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WO2009032266A3 - Dispersions of microparticles and microgels in hydrogels for drug delivery - Google Patents

Dispersions of microparticles and microgels in hydrogels for drug delivery Download PDF

Info

Publication number
WO2009032266A3
WO2009032266A3 PCT/US2008/010352 US2008010352W WO2009032266A3 WO 2009032266 A3 WO2009032266 A3 WO 2009032266A3 US 2008010352 W US2008010352 W US 2008010352W WO 2009032266 A3 WO2009032266 A3 WO 2009032266A3
Authority
WO
WIPO (PCT)
Prior art keywords
microgels
microparticles
bioactive agent
contact lens
ophthalmically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/010352
Other languages
French (fr)
Other versions
WO2009032266A2 (en
Inventor
Anuj Chauhan
Chi-Chung Li
Hyun-Jung Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Publication of WO2009032266A2 publication Critical patent/WO2009032266A2/en
Publication of WO2009032266A3 publication Critical patent/WO2009032266A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein microparticles or microgels of a crosslinked polymer, the microparticles or microgels having entrapped therein an ophthalmically bioactive agent, the crosslinked polymer comprising an ophthalmically acceptable material from which the bioactive agent is capable of diffusion into and migration through the contact lens and into the post-lens tear film when the contact lens is placed on the eye and wherein the degree of polymerization and/or crosslinking is such that the rate of diffusion into and migration through the contact lens of the ophthalmically bioactive agent is attenuated,
PCT/US2008/010352 2007-09-04 2008-09-04 Dispersions of microparticles and microgels in hydrogels for drug delivery Ceased WO2009032266A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93585607P 2007-09-04 2007-09-04
US60/935,856 2007-09-04

Publications (2)

Publication Number Publication Date
WO2009032266A2 WO2009032266A2 (en) 2009-03-12
WO2009032266A3 true WO2009032266A3 (en) 2009-05-07

Family

ID=40429612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/010352 Ceased WO2009032266A2 (en) 2007-09-04 2008-09-04 Dispersions of microparticles and microgels in hydrogels for drug delivery

Country Status (1)

Country Link
WO (1) WO2009032266A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9597227B2 (en) * 2013-03-15 2017-03-21 Abbott Medical Optics Inc. Trans-sclera portal for delivery of therapeutic agents
US9422315B2 (en) * 2014-12-05 2016-08-23 Momentive Performance Materials Japan Llc Organosiloxane composition having high refractive index and applications containing the same
CN104945570B (en) * 2015-07-03 2017-06-09 东南大学 A kind of Silica hydrogel contact lens and its surface reversion processing method
JP6715071B2 (en) 2016-04-27 2020-07-01 信越化学工業株式会社 Hydrolysis-resistant silicone compound and method for producing the same
CN116392389A (en) 2017-09-25 2023-07-07 佛罗里达大学研究基金会股份有限公司 Removal of preservatives from eye drops containing hydrophilic drugs
SE544779C2 (en) * 2018-05-18 2022-11-15 Henrik Kempe Template-imprinted polymer particles
SE544611C2 (en) * 2018-05-18 2022-09-20 Henrik Kempe Polymer particles
IL293976A (en) 2019-12-19 2022-08-01 Tearclear Corp Removing preservative from eye drops
JP2020097603A (en) * 2020-01-31 2020-06-25 信越化学工業株式会社 Hydrolysis resistant silicone compound and manufacturing method therefor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
US20030152636A1 (en) * 2000-02-23 2003-08-14 Nanopharm Ag Method of treating cancer
US20040096477A1 (en) * 2002-06-05 2004-05-20 Anuj Chauhan Ophthalmic drug delivery system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
US20030152636A1 (en) * 2000-02-23 2003-08-14 Nanopharm Ag Method of treating cancer
US20040096477A1 (en) * 2002-06-05 2004-05-20 Anuj Chauhan Ophthalmic drug delivery system

Also Published As

Publication number Publication date
WO2009032266A2 (en) 2009-03-12

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