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WO2009146147A3 - Target-responsive hydrogels - Google Patents

Target-responsive hydrogels Download PDF

Info

Publication number
WO2009146147A3
WO2009146147A3 PCT/US2009/039609 US2009039609W WO2009146147A3 WO 2009146147 A3 WO2009146147 A3 WO 2009146147A3 US 2009039609 W US2009039609 W US 2009039609W WO 2009146147 A3 WO2009146147 A3 WO 2009146147A3
Authority
WO
WIPO (PCT)
Prior art keywords
target
cross
responsive hydrogels
aptamers
hydrogels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/039609
Other languages
French (fr)
Other versions
WO2009146147A2 (en
Inventor
Weihong Tan
Yang Huanghao
Haipeng Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of Florida Research Foundation Inc
Original Assignee
University of Florida
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of WO2009146147A2 publication Critical patent/WO2009146147A2/en
Publication of WO2009146147A3 publication Critical patent/WO2009146147A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The subject invention provides methods for fast and easy engineering of target-responsive hydrogels based on aptamers. In a preferred embodiment, the hydrogels contain rationally-designed DNA aptamers as a cross-linker. Specifically exemplified herein is a system wherein competitive binding of a target to the aptamer causes a decrease of cross-linking density and, therefore, dissolution of the hydrogel for potential drug release and other applications.
PCT/US2009/039609 2008-04-05 2009-04-06 Target-responsive hydrogels Ceased WO2009146147A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12315808P 2008-04-05 2008-04-05
US61/123,158 2008-04-05
US12322508P 2008-04-07 2008-04-07
US61/123,225 2008-04-07

Publications (2)

Publication Number Publication Date
WO2009146147A2 WO2009146147A2 (en) 2009-12-03
WO2009146147A3 true WO2009146147A3 (en) 2010-01-21

Family

ID=41377873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/039609 Ceased WO2009146147A2 (en) 2008-04-05 2009-04-06 Target-responsive hydrogels

Country Status (1)

Country Link
WO (1) WO2009146147A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9063138B2 (en) 2009-10-15 2015-06-23 Robert Bosch Gmbh Device and method for indirect electronic condition control in biomolecule detection platforms
WO2011091307A1 (en) * 2010-01-23 2011-07-28 University Of Connecticut Affinity hydrogels for controlled protein release
US10285943B2 (en) 2010-12-02 2019-05-14 Greenmark Biomedical Inc. Aptamer bioconjugate drug delivery device
EP2802876A1 (en) * 2012-01-12 2014-11-19 Robert Bosch GmbH Device and method for indirect electronic condition control in biomolecule detection platforms
US10752873B2 (en) 2015-01-26 2020-08-25 Applied Biosensors, LLC Multi-analyte sensing using hydrogels and magnetometers
KR101912826B1 (en) 2016-10-25 2018-10-30 한국생산기술연구원 Hydrogels having specific molecular affinity and method for controling hydrogels volume using the same
JP2021519310A (en) 2018-03-28 2021-08-10 グリーンマーク バイオメディカル インコーポレイテッドＧｒｅｅｎＭａｒｋ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． Phosphate cross-linked starch nanoparticles and dental treatment
WO2020168200A1 (en) * 2019-02-14 2020-08-20 Carnegie Mellon University Extracellular vesicle functionalization using oligonucleotide tethers
US12433937B2 (en) 2019-08-30 2025-10-07 University Of Florida Research Foundation, Inc. Aptamer assemblies for protein crosslinking
CN111035757A (en) * 2019-12-20 2020-04-21 天津大学 Method for tumor immune-chemical combination therapy DNA nano preparation
WO2022120338A1 (en) * 2020-12-03 2022-06-09 University Of Florida Research Foundation, Inc. Aptamer assemblies for protein crosslinking
WO2024118776A1 (en) * 2022-11-29 2024-06-06 The Penn State Research Foundation Materials and methods for aptamer selection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068295A1 (en) * 2000-07-13 2002-06-06 Marc Madou Multimeric biopolymers as structural elements and sensors and actuators in microsystems
US6680377B1 (en) * 1999-05-14 2004-01-20 Brandeis University Nucleic acid-based detection
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
US20050089864A1 (en) * 2002-01-22 2005-04-28 Yingfu Li Signalling aptamer complexes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680377B1 (en) * 1999-05-14 2004-01-20 Brandeis University Nucleic acid-based detection
US20020068295A1 (en) * 2000-07-13 2002-06-06 Marc Madou Multimeric biopolymers as structural elements and sensors and actuators in microsystems
US20050089864A1 (en) * 2002-01-22 2005-04-28 Yingfu Li Signalling aptamer complexes
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUDITH M. HEALY ET AL.: "Pharmaeokineties and biodistribution of novel aptamer composition.", PHARMACEUTICAL RESEARCH., vol. 21, no. 12, December 2004 (2004-12-01), pages 2234 - 2246 *

Also Published As

Publication number Publication date
WO2009146147A2 (en) 2009-12-03

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