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WO2009101458A3 - Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine - Google Patents

Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine Download PDF

Info

Publication number
WO2009101458A3
WO2009101458A3 PCT/HU2009/000016 HU2009000016W WO2009101458A3 WO 2009101458 A3 WO2009101458 A3 WO 2009101458A3 HU 2009000016 W HU2009000016 W HU 2009000016W WO 2009101458 A3 WO2009101458 A3 WO 2009101458A3
Authority
WO
WIPO (PCT)
Prior art keywords
amorphous forms
desvenlafaxine fumarate
new polymorph
polymorph
desvenlafaxine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2009/000016
Other languages
English (en)
Other versions
WO2009101458A2 (fr
Inventor
László Pongó
Gyula Simig
József Barkóczy
Balázs VOLK
András DANCSÓ
Zsuzsanna SZENT-KIRÁLLYI
Adrienn HEGEDŰS
Lmre Markovits
Tamás GREGOR
László SZÁZDI
György RUZSICS
Kálmán NAGY
József DEBRECZENI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0800091A external-priority patent/HU0800091D0/hu
Priority claimed from HU0900062A external-priority patent/HU230652B1/hu
Application filed by Egis Pharmaceuticals PLC filed Critical Egis Pharmaceuticals PLC
Priority to EP09709502A priority Critical patent/EP2252573A2/fr
Publication of WO2009101458A2 publication Critical patent/WO2009101458A2/fr
Publication of WO2009101458A3 publication Critical patent/WO2009101458A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention porte sur de nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine répondant à la formule chimique (II), sur les formes polymorphes I ou III ou IV du fumarate de desvenlafaxine monohydraté et sur leurs procédés de préparation.
PCT/HU2009/000016 2008-02-14 2009-02-13 Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine Ceased WO2009101458A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09709502A EP2252573A2 (fr) 2008-02-14 2009-02-13 Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HUP0800091 2008-02-14
HU0800091A HU0800091D0 (en) 2008-02-14 2008-02-14 Novel polymorphs and amorph forms of desvenlafaxine fumarate
HUP0900062 2009-02-04
HU0900062A HU230652B1 (hu) 2009-02-04 2009-02-04 Desvenlafaxine fumarát monohidrát új polimorf módosulata

Publications (2)

Publication Number Publication Date
WO2009101458A2 WO2009101458A2 (fr) 2009-08-20
WO2009101458A3 true WO2009101458A3 (fr) 2010-04-08

Family

ID=89988755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2009/000016 Ceased WO2009101458A2 (fr) 2008-02-14 2009-02-13 Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine

Country Status (2)

Country Link
EP (1) EP2252573A2 (fr)
WO (1) WO2009101458A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011121452A2 (fr) 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Formes cristallines du fumarate de o-desméthylvenlafaxine
MX367362B (es) * 2016-06-29 2019-08-16 Alparis Sa De Cv Nuevas formas solidas de desvenlafaxina.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112669A2 (fr) * 1982-12-13 1984-07-04 American Home Products Corporation Dérivés de phényléthylamines et leurs produits intermédiaires
WO2000076955A1 (fr) * 1999-06-15 2000-12-21 American Home Products Corporation Enantiomeres de o-desmethyl venlafaxine
WO2009070311A2 (fr) * 2007-11-26 2009-06-04 Teva Pharmaceutical Industries Ltd. Formes cristallines de fumarate de o-desméthylvenlafaxine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0112669A2 (fr) * 1982-12-13 1984-07-04 American Home Products Corporation Dérivés de phényléthylamines et leurs produits intermédiaires
WO2000076955A1 (fr) * 1999-06-15 2000-12-21 American Home Products Corporation Enantiomeres de o-desmethyl venlafaxine
WO2009070311A2 (fr) * 2007-11-26 2009-06-04 Teva Pharmaceutical Industries Ltd. Formes cristallines de fumarate de o-desméthylvenlafaxine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YARDLEY J P ET AL: "2-PHENYL-2-(1-HYDROXYCYCLOALKYL)ETHYLAMINE DERIVATIVES: SYNTHESIS AND ANTIDEPRESSANT ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 33, no. 10, 1 October 1990 (1990-10-01), pages 2899 - 2905, XP000996354, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
EP2252573A2 (fr) 2010-11-24
WO2009101458A2 (fr) 2009-08-20

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