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WO2009031788A1 - Composition cosmétique comprenant de la vitamine c - Google Patents

Composition cosmétique comprenant de la vitamine c Download PDF

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Publication number
WO2009031788A1
WO2009031788A1 PCT/KR2008/005106 KR2008005106W WO2009031788A1 WO 2009031788 A1 WO2009031788 A1 WO 2009031788A1 KR 2008005106 W KR2008005106 W KR 2008005106W WO 2009031788 A1 WO2009031788 A1 WO 2009031788A1
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WO
WIPO (PCT)
Prior art keywords
vitamin
composition
aqueous phase
cosmetic composition
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2008/005106
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English (en)
Inventor
Jae Hong Lee
Dong Il Jang
Yun Joo Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COTDE Ltd
Original Assignee
COTDE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COTDE Ltd filed Critical COTDE Ltd
Priority to CN2008801054196A priority Critical patent/CN101795666B/zh
Priority to JP2010522816A priority patent/JP2010537976A/ja
Publication of WO2009031788A1 publication Critical patent/WO2009031788A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application

Definitions

  • the present invention relates to a composition capable of inhibiting oxidation of vitamin C, vitamin C having anti-wrinkling and skin whitening effects but having problems when used for topical applications due to its structural instability as a result of being easily oxidized by oxygen dissolved in water, so that the composition provides vitamin C in a state retaining its physiological activity. More particularly, the present invention relates to a cosmetic composition including a solid phase including vitamin C and an aqueous phase, which are separated from each other and are intended to be mixed immediately before use so as to ensure the stability of vitamin C for a long period of time.
  • Vitamin C also known as ascorbic acid, has many advantages when used as a topical application, and thus has been widely employed in cosmetic and topical pharmaceutical formulations.
  • Vitamin C serves as a cofactor for hydroxylation of lysine and proline residues of procollagen in the dermis to stimulate the synthesis of collagen, which improves skin elasticity and reduces fine lines and wrinkles (Dermato Surg. 31, 2005 July p814-817 Clin. Exp. Dermatol. 29(2), 2004 March pl68-175 Exp. Dermatol. 12(3), 2003 June p237-244).
  • Vitamin C functions to scavenge free radicals generated in the skin exposed to UV radiation and protectsthe skin against UV-induced damage (J Invest Dermatol. 126(5), 2006 May pi 185-1187 Free Radic Res. 40(2) 2006 Feb., p213- 221 J Invest Dermato. 125(4) 2005 Oct., p826-832). It also complements another antioxidant vitamin acting in the skin, vitamin E, upon vitamin E deficiency, and inhibits melanogenesis in epidermal melanocytes to prevent pigmentation (Int J Dermatol 43(8) 2004 Aug. p604-607Biofactors 21 p415-418). Owing to these beneficial effects, vitamin C has much potential as an ingredient for topical cosmetic and pharmaceutical formulations for treating and/or preventing the aging of skin associated with pigmentation or wrinkles.
  • vitamin C which is chemically defined as an -ketolactone wherein the second and third carbon atoms are double- bonded and contain hydroxyl groups, it easily loses its electrons and is oxidized in the presence of light, oxygen, water (high pH values or metal ions make ascorbic acid favorable to degradation) or the like, leading to the loss of innate physiological activities of vitamin C.
  • many efforts have been made to prepare a vitamin C solution stable to oxidation by atmospheric oxygen, and numerous publications describe techniques for overcoming the structural instability of vitamin C.
  • vitamin C can be unsusceptible to electron loss by being esterified or etherized at the hydroxyl group of the second or third carbon with a phosphate group (JP 7017989, JP 8034791, JP 98363316, JP 98201242, JP 10324627, USP 3,671,549, DE 1805958, USP 5,098,898,),or with a sulfate group or an alkyl group (2,3-di-O-acyl L-ascorbic acids (JP 63104971, DE 3613590), US-A-5,087,446, JP- A-69/115558 andJP-A-83/129892).
  • a phosphate group JP 7017989, JP 8034791, JP 98363316, JP 98201242, JP 10324627, USP 3,671,549, DE 1805958, USP 5,098,898,
  • a sulfate group or an alkyl group 2,3-di
  • US Pat. No. 2,400,171 discloses the stabilization of ascorbic acid through conversion to its calcium or zinc salt to maintain a stable aqueous solution in a pH value ranging from 7 to 7.3.
  • US Pat. No. 2,442,461 describes that an aqueous calcium ascorbate solution is stabilized by adding an aliphatic thiocarboxylic acid to maintain the pH of the solution in the range of 5.2 to 5.6.
  • US Pat. No. 2,585,580 discloses the stabilization of ascorbic acid with thio-sugars to maintain the pH of the resulting solution in the range of 4.0 to 6.5.
  • US Pat. No. 4,367,157 states that an aqueous solution of ascorbic acid is stabilized in the pH range of 4 to 7 by monothioglycerol.
  • Another stabilization method involves separating ascorbic acid from an oxidation factor not to make ascorbic acid oxidized.
  • US Pat. No. 4,372,874 (Modrovich) describes that ascorbic acid is stabilized by adding a desiccant to anascorbic acid solution to entrap water and to reduce the water content to below 0.5%.
  • US Pat. No. 5,140,043 (Darr et al.) discloses that ascorbic acid is stabilized by combining at least 1% ascorbic acid with water and a carrier comprising alkylene glycol and hydroxyalkylcellulose.
  • US Pat. No. 5,296,249 discloses micro-sized particles of ascorbic acid in a suspension medium in which the particles are insoluble.
  • US Pat. No. 5,308,621 (Taylor et al.) describes fine particulate ascorbic acid that is suspended in a pharmaceutical carrier (such as a glycol or petroleum jelly) for transdermal delivery.
  • a further method of stabilizing ascorbic acid is based on dissolving ascorbic acid powder in water right before use.
  • Korean Pat. No. 0178377 discloses a dermatological composition comprising ascorbic acid powder and a hydrophilic gelling agent resistant to acidity, which are stored in a state of being separated from each other and are mixed immediately before use.
  • FR-A-2,645,740 describes a composition comprising an oily phase, an aqueous phase and a solid phase to be mixed immediately before use.
  • the solid phase described in FR-A-2,645,740 contains one or more active agents (especially vitamin A) and an emulsifier, and is spatially separated from the two liquid phases. This provides for a long viable storage period of the composition before mixing the three phases. However, after the three phases are mixed, the composition is stable for a short period of time. Also, the mixture is a coarse emulsion that is not homogeneous. Further, the acidic active ingredient does not guarantee the stability of the emulsion.
  • ascorbic acid powder is separated from the acidity-resistant hydrophilic gelling agent, and the two ingredients are intended to be mixed immediately before use.
  • Themaintenance of ascorbic acid in a solid state before use makes it more stable than the case when it is dissolved in water.
  • the solid-state storage is difficult to completely block the penetration of water or oxygen molecules into ascorbic acid.
  • ascorbic acid powder is hydrated, oxidized and decolorized over time.
  • an object of the present invention is to provide a stable cosmetic composition of vitamin C, in which vitamin C is present in a solid state while being separated from a liquid to provide a long shelf-life under a condition excluding artificial temperature increase, intense light penetration, oxygen supply, or the like, the composition also guaranteeing the stability of vitamin C for a long period of time even after the solid vitamin C is mixed with the liquid, that is, even after use of the composition.
  • the present invention provides a cosmetic composition
  • a cosmetic composition comprising a solid phase including vitamin C and an aqueous phase, which are separated from each other and are intended to be mixed immediately before use so as to ensure the long-term stability of vitamin C,
  • the solid phase further includes one or more antioxidants selected from the group consisting of kojic acid, ⁇ -lipoic acid, proanthocyanidin, retinol, retinol derivatives, coenzyme QlO, cysteine antioxidants, selenium, pycnogenol, enzogenol and fingenol and
  • the aqueous phase is prepared by dissolving carbonate in demineralized or deionized water to reduce the amount of oxygen dissolved in the water and enhance water- in-stability of vitamin C for a long period of time.
  • vitamin C is present in an amount of 0.1-20%, the antioxidant in an amount of 0.1-10%, and the carbonate in an amount of 0.05-0.5%, based on the total weight of the composition.
  • the aqueous phase preferably further comprises one or more selected from the group consisting of a moisturizer, a surfactant, a thickener, a pH control agent and a sequestering agent.
  • the cosmetic composition containing vitamin C in a solid state separated from a liquid, has advantages of having a long shelf- life of three years or longer under a condition excluding artificial temperature increase, intense light penetration, oxygen supply, or the like, and of ensuring the stability of vitamin C for a long period of time even after the solid vitamin C is mixed with the liquid, that is, even after use of the composition.
  • the present invention is directed to a cosmetic composition
  • a cosmetic composition comprising a solid phase including vitamin C and an aqueous phase, which are separated from each other and are intended to be mixed immediately before use.
  • the solid and aqueous phases are placed in a container and are spatially separated from each other.
  • the container is not particularly limited, and any one known in the art may be used.
  • the solid phase including vitamin C as described above, further includes one or more antioxidants selected from the group consisting of kojic acid, ⁇ -lipoic acid, proanthocyanidin, retinol, retinol derivatives, coenzyme QlO, cysteine antioxidants, selenium, pycnogenol, enzogenol and fingenol.
  • the aqueous phase is prepared by dissolving carbonate in demineralized or deionized water to reduce the amount of dissolved oxygen in the water and enhance water-in- stability of vitamin C for a long period of time.
  • the cysteine antioxidants include cysteine, glutathione and N-acetyl cysteine, which have a sulhydryl (SH) group.
  • the proanthocyanidin is an antioxidant contained in extracts from grape seeds, pine bark, and the like. Examples of pine bark extracts containing proanthocyanidin include Pycnogenol from French pine tree bark, Enzogenol from New Zealand pine tree bark, and Fingenol from Finland pine tree bark.
  • antioxidants included in the solid phase those present in a liquid state, such as retinol and retinol derivatives, may be used in the form of being mixed with other solid ingredients to be solidified.
  • the liquid antioxidants may be artificially solidified through coating with a polymer, such as agar or collagen.
  • the antioxidants contained in the present composition have antioxidantactivity stronger than that of vitamin C, and are thus oxidized earlier than vitamin C in the face of external effects, resulting in the protection of vitamin C. This improves the stability of vitamin C, and ensures water-in- stability of vitamin C for a long period of at least six months.
  • a compartment containingthe solid phase is first open by pumping to allow for the solid phase to be mixed with the aqueous phase.
  • the mixing is completed with shaking using the hands.
  • the inventors of this application conducted various experiments and found that the vitamin C contained in the present composition is maintained in a stable state at room temperature for a period of at least six months after the two phases are mixed.
  • the six-month period is the average period during which a consumer starts to use a cosmetic product containing vitamin C and exhausts the contents.
  • the cosmetic composition according to the present invention enables the application of active ingredients onto the skin without decomposition thereof for the whole period of use.
  • the cosmetic composition of the present invention is characterized in that the active form of an ingredient is directly dissolved in an aqueous phase and applied to the skin.
  • the present composition is more effective than conventional ones.
  • the vitamin C is present in an amount of 0.1-20%, the antioxidant in an amount of 0.1-10%, and the carbonate in an amount of 0.05-0.5%, based on the total weight of the composition.
  • the carbonate is employed to eliminate oxygen molecules dissolved in the aqueous phase.
  • carbon dioxide CO2
  • Carbon dioxide which has better water solubility than oxygen, in turn replaces oxygen, resulting in a decrease in the amount of oxygen dissolved in the aqueous phase.
  • Examples of carbonate suitable for use in the present composition include sodium bicarbonate.
  • the aqueous phase may further include one or more selected from the group consisting of a moisturizer, a surfactant, a thickener, a pH control agent and a sequestering agent.
  • thickeners useful for use in the aqueous phase include, but are not limited to, xanthan gum, carbomer, guar gum, carrageenan gum, hydroxyl alkyl cellulose, sodium carboxy cellulose, polyacrylates, polyurethanes, polyacrylamides, and gelatin.
  • the aqueous phase may include one or more pH control agentsin order to avoid the acidification of the composition to a pH value less than 3.0 when the solid phase is mixed with the aqueous phase.
  • the pH control agent include sodium lactate, sodium citrate, and sodium acetate buffers.
  • the amount of the pH buffer may vary depending on the amount of the used acidic active ingredient and the final pH value.
  • the final pH value preferably ranges from 3.0 to 6.0, and more preferably from 3.5 to 5.5.
  • moisturizers suitable for use in the aqueous phase of the present composition include low molecular moisturizers, such as glycerin, glycols (e.g., ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, etc.), sodium pyrrolidone carboxylate, trehalose, lactic acid, lactate, and amino acids (e.g., arginine, glutamine, etc.); and high molecular moisturizers, such as collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, sodium hyaluronic acid, chondroitin sulfuric acid or salts thereof, and ⁇ -polyglutamic acid.
  • low molecular moisturizers such as glycerin, glycols (e.g., ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, etc.), sodium pyrrolidone carboxylate, trehalose, lactic
  • surfactants suitable for use in the present invention include oil-soluble surfactants or water-soluble surfactants.
  • oil-soluble surfactants include polysorbates, sorbitan fatty acids, fatty acid esters, and lecithins.
  • water- soluble surfactants include ethoxylated alkyl ether, and PEG hydrogenated caster oil.
  • oils suitable for use in the present invention include vegetable, synthetic, mineral, silicon and/or fluorinated oils.
  • the aqueous phase may include a metal- sequestering agent and may be prepared with demineralized or deionized water.
  • the sequestering agent is typically used in an amount of 0.01-0.2% based on the total weight of the composition.
  • the aqueous phase may further include other additives apart from thosementioned above, which are typically used in cosmetic industries, such as water-soluble active agents (which maintain the aqueous phase for a long time), preservatives, colorants, and perfumes.
  • water-soluble active agents suitable for use in the aqueous phase include floral water, thermal water, plant extracts (e.g., willow extract, Lithospermi Radix extract, safflower seed extract, and camomile extract, which serve as anti-inflammatory agents and demulcents), other plant extracts (e.g., greentea extract, tomato extract, grape extract, coffee extract, etc.) which are extracted with an organic solvent and dissolved in a cosmetic vehicle (e.g., 1,3-butylene glycol, ethanol, propylene glycol, etc.), panthenol and hyaluronic acid. These active agents typically make up to 5% of the total weight of the composition.
  • plant extracts e.g., willow extract, Lithospermi Radix extract, safflower seed extract, and camomile extract, which serve as anti-inflammatory agents and demulcents
  • other plant extracts e.g., greentea extract, tomato extract, grape extract, coffee extract, etc.
  • the solid and aqueous phases are placed in two separate containers, which are intended to be assembled into a single body upon use. That is, the solid phase is placed in one container, closed with a cap, and kept in a larger container containing the aqueous phase.
  • This packaging is described in FR-A-2,476,607, FR-A-2,453,793, FR- A-2,645,740, and Korean Pat. No. 0178377. Any packaging described in the literature is available. If the vitamin C is sensitive to light, it is preferable to use an opaque and/ or amber-colored container, which does not allow light penetration. Alternatively, light penetration can be blocked with a cover covering the body of the container.
  • the powdered vitamin C suitable for use in the present invention is provided in the form of L-ascorbic acid having a purity of 99-100%.
  • the cosmetic composition of the present invention may be used for reducing wrinkles, reducing or eliminating chloasmas and aging spots to obtain skin whitening effects, protecting the skin from UV irradiation, regenerating skin tissues, and preventing skin aging.
  • Vitamin C 99.0%, Cat. No. A5960
  • cysteine 98.0%, Cat. No. C7352
  • retinol 95.0%, Cat. No. R7632
  • alpha-lipoic acid 99.0%, Cat. No. T5625
  • compositions prepared in Examples 1 to 4 and a composition containing vitamin C alone, as a comparative example were assessed for vitamin C stability. After the compositions of Examples 1 to 4 and the comparative example were placed in a container, a solid phase was allowed to be mixed with an aqueous phase through pumping. Then, the container was stored in an incubator at 30? for a period of 28 weeks. A portion of the content of the container was collected every week and assessed for vitamin C content.
  • Vitamin C content was determined through high performance liquid chromatography (HPLC). Each composition sample was accurately weighed at 50 mg and diluted with water to form a volume of exactly 50 ml. 50 ml of each test sample thus obtained was passed through a 0.45-m syringe filter. 1 ml of the filtrate was diluted in water to give a final volume of 10 ml. As a standard,50 mg of ascorbic acid was dissolved in water to give a final volume of 50 ml, and 1 ml of the resulting solution was diluted in water to give a 10-ml volume. The test and standard solutions were analyzed through liquid chromatography, and peak areas of the test and standard samples (At and As) were calculated.
  • the vitamin C content wasexpressed as a percentage against the initial content, which was measured right after the vitamin C compositions were prepared.
  • Ascorbic acid concentration(%) [(the ascorbic acid content (mg/ml) the amount of dilution solvent dilution time 100 / sample weight (mg)) / indicated content ] 100
  • HPLC was performed using Younglin UV 930 D (Younglin Ins., Co., Ltd., Korea) under the following conditions.
  • L A gradualincrease in the L value indicates that a test sample is effective, that is, a lightening in skin color.
  • the comparison between two test samples was expressed as L (final L value L value before application).
  • a higher L value indicates a better skin whitening effect.
  • L values measured after the test period of 8 weeks are given in Table 3, below.
  • compositions according to the present invention exhibited skin whitening effects better than those of the composition of the Comparative Example.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
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  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition cosmétique permettant de renforcer la stabilité de la vitamine C sur une longue durée. La composition comprend une phase solide comprenant de la vitamine C et une phase aqueuse, ces phases étant séparées l'une de l'autre et étant destinées à être mélangées immédiatement avant usage. La composition permet d'inhiber l'oxydation de la vitamine C qui a des effets antirides et antiblanchiment de la peau, mais présente des problèmes lorsqu'elle est utilisée dans des applications topiques du fait de son instabilité structurale entraînant facilement une oxydation par l'oxygène dissous dans l'eau, et la composition contenant ainsi de la vitamine C dans un état qui bloque son activité physiologique. La phase solide comprend également un ou plusieurs antioxydants sélectionnés dans le groupe comprenant l'acide kojique, l'acide α-lipoïque, la proanthocyanidine, le rétinol, des dérivés de rétinol, une coenzyme QIO, des antioxydants de cystéine, le sélénium, le pycnogénol, l'enzogénol et le fingénol.
PCT/KR2008/005106 2007-09-04 2008-08-30 Composition cosmétique comprenant de la vitamine c Ceased WO2009031788A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2008801054196A CN101795666B (zh) 2007-09-04 2008-08-30 含有维生素c的化妆品组成物
JP2010522816A JP2010537976A (ja) 2007-09-04 2008-08-30 ビタミンｃを含む化粧品組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070089643A KR100819173B1 (ko) 2007-09-04 2007-09-04 장기간 안정적으로 비타민 씨를 적용할 수 있는 화장품조성물
KR10-2007-0089643 2007-09-04

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KR (1) KR100819173B1 (fr)
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WO (1) WO2009031788A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
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CN103070925A (zh) * 2012-12-25 2013-05-01 华中农业大学 用于治疗阿尔茨海默病的药物组合物
US8652531B2 (en) 2011-07-29 2014-02-18 Kimberly-Clark Worldwide, Inc. Indicator for oxygen generation
WO2014052880A1 (fr) * 2012-09-28 2014-04-03 Disilvestro Robert Suppléments nutritionnels destinés à la santé oculaire et procédés apparentés
US9181093B2 (en) 2011-07-29 2015-11-10 Avent, Inc. Two part oxygen generating system
WO2017150891A1 (fr) * 2016-03-04 2017-09-08 주식회사 넥스모스 Procédé d'anti-oxydation pour substance anti-oxydante, et substance et utilisation associées
WO2017195951A1 (fr) * 2016-05-12 2017-11-16 주식회사 넥스모스 Supplément cosmétique et nutritionnel utilisant un aptamère et procédé de production associé
WO2018074763A1 (fr) * 2016-10-19 2018-04-26 주식회사 넥스모스 Procédé de prévention de l'oxydation d'un matériau antioxydant à l'aide d'un aptamère, matériau et utilisation de celui-ci
WO2018092968A1 (fr) * 2016-11-18 2018-05-24 주식회사 넥스모스 Boisson et aliment antioxydants et vitaminés utilisant un aptamère, et leur procédé de production
WO2020007563A1 (fr) * 2018-07-03 2020-01-09 Unilever N.V. Kit de soin de la peau
CN117298008A (zh) * 2023-09-18 2023-12-29 栈秋(上海)生物科技有限公司 一种化妆品活性成分锁鲜方法及应用
CN118649103A (zh) * 2024-07-17 2024-09-17 广东丸美生物技术股份有限公司 一种兼具舒缓、美白和紧致功效的组合物及其应用

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JP5995453B2 (ja) * 2012-01-31 2016-09-21 アサヌマ コーポレーション株式会社 化粧料及びその製造方法
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CN108618974B (zh) * 2018-06-26 2021-02-05 广州市瓷颜化妆品有限公司 一种富含维生素c的分离式面膜及其制备方法
CN108836890B (zh) * 2018-07-06 2021-01-05 广州市瓷颜化妆品有限公司 一种高含量维c分离式面膜及其制备方法
JP7098198B2 (ja) * 2019-10-08 2022-07-11 株式会社東洋新薬 美容組成物
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CN113476332A (zh) * 2021-05-19 2021-10-08 谢志辉生物医药研究院(广州)有限公司 一种稳定的维生素c制剂及其使用方法
KR102350285B1 (ko) * 2021-05-26 2022-01-13 (주)나우코스 비타민c 유도체와 머루포도 추출물을 포함하는 피부 미백용 화장품 조성물
KR20250041294A (ko) 2023-09-18 2025-03-25 땡큐네이처 주식회사 워터리스 비타민 엠플 및 이를 포함하는 화장품
CN117821156A (zh) * 2023-11-22 2024-04-05 美出莱(杭州)化妆品有限责任公司 一种牡丹籽复合发酵油的制备方法

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT5784B (lt) 2009-12-29 2011-10-25 Alvyda GUDELEVIČIŪTĖ Kosmetinės kompozicijos su padidintu antioksidaciniu ir drėkinamuoju poveikiu
US8652531B2 (en) 2011-07-29 2014-02-18 Kimberly-Clark Worldwide, Inc. Indicator for oxygen generation
US9181093B2 (en) 2011-07-29 2015-11-10 Avent, Inc. Two part oxygen generating system
WO2014052880A1 (fr) * 2012-09-28 2014-04-03 Disilvestro Robert Suppléments nutritionnels destinés à la santé oculaire et procédés apparentés
US9271955B2 (en) 2012-09-28 2016-03-01 Ohio State Innovation Foundation Nutritional supplements for eye health and related methods
CN103070925A (zh) * 2012-12-25 2013-05-01 华中农业大学 用于治疗阿尔茨海默病的药物组合物
WO2017150891A1 (fr) * 2016-03-04 2017-09-08 주식회사 넥스모스 Procédé d'anti-oxydation pour substance anti-oxydante, et substance et utilisation associées
WO2017150785A1 (fr) * 2016-03-04 2017-09-08 주식회사 넥스모스 Procédé d'anti-oxydation pour substance anti-oxydante, et substance et utilisation associées
WO2017195951A1 (fr) * 2016-05-12 2017-11-16 주식회사 넥스모스 Supplément cosmétique et nutritionnel utilisant un aptamère et procédé de production associé
WO2017196077A1 (fr) * 2016-05-12 2017-11-16 주식회사 넥스모스 Additif cosmétique et nutritionnel utilisant un aptamère et procédé pour le produire
WO2018074763A1 (fr) * 2016-10-19 2018-04-26 주식회사 넥스모스 Procédé de prévention de l'oxydation d'un matériau antioxydant à l'aide d'un aptamère, matériau et utilisation de celui-ci
WO2018092968A1 (fr) * 2016-11-18 2018-05-24 주식회사 넥스모스 Boisson et aliment antioxydants et vitaminés utilisant un aptamère, et leur procédé de production
WO2020007563A1 (fr) * 2018-07-03 2020-01-09 Unilever N.V. Kit de soin de la peau
CN117298008A (zh) * 2023-09-18 2023-12-29 栈秋(上海)生物科技有限公司 一种化妆品活性成分锁鲜方法及应用
CN118649103A (zh) * 2024-07-17 2024-09-17 广东丸美生物技术股份有限公司 一种兼具舒缓、美白和紧致功效的组合物及其应用

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