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WO2009035384A1 - Dispositif filtre amovible - Google Patents

Dispositif filtre amovible Download PDF

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Publication number
WO2009035384A1
WO2009035384A1 PCT/SE2007/050644 SE2007050644W WO2009035384A1 WO 2009035384 A1 WO2009035384 A1 WO 2009035384A1 SE 2007050644 W SE2007050644 W SE 2007050644W WO 2009035384 A1 WO2009035384 A1 WO 2009035384A1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
filter device
medical
fluid container
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2007/050644
Other languages
English (en)
Inventor
Anna ELLSTRÖM
Kjell Andreasson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carmel Pharma AB
Original Assignee
Carmel Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmel Pharma AB filed Critical Carmel Pharma AB
Priority to PCT/SE2007/050644 priority Critical patent/WO2009035384A1/fr
Publication of WO2009035384A1 publication Critical patent/WO2009035384A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A61M2005/1623—Details of air intake
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes

Definitions

  • the present invention relates to medical filter devices and especially attachable medical filter devices arranged with a piercing member, it also relates to a drug administration system comprising such a medical filter device.
  • Filter devices and especially medical filter devices are commonly used to filter fluids flowing from one fluid container to another fluid container or between a fluid container and a patient.
  • Such filter devices usually have connection means at each end to connect at least two fluid containers.
  • a filter body is arranged between each end to filter the passing fluid and thereby prevent contaminants from entering the blood stream of the patient, or in cases were filtration is done between two fluid containers, to prevent contaminants from entering one of the fluid containers.
  • a filter device having a rubber stopper puncture part, a sterile filter and a syringe connection part is described.
  • the rubber stopper puncture part exhibits connection means for connection to a fluid container.
  • the filter device removes the need for a needle on the syringe itself, since the filter device is equipped with a puncture part.
  • the filter device filters the liquid flowing from the syringe and thereby removes any impurities, or at least a part thereof, before it enters the connected fluid container.
  • the filter device uses a wet filter which is said to sterilize the fluid before it enters the connected fluid container.
  • Filter devices like the filter device described in the patent publication JP 2003339876 A2 are specifically adapted to filter liquids between two fluid containers. However, when filtering a gas, different filter properties may be required. Additionally, the syringe connection part significantly reduces the filter area exposed to the environment, and thereby eliminates or reduces the efficiency and the utilization degree of the filter body.
  • the apparatus includes a reusable main supply system, a disposable fluid administration system, and a transfer syringe.
  • the transfer syringe is used to transfer fluid from the main supply system to the fluid administration system.
  • the administration system includes an air valve and a filter to allow for complete drainage of the fluid in the fluid administration system while reducing the risk for contamination of the fluid. While the fluid enters the blood stream of the patient, the pressure inside the fluid container decreases and a negative pressure is established inside the fluid container.
  • the air valve and the filter are integrated with the administration system in systems like the one just described, and normalize the pressure inside the fluid container during drug administration.
  • a device for mixing medical fluids and a method for enabling such a mixing are described.
  • the device exhibits an inlet port, an injection port, an outlet port, a first duct between the injection port and the inlet port, and a second duct between the inlet port and the outlet port.
  • the injection port is sealed by a fluid-proof membrane. Mixing devices like these do not provide for any normalization of the pressure.
  • Normalization of the pressure is not a necessary function, but provides for a valuable benefit since it renders a mixing device more flexible in terms of usage with different fluid containers.
  • An increasing negative pressure i.e. a vacuum, makes the transfer of the fluid from the fluid container to the patient more difficult since the flow, and thereby also the amount of medicament, changes with time as the negative pressure increases in the fluid container. This effect becomes readily apparent when using rigid fluid containers, and could, in those cases, stop the fluid administration fully, if not tended to.
  • Administration systems with integrated valves and filters are however expensive and complicated to manufacture since they usually require that several separate parts are assembled. Additionally they require a separate air channel in the spike for the incoming air to normalize the pressure.
  • an attachable filter device for filtering a fluid which is adapted to be attached to a fluid container.
  • the fluid flows in a first direction into said fluid container.
  • the filter device comprises a filter housing comprising at least one filter. Said filter housing is arranged in fluid communication with a hollow piercing member, the filter device further preferably comprises a clack valve function to prevent liquid from passing in a second direction opposite of said first direction.
  • the piercing member provides for a gas inlet after connection with said fluid container.
  • the filter used in the filter device, is a dry filter adapted to filter a gaseous fluid flowing in the first direction.
  • a medical filter device according to the present invention provides a flexible way to normalize the pressure inside fluid containers and thereby also a drug administration system while at the same time filtering the incoming gas.
  • One embodiment of the present invention comprises a separate clack valve to provide for the clack valve function in the filter housing.
  • the embodiment is particularly advantageous since it removes the dry filter from any contact with liquid, which could harm the dry filter and its gas filtering properties.
  • at least one of the dry filters can exhibit the clack valve function.
  • the clack valve can be arranged between the second end of said hollow piercing member and said at least one filter.
  • the medical filter device can be provided with a dry filter having a minimum water breakthrough > 5 minutes at 0.069 bar, this is especially beneficial if liquid is exposed to the dry filter, in order to prevent any leakage from the fluid container which could harm nursing personal or the environment.
  • at least one dry filter is liquid impermeable.
  • the filter housing may also comprise a filter comprising activated carbon to provide for adequate filtration of the incoming gas.
  • the filter device according to the present invention may have at least one dry filter adapted to filter bacterial and viral organisms from the gas flow. This is preferred since it will provide for a substantially sterile filtration of the gas flow.
  • the filter device is preferably equipped with connection means to temporarily or permanently attach the attachable medical filter device a fluid container.
  • the connection means may be in the form of an adhesive layer or at least one, preferably two, protruding members adapted to engage corresponding members on an injection port. A combination of an adhesive layer and protruding members is of course also possible.
  • the filter device may comprise a movable protective member which can be moved between a first and a second position, wherein when the protective member is in the first position, the piercing member is at least partly exposed, and when the protective member is in the second position, the piercing member is covered by the protective member.
  • the protective member preferably comprises a fluid-proof barrier membrane to provide for a liquid tight seal when connected to the fluid container. Additionally, the protective member may comprise connection means.
  • the medical filter device is adapted to provide for the gas inlet via an injection port for injecting medicament to the fluid container.
  • the gas inlet for normalization of the pressure inside the fluid container utilizes the existing fluid communicating channel.
  • the medical filter device is adapted to provide for the gas inlet on the surface on a pierceable fluid container. This is done by simply inserting the piercing member through the surface and thereafter attaching the filter device to the surface of the fluid container.
  • the mentioned gas is intended to be air, hence the gas inlet is preferably an air inlet.
  • fluid is meant either a gas, e.g. air, or a liquid, e.g. water.
  • dry filter a filter which is specifically intended to filter a gas, e.g. air, in a normal hospital environment, hence filters which are intended to filter liquids are per this definition not dry filters but wet filters.
  • medical filter device a filter device which is used in e.g. hospitals, hospital-like environments, the pharmaceutical industry, home care, first aid etc. Such medical devices are very often restricted to certain manufacturing or quality regulations due to the risk for contamination.
  • Figure 1 shows a patient during administration of a medicament.
  • Figure 2a shows a cross section of a medical filter device according to one embodiment of the present invention.
  • Figure 2b shows a front view of the medical filter device shown in figure 2a.
  • Figure 3 shows a partly a side view and partly a cross section of a medical filter device according to one embodiment of the present invention.
  • Figure 4 shows a medical filter device according to the present invention being used together with an administration system comprising a mixing device.
  • Figure 1 shows a patient 100 being administrated with a medicament by means of an administration system 105 and via an infusion line 101 connected to a fluid container 102.
  • the fluid container 102 Before administration of the medicament, the fluid container 102 has been prepared with medication using an injector (not shown) via an injection port 103 arranged on the fluid container 102.
  • a medical filter device 104 is connected to the injection port 103 to normalize the pressure inside the fluid container 102 during administration of the medicament.
  • FIG. 2a-2b shows an embodiment of a medical filter device 200 according to the present invention.
  • the medical filter device 200 exhibits a hollow piercing member 201 in the form of a hollow needle.
  • the piercing member 201 has a first end 202 with a piercing tip 203 and a second end 204.
  • a filter housing 205 is fixed in the proximity of the second end 204 of the piercing member 201.
  • the filter housing 205 comprises a disc shaped housing 206 comprising a surrounding wall 207 which stretches around the periphery of a circular base 208.
  • the surrounding wall 207 has an outer surface 209 and an inner surface 210.
  • a second side 21 1 is arranged opposite the circular base 208.
  • the second side 21 1 comprises a gas inlet opening 212.
  • the gas inlet opening 212 extends over the whole second side 211 up to the surrounding wall 207.
  • a dry filter 220 having a first and a second side 221 , 222 and a thickness F t , is adhered to the end of the surrounding wall 207 so as to cover the gas inlet opening 212.
  • hot-melt adhesive has been applied around the periphery of first side 221 of the dry filter 220 to attach the dry filter 220 to the surrounding wall 207 and thereby also create a gas tight sealing between the dry filter 220 and the surrounding wall 207.
  • the thickness of the surrounding wall W t is equal, or thicker, to the thickness of the dry filter F t .
  • the medical filter device 200 has a gas flow direction A.
  • the gas flow enters the dry filter 220 mainly from the second side 222 of the dry filter 220.
  • the gas flow may enter partly around the periphery of the dry filter 220, if the dry filter 220 is attached as shown in figure 2a.
  • the gas exits the dry filter 220 on the first side 221 , to enter inside the filter housing 205.
  • the filter housing 205 which is in fluid communication with the hollow piercing member 201 , directs the gas to the hollow piercing member 201 , whereby the gas exits from the medical filter device 200 at the piercing tip 203 of the piercing member 201.
  • the gas flow is imparted by the negative pressure inside the fluid container, which in turn is imparted by the flow of the medicament, e.g. into the blood stream of the patient.
  • the circular base 208 has an outer side and an inner side 226, 227, wherein the inner side 227 faces the first side 221 of the dry filter 220 and the outer side 226 faces away from the dry filter 220.
  • the second end 204 of the piercing member 201 is attached to the circular first front wall 208 of the filter housing 205 at a reinforced attachment point 225.
  • the reinforced attachment point 225 provides stability to the hollow piercing member 201 and comprises, in the shown embodiment, a conical shaped thickening of the circular base 208, extending inwards from the inner side 227 of the circular base 208.
  • Connection means in the form of an adhesive layer 228 is arranged on the outer side 226 of the circular base 208 in order to keep the filter device 200 attached to a surface while at the same time creating a gas tight sealing around the hollow piercing member 201 after penetration of a surface.
  • An adhesive layer 228 is preferably used when the filter device 200 is used to create a gas inlet directly on the surface of a pierceable fluid container.
  • the adhesive layer 228 is, in those cases, also adapted to create a gas and liquid tight sealing around the piercing member 201.
  • Connection means in the form of two protruding members 229 can also be used in order to connect the filter device 200 to a fluid container or e.g. a spike device.
  • the protruding members 229 are in such case inserted into corresponding grooves on a corresponding connection member to lock the filter device 200 from movement along the direction of the hollow piercing member 201.
  • An example of such a corresponding connection member is more fully described in WO 03/086529.
  • a fluid-proof membrane (not shown) may be arranged around the piercing member.
  • the fluid-proof membrane may be used regardless of whether any adhesive is used or not, preferably it is used in combination with the connection means and especially the protruding members 229 as just described.
  • the filter housing 205 is in the shown embodiment, additionally provided with a second and a third dry filter 230, 240.
  • the first, second and third filter 220, 230, 240 respectively has a first, second and third filter area, wherein the first filter area is preferably larger than the second filter area, which is preferably larger than the third filter area.
  • At least one of the second and third dry filters 230, 240 is arranged to specifically filter certain toxic or high risk compounds.
  • the second dry filter 230 can be specifically designed to capture specific allergy provoking and/or allergenic substances
  • the third dry filter 240 can be an activated carbon filter such as a non-woven activated carbon filter.
  • the second and third dry filters may of course be adapted dependent on the air environment in which the filter devices are used.
  • the filter housing 205 comprises at least two different inner diameters D1 and D2, preferably D2>D1 so that a large filter area can be obtained while still allow for the filter device 200 to be attached into a relatively small connection port such as an injection port.
  • the filter is preferably arranged in that section of the filter housing 205 which is provided with the larger inner diameter D2.
  • the difference in the inner diameter corresponds to a difference in the outer diameter.
  • the filter housing 205 can be provided with at least two different inner diameters, preferably more than two different inner diameters. The inner diameter if preferably increasing, step wise or continuous, towards the second side 21 1 of the filter housing 205.
  • Preferred filters are hydrophobic filters, or filters treated to be hydrophobic, these filters are preferred in cases were no clack-valve is used.
  • a clack valve is preferably arranged to the filter housing regardless of filter type used, since is will allow for any kind of filter to be used with the filter housing.
  • Hydrophilic filters may be used but preferably only in combination with a clack valve.
  • a filter which may be used as a dry filter 220, a second or a third dry filter 230, 240 is available under the trade mark Versapor® R membrane, which is a FluoRepelTM treated membrane.
  • the Versapor® filter is an acrylic copolymer cast on a nonwoven nylon support, such as a non-woven polyester support.
  • a dry filter 220, a second or a third dry filter 230, 240 which can be used according to the present invention is available under the trade mark Pallflex® from PALL, 2200 Northern Boulevard, East Hills, NY 1 1548, USA.
  • Such a dry filter comprises ceramic bonded hydrophobic glass and has a bacterial removal efficiency of 99.999% with test organisms Brevundimonas diminuta. Test organism: Serratia marcescens (0.45 ⁇ m) Brevundimonas diminuta (0.30 ⁇ m).
  • the dry filter has a viral removal efficiency of 99.999% with MS-2 Bacteriophage.
  • the dry filter can filtrate with a typical air flow rate of about 15 dm 3 /min at 0.069 bar.
  • a dry filter having a high air flow rate capacity is beneficial since it reduces the force needed to suck air into the fluid container.
  • the dry filter also preferably have the following properties:
  • the effective filtration area of a dry filter is 11.2 cm 2 , in a preferred embodiment the effective filtration area is approximately 1-15 cm 2 , preferably 1-10 cm 2 , most preferably 1- 5 cm 2 .
  • a sterilization filter used, usually a sterilization filter have a pore size of ⁇ 0.2 ⁇ m measured according to Pall Corporation standard test for pore size.
  • a clack valve 250 is arranged in the proximity of the second end 204 of the piercing member 201 in order to prevent any liquid from flowing in a direction opposite of the gas flow direction A.
  • the filter device 300 comprises a filter housing 305, with the same components and construction as described earlier with reference to figure 2a and 2b.
  • a protective housing 350 is covering the hollow piercing member 301.
  • the protective housing 350 provides for a protective chamber 351 by means of a first hollow
  • the first hollow cylinder 352 is slideable between a first secured position (as shown in figure 3) in which the hollow piercing member 301 and its piercing tip 303 is inside the protective chamber 351 , i.e. protected by the protective housing 350, and a second unsecured position, in which the hollow piercing member 301 and its piercing tip 303 is outside the protective chamber
  • a fluid-proof membrane 355 is arranged at the first end 353 of the first hollow cylinder 352, in order to be included in a double-membrane bayonet coupling with e.g. an injection port.
  • a double membrane coupling is described in greater detail in the U. S. Patent No. 4,564, 054 (Gustavsson).
  • the first end 353 of the first hollow cylinder 352 comprises connection means in the form of two protruding members 329 as
  • the first hollow cylinder 352 is as mentioned slideable, it slides into a second hollow cylinder 356 which then at least partly encompasses the first hollow cylinder 351 (not shown). Additionally, a locking member 357 is arranged on the second hollow cylinder 25 356, which can lock the first hollow cylinder 352 in the secured position. The locking member 357 prevents any accidental movement, and thereby opening, of the first hollow cylinder 351 , when the first hollow cylinder 351 is in the secured position as shown in figure 3.
  • the filter housing 305 is attached to, or forms an integral part of, the second hollow cylinder 356.
  • a fluid container 400 (partly shown) comprising medicament has been prepared with a mixing device 401 35 by injecting medicament using an injector (not shown) via an injection port 402 having a fluid proof barrier 403.
  • a mixing device is described in greater detail in WO 03/086529.
  • the level of fluid inside the fluid container 400 is continuously decreasing.
  • the effect of a decreasing fluid level results in that the pressure inside the fluid container 400 decreases. In order to provide for an uninterrupted and steady flow, such negative pressure inside the fluid container needs to be normalized.
  • the mixing device 401 comprises as mentioned, an injection port 402.
  • the injection port comprises connection means in the form of two guiding members 406 which are intended to accept and guide corresponding connection means of the medical filter device (the two protruding members 229, 329 arranged on the medical filter device 200, 300).
  • An injection fluid channel 407 provides for a fluid communication between the injection port 402 and the fluid container 400.
  • the medical filter device 300 uses the injection fluid channel 407, when connected to the injection port 402, to provide for the gas inlet in order to normalize the pressure inside the fluid container 400.
  • a filter device according to the present invention as descried in figure 2a-2b When a filter device according to the present invention as descried in figure 2a-2b is used, it can be attached directly to the surface of the fluid container 400 by means of the adhesive layer 228. It is to be noted that the filter device 200 according to the present invention as described in figure 2a-2b can also be connected to the injection port 402 as shown in figure 4, preferably by the connection means 229. Although the connection means 229 secures a firm connection and a proper double bayonet coupling, they are not essential since the piercing member 201 inserted into the fluid proof barrier 403 can be held in position by the fluid-proof barrier 403, this is however less preferred since the risk for leakage is increased.
  • the attachable medical filter device 300 can be connected to the injection port 402 and thereby provide for a gas inlet for pressure normalization to the fluid container 400, while at the same time filtering the incoming gas via at least on dry filter 420, 430, 440. By filtering the incoming gas, risk of contamination of the medicament in the fluid container is significantly reduced.
  • a double membrane coupling is provided towards the fluid-proof membrane 403 and the fluid-proof membrane 355, ensuring that the risk of contamination to the medicament, and thereby also the patient, is significantly reduced.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif filtre médical amovible (104, 200, 300) conçu pour être fixé sur un récipient de fluide (102, 400). Ce dispositif filtre médical (104, 200, 300) sert à filtrer un gaz s'écoulant dans un premier sens (A) dans le récipient (102, 400). Le dispositif (104, 200, 300) comprend un logement de filtre (205, 305) pourvu d'au moins un filtre (220, 230, 240, 320, 330, 340). Le logement (205, 305) est en communication de fluide avec un élément perforant creux (201, 301), tel qu'une aiguille. Le dispositif filtre (104, 200, 300) peut également être pourvu d'une soupape à clapet destinée à empêcher un liquide de s'écouler dans un deuxième sens opposé au premier sens (A). Le dispositif filtre médical (104, 200, 300) fournit au récipient de fluide (102, 400) un orifice d'entrée de gaz permettant une normalisation de pression après la fixation au récipient de fluide (102, 400). En outre, le filtre (220, 230, 240, 320, 330, 340) est un filtre sec conçu pour filtrer un gaz s'écoulant dans un premier sens (A) dans le récipient de fluide (102, 400). Le dispositif filtre médical (104, 200, 300) selon l'invention permet de normaliser avec flexibilité la pression à l'intérieur du récipient de fluide (102, 400) tout en filtrant le gaz entrant.
PCT/SE2007/050644 2007-09-11 2007-09-11 Dispositif filtre amovible Ceased WO2009035384A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/SE2007/050644 WO2009035384A1 (fr) 2007-09-11 2007-09-11 Dispositif filtre amovible

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SE2007/050644 WO2009035384A1 (fr) 2007-09-11 2007-09-11 Dispositif filtre amovible

Publications (1)

Publication Number Publication Date
WO2009035384A1 true WO2009035384A1 (fr) 2009-03-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2007/050644 Ceased WO2009035384A1 (fr) 2007-09-11 2007-09-11 Dispositif filtre amovible

Country Status (1)

Country Link
WO (1) WO2009035384A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2959878A1 (fr) * 2010-05-27 2015-12-30 J&J Solutions, Inc. Système de transfert de fluide fermé
US9877895B2 (en) 2013-08-02 2018-01-30 J&J Solutions, Inc. Compounding systems and methods for safe medicament transport
US10888496B2 (en) 2015-09-17 2021-01-12 Corvida Medical, Inc. Medicament vial assembly
US10894317B2 (en) 2015-10-13 2021-01-19 Corvida Medical, Inc. Automated compounding equipment for closed fluid transfer system
WO2025036777A1 (fr) * 2023-08-11 2025-02-20 B. Braun Melsungen Ag Perforateur médical avec protection contre l'évacuation de gaz

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822700A (en) * 1973-03-16 1974-07-09 M Pennington Intravenous solution dispenser
US4396016A (en) * 1977-09-07 1983-08-02 Becker Karl E Intravenous solution flow regulator
US4473094A (en) * 1981-06-12 1984-09-25 Anchor Continental Incorporated Air inlet
US4857068A (en) * 1986-12-22 1989-08-15 Miles Laboratories, Inc. Universal spike for use with rigid and collapsible parenteral fluid dispensing container

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822700A (en) * 1973-03-16 1974-07-09 M Pennington Intravenous solution dispenser
US4396016A (en) * 1977-09-07 1983-08-02 Becker Karl E Intravenous solution flow regulator
US4473094A (en) * 1981-06-12 1984-09-25 Anchor Continental Incorporated Air inlet
US4857068A (en) * 1986-12-22 1989-08-15 Miles Laboratories, Inc. Universal spike for use with rigid and collapsible parenteral fluid dispensing container

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2959878A1 (fr) * 2010-05-27 2015-12-30 J&J Solutions, Inc. Système de transfert de fluide fermé
US9351906B2 (en) 2010-05-27 2016-05-31 J & J Solutions, Inc. Closed fluid transfer system with syringe adapter
US9358182B2 (en) 2010-05-27 2016-06-07 J & J Solutions, Inc. Closed fluid transfer system with syringe adapter
US9364396B2 (en) 2010-05-27 2016-06-14 J & J Solutions, Inc. Closed fluid transfer system with syringe adapter
US9370466B2 (en) 2010-05-27 2016-06-21 J&J Solutions, Inc. Closed fluid transfer system with syringe adapter
US9381137B2 (en) 2010-05-27 2016-07-05 J & J Solutions, Inc. Closed fluid transfer system with syringe adapter
US10238576B2 (en) 2010-05-27 2019-03-26 J & J Solutions, Inc. Closed fluid transfer system
US11219577B2 (en) 2010-05-27 2022-01-11 Corvida Medical, Inc. Closed fluid transfer system
US9877895B2 (en) 2013-08-02 2018-01-30 J&J Solutions, Inc. Compounding systems and methods for safe medicament transport
US10888496B2 (en) 2015-09-17 2021-01-12 Corvida Medical, Inc. Medicament vial assembly
US10894317B2 (en) 2015-10-13 2021-01-19 Corvida Medical, Inc. Automated compounding equipment for closed fluid transfer system
WO2025036777A1 (fr) * 2023-08-11 2025-02-20 B. Braun Melsungen Ag Perforateur médical avec protection contre l'évacuation de gaz

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