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WO2009153368A2 - Dispositif pour la présentation de stimuli tactiles avec enregistrement simultané d'électroencéphalographe - Google Patents

Dispositif pour la présentation de stimuli tactiles avec enregistrement simultané d'électroencéphalographe Download PDF

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Publication number
WO2009153368A2
WO2009153368A2 PCT/ES2009/000320 ES2009000320W WO2009153368A2 WO 2009153368 A2 WO2009153368 A2 WO 2009153368A2 ES 2009000320 W ES2009000320 W ES 2009000320W WO 2009153368 A2 WO2009153368 A2 WO 2009153368A2
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WO
WIPO (PCT)
Prior art keywords
stimuli
stimulus
tactile stimuli
tactile
presentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2009/000320
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English (en)
Spanish (es)
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WO2009153368A3 (fr
Inventor
José Manuel REALES AVILÉS
Soledad BALLESTEROS JIMÉNEZ
Francisco MUÑOZ MUÑOZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Nacional de Educacion a Distancia UNED
Original Assignee
Universidad Nacional de Educacion a Distancia UNED
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Publication date
Application filed by Universidad Nacional de Educacion a Distancia UNED filed Critical Universidad Nacional de Educacion a Distancia UNED
Publication of WO2009153368A2 publication Critical patent/WO2009153368A2/fr
Publication of WO2009153368A3 publication Critical patent/WO2009153368A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/383—Somatosensory stimuli, e.g. electric stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses

Definitions

  • the device object of this patent is designed to present tactile surfaces by real movement of the stimulus (as opposed to simulated movement).
  • Jiang et al. (1997) used a drum as a tactile stimulator. This drum had different surfaces with points protruding from it and varying from 2 mm to 5 mm. The rotation speed of the drum could be varied from 53 mm / s to 105 mm / s. The force that the drum exerted on the stimulated skin could also be controlled.
  • Essick et al. (1999) used a device consisting of a mechanical arm designed to present stimuli to the cheek of the perceivers. The device allowed to control two axes of movement: anterior-posterior and up-down.
  • the speed of the stimulus could be varied between the values 0.5, 5 or 50 cm / s.
  • the aforementioned mechanisms allow to present surfaces in a controlled way to the tactile system in physiological and psychophysical studies (Tiest and Kappers, 2006, 2007, 2008) and, in addition, they allow to study the tactile perception using neuroimaging techniques or electrophysiological records. Examples of the combined use of tactile stimulators and neuro-imaging techniques are found in the Helix system that allows various stimular combinations on the skin to be presented by means of a lateral movement cylinder (Ingeholm et al., 2006). Another example is Dodecapus, a pneumatic system used to present air puffs in various places of the body surface (Huang and Sereno, 2007).
  • None of the aforementioned devices has been specifically designed to allow the presentation of touch surfaces that may vary in different tactile dimensions (e.g., texture or hardness) and that allow concurrent registration of electroencephalographic variables.
  • the device object of this patent comes to cover this lack.
  • a key aspect of the designed device has been to be able to achieve a perfect synchronization between the presentation of the stimulus and the recording of the electrical potential in various places of the scalp.
  • Gillauer and Eimer (2007) solved this problem using very simple electrically controlled stimuli.
  • Magnetic source imaging reveal normal tactile evoked activity of the human primary and secondary somatosensory cortex. Neurosci Lett. 323, 137-40.
  • Dodecapus An MR-compatible system for somatosensory stimulation. Neuroima ⁇ e. 34, 1060-73.
  • the Helix a multj-modal tactile stimulator for human functional neuroimaging. J Neurosci Methods.
  • NeuroDhvsiol 77, 1656-62. Kenaley, GL and Cutkosky, MR (1989). Electrorheological fiuid-based robotic fingere with tactile sensing. Proc IEEE lnt Conf On robotics & Automation, Scottsdale. Pp 132-136.
  • a ⁇ Spinning Wheel composed of two main parts: a rotating circular platform and an interface that controls the platform and adapts the electrical signals that are sent to the EEG registration system.
  • the turntable is a black methacrylate disk that rotates in the horizontal plane that has twelve holes integrated in the upper part of it where the stimuli are secured.
  • Under the platform there is a set of pins that encode the stimulus based on its position on the platform.
  • Each set of plugs are read by a linear array of photoelectric sensors that generate a binary code that is stored in a transient memory (buff) before being sent to the EEG recording device. Prior storage of the stimulus code is a necessary requirement for send the synchronization signal in a single pulse.
  • the device allows to study the electroencephalographic response of the touch system in humans by presenting tactile stimuli with various textures to the fingertip.
  • This system has been specifically designed to obtain ERPs (Event Related Potentials) to each stimulus by means of synchronization between the presentation of the stimulus to the surface of the skin and the sending of an electrical signal to the EEG recording apparatus (in our case NuAmps systems , Neuroscan ® ).
  • ERPs Event Related Potentials
  • Figure 1 Elevation image of the turntable with the insertion holes occupied by all the stimuli. In the image you can see the fixing screws located on the outside of each hole. On the opposite side you can see the firing pin located in the front part of each stimulus.
  • Figure 3 Side view of the upper photosensor and one of the horizontal pins that trigger the code to the EEG recording device.
  • Figure 4. Electronic control circuit of the turntable.
  • Figure 5. Electronic circuit for generating and sending signals to NeuroScan.
  • the base platform of the device is composed of a turntable used to present the orthohedra that make up the stimulate set (see Figure 1).
  • the platform is fixed on an axis of rotation that is driven by a servomotor.
  • the radius of the platform is 24.6 cm (perimeter of 154.56 cm).
  • the stimuli placed in the 12 insertion holes of the turntable move at a constant angular velocity while its rough (textured) surface comes into contact with the fingertip's finger (normally, the index finger).
  • the platform and the main structure of the device were constructed in black methacrylate.
  • the speed of rotation of the platform can be controlled directly by a potentiometer located in the front base of the interface. This speed can be adjusted linearly in a range from 0.029 rad / sec to 0.41 rad / sec.
  • the turntable has twelve rectangular holes to insert the stimuli. These holes are located in the outer circumference of the platform.
  • the stimuli are screwed to the gaps to prevent their displacement due to friction with the finger.
  • the internal dimensions of the coupling holes are 4 x 6.2 cm 2 .
  • the angle subtended by each stimulus is 13.42 °.
  • the SOA time interval between the beginning of two stimuli or Stimulus Onset Asynchrony
  • the ITI interval between the completion of a stimulus and the start of the next stimulus or InterTr ⁇ al Interval
  • the number of stimuli and, therefore, coupling holes used will depend on the experimental design. It is not necessary to use all the gaps in each test.
  • each coupling gap allows a certain degree of variation in the coupling position (jitie ⁇ thus avoiding the possible expectations that could be generated in the study participants.
  • a photosensor is activated thanks to a pin aligned with the front part of the stimulus ( Figure 3).
  • the plug triggers the firing of an electrical signal previously stored in a buffet that is sent to the EEG registration system.
  • the system hardware Before triggering the signal, the system hardware has stored the stimulus position using a different specific code for each of the possible stimuli.
  • the code of the specific stimulus presented to the recipient in each test is defined by a different distribution of radially aligned pins from the external part of the platform to the internal one. These pins are placed in the space between two coupling holes located below the platform (see Figure 2).
  • the code of the next stimulus that the subject will perceive is generated and stored before the stimulus effectively reaches the finger of the perceiver.
  • the stimulus initially contacts the fingertip with a special pin located at the top and aligned with the stimulus, it is the one that generates the trigger of the previously stored code.
  • the trigger system consists of a 4-bit code. This code allows each of the twelve positions of the coupling holes to be encoded as it would allow discriminating up to a maximum of 16 positions (2 4 ).
  • the Sean Acquire module of the Neuroscan ® company allows you to read, record and visualize the specific code of each stimulus. This code is essential for the processing of the EEG (eg, for times or averaged).
  • the platform rotates at a constant speed thanks to a servomotor of direct current (DC) model RF-500TB-12560. This engine allows the speed to remain constant regardless of the transverse forces applied to the stimulus. The constancy of the speed of rotation of the platform is a necessary requirement to ensure that the speed does not decrease when the stimulus contacts the fingertip.
  • the electronic circuits that control the device are located in the Merface ( Figures 4 and 5).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • User Interface Of Digital Computer (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Input From Keyboards Or The Like (AREA)

Abstract

L'invention concerne un dispositif mécanique et électronique pour présenter des surfaces comprenant différentes textures au toucher. Ce dispositif comporte une plateforme rotative pourvue de 12 creux de couplage pour introduire des stimuli comprenant différentes textures et les présenter au bout du doigt d'un sujet. La vitesse de rotation de la plateforme peut être régulée sur une plage étendue (de 0,029 rad/sec à 0,41 rad/sec) au moyen d'un servomoteur à courant continu. Un ensemble de fiches et de capteurs photoélectriques permet d'identifier les stimuli et d'envoyer des signaux de synchronisation qui indiquent le début de l'exploration tactile à des dispositifs externes de type équipements d'enregistrement électroencéphalographique. Les signaux électriques de synchronisation sont composés d'un code de quatre bits qui est stocké temporairement dans un tampon, et sont destinés à être envoyés au dispositif externe au moment précis auquel le stimulus touche le bout du doigt du sujet.
PCT/ES2009/000320 2008-06-16 2009-06-08 Dispositif pour la présentation de stimuli tactiles avec enregistrement simultané d'électroencéphalographe Ceased WO2009153368A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200801805 2008-06-16
ES200801805A ES2342249B1 (es) 2008-06-16 2008-06-16 Dispositivo para la presentacion de estimulos tactiles con registro concurrente del eeg.

Publications (2)

Publication Number Publication Date
WO2009153368A2 true WO2009153368A2 (fr) 2009-12-23
WO2009153368A3 WO2009153368A3 (fr) 2010-02-18

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PCT/ES2009/000320 Ceased WO2009153368A2 (fr) 2008-06-16 2009-06-08 Dispositif pour la présentation de stimuli tactiles avec enregistrement simultané d'électroencéphalographe

Country Status (2)

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ES (1) ES2342249B1 (fr)
WO (1) WO2009153368A2 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5788648A (en) * 1997-03-04 1998-08-04 Quantum Interference Devices, Inc. Electroencephalographic apparatus for exploring responses to quantified stimuli
AUPQ404899A0 (en) * 1999-11-16 1999-12-09 Price, Gregory Walter Dr Aprocess of interactive stimulation of the brain as a means of modifying the electroencephalogram so as to modify particular electrophysiological respon ses
US6993381B2 (en) * 2002-10-25 2006-01-31 Connolly John F Linking neurophysiological and neuropsychological measures for cognitive function assessment in a patient
WO2009018374A1 (fr) * 2007-07-30 2009-02-05 Neurofocus, Inc. Stimulus de neuro-réponse et estimateur de résonance d'attribut de stimulus

Also Published As

Publication number Publication date
ES2342249A1 (es) 2010-07-02
WO2009153368A3 (fr) 2010-02-18
ES2342249B1 (es) 2011-05-16

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