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WO2009034980A1 - 生体摂取物の製造方法及びこれにより得られた生体摂取物 - Google Patents

生体摂取物の製造方法及びこれにより得られた生体摂取物 Download PDF

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Publication number
WO2009034980A1
WO2009034980A1 PCT/JP2008/066286 JP2008066286W WO2009034980A1 WO 2009034980 A1 WO2009034980 A1 WO 2009034980A1 JP 2008066286 W JP2008066286 W JP 2008066286W WO 2009034980 A1 WO2009034980 A1 WO 2009034980A1
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WO
WIPO (PCT)
Prior art keywords
ingesta
biological
fluid
treated
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066286
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English (en)
French (fr)
Inventor
Masakazu Enomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
M Technique Co Ltd
Original Assignee
M Technique Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M Technique Co Ltd filed Critical M Technique Co Ltd
Priority to JP2009532190A priority Critical patent/JP4849647B2/ja
Priority to US12/677,263 priority patent/US8927020B2/en
Priority to CN200880113038.2A priority patent/CN101896164B/zh
Priority to EP08830200.5A priority patent/EP2196194B1/en
Publication of WO2009034980A1 publication Critical patent/WO2009034980A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/70—Spray-mixers, e.g. for mixing intersecting sheets of material
    • B01F25/74—Spray-mixers, e.g. for mixing intersecting sheets of material with rotating parts, e.g. discs
    • B01F25/741—Spray-mixers, e.g. for mixing intersecting sheets of material with rotating parts, e.g. discs with a disc or a set of discs mounted on a shaft rotating about a vertical axis, on top of which the material to be thrown outwardly is fed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2712—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with ribs, ridges or grooves on one surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2714—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator the relative position of the stator and the rotor, gap in between or gap with the walls being adjustable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

　従来の方法に比べ、低エネルギーで目的とする粒子径の生体摂取物を得ることができる製造方法を提供することを課題とするものであって、薬理活性物質を含有する分散相の被処理流動体と、少なくとも分散溶媒よりなる連続相の被処理流動体とを、各々独立した状態を保持したまま、それぞれの相に対応する独立した経路を通じて、対向して配設された近接・離反可能な処理用面をもつ、少なくとも一方が他方に対して回転する処理用面の間にできる薄膜流体中で混合することにより、分散相の被処理流動体に含まれた成分が所望の粒子径を有する微小粒子となる。
PCT/JP2008/066286 2007-09-10 2008-09-10 生体摂取物の製造方法及びこれにより得られた生体摂取物 Ceased WO2009034980A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009532190A JP4849647B2 (ja) 2007-09-10 2008-09-10 生体摂取物の製造方法及びこれにより得られた生体摂取物
US12/677,263 US8927020B2 (en) 2007-09-10 2008-09-10 Method for producing biologically ingestible material and biologically ingestible material obtained therefrom
CN200880113038.2A CN101896164B (zh) 2007-09-10 2008-09-10 生物摄取物的制造方法
EP08830200.5A EP2196194B1 (en) 2007-09-10 2008-09-10 Process for producing biological ingesta and biological ingesta obtained thereby

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-233557 2007-09-10
JP2007233557 2007-09-10

Publications (1)

Publication Number Publication Date
WO2009034980A1 true WO2009034980A1 (ja) 2009-03-19

Family

ID=40451987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066286 Ceased WO2009034980A1 (ja) 2007-09-10 2008-09-10 生体摂取物の製造方法及びこれにより得られた生体摂取物

Country Status (5)

Country Link
US (1) US8927020B2 (ja)
EP (1) EP2196194B1 (ja)
JP (2) JP4849647B2 (ja)
CN (1) CN101896164B (ja)
WO (1) WO2009034980A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012165000A1 (ja) * 2011-05-28 2015-02-23 エム・テクニック株式会社 強制薄膜式流体処理装置を用いた処理物の付着防止方法
CN104372059A (zh) * 2014-11-11 2015-02-25 华南理工大学 一种离子液体微乳相酶催化体系催化合成甾醇酯的方法
JP2022521375A (ja) * 2019-03-08 2022-04-07 ザ プロクター アンド ギャンブル カンパニー 分散した液体有益剤液滴を有する構造化水性組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009034980A1 (ja) * 2007-09-10 2009-03-19 M.Technique Co., Ltd. 生体摂取物の製造方法及びこれにより得られた生体摂取物
JP4849648B2 (ja) * 2007-11-09 2012-01-11 エム・テクニック株式会社 エマルションの製造方法
EP2418015B1 (en) * 2008-11-25 2016-01-06 M. Technique Co., Ltd. Fluid treatment equipment and treatment method
CN103492063B (zh) * 2011-04-26 2016-10-12 M技术株式会社 微粒的制造方法

Citations (8)

* Cited by examiner, † Cited by third party
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JPH01147580A (ja) 1987-12-04 1989-06-09 Minolta Camera Co Ltd クリーニング装置
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
JPH04504527A (ja) * 1989-01-27 1992-08-13 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 小胞形成方法
JP2003119120A (ja) 2001-10-12 2003-04-23 Masahiko Abe リポソームの製造方法、及び該リポソームを含有する化粧料、及び皮膚外用剤
JP2004049957A (ja) 2002-07-16 2004-02-19 M Technique Co Ltd 分散乳化装置及び分散乳化方法
JP2005002055A (ja) * 2003-06-12 2005-01-06 Terumo Corp 生理活性物質を含有するリポソームを製造する方法および該方法により得られる生理活性物質を含有するリポソーム
JP2005169259A (ja) * 2003-12-11 2005-06-30 Shigeki Toyama 微粒子の製造方法及び装置
JP2007522205A (ja) * 2004-08-06 2007-08-09 バイオスペクトラム，インコーポレイテッド 多重層リポソームおよびその製造方法

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JPH06256212A (ja) * 1993-03-01 1994-09-13 Nippon Kayaku Co Ltd オーレオバシジン類のリポソーム製剤
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DE19746432A1 (de) * 1997-10-21 1999-04-22 Schwaiger Heinz Johann Verfahren zur Herstellung einer beständig homogenen Klaremulgierung von Heilpflanzenextrakten in kaltgepresstem Olivenöl sowie Vorrichtung zu dessen Umsetzung
GB9903474D0 (en) * 1999-02-17 1999-04-07 Univ Newcastle Process for the conversion of a fluid phase substrate by dynamic heterogenous contact with an agent
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JP4782426B2 (ja) 2003-03-21 2011-09-28 ケミラ オユイ 乳濁液または分散液を連続的に作製するための装置および方法
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01147580A (ja) 1987-12-04 1989-06-09 Minolta Camera Co Ltd クリーニング装置
JPH04504527A (ja) * 1989-01-27 1992-08-13 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 小胞形成方法
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
JP2003119120A (ja) 2001-10-12 2003-04-23 Masahiko Abe リポソームの製造方法、及び該リポソームを含有する化粧料、及び皮膚外用剤
JP2004049957A (ja) 2002-07-16 2004-02-19 M Technique Co Ltd 分散乳化装置及び分散乳化方法
JP2005002055A (ja) * 2003-06-12 2005-01-06 Terumo Corp 生理活性物質を含有するリポソームを製造する方法および該方法により得られる生理活性物質を含有するリポソーム
JP2005169259A (ja) * 2003-12-11 2005-06-30 Shigeki Toyama 微粒子の製造方法及び装置
JP2007522205A (ja) * 2004-08-06 2007-08-09 バイオスペクトラム，インコーポレイテッド 多重層リポソームおよびその製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012165000A1 (ja) * 2011-05-28 2015-02-23 エム・テクニック株式会社 強制薄膜式流体処理装置を用いた処理物の付着防止方法
CN104372059A (zh) * 2014-11-11 2015-02-25 华南理工大学 一种离子液体微乳相酶催化体系催化合成甾醇酯的方法
JP2022521375A (ja) * 2019-03-08 2022-04-07 ザ プロクター アンド ギャンブル カンパニー 分散した液体有益剤液滴を有する構造化水性組成物

Also Published As

Publication number Publication date
EP2196194A1 (en) 2010-06-16
JP2012062316A (ja) 2012-03-29
US8927020B2 (en) 2015-01-06
CN101896164B (zh) 2014-10-22
JP4849647B2 (ja) 2012-01-11
EP2196194A4 (en) 2012-12-26
JP5424427B2 (ja) 2014-02-26
CN101896164A (zh) 2010-11-24
EP2196194B1 (en) 2017-08-09
US20100330153A1 (en) 2010-12-30
JPWO2009034980A1 (ja) 2010-12-24

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