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WO2009037718A3 - Process for preparing 3-(2-(dimethylamino)ethyl)-n- methyl-1h-indole-5-methanesulfonamide and product thereof - Google Patents

Process for preparing 3-(2-(dimethylamino)ethyl)-n- methyl-1h-indole-5-methanesulfonamide and product thereof Download PDF

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Publication number
WO2009037718A3
WO2009037718A3 PCT/IN2008/000592 IN2008000592W WO2009037718A3 WO 2009037718 A3 WO2009037718 A3 WO 2009037718A3 IN 2008000592 W IN2008000592 W IN 2008000592W WO 2009037718 A3 WO2009037718 A3 WO 2009037718A3
Authority
WO
WIPO (PCT)
Prior art keywords
methanesulfonamide
indole
dimethylamino
ethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000592
Other languages
French (fr)
Other versions
WO2009037718A8 (en
WO2009037718A2 (en
Inventor
O. D. Tyagi
Purendhar Koilkonda
Jitendra Sharma
R. V. N. Vikas Chandradev
R. Sridhar
Saswata Lahiri
A. V. Mouneshwar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2009037718A2 publication Critical patent/WO2009037718A2/en
Publication of WO2009037718A8 publication Critical patent/WO2009037718A8/en
Publication of WO2009037718A3 publication Critical patent/WO2009037718A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of 3-(2- (dimethylamino) ethyl)-N-methyl- 1 H-indole-5-methanesulfonamide (sumatriptan) acid addition salt and the base having enhanced yield and purity. Further the present invention also provides a novel crystalline sumatriptan base.
PCT/IN2008/000592 2007-09-17 2008-09-16 Process for preparing 3-(2-(dimethylamino)ethyl)-n- methyl-1h-indole-5-methanesulfonamide and product thereof Ceased WO2009037718A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2078CH2007 2007-09-17
IN2078/CHE/2007 2007-09-17

Publications (3)

Publication Number Publication Date
WO2009037718A2 WO2009037718A2 (en) 2009-03-26
WO2009037718A8 WO2009037718A8 (en) 2009-05-28
WO2009037718A3 true WO2009037718A3 (en) 2010-01-21

Family

ID=40468565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000592 Ceased WO2009037718A2 (en) 2007-09-17 2008-09-16 Process for preparing 3-(2-(dimethylamino)ethyl)-n- methyl-1h-indole-5-methanesulfonamide and product thereof

Country Status (1)

Country Link
WO (1) WO2009037718A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102212027B (en) * 2011-05-04 2012-12-12 苏州莱克施德药业有限公司 Preparation method for sumatriptan

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
US20060106227A1 (en) * 2002-06-13 2006-05-18 Dr Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060106227A1 (en) * 2002-06-13 2006-05-18 Dr Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions

Also Published As

Publication number Publication date
WO2009037718A8 (en) 2009-05-28
WO2009037718A2 (en) 2009-03-26

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