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WO2009037539A3 - Traitement d'états pathologiques œstrogénodépendants chez des femmes pré-ménopausées - Google Patents

Traitement d'états pathologiques œstrogénodépendants chez des femmes pré-ménopausées Download PDF

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Publication number
WO2009037539A3
WO2009037539A3 PCT/IB2008/002296 IB2008002296W WO2009037539A3 WO 2009037539 A3 WO2009037539 A3 WO 2009037539A3 IB 2008002296 W IB2008002296 W IB 2008002296W WO 2009037539 A3 WO2009037539 A3 WO 2009037539A3
Authority
WO
WIPO (PCT)
Prior art keywords
menopausal women
oestrogen
treatment
dependant
dependant conditions
Prior art date
Application number
PCT/IB2008/002296
Other languages
English (en)
Other versions
WO2009037539A2 (fr
Inventor
Ernest Loumaye
Jean-Pierre Gotteland
Original Assignee
Preglem Sa
Ernest Loumaye
Jean-Pierre Gotteland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Preglem Sa, Ernest Loumaye, Jean-Pierre Gotteland filed Critical Preglem Sa
Priority to JP2010524589A priority Critical patent/JP5543920B2/ja
Priority to BRPI0817045 priority patent/BRPI0817045A2/pt
Priority to CA2698814A priority patent/CA2698814A1/fr
Priority to EP08806991A priority patent/EP2207544A2/fr
Priority to US12/678,674 priority patent/US20100204146A1/en
Publication of WO2009037539A2 publication Critical patent/WO2009037539A2/fr
Publication of WO2009037539A3 publication Critical patent/WO2009037539A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention porte sur un procédé pour traiter et/prévenir des troubles du cycle ovarien, la sécrétion non compensée prolongée d'œstrogènes et/ou la formation de kystes folliculaires ovariens chez des femmes en pré-ménopause dont les ovaires sont fonctionnels lorsqu'elles sont traitées avec des inhibiteurs de stéroïde sulfatase (STS-I) pour un état pathologique œstrogénodépendant.
PCT/IB2008/002296 2007-09-17 2008-09-04 Traitement d'états pathologiques œstrogénodépendants chez des femmes pré-ménopausées WO2009037539A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2010524589A JP5543920B2 (ja) 2007-09-17 2008-09-04 閉経前の女性におけるエストロゲン依存症状の治療
BRPI0817045 BRPI0817045A2 (pt) 2007-09-17 2008-09-04 Tratamento de condições estrogênio-dependentes em mulheres pré-menopáusicas
CA2698814A CA2698814A1 (fr) 2007-09-17 2008-09-04 Traitement d'etats pathologiques oestrogenodependants chez des femmes pre-menopausees
EP08806991A EP2207544A2 (fr) 2007-09-17 2008-09-04 Traitement d'états pathologiques strogénodépendants chez des femmes pré-ménopausées
US12/678,674 US20100204146A1 (en) 2007-09-17 2008-09-04 Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96010907P 2007-09-17 2007-09-17
US60/960,109 2007-09-17

Publications (2)

Publication Number Publication Date
WO2009037539A2 WO2009037539A2 (fr) 2009-03-26
WO2009037539A3 true WO2009037539A3 (fr) 2009-07-16

Family

ID=40468492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002296 WO2009037539A2 (fr) 2007-09-17 2008-09-04 Traitement d'états pathologiques œstrogénodépendants chez des femmes pré-ménopausées

Country Status (7)

Country Link
US (1) US20100204146A1 (fr)
EP (1) EP2207544A2 (fr)
JP (1) JP5543920B2 (fr)
KR (1) KR20100068287A (fr)
BR (1) BRPI0817045A2 (fr)
CA (1) CA2698814A1 (fr)
WO (1) WO2009037539A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2647378A1 (fr) 2012-04-05 2013-10-09 PregLem S.A. Régime inhibiteur de la sulfatase stéroïde pour le traitement de l'endométriose
EP2647379A1 (fr) 2012-04-05 2013-10-09 PregLem S.A. Utilisation combinée d'un inhibiteur de la sulfatase stéroïde pour le traitement de l'endométriose
WO2014140217A1 (fr) * 2013-03-14 2014-09-18 Laboratoire Hra-Pharma Procédé permettant de planifier l'ovulation
KR101686986B1 (ko) * 2014-07-28 2016-12-16 에스케이케미칼주식회사 류프로라이드를 포함하는 속효성과 지속성을 동시에 갖는 약제학적 조성물
KR102397510B1 (ko) 2014-12-23 2022-05-13 주식회사 젬백스앤카엘 난소 기능 보존용 펩티드 및 이를 포함하는 조성물
CN110446456B (zh) 2017-03-31 2022-11-15 比奥拉治疗股份有限公司 用于可摄入装置的定位系统和方法
CN110809473A (zh) * 2017-06-01 2020-02-18 延世大学校产学协力团 用于预防或治疗骨相关疾病的药物组合物
WO2019110688A1 (fr) * 2017-12-05 2019-06-13 Ferring B.V. Composition comprenant du dégarélix pour une utilisation dans le traitement du cancer du sein
WO2023150267A1 (fr) * 2022-02-03 2023-08-10 Maison Amori Oqvpo Llc Méthodes, compositions et utilisations pour le traitement du cancer par la fourniture de médicaments qui induisent la mitose ciblée des cellules tumorales avant de fournir une chimiothérapie ou une radiothérapie et kits associés

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP1193250A1 (fr) * 1999-07-06 2002-04-03 Teikoku Hormone Mfg. Co., Ltd. Derives phenyl-sulfamates
WO2003006027A1 (fr) * 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combinaison de drospirenone et d'un sulfamate d'oestrogene destinee a une hormonotherapie substitutive
WO2004101545A1 (fr) * 2003-05-16 2004-11-25 Laboratoire Theramex Derives de sulfamate benzothiophene utilises en tant qu'inhibiteurs de la steroide sulfatase
EP1568381A1 (fr) * 2002-10-09 2005-08-31 Kyowa Hakko Kogyo Co., Ltd. Remede destine a un cancer hormone-dependant

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
GB9118478D0 (en) 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
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WO1996015794A1 (fr) * 1994-11-22 1996-05-30 Balance Pharmaceuticals, Inc. Compositions et methodes de contraception et de traitement de troubles gynecologiques benins
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BR0214373A (pt) 2001-11-21 2004-10-13 Sterix Ltd Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase
PE20040167A1 (es) 2002-03-28 2004-05-26 Novartis Ag Amidas del acido sulfamico
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SI1624878T1 (sl) * 2003-05-22 2007-02-28 Pantarhei Bioscience Bv Uporaba sestavkov, ki obsegajo estrogensko komponento, za zdravljenje in preprecevanje muskuloskeletne bolecine
EP1694650A1 (fr) 2003-12-15 2006-08-30 Laboratoire Theramex Derives de 1-n-phenyl-amino-1h-imidazole et compositions pharmaceutiques les contenant
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193250A1 (fr) * 1999-07-06 2002-04-03 Teikoku Hormone Mfg. Co., Ltd. Derives phenyl-sulfamates
WO2003006027A1 (fr) * 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combinaison de drospirenone et d'un sulfamate d'oestrogene destinee a une hormonotherapie substitutive
EP1568381A1 (fr) * 2002-10-09 2005-08-31 Kyowa Hakko Kogyo Co., Ltd. Remede destine a un cancer hormone-dependant
WO2004101545A1 (fr) * 2003-05-16 2004-11-25 Laboratoire Theramex Derives de sulfamate benzothiophene utilises en tant qu'inhibiteurs de la steroide sulfatase

Also Published As

Publication number Publication date
JP5543920B2 (ja) 2014-07-09
JP2010539153A (ja) 2010-12-16
BRPI0817045A2 (pt) 2015-03-24
KR20100068287A (ko) 2010-06-22
US20100204146A1 (en) 2010-08-12
CA2698814A1 (fr) 2009-03-26
EP2207544A2 (fr) 2010-07-21
WO2009037539A2 (fr) 2009-03-26

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