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WO2009102024A1 - Préparation solide moussante pour le nettoyage de la cavité orale - Google Patents

Préparation solide moussante pour le nettoyage de la cavité orale Download PDF

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Publication number
WO2009102024A1
WO2009102024A1 PCT/JP2009/052419 JP2009052419W WO2009102024A1 WO 2009102024 A1 WO2009102024 A1 WO 2009102024A1 JP 2009052419 W JP2009052419 W JP 2009052419W WO 2009102024 A1 WO2009102024 A1 WO 2009102024A1
Authority
WO
WIPO (PCT)
Prior art keywords
solid preparation
foaming
tongue
bad breath
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/052419
Other languages
English (en)
Japanese (ja)
Inventor
Ichiro Fujimoto
Hiroyuki Katsuyama
Toshiyuki Ogata
Toshio Takiguchi
Kenji Osawa
Atsushi Narise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lotte Co Ltd
Original Assignee
Lotte Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lotte Co Ltd filed Critical Lotte Co Ltd
Publication of WO2009102024A1 publication Critical patent/WO2009102024A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont

Definitions

  • the present invention relates to a foamable solid preparation for oral cleaning, which contains an insoluble fiber component and a foaming component and acts on the tongue.
  • the insoluble fiber component is a citrus plant and / or a rose family apple genus plant and / or
  • the present invention relates to a foamable solid preparation for oral cleaning, which is derived from a camellia plant and the foaming component is carbonate.
  • halitosis is generally classified into physiological halitosis, meal-derived halitosis, and disease-derived halitosis.
  • physiological halitosis is generally classified into physiological halitosis, meal-derived halitosis, and disease-derived halitosis.
  • Tongue moss is composed of waste protein and bacteria in the oral cavity.
  • Patent Document 1 As a means for removing tongue coating with food, a method of degrading with an enzyme (Patent Document 1) is known. However, it was difficult to take time until the effect was obtained. In addition, as a method for physically removing tongue coating, a solid composition for oral cavity in which insoluble plant fibers are blended into a solid base material, and fiber protrusions are formed on the surface by dissolution of the solid base material, thereby removing tongue coating. has been reported (Patent Document 2).
  • Non-patent Document 1 the bad breath suppression and tongue coating removal effect of candy blended with Yuzu fiber as a rough material has been reported.
  • the present invention is to provide an effervescent solid preparation for oral cleaning that can effectively remove tongue coating which is a main cause of physiological bad breath and is effective immediately.
  • insoluble plant fibers and foaming ingredients are contained in solid preparations such as tablets, lozenges, candy, and tablet confectionery, and are allowed to act on the tongue by applying them on the tongue.
  • Tongue moss which is the main cause of physiological bad breath, is physically separated from the tongue by the fine protrusions that are formed, and the tongue moss separated by the foaming effect of the foaming component is effectively recovered and removed, thereby removing the conventional tongue coating
  • the present invention mainly has the following configuration.
  • a foamable solid preparation for oral cleaning containing an insoluble plant fiber and a foaming component containing an insoluble plant fiber and a foaming component.
  • a foamable solid preparation for oral cleaning characterized in that the content of the insoluble plant fiber described in (1) above is 0.1 to 10% by weight.
  • An effervescent solid preparation for mouth washing wherein the insoluble plant fiber according to (1) or (2) is derived from a citrus plant and / or a rose family, and / or a camellia plant.
  • the foamable solid preparation for oral cleaning according to any one of (1) to (5) above, further comprises an enzyme.
  • an effervescent solid preparation for oral cleaning which has an immediate effect and has an effect of removing tongue coating effectively.
  • the tongue coating is physically scraped by the fine protrusions of the insoluble natural fiber formed on the surface of the solid preparation, Tongue moss scraped by combining foaming components can be efficiently recovered, physically acting to clean the tongue surface and oral cavity, and immediately effective immediately after application in the oral cavity, Moreover, it is possible to maintain the bad breath removing effect for a long time. Moreover, since this invention gives a favorable touch in an oral cavity by using an insoluble plant fiber, and a refreshing feeling increases more by using a foaming component, taste property is also favorable.
  • the plant and foaming ingredients that are the raw materials of the present invention are all used as food materials, herbal teas, and natural additives for a long time, and there is no problem with regard to their safety. It is preferable. Furthermore, the effect of removing bad breath could be further enhanced by adding an enzyme, preferably an oxidase.
  • candy, tablets, and tablet confections are superior to methods such as a tongue brush because they are excellent in portability and can be taken at any time without worrying about time, and the effects can be immediately experienced.
  • the foamable solid preparation for oral cleaning of the present invention is a solid preparation taken by dissolving in the oral cavity, such as a tablet such as a troche, a candy, and a candy, and is classified as a pharmaceutical, a quasi-drug or a food. is there.
  • a tablet form such as a troche is particularly preferred.
  • insoluble plant fibers and foaming ingredients were mixed into a solid preparation and allowed to act on the tongue.
  • the amount of tongue coating is reduced by more effective physical recovery of the tongue coating that has been scraped and then scraped off more effectively with the foaming component, and has a significantly higher tongue coating removal effect compared to conventional tongue coating removal compositions. It was confirmed that it was expressed with immediate effect, and as a result, a bad breath removal effect could be obtained and the product of the present invention was completed. Furthermore, the bad breath removal effect was able to be improved by mix
  • insoluble plant fiber As a result of various studies, it is preferable to use natural plant fiber derived from fruits and the like in terms of tongue coating removal effect, bad breath removal effect, oral touch, etc. It was found.
  • This insoluble plant fiber is a natural insoluble plant fiber obtained by drying a fruit peel, leaf, pulp, fruit, wood, bark, root, preferably fruit, pulverizing with a mill, etc., and sieving.
  • plant fiber components include insoluble cellulose and insoluble pectin.
  • insoluble means a property that, when contained in the oral cavity, does not dissolve in saliva or is difficult to dissolve.
  • Citrus fruits of the present invention include Citrus iyo, Citrus grandis, Citrus unshu, Citrus tangerina, Orange (Citrus sinensis), Cavos citrus, cavo citrus cicus, cavius. (Citrus kinokuni), grapefruit (Citrus paradis), sunfish (Citrus sulcata), seekershire (Citrus depressa), citron (Citrus medica), sudachi (Citrus sudachiait, daichirata citrus) um), Natsumikan (Citrus natsudaidai), Naburu (Citrus sinensis), Hassaku (Citrus hasasaku), Hyuganatsu (Citrus tamuraa), Bergamot (Citrus bergamit, Citrus bergait) , Lemon (Citrus limon), kumquat (Fortunella japonica), etc., examples of the genus Rosaceae include apples of the genus apples, great white apples, Ezono
  • Insoluble plant fibers can be obtained by subjecting the skin, leaves, pulp, fruits, wood, bark, roots, preferably fruits, to a drying treatment by hot air blowing drying method, etc., and then pulverizing and sieving. If the particle size of the insoluble plant fiber is too fine, the texture is good, but the resistance (the ability to remove tongue coating) is small, and if the particle size is too coarse, the feeling of foreign matter is strong and unsuitable for use. Accordingly, the particle size is preferably in the range of about 1 to 200 ⁇ m.
  • the blending amount of the insoluble plant fiber is preferably about 0.1 to 10.0% by weight of dry powder in the solid preparation. In consideration of palatability, about 0.5 to 2.0% by weight is preferable.
  • a carbon dioxide generating component containing carbonate is preferable.
  • the carbonate include sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, sodium sesquicarbonate, etc. Among them, sodium hydrogen carbonate is particularly preferable.
  • the blending amount of the foamable component is about 1 to 15% by weight in the preparation in order to sufficiently remove tongue coating due to good foaming properties, but 3.0 to 10.0% by weight is particularly preferable.
  • an enzyme can be appropriately added to the oral cleaning solid preparation of the present invention.
  • an oxidase can be preferably used.
  • examples of oxidase include polyphenol oxidase.
  • the blending amount is preferably about 0.01 to 1.0% by weight in the preparation.
  • a general deodorant can be additionally used as appropriate in the oral cleaning solid preparation of the present invention, and a naturally-derived deodorant can be used.
  • Natural deodorants include Camellia plant green tea, Oolong tea and black tea (Camellia sinensis), Rosaceae Raspberry genus tea (Rubus suavissimus), Raspberry (Rubus idaeus), Eucalyptus gulberry, etc. Although it is suitable as a raw material for deodorizing ingredients in terms of taste and effect, there is no particular rule.
  • the peels, leaves, pulp, fruits, wood, bark, roots of these plants, preferably dried leaves thereof, are prepared using conventional extraction methods and extraction solvents, and appropriately mixed in the preparation. For example, it can be blended in the range of about 0.01 to 0.5% by weight.
  • sugars such as sucrose, glucose, lactose, starch, dextrin, etc.
  • sugar alcohols such as reduced maltose, sorbitol, erythritol, celluloses, dietary fiber, vitamins, caffeine, etc.
  • sweeteners such as aspartame, sucralose, and acesulfame potassium
  • acidulants such as citric acid can be appropriately blended.
  • a tablet is preferable and can be produced according to a conventional method.
  • the solid preparation for oral cleaning of the present invention needs to be directly put into the mouth, scraped out the tongue coating while being dissolved in the mouth on the tongue, and further foamed in order to act effectively in the oral cavity.
  • Sample preparation The following samples were used for this test. 1) Sample 1: 50 g of yuzu juice squeezed residue obtained by squeezing yuzu ripe fruit was dried with warm air to obtain 10.4 g of a dried product. The dried product was pulverized by a mill to prepare insoluble plant fibers having a particle size of about 1 to 200 ⁇ m (average 50 ⁇ m). Next, 100 ml of 50% ethanol was added to 10 g of dried tea leaf powder, and extraction was performed while refluxing for 1 hour with a reflux condenser. The obtained extract was filtered off, the solvent was removed, and freeze-dried to obtain 2.39 g of a natural deodorant as an extract.
  • Sample 5 A tablet was prepared by adding 1.0% by weight of insoluble plant fiber and 10.0% by weight of the foaming component of Sample 1.
  • Sample 6 Among Sample 1, a tablet was prepared by adding 5.0% by weight of the foaming component and not adding insoluble plant fiber.
  • Sample 7 A tablet was prepared by changing the blending amount of the insoluble plant fiber to 0.5% by weight.
  • Sample 8 A tablet was prepared by changing the blending amount of insoluble plant fiber to 2.0% by weight.
  • Sample 9 Among samples 1, a tablet to which no natural deodorant was added was prepared.
  • Sample 10 Among samples 1, a tablet to which no oxidase was added was prepared.
  • Sample 11 As a comparative control of the foaming component, a tablet containing 3.0% by weight of proteolytic enzyme in Sample 1 and not containing insoluble plant fiber and foaming component was prepared. 12) Sample 12: As a comparative control of the foaming component, among the samples 1, 3.0% by weight of proteolytic enzyme was added, and a tablet without the foaming component was prepared. 13) Sample 13: As a control for comparison of insoluble plant fiber, 0.2% by weight of copper chlorophyllin sodium as a bad breath preventing component of Sample 1 was added, and a tablet to which insoluble plant fiber and foaming component were not added was prepared. 14) Sample 14: As a control for comparison of insoluble plant fiber, among samples 1, 0.2% by weight of copper chlorophyllin sodium as a bad breath prevention component was added, and a tablet without the addition of insoluble plant fiber was prepared.
  • the insoluble plant fiber of the present invention had a stronger effect of removing tongue coating than copper chlorophyllin sodium.
  • the bad breath removal effect is recognized by including the insoluble plant fiber having a tongue coating removal effect and the foaming component, and further, the combined use of the foaming component shows a remarkably excellent bad breath removal effect and a sustained effect immediately after use. It was found that the feel given to the oral cavity was preferable. Furthermore, by including an oxidase, a more excellent deodorizing effect was obtained.
  • Tablet 1 (wt%) Reduced maltose 70.7 Dietary fiber 10.0 Insoluble plant fiber (derived from Yuzu) 1.0 Sodium bicarbonate 5.0 Green tea extract 0.1 Coloring agent 0.5 Emulsifier 1.5 Acidulant 10.0 Sweetener 0.1 Enzyme (polyphenol oxidase) 0.1 Fragrance 1.0
  • This tablet was excellent in both the immediate effect, sustainability and taste of the tongue coating removal effect and the bad breath prevention effect.
  • the foamable solid preparation for oral cleaning of the present invention can be used as a solid composition for oral cavity having a strong tongue coating removing effect, an immediate effect of removing bad breath, and a portability having taste.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biophysics (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une préparation solide moussante à action rapide pour le nettoyage de la cavité orale, qui permet d'éliminer efficacement le revêtement de la langue, agent causal principal de la mauvaise haleine physiologique. Grâce aux fines projections formées sur la surface de la préparation, le traitement de la face supérieure de la langue avec une préparation solide qui contient une fibre végétale insoluble et un composant moussant permet de séparer mécaniquement de la langue le revêtement de la langue qui est l'agent causal principal de la mauvaise haleine physiologique. Les fragments du revêtement de la langue séparés sont recueillis et éliminés de manière efficace par l'effet de moussage du composant moussant. Une préparation solide moussante pour le nettoyage de la cavité orale, qui a un effet remarquable sur l'élimination du revêtement de la langue et un effet à action rapide de prévention de la mauvaise haleine, qui peut être exercée de manière soutenue pendant une longue durée, peut ainsi être obtenue.
PCT/JP2009/052419 2008-02-14 2009-02-13 Préparation solide moussante pour le nettoyage de la cavité orale Ceased WO2009102024A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008033773A JP5809775B2 (ja) 2008-02-14 2008-02-14 口腔洗浄用発泡性固形製剤
JP2008-033773 2008-02-14

Publications (1)

Publication Number Publication Date
WO2009102024A1 true WO2009102024A1 (fr) 2009-08-20

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ID=40957054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/052419 Ceased WO2009102024A1 (fr) 2008-02-14 2009-02-13 Préparation solide moussante pour le nettoyage de la cavité orale

Country Status (3)

Country Link
JP (1) JP5809775B2 (fr)
KR (1) KR101590649B1 (fr)
WO (1) WO2009102024A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082951A3 (fr) * 2012-11-27 2014-12-18 Unilever Plc Compositions de soins bucco-dentaires
CN105705128A (zh) * 2013-11-14 2016-06-22 荷兰联合利华有限公司 口腔护理组合物
CN107397805A (zh) * 2017-07-07 2017-11-28 山东统盛医药科技有限公司 改善口腔卫生、预防并治疗口腔疾病的组合物及制备方法
WO2025106972A1 (fr) * 2023-11-17 2025-05-22 Teeth Tabs PLLC Composition de traitement dentaire effervescente en comprimés, et procédés

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101591410B1 (ko) 2014-03-18 2016-02-03 김현수 안정성이 강화된 발포 조성물 및 그 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07238008A (ja) * 1994-01-07 1995-09-12 Kao Corp 口腔用発泡性固形組成物
JPH10236935A (ja) * 1996-08-02 1998-09-08 Kao Corp 口腔用固形製剤
JP2002531480A (ja) * 1998-12-05 2002-09-24 スウング カプセル シーオー．，エルティーディー． 口腔清浄用発泡タブレットおよびその製造方法
JP2005281230A (ja) * 2004-03-30 2005-10-13 Lotte Co Ltd 口腔用固形組成物

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* Cited by examiner, † Cited by third party
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JPH0753174B2 (ja) * 1987-06-12 1995-06-07 ライオン株式会社 消臭剤
KR100769573B1 (ko) * 2001-07-02 2007-10-23 주식회사 엘지생활건강 효소를 포함하는 정제형 구강세정제 조성물
WO2003090704A1 (fr) * 2002-04-23 2003-11-06 Ezaki Glico Co., Ltd. Aliments ayant pour effet d'eliminer la mauvaise haleine
JP2004321077A (ja) * 2003-04-24 2004-11-18 Meiji Seika Kaisha Ltd ラッカーゼ封入カプセルを含有するガム
FR2860154B1 (fr) * 2003-09-29 2006-02-03 Chris Cardon Composition pour le traitement de la mauvaise haleine
JP4761017B2 (ja) * 2004-04-01 2011-08-31 ライオン株式会社 口臭抑制用口腔内貼付剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07238008A (ja) * 1994-01-07 1995-09-12 Kao Corp 口腔用発泡性固形組成物
JPH10236935A (ja) * 1996-08-02 1998-09-08 Kao Corp 口腔用固形製剤
JP2002531480A (ja) * 1998-12-05 2002-09-24 スウング カプセル シーオー．，エルティーディー． 口腔清浄用発泡タブレットおよびその製造方法
JP2005281230A (ja) * 2004-03-30 2005-10-13 Lotte Co Ltd 口腔用固形組成物

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014082951A3 (fr) * 2012-11-27 2014-12-18 Unilever Plc Compositions de soins bucco-dentaires
CN104837468A (zh) * 2012-11-27 2015-08-12 荷兰联合利华有限公司 口腔护理组合物
CN104837468B (zh) * 2012-11-27 2018-04-24 荷兰联合利华有限公司 口腔护理组合物
CN105705128A (zh) * 2013-11-14 2016-06-22 荷兰联合利华有限公司 口腔护理组合物
CN105705128B (zh) * 2013-11-14 2019-06-28 荷兰联合利华有限公司 口腔护理组合物
CN107397805A (zh) * 2017-07-07 2017-11-28 山东统盛医药科技有限公司 改善口腔卫生、预防并治疗口腔疾病的组合物及制备方法
WO2025106972A1 (fr) * 2023-11-17 2025-05-22 Teeth Tabs PLLC Composition de traitement dentaire effervescente en comprimés, et procédés

Also Published As

Publication number Publication date
JP2009191023A (ja) 2009-08-27
KR20100124702A (ko) 2010-11-29
KR101590649B1 (ko) 2016-02-01
JP5809775B2 (ja) 2015-11-11

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