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WO2009033588A3 - Self-controlled insulin delivery system - Google Patents

Self-controlled insulin delivery system Download PDF

Info

Publication number
WO2009033588A3
WO2009033588A3 PCT/EP2008/007149 EP2008007149W WO2009033588A3 WO 2009033588 A3 WO2009033588 A3 WO 2009033588A3 EP 2008007149 W EP2008007149 W EP 2008007149W WO 2009033588 A3 WO2009033588 A3 WO 2009033588A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucose
liposome
insulin
self
delivery system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/007149
Other languages
French (fr)
Other versions
WO2009033588A2 (en
Inventor
Wolfgang Burkhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of WO2009033588A2 publication Critical patent/WO2009033588A2/en
Anticipated expiration legal-status Critical
Publication of WO2009033588A3 publication Critical patent/WO2009033588A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a glucose sensitive vesicle (preferably a multi-lamellar liposome) comprising an insulin-independent glucose transporter integrated into the membrane of the liposome, which further comprises glucokinase, insulin, Mg++ and ATP. Glucose diffuses into the liposome depending on its concentration and will be converted to glucose-6-phosphate. The accumulation of glucose-6-phosphate eventually causes the vesicle to burst. Thus, these liposomes allow an automatic adjustment of insulin levels in a glucose-dependent manner and are, therefore, useful for the treatment of diabetic patients.
PCT/EP2008/007149 2007-09-11 2008-09-02 Self-controlled insulin delivery system Ceased WO2009033588A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07116131 2007-09-11
EP07116131.9 2007-09-11

Publications (2)

Publication Number Publication Date
WO2009033588A2 WO2009033588A2 (en) 2009-03-19
WO2009033588A3 true WO2009033588A3 (en) 2010-05-20

Family

ID=39872867

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/007149 Ceased WO2009033588A2 (en) 2007-09-11 2008-09-02 Self-controlled insulin delivery system

Country Status (1)

Country Link
WO (1) WO2009033588A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110110253A (en) 2009-01-28 2011-10-06 스마트쎌스, 인크. Crystalline Insulin-Conjugates
CA2750252A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
CA2750223A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
ES2791683T3 (en) 2009-01-28 2020-11-05 Smartcells Inc Conjugated systems for controlled drug delivery
EP2408470A4 (en) 2009-03-20 2012-08-29 Smartcells Inc Soluble non-soluble insulin conjugates and their uses
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
JP2013535467A (en) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド Recombinantly expressed insulin polypeptide and uses thereof
EP2598522A4 (en) 2010-07-28 2014-11-12 Smartcells Inc RECOMBINANT LECTINES, LECTINES WITH MODIFIED BINDING SITE AND USES THEREOF
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
CN105792852B (en) 2013-10-04 2019-12-10 默沙东公司 Glucose-responsive insulin conjugates
WO2017223085A2 (en) * 2016-06-20 2017-12-28 The Regents Of The University Of Michigan Compositions and methods for delivery of biomacromolecule agents
MX2022002980A (en) 2019-09-16 2022-04-06 Amgen Inc METHOD FOR THE EXTERNAL STERILIZATION OF A DRUG SUPPLY DEVICE.
EP4196095A4 (en) * 2020-08-13 2024-10-16 The Regents Of The University Of Colorado, A Body Corporate PHOSPHOLIPID BILAYERS THAT CATALYTICALLY PROMOTE PROTEIN FOLDING, INHIBIT AND REVERSE PROTEIN AGGREGATES FORMATION, AND METHODS OF TREATING NEURODEGENERATIVE DISEASES USING SUCH PHOSPHOLIPID BILAYERS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007092161A2 (en) * 2006-02-07 2007-08-16 University Of Louisville Research Foundation, Inc. A direct cellular energy delivery system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007092161A2 (en) * 2006-02-07 2007-08-16 University Of Louisville Research Foundation, Inc. A direct cellular energy delivery system

Also Published As

Publication number Publication date
WO2009033588A2 (en) 2009-03-19

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