure, or detection of an inhalation, and/or another suitable trigger.
  • the nitrogen-enriched gas (including any other adsorbed components) is also released from the respective first or second sieve bed 12, 14 and is vented out of the system 10 through a vent conduit for the respective first or second sieve bed 12, 14.
  • a "masked" time or the like language may be defined as follows. Following a dynamically adjusted user oxygen delivery phase from the first or second sieve bed 12, 14, breath detection may be "masked” for a predetermined masking time, for example, during the dynamically adjusted oxygen delivery phase and during a predetermined amount of time following the delivery phase. It is understood that such predetermined masking time may be configured to prevent the triggering of another dynamically adjusted user oxygen delivery phase before sufficient substantially oxygen- enriched gas is available from the other of the second or first sieve bed 14, 12. As used herein, sufficient substantially oxygen-enriched gas may be a pulse having a desired oxygen content. In an embodiment, the predetermined masking time may be short in duration.
  • the predetermined masking time may be about 500 milliseconds in length. In an alternate embodiment, this masking time may also be dynamically adjusted, e.g., based on the average breath rate. Further, in order to accommodate a maximum breathing rate of 30 Breaths Per Minute (BPM), a maximum mask time of 2 seconds may be used, if desired.
  • BPM Breaths Per Minute
  • venting occurs after each oxygen delivery phase and after counterfilling, each described further hereinbelow.
  • the gas not adsorbed by the nitrogen- adsorption material i.e., the oxygen-enriched gas
  • the gas not adsorbed by the nitrogen- adsorption material i.e., the oxygen-enriched gas
  • the user outlet 30 is delivered to the patient/user through the user outlet 30.
  • delivery of the bolus mass of oxygen-enriched gas occurs during or within a predetermined amount of time (i.e., a masked time) after the oxygen delivery phase from the respective first or second sieve bed 12, 14.
  • the oxygen delivery system 10 may be configured to trigger an output of a predetermined volume of the oxygen-enriched gas from the sieve bed 12 upon detection of an inhalation by the user. Detection of an inhalation may be accomplished any number of ways.
  • a breath detection device 46 is used.
  • the predetermined bolus mass which is at least a portion of the oxygen-enriched gas produced, is output through the user conduit 28 and to the user outlet 30 during an oxygen delivery phase.
  • the first and second sieve beds 12, 14 are configured to transmit that "left-over" oxygen enriched gas, if any, to the other of the first or second sieve bed 12, 14. This also occurs after each respective oxygen delivery phase.
  • the portion of the remaining oxygen-enriched gas is transmitted via a counterfill flow conduit 48.
  • the transmission of the remaining portion of the oxygen-enriched gas from one of the first or second sieve beds 12, 14 to the other first or second sieve beds 12, 14 may be referred to as "counterfilling.”
  • the counterfill flow conduit 48 is configured with a counterfill flow valve 50.
  • the counterfill flow valve 50 is a two- way valve.
  • the counterf ⁇ ll flow valve 50 is opened to allow the counterf ⁇ lling of the respective first and second sieve beds 12, 14.
  • the sieve bed pressure sensors 37, 39, and the sieve bed temperature sensor 44 measure internal system parameters of the sieve bed, and in the case of the sieve bed temperature sensor 44, measures temperature either in the sieve beds 12, 14 or adjacent thereto, giving a relatively accurate temperature in the temperatures in the sieve beds 12, 14.
  • the ambient pressure sensor 45 and the ambient temperature pressure sensor 47 measure ambient atmospheric parameters, all of which are inputs to the controller 54.
  • the controller 54 uses a feed forward control to affect output from the controller 54.
  • the feed forward control receives, at least one of the sieve bed pressures, at least one of the sieve bed temperatures, and at least one atmospheric parameter to execute one or more algorithms for controlling a delivering a bolus mass to a user.
  • the controller 54 receives a signal for a desired (or predetermined) bolus mass from bolus mass input selector 59.
  • the bolus mass is selected from one of a number of settings on input selector 59, generally located on the exterior of the oxygen generating device 10.
  • the bolus size in one embodiment being in functional increments beginning at 8.5 ml per setting, is typically prescribed by the patient's health care provider. Thus, a setting of "2" would equate to a 17 ml bolus being the predetermined bolus size selected.
  • a bolus generating system 70 shown in FIG. 2, will generate a bolus mass to be delivered to the user that varies in size from the predetermined gas bolus mass selected by 10% or less.
  • controller 54 takes various inputs from bolus generating system 70, uses the flow equations below, and determines the mass of the bolus to be delivered by integrating the flow equations over time for each segment of flow, shown in FIG. 4. By evaluating the integrated flow equations with various valve timing scenarios, it is possible to determine the appropriate timing for valves 32 or 34 to deliver a desired bolus mass that is about the desired bolus mass or selected predetermined bolus mass. Details of the equations are as follows:
  • ⁇ P represents the gauge sieve pressure
  • Pi is the absolute sieve pressure.
  • R is the universal gas constant
  • T temperature in Kelvin
  • Ci and C 2 are calibration constants.
  • This equation represents the peak flow that would occur if the patient valve 32 or 34 were open long enough for peak flow to be reached, and assumes that the pressure from one or the other of sieve beds 12, 14 are held constant while flow continues. Since the patient valve 32, 34 is only open for a short period of time, a constant pressure assumption can be used to provide accurate valve timing.
  • calibration constants must be determined.
  • a set of calibration tests are performed for a representative oxygen concentrator 10 in an environmental chamber, the calibration constants being selected to match the empirical data from the calibration tests.
  • a value of 0.2 was used for C 2
  • Ci was calculated in order to match the actual peak flow recorded on a representative oxygen concentrator at 2LPM flow setting and at 23°C and 900 Feet (altitude). Iterations of the equation with different values for C 2 can be done until the results from the equation acceptably match the empirical data.
  • Equation [1] Relevant data is gathered and is used in equation [1] to create a matrix of estimated peak flow for 3 parameters (Sieve Pressure, Temperature, and Barometric Pressure). C 2 is chosen so that the peak flow is 23 SLPM at 900 feet and 23C (296K), and Ci is varied so that the other portions of the matrix fit empirical results. For the representative system, Equation [1] gives acceptable estimates of the empirical data. Once the constants Ci and C 2 are determined, they are hard coded into the equation residing in controller 54.
  • (ti-tc) Cdose, a calibration value representing the time for the valve to close.
  • PTT Patient Time
  • Equation [3] Before Equation [3] can be used, however, the constants ⁇ r , Tf and C c i ose are determined.
  • a reasonably accurate approximation of the time constants can be scaled from a plot of a representative flow curve, and C c i ose can be determined by superimposing a plot of valve control timing over the flow curve.
  • the constants ⁇ r , if and C c i ose may be determined at a single set of conditions yet remain applicable to the range of conditions.
  • Patient Time is iterative Iy determined using a known bolus value and Q mp (peak flow). The determined PTT time can be compared to empirical data.
  • a second verification method is to use empirical PTT times and Qmp (peak flow). The calculated bolus values can then be compared to empirical bolus values.
  • the bolus determined by using the method above and delivered to the user is within about 10% of the predetermined bolus initially selected from bolus mass input selector 59.
  • a substantially accurate bolus can be delivered to the user utilizing inputs including sieve pressure, temperature and barometric pressure as inputs to the equations provided with calibration constants determined at a single temperature and barometric pressure.
  • controller 54 receives a signal from sieve bed pressure sensors 37, 39, temperature sensor 44 located within housing 11 and adjacent to sieve beds 12, 14 and an ambient atmospheric parameter sensor, which is one of ambient pressure sensor 45 or an ambient temperature sensor 47. Controller also receives a signal indicating the desired (or predetermined) gas bolus mass from bolus mass input selector 59. With these inputs, controller, using the above equations, determines when to open and close patient valves 32 or 34 to release the desired gas bolus mass to the user.

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Separation Of Gases By Adsorption (AREA)

Abstract

Cette invention se rapporte à un concentrateur d'oxygène pulsé. Il comprend un sélecteur destiné à déterminer la masse souhaitée d'un bol de gaz délivré à un utilisateur et au moins un tamis qui présente un gaz interne et une pression de gaz interne à l'intérieur d'un volume défini par le ou les tamis. Au moins un capteur de pression est connecté de manière opérationnelle au ou aux tamis de manière à mesurer la pression de gaz interne du tamis. Au moins un capteur connecté de manière opérationnelle au concentrateur d'oxygène, de manière à mesurer au moins un paramètre atmosphérique ambiant, est également prévu et au moins un capteur de température est connecté au ou aux tamis. Au moins une valve se trouve en communication fluidique avec le ou les tamis et est configurée de manière à réguler la distribution dudit gaz interne à un utilisateur. Un système de commande à action prévisionnelle est prévu et reçoit des paramètres d'entrée du ou des capteurs de pression, du ou des capteurs atmosphériques ambiants ou du ou des capteurs de température et du sélecteur. Au moins un paramètre de sortie commandé est configuré de manière à commander la ou les valves de manière à fournir une masse de bol à l'utilisateur.
PCT/US2009/034610 2008-02-22 2009-02-20 Génération de bol de concentrateur d'oxygène pulsé Ceased WO2009105597A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6666508P 2008-02-22 2008-02-22
US61/066,665 2008-02-22

Publications (1)

Publication Number Publication Date
WO2009105597A1 true WO2009105597A1 (fr) 2009-08-27

Family

ID=40985910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/034610 Ceased WO2009105597A1 (fr) 2008-02-22 2009-02-20 Génération de bol de concentrateur d'oxygène pulsé

Country Status (1)

Country Link
WO (1) WO2009105597A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2524714A4 (fr) * 2010-01-15 2014-10-01 Ikiken Co Ltd Dispositif de concentration d'oxygène
WO2019036768A1 (fr) * 2017-08-25 2019-02-28 ResMed Pty Ltd Procédés et appareil destinés au traitement d'un trouble respiratoire
US10232303B2 (en) 2013-12-20 2019-03-19 Koninklijke Philips N.V. Sensor system and oxygen separator comprising a sensor system
WO2021056065A1 (fr) * 2019-09-24 2021-04-01 ResMed Asia Pte Ltd Procédés et appareil de commande d'un concentrateur d'oxygène
WO2021091496A1 (fr) * 2019-11-07 2021-05-14 ResMed Asia Pte Ltd Procédés et appareil de commande d'un concentrateur d'oxygène
CN115779209A (zh) * 2022-11-21 2023-03-14 四川千里倍益康医疗科技股份有限公司 自适应海拔的脉冲式制氧机控制方法及脉冲式制氧机
EP4262949A4 (fr) * 2020-12-21 2024-11-06 Ventec Life Systems, Inc. Systèmes de ventilateur à distribution d'oxygène intégrée, et dispositifs et procédés associés
US12370333B2 (en) 2018-05-13 2025-07-29 Ventec Life Systems, Inc. Portable medical ventilator system using portable oxygen concentrators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916630A (en) * 1988-09-30 1990-04-10 The United States Of America As Represented By The Secretary Of The Air Force Bed tester for molecular sieve oxygen concentrator
US20060230929A1 (en) * 2005-04-05 2006-10-19 Bliss Peter L Portable oxygen concentrator
US20060266357A1 (en) * 2004-10-12 2006-11-30 Airsep Corporation Oxygen concentrator with variable ambient pressure sensing control means

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916630A (en) * 1988-09-30 1990-04-10 The United States Of America As Represented By The Secretary Of The Air Force Bed tester for molecular sieve oxygen concentrator
US20060266357A1 (en) * 2004-10-12 2006-11-30 Airsep Corporation Oxygen concentrator with variable ambient pressure sensing control means
US20060230929A1 (en) * 2005-04-05 2006-10-19 Bliss Peter L Portable oxygen concentrator

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2524714A4 (fr) * 2010-01-15 2014-10-01 Ikiken Co Ltd Dispositif de concentration d'oxygène
US10232303B2 (en) 2013-12-20 2019-03-19 Koninklijke Philips N.V. Sensor system and oxygen separator comprising a sensor system
US11446457B2 (en) 2017-08-25 2022-09-20 ResMed Pty Ltd Methods and apparatus for treating a respiratory disorder
WO2019036768A1 (fr) * 2017-08-25 2019-02-28 ResMed Pty Ltd Procédés et appareil destinés au traitement d'un trouble respiratoire
US12434026B2 (en) 2018-05-13 2025-10-07 Ventec Life Systems, Inc. Portable medical ventilator system using portable oxygen concentrators
US12370333B2 (en) 2018-05-13 2025-07-29 Ventec Life Systems, Inc. Portable medical ventilator system using portable oxygen concentrators
WO2021056065A1 (fr) * 2019-09-24 2021-04-01 ResMed Asia Pte Ltd Procédés et appareil de commande d'un concentrateur d'oxygène
US20220379066A1 (en) * 2019-11-07 2022-12-01 ResMed Asia Pte. Ltd. Methods and apparatus for control of oxygen concentrator
CN114929318A (zh) * 2019-11-07 2022-08-19 瑞思迈亚洲私人有限公司 用于控制氧气浓缩器的方法和设备
WO2021091496A1 (fr) * 2019-11-07 2021-05-14 ResMed Asia Pte Ltd Procédés et appareil de commande d'un concentrateur d'oxygène
EP4262949A4 (fr) * 2020-12-21 2024-11-06 Ventec Life Systems, Inc. Systèmes de ventilateur à distribution d'oxygène intégrée, et dispositifs et procédés associés
US12440634B2 (en) 2020-12-21 2025-10-14 Ventec Life Systems, Inc. Ventilator systems with integrated oxygen delivery, and associated devices and methods
CN115779209A (zh) * 2022-11-21 2023-03-14 四川千里倍益康医疗科技股份有限公司 自适应海拔的脉冲式制氧机控制方法及脉冲式制氧机

Similar Documents

Publication Publication Date Title
WO2009105597A1 (fr) Génération de bol de concentrateur d'oxygène pulsé
US7722698B2 (en) Method of determining the purity of oxygen present in an oxygen-enriched gas produced from an oxygen delivery system
US11185656B2 (en) Pulsed pressure swing adsorption system and method
US20080110462A1 (en) Oxygen delivery system
JP6438301B2 (ja) 酸素濃縮器の供給ラインの過圧保護
CN102164540B (zh) 医用换气机中患者呼吸努力动态的模型预测在线识别
JP5944396B2 (ja) 機械的なベンチレータに関する圧力ラインパージシステム
US20060266357A1 (en) Oxygen concentrator with variable ambient pressure sensing control means
CN103893865B (zh) 一种呼吸机涡轮容量控制通气的方法
EP3463538B1 (fr) Concentrateur de gaz oxygène présentant un accumulateur de sortie
US20110315140A1 (en) Portable oxygen concentrator
US20210001075A1 (en) Mechanical ventilator with non-invasive option
US20200368482A1 (en) O2 concentrator with sieve bed bypass and control method thereof
EP2575942B1 (fr) Système respiratoire à estimation de flux
EP2093188A2 (fr) Procédé de génération d'un gaz enrichi en oxygène pour un utilisateur
WO2007001836A2 (fr) Systeme de mesure de dispositif respiratoire
JP2013536748A5 (fr)
US20250229043A1 (en) Oxygen concentrator system
JP2021509306A (ja) 呼吸器疾患治療のための方法および装置
US6422237B1 (en) Respirator with a breathing circuit
CN114209950A (zh) 一种双模制氧机及其供氧方法
CN101180100B (zh) 用于测定在电路控制的生氧呼吸器中的可呼吸空气的残气量的方法和装置
US20090229460A1 (en) System for generating an oxygen-enriched gas
WO2022263965A1 (fr) Dispositif respiratoire
US9259545B2 (en) Process for checking the function of a respiration system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09711703

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09711703

Country of ref document: EP

Kind code of ref document: A1