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WO2009034958A1 - タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法 - Google Patents

タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法 Download PDF

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Publication number
WO2009034958A1
WO2009034958A1 PCT/JP2008/066206 JP2008066206W WO2009034958A1 WO 2009034958 A1 WO2009034958 A1 WO 2009034958A1 JP 2008066206 W JP2008066206 W JP 2008066206W WO 2009034958 A1 WO2009034958 A1 WO 2009034958A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
stabilizer
protein stabilizer
producing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066206
Other languages
English (en)
French (fr)
Inventor
Kouji Tamori
Eiji Takamoto
Toshihiro Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JSR Corp
Original Assignee
JSR Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JSR Corp filed Critical JSR Corp
Priority to JP2009532181A priority Critical patent/JP5387850B2/ja
Publication of WO2009034958A1 publication Critical patent/WO2009034958A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/14—Methyl esters, e.g. methyl (meth)acrylate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)

Abstract

タンパク安定化剤は、単独重合した場合に、０°C以上８０°C以下に下限臨界溶解温度を有するホモポリマーを形成する性質を有するモノマー（Ａ）と、単独重合した場合に、下限臨界溶解温度を有さない非イオン性水溶性ホモポリマーを形成する性質を有するモノマー（Ｂ）と、を含有するモノマー混合物を重合することにより形成された水溶性ポリマーを含む。
PCT/JP2008/066206 2007-09-12 2008-09-09 タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法 Ceased WO2009034958A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009532181A JP5387850B2 (ja) 2007-09-12 2008-09-09 タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-236121 2007-09-12
JP2007236121 2007-09-12

Publications (1)

Publication Number Publication Date
WO2009034958A1 true WO2009034958A1 (ja) 2009-03-19

Family

ID=40451965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066206 Ceased WO2009034958A1 (ja) 2007-09-12 2008-09-09 タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法

Country Status (2)

Country Link
JP (1) JP5387850B2 (ja)
WO (1) WO2009034958A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010196048A (ja) * 2009-01-30 2010-09-09 Kose Corp 新規な水溶性ポリマー及びそれを含有する化粧料又は皮膚外用剤
JP2018165300A (ja) * 2017-03-28 2018-10-25 藤倉化成株式会社 可逆的付加開裂連鎖移動重合方法、アクリル系重合体、及びアクリル系ブロック共重合体
JP2019142787A (ja) * 2018-02-16 2019-08-29 Jsr株式会社 タンパク安定化剤
CN113264997A (zh) * 2021-04-13 2021-08-17 康汉医药(广州)有限公司 一种蛋白药物在常温、高温条件下保存的方法
CN115698106A (zh) * 2020-04-17 2023-02-03 小利兰斯坦福大学董事会 用于生物制药调配物的聚合物赋形剂
US12144862B2 (en) 2022-05-23 2024-11-19 The Board Of Trustees Of The Leland Stanford Junior University Antibody biopharmaceutical formulations including polymer excipients

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10513433A (ja) * 1993-02-02 1998-12-22 ゾーマ コーポレイション 殺菌性、浸透性が向上したタンパク質及び界面活性剤を含有する医薬組成物
JP2003289861A (ja) * 2002-04-03 2003-10-14 San Contact Lens:Kk 蛋白分解酵素を安定化させるための修飾担体、当該修飾担体により化学修飾された蛋白分解酵素および当該蛋白分解酵素の製造方法
JP2006516038A (ja) * 2002-08-09 2006-06-15 オタワ ヘルス リサーチ インスティテュート 生合成基質およびその用法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10513433A (ja) * 1993-02-02 1998-12-22 ゾーマ コーポレイション 殺菌性、浸透性が向上したタンパク質及び界面活性剤を含有する医薬組成物
JP2003289861A (ja) * 2002-04-03 2003-10-14 San Contact Lens:Kk 蛋白分解酵素を安定化させるための修飾担体、当該修飾担体により化学修飾された蛋白分解酵素および当該蛋白分解酵素の製造方法
JP2006516038A (ja) * 2002-08-09 2006-06-15 オタワ ヘルス リサーチ インスティテュート 生合成基質およびその用法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRYJAK ET AL.: "Storage stabilization and purification of enzyme by water-soluble synthetic polymers", ENZYME AND MICROBIAL TECHNOLOGY, vol. 16, no. 7, 1994, pages 616 - 621 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010196048A (ja) * 2009-01-30 2010-09-09 Kose Corp 新規な水溶性ポリマー及びそれを含有する化粧料又は皮膚外用剤
JP2018165300A (ja) * 2017-03-28 2018-10-25 藤倉化成株式会社 可逆的付加開裂連鎖移動重合方法、アクリル系重合体、及びアクリル系ブロック共重合体
JP2019142787A (ja) * 2018-02-16 2019-08-29 Jsr株式会社 タンパク安定化剤
CN115698106A (zh) * 2020-04-17 2023-02-03 小利兰斯坦福大学董事会 用于生物制药调配物的聚合物赋形剂
EP4136224A4 (en) * 2020-04-17 2024-05-22 The Board of Trustees of the Leland Stanford Junior University POLYMERIC EXCIPIENTS FOR BIOPHARMACEUTICAL FORMULATIONS
US12077621B2 (en) 2020-04-17 2024-09-03 The Board Of Trustees Of The Leland Stanford Junior Univeristy Polymer excipients for biopharmaceutical formulations
US12187828B2 (en) 2020-04-17 2025-01-07 The Board Of Trustees Of The Leland Stanford Junior Univeristy Polymer excipients for biopharmaceutical formulations
CN113264997A (zh) * 2021-04-13 2021-08-17 康汉医药(广州)有限公司 一种蛋白药物在常温、高温条件下保存的方法
US12144862B2 (en) 2022-05-23 2024-11-19 The Board Of Trustees Of The Leland Stanford Junior University Antibody biopharmaceutical formulations including polymer excipients
US12472260B2 (en) 2022-05-23 2025-11-18 The Board Of Trustees Of The Leland Stanford Junior University Antibody biopharmaceutical formulations including polymer excipients

Also Published As

Publication number Publication date
JPWO2009034958A1 (ja) 2010-12-24
JP5387850B2 (ja) 2014-01-15

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