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WO2009039586A3 - Biomarkers for parkinson's disease - Google Patents

Biomarkers for parkinson's disease Download PDF

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Publication number
WO2009039586A3
WO2009039586A3 PCT/AU2008/001437 AU2008001437W WO2009039586A3 WO 2009039586 A3 WO2009039586 A3 WO 2009039586A3 AU 2008001437 W AU2008001437 W AU 2008001437W WO 2009039586 A3 WO2009039586 A3 WO 2009039586A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
parkinson
disease
progression
predict
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2008/001437
Other languages
French (fr)
Other versions
WO2009039586A2 (en
Inventor
Yue Huang
Dominic Rowe
Glenda Halliday
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Powmri Ltd
Original Assignee
Powmri Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007905305A external-priority patent/AU2007905305A0/en
Application filed by Powmri Ltd filed Critical Powmri Ltd
Publication of WO2009039586A2 publication Critical patent/WO2009039586A2/en
Publication of WO2009039586A3 publication Critical patent/WO2009039586A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to the use of two biomarkers, namely α-synuclein and tau, to predict the rate of progression, or to predict the risk of progression at a predetermined rate, of Parkinson's Disease in a subject.
PCT/AU2008/001437 2007-09-28 2008-09-26 Biomarkers for parkinson's disease Ceased WO2009039586A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2007905305 2007-09-28
AU2007905305A AU2007905305A0 (en) 2007-09-28 Biomarkers for Parkinson's disease

Publications (2)

Publication Number Publication Date
WO2009039586A2 WO2009039586A2 (en) 2009-04-02
WO2009039586A3 true WO2009039586A3 (en) 2009-10-29

Family

ID=40511925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2008/001437 Ceased WO2009039586A2 (en) 2007-09-28 2008-09-26 Biomarkers for parkinson's disease

Country Status (1)

Country Link
WO (1) WO2009039586A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3707507A4 (en) * 2017-11-08 2021-11-03 Bio Shai Ltd. Methods for prognosis or treatment of parkinson's disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002053A2 (en) * 1998-07-03 2000-01-13 Innogenetics N.V. Differential diagnosis of neurodegeneration
US20050215562A1 (en) * 2003-06-23 2005-09-29 Patrick Tremblay Methods for treating protein aggregation disorders
WO2007011907A2 (en) * 2005-07-19 2007-01-25 University Of Rochester Alpha-synuclein antibodies and methods related thereto
WO2007014226A2 (en) * 2005-07-26 2007-02-01 The Board Of Trustees Of The University Of Illinois Compounds for the treatment of neurodegeneration and stroke
WO2007109851A1 (en) * 2006-03-29 2007-10-04 Velacor Therapeutics Pty Ltd Treatment of neurodegenerative diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002053A2 (en) * 1998-07-03 2000-01-13 Innogenetics N.V. Differential diagnosis of neurodegeneration
US20050215562A1 (en) * 2003-06-23 2005-09-29 Patrick Tremblay Methods for treating protein aggregation disorders
WO2007011907A2 (en) * 2005-07-19 2007-01-25 University Of Rochester Alpha-synuclein antibodies and methods related thereto
WO2007014226A2 (en) * 2005-07-26 2007-02-01 The Board Of Trustees Of The University Of Illinois Compounds for the treatment of neurodegeneration and stroke
WO2007109851A1 (en) * 2006-03-29 2007-10-04 Velacor Therapeutics Pty Ltd Treatment of neurodegenerative diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Biomed & Pharmacother", vol. 53, article MIZUNO, Y. ET AL.: "Genetics of Parkinson's Disease", pages: 109 - 16, XP000864439, DOI: doi:10.1016/S0753-3322(99)80075-4 *
CHIBA-FALEK, 0. ET AL.: "Regulation of a-Synuclein Expression by Poly (ADP Ribose) Polymerase-1 (PARP-1) Binding to the NACP-Rep1 Polymorphic Site Upstream of the SCNA Gene", AM. J. HUM. GENET., vol. 76, 2005, pages 478 - 492 *
GOEDERT, M.: "Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and a-synucleinopathies", PHIL. TRANS. R. SOC. LOND. B, vol. 354, 1999, pages 1101 - 1118 *
HIGUCHI, M. ET AL.: "Pathobiological features in neurodegenerative diseases: an overview", INTERNATIONAL CONGRESS SERIES, vol. 1260, 2004, pages 69 - 75 *
LUCKING, C.B. ET AL.: "Alpha-synuclein and Parkinson's disease", CMLS, CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 57, 2000, pages 1894 - 1908 *
PASTOR, P. ET AL.: "Significant Association between the tau Gene AO/AO Genotype and Parkinson's Disease", ANN. NEUROL., vol. 47, 2000, pages 242 - 245 *

Also Published As

Publication number Publication date
WO2009039586A2 (en) 2009-04-02

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