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WO2009034464A3 - Indole related compounds with physiological activity - Google Patents

Indole related compounds with physiological activity Download PDF

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Publication number
WO2009034464A3
WO2009034464A3 PCT/IB2008/002387 IB2008002387W WO2009034464A3 WO 2009034464 A3 WO2009034464 A3 WO 2009034464A3 IB 2008002387 W IB2008002387 W IB 2008002387W WO 2009034464 A3 WO2009034464 A3 WO 2009034464A3
Authority
WO
WIPO (PCT)
Prior art keywords
related compounds
physiological activity
compounds
formula
indole related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/002387
Other languages
French (fr)
Other versions
WO2009034464A2 (en
Inventor
Phillip J Robinson
Adam Mccluskey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Research Institute
Newcastle Innovation Ltd
Original Assignee
Childrens Medical Research Institute
Newcastle Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007904967A external-priority patent/AU2007904967A0/en
Application filed by Childrens Medical Research Institute, Newcastle Innovation Ltd filed Critical Childrens Medical Research Institute
Publication of WO2009034464A2 publication Critical patent/WO2009034464A2/en
Publication of WO2009034464A3 publication Critical patent/WO2009034464A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of Formula I or Ia having dynamin protein inhibitory activity. Compounds embodied by the invention have application in inhibiting cellular endocytosis and cytokinesis, and may be used in the prophylaxis or treatment of various diseases and conditions involving endocytosis or cell proliferation, such as seizures, epilepsy and cancer. Particularly preferred compounds provided by Formula I and Ia are indoles.
PCT/IB2008/002387 2007-09-12 2008-09-12 Indole related compounds with physiological activity Ceased WO2009034464A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2007904967 2007-09-12
AU2007904967A AU2007904967A0 (en) 2007-09-12 Indole based dynamin GTPase inhibitors
AU2007904991A AU2007904991A0 (en) 2007-09-13 Indole based dynamin GTPase inhibitors II
AU2007904991 2007-09-14
AU2007905276A AU2007905276A0 (en) 2007-09-27 Compounds with physiological activity
AU2007905276 2007-09-27

Publications (2)

Publication Number Publication Date
WO2009034464A2 WO2009034464A2 (en) 2009-03-19
WO2009034464A3 true WO2009034464A3 (en) 2009-05-22

Family

ID=40452627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002387 Ceased WO2009034464A2 (en) 2007-09-12 2008-09-12 Indole related compounds with physiological activity

Country Status (1)

Country Link
WO (1) WO2009034464A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012527407A (en) 2009-05-21 2012-11-08 チルドレンズ メディカル リサーチ インスティテュート Use of Dynamin Ring Stabilizer
CN105884675A (en) * 2014-09-24 2016-08-24 中国药科大学 N-substituted indole carboxylic acid derivative and its preparation method and medical use
CN109152777A (en) * 2016-05-20 2019-01-04 武田药品工业株式会社 The treatment of pain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3289770A (en) * 1963-08-14 1966-12-06 Bolkow Gmbh Helicopter rotor system
US3489429A (en) * 1967-12-18 1970-01-13 American Home Prod 1-loweralkanoyl-3-(2-substituted ethyl)indoles
EP0003902A1 (en) * 1978-02-21 1979-09-05 Ex-Cell-O Corporation A biaxial, double-spindle turning machine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3289770A (en) * 1963-08-14 1966-12-06 Bolkow Gmbh Helicopter rotor system
US3489429A (en) * 1967-12-18 1970-01-13 American Home Prod 1-loweralkanoyl-3-(2-substituted ethyl)indoles
EP0003902A1 (en) * 1978-02-21 1979-09-05 Ex-Cell-O Corporation A biaxial, double-spindle turning machine

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
ARCHIV DER PHARMAZIE UND BERICHTE DER DEUTSCHEN PHARMAZEUTISCHEN GESELLSCHAFT, vol. 300, no. 12, 1967, pages 1038 - 41 *
ARCHIV DER PHARMAZIE UND BERICHTE DER DEUTSCHEN PHARMAZEUTISCHEN GESELLSCHAFT, vol. 303, no. 11, 1970, pages 865 - 8 *
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 21, 2004, pages 5441 - 5444 *
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 43, no. 10, 1995, pages 1692 - 5 *
CHEMISCHE BERICHTE, vol. 90, 1957, pages 1419 - 24 *
CHEMISCHE BERICHTE, vol. 99, no. 3, 1966, pages 889 - 94 *
DATABASE CAPLUS BRIMBLECOMBE, ROGER W.: "Hyperthermic effects of some tryptamine derivatives in relation to their behavioral activity", Database accession no. 67:107054 *
DATABASE CAPLUS DASSONVILLE, A ET AL: "New N-pyridinyl(methyl)indolalkanamides acting as topical inflammation Inhibitors", Database accession no. 141:424097 *
DATABASE CAPLUS EICHELE, O. ET AL: ""Base-substituted tryptamines and tryptophols. I Synthesis of derivatives substituted in the I-position", Database accession no. 68:87091 *
DATABASE CAPLUS EICHELE, O. ET AL: "Basically substituted tryptamines and tryptopholsII. Pharmacological evaluation of derivatives basically substituted in l- and 2-positions", Database accession no. 74:21674 *
DATABASE CAPLUS FAUL, M. M., ET AL: "A New, EffiAcient Method for the Synthesis of Bisindolylmaleimides", Database accession no. 129:202825 *
DATABASE CAPLUS GLENNON, RICHARD A. ET AL: "Synthesis and evaluation of a novel series of N,N dimethylisotryptamines", Database accession no. 100:22986 *
DATABASE CAPLUS GUENJOER, TIMUR ET AL.: "New synthesis of 1-substituted 3-(2-aminoethyl)indoles", Database accession no. 121:179446 *
DATABASE CAPLUS KAMIYA, SHOJI ET AL: "Thromboxane A2 synthetase inhibitors with histamine Hl- blocking activity: synthesis and evaluation of a new series of indole derivatives", Database accession no. 124:75545 *
DATABASE CAPLUS LOVE, B: "Facile Synthesis of N- Dialkylaminomethyl-Substituted Heterocycles", Database accession no. 146:251779 *
DATABASE CAPLUS SWAMINATHAN, SAMBASIVA. ET AL: "N-Isogramine and several related N-Mannich bases of indole", Database accession no. 64:84562 *
DATABASE CAPLUS THESING, JAN. ET AL: "Chemistry of indole. X Mannich bases from 3- substituted indoles", Database accession no. 54:44589 *
DATABASE CAPLUS WOLINSKY, J. ET AL: "Reaction of 3-propylindole with aldehydes. Preparation of 2-(a-aminoalkyl)indoles", Database accession no. 74:76254 *
INTERNATIONAL JOURNAL OF NEUROPHARMACOLOGY, vol. 6, no. 5, 1967, pages 423 - 9 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 1, 1984, pages 41 - 5 *
JOURNAL OF ORGANIC CHEMISTRY, vol. 63, no. 17, 1998, pages 6053 - 6058 *
JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 2, 2007, pages 630 - 632 *
SYNTHETIC COMMUNICATIONS, vol. 24, no. 16, 1994, pages 2247 - 56 *
TETRAHEDRON, vol. 26, no. 23, 1970, pages 5427 - 35 *

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Publication number Publication date
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