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WO2009157014A3 - A process for preparing hmg-coa reductase inhibitors and intermediates - Google Patents

A process for preparing hmg-coa reductase inhibitors and intermediates Download PDF

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Publication number
WO2009157014A3
WO2009157014A3 PCT/IN2009/000065 IN2009000065W WO2009157014A3 WO 2009157014 A3 WO2009157014 A3 WO 2009157014A3 IN 2009000065 W IN2009000065 W IN 2009000065W WO 2009157014 A3 WO2009157014 A3 WO 2009157014A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
coa reductase
reductase inhibitors
preparing hmg
hmg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000065
Other languages
French (fr)
Other versions
WO2009157014A2 (en
Inventor
Shriprakash Dhar Dwivedi
Anil Ganpat Holkar
Dhimant Jasubhai Patel
Mahesh L. Rupapara
Mayur R. Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of WO2009157014A2 publication Critical patent/WO2009157014A2/en
Publication of WO2009157014A3 publication Critical patent/WO2009157014A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for synthesizing calcium salt of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid (Rosuvastatin Calcium) in high purity.
PCT/IN2009/000065 2008-01-30 2009-01-28 A process for preparing hmg-coa reductase inhibitors and intermediates Ceased WO2009157014A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN210MU2008 2008-01-30
IN210/MUM/2008 2008-01-30

Publications (2)

Publication Number Publication Date
WO2009157014A2 WO2009157014A2 (en) 2009-12-30
WO2009157014A3 true WO2009157014A3 (en) 2010-07-22

Family

ID=41350043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000065 Ceased WO2009157014A2 (en) 2008-01-30 2009-01-28 A process for preparing hmg-coa reductase inhibitors and intermediates

Country Status (1)

Country Link
WO (1) WO2009157014A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227696B1 (en) 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
CN102219749B (en) * 2010-04-14 2013-07-17 上海京新生物医药有限公司 A kind of method for preparing rosuvastatin calcium
WO2012038785A1 (en) * 2010-09-21 2012-03-29 Biocon Limited Polymorphs of rosuvastatin acetonide calcium ((3r,5s,6e)-7-[4-(4- fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimn)in-5- yl)vinyl)-2,2-dimethyl-l,3-dioxan-4-yl) acetic acid calcium salt
CN103467458B (en) * 2012-06-07 2016-08-03 上海迪赛诺药业有限公司 Rosuvastain calcium and the preparation method of intermediate thereof
WO2013181828A1 (en) * 2012-06-07 2013-12-12 上海迪赛诺药业有限公司 Preparation method of rosuvastatin calcium and intermediates thereof
CN105669561B (en) * 2014-11-19 2018-11-27 南京博优康远生物医药科技有限公司 A kind of preparation method of -2 (1H) -one of 4- (4- fluorophenyl) -5- alkoxy carbonyl -6- isopropyl -3,4- dihydro-pyrimidin
CN104557885B (en) * 2014-12-23 2017-07-07 广东东阳光药业有限公司 A kind of preparation method of Rosuvastatin impurity A
CN104788387A (en) * 2015-04-17 2015-07-22 浙江海森药业有限公司 Preparation method for high-purity rosuvastatin calcium
CN104817505A (en) * 2015-04-23 2015-08-05 南京博优康远生物医药科技有限公司 Method of preparing N-[4-(4-fluorophenyl)-5-hydroxymethyl-6-isopropyl-pyrimidine-2-yl]-N-methylmethanesulfonamide
CN111718334B (en) * 2019-03-20 2022-09-30 鲁南制药集团股份有限公司 Rosuvastatin calcium intermediate compound
CN114280181B (en) * 2021-12-23 2024-06-18 浙江海翔川南药业有限公司 Rosuvastatin intermediate and detection method of related substances thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103977A2 (en) * 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
US20050124639A1 (en) * 2003-12-04 2005-06-09 Narendra Joshi Process for the preparation of pyrimidine derivatives
WO2006126035A2 (en) * 2005-05-26 2006-11-30 Richter Gedeon Vegyészeti Gyár Rt. Process for the preparation of rosuvastatin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103977A2 (en) * 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
US20050124639A1 (en) * 2003-12-04 2005-06-09 Narendra Joshi Process for the preparation of pyrimidine derivatives
WO2006126035A2 (en) * 2005-05-26 2006-11-30 Richter Gedeon Vegyészeti Gyár Rt. Process for the preparation of rosuvastatin

Also Published As

Publication number Publication date
WO2009157014A2 (en) 2009-12-30

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