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WO2009150539A3 - Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins - Google Patents

Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins Download PDF

Info

Publication number
WO2009150539A3
WO2009150539A3 PCT/IB2009/006247 IB2009006247W WO2009150539A3 WO 2009150539 A3 WO2009150539 A3 WO 2009150539A3 IB 2009006247 W IB2009006247 W IB 2009006247W WO 2009150539 A3 WO2009150539 A3 WO 2009150539A3
Authority
WO
WIPO (PCT)
Prior art keywords
toxins
hector
directed against
androctonus
variable domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/006247
Other languages
French (fr)
Other versions
WO2009150539A2 (en
Inventor
Balkiss Bouhaouala
Mohamed El Ayeb
Serge Muyldermans
Rahma Ben Abderrazek
Issam Hmila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Institut Pasteur de Tunis
Original Assignee
Institut Pasteur
Institut Pasteur de Tunis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur, Institut Pasteur de Tunis filed Critical Institut Pasteur
Publication of WO2009150539A2 publication Critical patent/WO2009150539A2/en
Publication of WO2009150539A3 publication Critical patent/WO2009150539A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to variable domains of camelid heavy- chain antibodies directed against Androctonus australis hector (Aah) toxins and uses thereof for preparing therapeutic or diagnostic agents.
PCT/IB2009/006247 2008-06-10 2009-06-10 Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins Ceased WO2009150539A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TN08251 2008-06-10
TN08251 2008-06-10

Publications (2)

Publication Number Publication Date
WO2009150539A2 WO2009150539A2 (en) 2009-12-17
WO2009150539A3 true WO2009150539A3 (en) 2010-04-01

Family

ID=41278727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/006247 Ceased WO2009150539A2 (en) 2008-06-10 2009-06-10 Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins

Country Status (1)

Country Link
WO (1) WO2009150539A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2745473C (en) 2008-12-05 2019-07-30 University Of Guelph Anti-cobra toxin antibody fragments and method of producing a vhh library
US11339208B1 (en) 2012-05-31 2022-05-24 United States Of America As Represented By The Secretary Of The Air Force Camelidae single-domain antibodies against Yersinia pestis and methods of use
US20170267784A1 (en) 2014-10-23 2017-09-21 Singh Molecular Medicine, Llc Single domain antibodies directed against intracellular antigens
TWI746473B (en) * 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 Single domain antibodies directed against intracellular antigens
CN106929513A (en) * 2017-04-07 2017-07-07 东南大学 The nano antibody of mRNA codings and its application
CN109096394B (en) * 2018-09-21 2021-11-05 成都阿帕克生物科技有限公司 Nano antibody of B subunit of anti-staphylococcal protein A, nucleic acid molecule and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1816198A1 (en) * 1995-04-25 2007-08-08 Vrije Universiteit Brussel Variable fragments of immunoglobulins-use for therapeutic or veterinary purposes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1816198A1 (en) * 1995-04-25 2007-08-08 Vrije Universiteit Brussel Variable fragments of immunoglobulins-use for therapeutic or veterinary purposes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEVAUX CHRISTIANE ET AL: "Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom", TOXICON, vol. 43, no. 6, May 2004 (2004-05-01), pages 661 - 669, XP009126047, ISSN: 0041-0101 *
HMILA I ET AL: "VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 14, 1 August 2008 (2008-08-01), pages 3847 - 3856, XP023437111, ISSN: 0161-5890, [retrieved on 20080709] *
MARTIN M-F ET AL: "Purification and amino acid sequence of toxin I'' from the venom of the North African scorpion Androctonus australis Hector", TOXICON, ELMSFORD, NY, US, vol. 22, no. 5, 1 January 1984 (1984-01-01), pages 695 - 703, XP023763033, ISSN: 0041-0101, [retrieved on 19840101] *
MEDDEB-MOUELHI FATMA ET AL: "Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins", TOXICON, ELMSFORD, NY, US, vol. 42, no. 7, 1 December 2003 (2003-12-01), pages 785 - 791, XP009125980, ISSN: 0041-0101 *

Also Published As

Publication number Publication date
WO2009150539A2 (en) 2009-12-17

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