WO2009030149A1 - Metallic-base antiseptic patch, its preformed body, its preparing method using magnetron sputtering and its use - Google Patents

Abstract

A metallic-base antiseptic patch consists of metal antiseptic layer, metallic base body and sticking layer. The metal antiseptic layer is coated on the metallic base body by magnetron sputtering. The sticking layer is stuck on the bottom of the metallic base body. The preparing method of the metallic-base antiseptic patch includes coating the metal antiseptic layer on the metallic base body by magnetron sputtering. The metallic-base antiseptic patch can be used in mobile telephone, computer keyboard, cloth or wallet for bacteriostasis.

Description

Metal-based antibacterial patch, preform thereof, preparation method and application by magnetron sputtering method

 The invention relates to a metal-based antibacterial patch and a preparation method thereof, and more particularly to a metal-based antibacterial patch capable of providing metal ion sterilization, and also relates to a preform of the patch, a preparation method and application thereof . Background technique

 It is well known that harmful bacteria are an important factor in human disease and affecting health. Therefore, how to eliminate and suppress harmful bacteria is one of the important topics studied by scientists all over the world since the discovery of bacteria. With the continuous development of science and technology, a variety of antibacterial materials are emerging.

 In recent years, with the rapid development of the economy and the improvement of living standards, the antibacterial requirements for daily necessities have become higher and higher.

 Chinese Patent Authorization Announcement CN1162075C discloses an antibacterial and environmentally-friendly functional lining and a production method, which is permeable with ANTIBIO-994 antibacterial agent in the base fabric. The antibacterial agent is mainly used for sterilization, but after long-term washing, the antibacterial effect is remarkably reduced.

 China Patent Licensing Publication CN2528257Y discloses a shoe lining sheet having an antibacterial and fragrant function, which is needle-punched into a sheet from a polyester staple fiber and coated with a layer of propyl bismuth on the outer layer of the polyester staple fiber. An octadecyl quaternary ammonium chloride and a coating capable of slow release of a slight scent, the shoe lining sheet repels odor by releasing a slight fragrance.

 The above antibacterial product uses a fiber fabric as a carrier, and then the antibacterial filler is placed in the carrier to constitute an antibacterial product, and the durability thereof is limited, and such a problem is solved by the antibacterial action of the metal material.

Chinese Patent Authorization Announcement CN1410587 discloses a surface copper-containing antibacterial stainless steel and a manufacturing process thereof, and the surface copper-containing antibacterial stainless steel comprises a galvanized substrate containing a ε-Cu plating layer, and the copper plating layer has a copper content of 1.5-30wt. %. In the preparation of the antibacterial stainless steel, it is necessary to use an infiltrant of CuO, CuCl and NH ₄ C1, which will generate waste liquid during the preparation process, which may cause environmental pollution if not treated properly. In addition, the composition and composition of the alloy layer obtained by the plating have many limitations, and therefore, the antibacterial Sex will be restricted.

 Chinese Patent Publication No. CN1158363 discloses a stainless steel which is improved in antibacterial property by adding 0.4-5.0% by weight of copper and a copper-rich phase precipitated at a ratio of 0.2% by volume.

 A copper-silver bimetallic colloidal antibacterial agent and a preparation method thereof are disclosed in Chinese Patent Publication No. CN1262043. A silver-ion-protected silver ion is added to the copper colloid to cause a silver ion to undergo a replacement reaction with copper, and a part or all of the surface of the copper particle is coated with silver particles to form a copper-silver bimetallic colloidal antibacterial agent.

 Although the above prior art exists, there is still a potential demand for further development of an antibacterial product having superior antibacterial properties, stable quality, and good durability; further development and manufacture are convenient, and various antibacterial metals can be conveniently combined. And antibacterial products that do not pollute the environment during manufacturing and use. Summary of the invention

 In order to overcome various defects existing in the prior art, an object of the present invention is to provide a metal-based antibacterial patch which uses a metal element as an antibacterial source layer and a metal material as a matrix to provide quality. Metal-based antibacterial patch with excellent stability and durability.

 The present invention provides a metal-based antimicrobial patch.

 A metal-based antibacterial patch according to an embodiment of the present invention, characterized in that it consists of a metal antibacterial source layer, a metal substrate and an adhesive layer, which is deposited by magnetron sputtering or one or more The metal is formed on the upper portion of the metal substrate, and the adhesive layer is disposed on the bottom of the metal substrate.

The metal-based antibacterial patch of the present invention has a metal material as a matrix, and is closely combined with a metal antibacterial source layer deposited thereon by magnetron sputtering, thereby improving antibacterial durability; and the metal antibacterial source layer It is deposited on the metal substrate by magnetron sputtering, so it can be used on a metal substrate of various metal materials; and the metal antibacterial source layer produced by the magnetron sputtering method is nanometer-scale, and can also be used in combination. A variety of antibacterial metals, so the antibacterial effect is good; and the metal material of the metal antibacterial source layer and the metal material of the metal matrix can be combined as needed; and the metal antibacterial source layer is produced by magnetron sputtering, and no chemical substances remain. , thereby preventing environmental pollution caused by chemical residues. A metal-based antimicrobial patch according to a preferred embodiment of the present invention is characterized in that one or more metal substrates are provided between the metal antibacterial source layer and the adhesive layer. In order to solve the problem of bonding between various metals and to make a better combination between the metals, a multilayer substrate can be provided.

 A metal-based antimicrobial patch according to a preferred embodiment of the present invention is characterized in that the multilayer metal substrate can be made of the same or different materials.

 A metal-based antimicrobial patch according to a preferred embodiment of the present invention is characterized in that the adhesive layer is an adhesive layer similar to a wound patch, and any adhesive layer having a tackiness can be used. The adhesive layer is mainly for fixing the metal-based antimicrobial patch to the article to be used, thereby improving the arbitrariness of use.

 The metal antibacterial source layer preferably contains gold, vanadium, chromium, manganese, iron, cobalt, nickel, copper One or more alloys of silver, rare earth elements, and tin.

 Preferably, the metal antibacterial source layer is gold, copper, silver, iron or an element. The above metals are non-toxic and stable in performance, so they are preferred.

 Further preferably, the metal antibacterial source layer is copper, silver or an alloy of copper and silver, which is preferred because it has a good antibacterial effect.

 According to a preferred embodiment of the present invention, all metal substrates which can be deposited thereon by a magnetron sputtering method and which are non-toxic and harmless can be used, wherein the preferred metal substrate is magnesium, aluminum or titanium. , a metal of vanadium, chromium, manganese, iron, cobalt, copper, rhenium, zirconium, hafnium, phase, palladium, silver, platinum, or an alloy thereof, or an atomic ratio of 20% or more of the element An alloy of metals. The above metals are common metals and are known to be harmless to the human body or elements required by the human body. They are used as a metal matrix, which is safe and durable, and has a certain antibacterial effect itself, and is closely combined with the metal antibacterial source layer thereon.

 A metal-based antibacterial patch according to a particularly preferred embodiment of the present invention, characterized in that the metal antibacterial source layer is copper, silver or a copper-silver alloy, and the metal substrate is a copper sheet, a silver sheet or an aluminum sheet, and such a combination is most preferable. The metal antibacterial source layer is tightly combined with the metal substrate, is harmless to the human body, and greatly improves the antibacterial effect and antibacterial durability.

According to a preferred embodiment of the present invention, the metal-based antimicrobial patch has a thickness of 0.00005 to 1 mm. If the thickness of the metal antibacterial source layer is less than 0.00005 mm, the durability of the metal-based antibacterial patch may be affected. If the thickness of the metal antibacterial source layer is higher than 1 mm, It is inconvenient to use, and the above thickness makes the metal-based antibacterial patch and the human body have better practicality when used in direct and indirect contact with the human body, and does not cause or cause foreign body sensation. Considering the durability and high-efficiency antibacterial property of the metal-based antibacterial patch, the thickness of the metal antibacterial source layer is preferably 0.001 to 0.8 mm, more preferably 0.005 to 0.1 mm.

 A metal-based antimicrobial patch according to a preferred embodiment of the present invention, characterized in that the thickness of each of the metal substrates is preferably 0.0005 to 1 mm. The above thickness is more practical when used in direct and indirect contact with the human body so as not to cause or cause a foreign body sensation.

 According to the metal-based antimicrobial patch of the preferred embodiment of the present invention, it is preferable that the total thickness of the metal antibacterial source layer and the metal substrate is preferably 0.001 to 2 mm. The above thickness is more practical when used in direct and indirect contact with the human body so as not to cause or cause a foreign body sensation.

 A metal-based antibacterial patch according to a preferred embodiment of the present invention, characterized in that the metal substrate is preferably a copper sheet, an iron sheet, a silver sheet or an aluminum sheet having a thickness of 0.002 to 1.5 mm, or a thickness of 0.002 - 1.5 mm. Copper-based alloy sheets, iron-based alloy sheets, silver-based alloy sheets or aluminum-based alloy sheets. The above thickness is more practical when used in direct and indirect contact with the human body so as not to cause or a little foreign body sensation; and the above metal is not harmful to the human body, and the overall antibacterial durability of the metal-based antibacterial patch can be improved.

 A method of preparing a metal-based antimicrobial patch according to a preferred embodiment of the present invention, characterized in that a metal antibacterial source layer having two or more metal elements is simultaneously deposited on a metal substrate during magnetron sputtering deposition Formed from two or more metal elements. The metal antibacterial source layer has two or more kinds of metal elements uniformly, and works at the same time, thereby improving the antibacterial effect, expanding the antibacterial range and the applicable occasion.

 The invention also provides a preparation method for preparing the above metal-based antibacterial patch, characterized in that the method comprises the steps of: depositing one or more metals on the upper part of the metal substrate by magnetron sputtering to form a metal antibacterial source layer, The adhesive layer is placed on the bottom of the metal substrate.

 Preferably, in the above magnetron sputtering method, different targets are mounted on a plurality of target stages of the magnetron sputtering apparatus, and two kinds of metal substrates can be simultaneously deposited during magnetron sputtering deposition. A metal antibacterial source layer of two or more metal materials. The method allows two or more metal materials to be uniformly deposited on the metal substrate, thereby improving the antibacterial effect of the metal-based antimicrobial patch.

Preferably, the method of depositing a metal antibacterial source layer on the upper portion of the metal substrate by magnetron sputtering Includes the following steps:

 (1) mounting the target of the metal antibacterial source layer on the target platform;

 (2) cleaning and drying the metal substrate and mounting it on the substrate turntable;

(3) vacuuming, so that the sputtering chamber vacuum degree reaches 3xlO_ ⁴ Pa;

 (4) Introducing high-purity argon into the sputtering chamber to achieve the desired argon partial pressure of 0.5 ~ 1.5Pa; (5) Pre-sputtering target for 1 ~ 5min, current 0.1 ~ 0·3Α, voltage 30 ~ 300V ;

 (6) Reverse sputtering of the metal substrate 5 ~ lOmin, current 5 ~ 15A;

 (7) Turn on the target power supply of the sputter deposition target, the current is 0.01 ~ 0.2A, the voltage is 200 ~ 350V, and the target is deposited for 5 ~ 10min.

 The metal-based antibacterial patch prepared by the above method has stable performance and improved antibacterial durability.

 The magnetron sputtering method used in the application of the present invention is not limited to the above specific method, as long as the metal antibacterial source layer is deposited on the metal substrate of the present invention by using a known magnetron sputtering method, which is within the protection scope of the present application. .

 The present invention also provides the use of the above metal-based antimicrobial patch for sterilizing a mobile phone, a computer keyboard, a garment or a wallet.

 The invention also provides a preform for a metal-based antibacterial patch comprising a metal antibacterial source layer and a metal matrix, the metal antibacterial source layer depositing the metal matrix by one or more metals by magnetron sputtering Formed on the top.

 The invention also provides a metal-based antibacterial patch, comprising: a metal antibacterial source layer, a metal substrate and an adhesive layer, wherein the metal antibacterial source layer deposits one or more metals by magnetron sputtering The upper portion of the metal substrate is formed, and the adhesive layer is disposed at the bottom of the metal substrate.

The invention also provides a metal-based antibacterial patch comprising a metal antibacterial source layer, a metal substrate and an adhesive layer, the metal antibacterial source layer being one or more metal ions, atoms and/or radicals by magnetron sputtering. Formed on the upper portion of the metal substrate, the adhesive layer is disposed on the bottom of the metal substrate. The beneficial effects of the present invention are as follows: (1) The use of a metal material as a carrier improves the durability of the antibacterial; (2) and the metal antibacterial source layer is deposited on the upper portion of the metal substrate by magnetron sputtering to form Preform, so it can be used on a variety of metal materials; (3) The metal material in the metal antibacterial source layer deposited by magnetron sputtering is nanometer-scale, and the antibacterial effect is good; (4) A combination of a variety of different antimicrobial metals, so it is convenient to choose the material with the best antibacterial effect according to your needs;

(5) The type of the antibacterial metal material of the metal antibacterial source layer and the metal material of the metal matrix may be combined as needed to make the bonding between them tight and enhance the durability; (6) using magnetron sputtering, no residue Chemical substances, thus preventing environmental pollution caused by chemical residues.

 The embodiments of the present invention will be further described with reference to the accompanying drawings, and the embodiments of the present invention are not intended to limit the scope of the present invention. The scope of the invention is subject to change and modifications, and the scope of the invention is defined by the appended claims. DRAWINGS

 1 is a cross-sectional view of a metal-based antimicrobial patch according to an embodiment of the present invention;

 2 is a cross-sectional view of a metal-based antimicrobial patch according to another embodiment of the present invention; wherein: a metal antibacterial source layer, a 2-metal substrate, a 3-adhesive layer, and a 4-metal substrate A. detailed description

 The invention relates to a metal-based antibacterial patch which uses a metal material as a base, and is characterized in that it comprises a metal antibacterial source layer 1, a metal substrate 2 and an adhesive layer 3. The upper part of the metal substrate is a metal antibacterial source layer 1, and the metal substrate 2 The bottom of the layer is the adhesive layer 3.

 The total thickness of the metal antibacterial source layer 1 and the metal substrate 2 is preferably 0.001 to 2 mm.

 In the embodiment of the present invention, the adhesive layer 3 may be a conventional paper single-sided adhesive tape, such as a sticker for wounds, or other adhesive layer.

 In another embodiment of the present invention, the metal substrate 2 is preferably a copper sheet, an iron sheet, a silver sheet or an aluminum sheet having a thickness of 0.002 to 1.5 mm, or a copper-based alloy sheet having a thickness of 0.002 to 1.5 mm, and iron. Base alloy sheet, silver-based alloy sheet or aluminum-based alloy sheet.

 In another embodiment of the invention, the metal antibacterial source layer is preferably gold, copper, silver, iron or a word.

Since the metal-based antibacterial patch of the present invention uses a metal material as a matrix (or carrier) and the antibacterial agent also uses a metal element, the inventors have adopted advanced techniques to prepare a preform for a metal-based antibacterial patch (including Metal antibacterial source layer 1 and metal matrix 2). In the method for preparing a metal-based antibacterial patch according to an embodiment of the present invention, a metal antibacterial source layer 1 is first prepared on a metal substrate 2 by a magnetron sputtering method, and a preform of a metal-based antibacterial patch is obtained. The method may be conventional. A magnetron sputtering method, for example, preferably, the method comprises the steps of:

 (1) mounting the target of the metal antibacterial source layer 1 on the target platform;

 (2) cleaning and drying the metal substrate 2, and mounting it on the substrate turntable;

(3) vacuuming, so that the sputtering amine chamber vacuum reaches 3xl (T ⁴ Pa;

 (4) Introducing high-purity argon into the sputtering chamber to achieve the desired argon partial pressure of 0.5 ~ 1.5Pa; (5) Pre-sputtering target for 1 ~ 5min, current 0.1 ~ 0·3Α, voltage 30 ~ 300V ;

 (6) Reverse sputtering of the metal substrate 2 5 ~ lOmin, current 5 ~ 15A;

 (7) Turn on the target power supply of the sputter deposition target, the current is 0.01 ~ 0.2A, the voltage is 200 ~ 350V, and the target is removed after 5 ~ 10min, so that the metal antibacterial source layer is magnetron sputtered on the metal substrate 2. The preform is obtained by the above-mentioned method, and the metal antibacterial source layer on the metal substrate is deposited and has good durability.

 Finally, the metal substrate of the preform obtained by the step (7) is pasted onto the adhesive layer 3 to obtain a metal-based antibacterial patch.

 In the preparation method disclosed in the present invention, different targets can be mounted on a plurality of target stages of the magnetron sputtering apparatus, and two or more types can be simultaneously deposited in the magnetron sputtering deposition process. The antibacterial source, the metal antibacterial source layer with various metal materials thus obtained, the different metal materials are distributed, the durability is good, and the antibacterial effect is good.

 The metal-based antibacterial patch of the invention releases the metal particles and metal atoms by the antibacterial metal element on the patch through the corrosive substances such as lactic acid and the mechanical friction in the sweat secreted by the human body under the temperature and humidity conditions of the human body. And metal ions, which play an antibacterial and bactericidal role.

 The metal antibacterial patch prepared by the invention can be designed as an antibacterial patch applied to a mobile phone, an antibacterial patch for a computer keyboard, an antibacterial patch for clothing (shoes, socks, clothes) according to different applications. Antibacterial patches for wallets, etc.

 For example, it is used as an antibacterial patch on a mobile phone, and its size matches the size of the phone's keyboard. For example, an antibacterial patch used as a computer keyboard, the size of which matches the keyboard size of the computer.

For example, it can be used as an antibacterial patch for clothing, and can be designed into various shapes, such as a circular shape, a square shape, and a special shape, and can be arbitrarily attached to any part of the clothing according to the user's preference and needs. The term "metal antibacterial source layer" in the present application is a broad concept, and depending on the metal material used, the antibacterial effecting component may be a metal particle, a metal ion, a metal atom, a metal atomic group and/or a metal. Compounds, etc.

 Example 1: Metal-based antibacterial patch for shoes

 The metal substrate 2 is made of a copper sheet having a thickness of 1 mm, and the material of the metal antibacterial source layer 1 is elemental copper. In the present embodiment, the preform of the metal-based antibacterial patch for the shoe having the metal antibacterial source layer 1 prepared by the magnetron sputtering method on the metal substrate 2 has the following steps:

 (1) mounting a single-mass copper target on a target platform;

 (2) The copper sheet is washed with alcohol, dried, and then mounted on a substrate turntable;

(3) vacuuming, so that the sputtering amine chamber vacuum reaches 3xl (T ⁴ Pa;

 (4) introducing high purity argon into the sputtering chamber to achieve a desired partial pressure of argon of 0.5 Pa;

 (5) Pre-sputtering target for 3 min, current 0.3 A, voltage 50V;

 (6) Reverse sputtering of copper sheet for 5 min, current 5A;

 (7) Turn on the target power supply of the sputter deposition target, the current is 0.1A, the voltage is 350V, and the target is deposited for 10 minutes, then the preform is prepared by magnetron sputtering on the copper sheet with the copper metal antibacterial source layer. The copper metal antibacterial source layer has a thickness of 0.52 mm.

 Finally, the bottom of the copper sheet of the preform obtained by the step (7) is pasted with a similar adhesive layer, that is, a product of a metal-based antibacterial patch for shoes.

 The prepared shoe-based metal-based antibacterial patch was placed in the user's right shoe for 5 hours, and after observation by an optical microscope, the red bacterium and the staphylococcus in the right shoe were significantly more than the antibacterial paste of the present invention. The left shoe of the piece is reduced by 20%. After 3 days of use, the T. rubrum and Staphylococcus in the right shoe were reduced by more than 95% compared to the T. rubrum and Staphylococcus in the left shoe.

 The same process conditions as described above were used, except that: On the other target of the magnetron sputtering apparatus, a silver target was mounted, and both copper and silver elements were deposited. The preparation of the preform is the following steps: (1) mounting the elemental copper target on the first target stage, and the elemental silver target is mounted on the second target stage;

(2) The copper sheet is washed with a sprinkle and then dried, and then mounted on a substrate turntable;

(3) vacuuming, so that the sputtering chamber vacuum degree reaches 3xlO_ ⁴ Pa;

 (4) introducing high purity argon into the sputtering chamber to achieve a desired partial pressure of argon of 0.5 Pa;

(5) Simultaneous pre-sputtering target: Pre-sputtered copper target for 3 min, current 0.3A, voltage 50V, pre Sputtering 4 艮 target for 3 min, current 0.3 A, voltage 50V,;

 (6) Reverse sputtering of copper sheet for 5 min, current 5A;

 (7) Turn on the target power supply of the sputter-deposited copper target, the current is 0.1A, the voltage is 350V, and the target power source of the sputter-deposited silver target is turned on, the current is 0.1 A, the voltage is 350V, and the target is deposited for 1 min, then it is obtained. A preform having a copper metal ion and a silver metal antibacterial source layer was magnetron sputtered on the copper sheet, and the thickness of the metal antibacterial source layer was measured to be 0.59 mm.

 Finally, the bottom of the copper sheet of the preform obtained by the step (7) is pasted with a paste layer similar to the wound patch, thereby obtaining a product of the metal-based antimicrobial patch for shoes.

 The obtained shoe-based metal-based antibacterial patch was placed in the user's right shoe for 5 hours, and after observation by an optical microscope, the E. coli in the right shoe was significantly reduced compared with the left shoe not using the antibacterial patch of the present invention. 28%. After 3 days of use, the red T. rubrum and staphylococci in the right shoe were more than 97% lower than the T. rubrum and staphylococcus in the left shoe. Example 2: Metal-based antibacterial patch for computer keyboard

 The metal substrate 2 is made of a 1 mm thick aluminum sheet, and the metal antibacterial source layer 1 is made of elemental copper. In the present embodiment, the preform of the metal-based antibacterial patch for the computer keyboard using the magnetron sputtering method to prepare the metal antibacterial source layer 1 on the metal substrate 2 has the following steps:

 (1) mounting a single-mass copper target on a target platform;

 (2) The aluminum sheet is washed with alcohol, dried, and then mounted on a substrate turntable;

(3) vacuuming, so that the sputtering amine chamber vacuum reaches 3x l (T ⁴ Pa;

 (4) introducing high purity argon into the sputtering chamber to achieve a desired partial pressure of argon of 0.5 Pa;

 (5) Pre-sputtering target for 3 min, current 0.3 A, voltage 50V;

 (6) Reverse sputtering of aluminum sheet for 5 min, current 5A;

 (7) Turn on the target power supply of the sputter deposition target, the current is 0.1A, the voltage is 350V, and the target is deposited for 10 minutes, and then the preform is prepared by magnetron sputtering on the aluminum sheet with the copper metal antibacterial source layer. The copper metal antibacterial source layer has a thickness of 0.45 mm.

 Finally, the bottom of the aluminum sheet of the preform obtained by the step (7) is pasted with a similar adhesive layer, that is, a product of a metal-based antibacterial patch for a computer keyboard.

Pasting the above-mentioned computer keyboard with a metal-based antibacterial patch on the first laptop After 10 hours of use on the keyboard, after observation by optical microscopy, the red tape on the keyboard of the first laptop, Staphylococcus aureus, Staphylococcus aureus, Streptococcus, Escherichia coli was significantly better than the antibacterial patch of the present invention. The second laptop has a 50% reduction on the keyboard. Example 3: Metal-based antibacterial patch for women's underwear

 The metal substrate 2 is made of a 1 mm thick silver piece, and the metal antibacterial source layer 1 is made of elemental copper. In the present embodiment, the preform of the metal-based antibacterial patch for the underwear of the underwear is prepared by the magnetron sputtering method on the metal substrate 2 by the magnetron sputtering method.

 (1) mounting a single-mass copper target on a target platform;

 (2) The silver piece is washed with alcohol, dried, and then mounted on a substrate turntable;

(3) vacuuming, so that the sputtering amine chamber vacuum reaches 3x l (T ⁴ Pa;

 (4) introducing high purity argon into the sputtering chamber to achieve a desired partial pressure of argon of 0.5 Pa;

 (5) Pre-sputtering target for 3 min, current 0.3 A, voltage 50V;

 (6) Reverse sputtering of silver sheet for 5 min, current 5A;

 (7) The target power supply of the sputter deposition target is turned on, the current is 0.1 A, the voltage is 350 V, and the target is deposited for 10 min, and then the preform is prepared by magnetron sputtering on the silver sheet with the copper metal antibacterial source layer. The copper metal antibacterial source layer has a thickness of 0.45 mm.

 Finally, the bottom of the silver sheet of the preform obtained by the step (7) is pasted with a similar adhesive layer, that is, a product of a metal-based antibacterial patch for women's underwear.

 The above-mentioned women's underwear was pasted with a metal-based antibacterial patch on the underwear of the lower right part of the user for 10 hours. After observation by an optical microscope, the mold, staphylococcus and Escherichia coli under the right armpit of the women's underwear were significantly better than The left ankle of the antibacterial patch of the present invention was reduced by 79%.

Claims

Claim A metal-based antibacterial patch comprising: a metal antibacterial source layer, a metal substrate, and an adhesive layer, wherein the metal antibacterial source layer deposits one or more metals on the metal by magnetron sputtering The upper portion of the base body is formed, and the adhesive layer is disposed at the bottom of the metal base.  The metal-based antimicrobial patch according to claim 1, wherein one or more metal substrates are provided between the metal antibacterial source layer and the adhesive layer.  The metal-based antimicrobial patch according to claim 1, wherein the metal of the metal antibacterial source layer is a metal having a bactericidal action.  The metal-based antimicrobial patch according to any one of claims 1 to 3, wherein the metal substrate is selected from the group consisting of magnesium, aluminum, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, a metal of copper, rhodium, zirconium, hafnium, phase, palladium, silver, platinum or an alloy thereof, or an alloy of other metals containing an atomic ratio of 20% or more of the element.  The metal-based antibacterial patch according to any one of claims 1 to 4, wherein the metal antibacterial source layer contains a metal, vanadium, chromium, manganese, iron, cobalt, nickel, copper, Word, silver, rare earth element, a metal in tin or an alloy of more than one metal.  The metal-based antimicrobial patch according to claim 5, wherein the metal antibacterial source layer is copper, silver or a copper-silver alloy, and the metal substrate is a copper sheet, a silver sheet or an aluminum sheet.  The metal-based antimicrobial patch according to any one of claims 1 to 5, wherein the metal antibacterial source layer is gold, copper, silver, iron, and/or rhodium.  The metal-based antimicrobial patch according to any one of claims 1 to 7, wherein the metal antibacterial source layer has a thickness of 0.00005 to 1 mm.  The metal-based antimicrobial patch according to any one of claims 1 to 8, wherein each of the metal substrates has a thickness of 0.00005 to 1 mm.  The metal-based antimicrobial patch according to any one of claims 1 to 9, wherein the metal antibacterial source layer and the metal substrate have a total thickness of 0.001 to 2 mm. The metal-based antibacterial patch according to any one of claims 1 to 5, wherein the metal substrate is a copper piece, an iron piece, a silver piece or an aluminum piece having a thickness of 0.002 to 1.5 mm, or A copper-based alloy sheet, an iron-based alloy sheet, a silver-based alloy sheet or an aluminum-based alloy sheet having a thickness of 0.002 to 1.5 mm. The metal-based antibacterial patch according to claim 1, wherein the metal antibacterial source layer having two or more metal elements is simultaneously deposited on the metal substrate during magnetron sputtering deposition. Or formed by two or more metal elements.  The method for preparing a metal-based antibacterial patch according to any one of claims 1 to 11, wherein the method comprises the steps of: depositing one or more metals on the metal by magnetron sputtering On the upper portion of the substrate, a metal antibacterial source layer is formed, and the adhesive layer is placed on the bottom of the metal substrate.  The method for preparing a metal-based antibacterial patch according to claim 13, wherein in the magnetron sputtering method, different targets are mounted on a plurality of target stages of the magnetron sputtering apparatus, and magnetic During the controlled sputtering deposition, a metal antibacterial source layer having two or more metal elements is simultaneously deposited on the metal substrate.  The method for preparing a metal-based antimicrobial patch according to claim 13 or 14, wherein the step of depositing the metal antibacterial source layer on the upper portion of the metal substrate by magnetron sputtering comprises the following steps:  (1) mounting the target of the metal antibacterial source layer on the target platform;  (2) cleaning and drying the metal substrate and mounting it on the substrate turntable; (3) vacuuming, so that the vacuum of the sputtering amine chamber reaches 3xl - ⁴ Pa;  (4) introducing high purity argon gas into the sputtering chamber to achieve a desired partial pressure of argon gas of 0.5 to 1.5 Pa;  (5) Pre-sputtering target 1 ~ 5min, current 0.1 ~ 0.3 A, voltage 30 ~ 300V;  (6) Reverse sputtering of the metal substrate 5 ~ lOmin, current 5 ~ 15A;  (7) Turn on the target power supply of the sputter deposition target, the current is 0.01 ~ 0.2A, the voltage is 200 ~ 350V, and the target is deposited for 5 ~ 10min.  16. Use of a metal-based antimicrobial patch according to any one of claims 1 to 12 for sterilizing a mobile phone, a computer keyboard, a garment or a wallet.  17. A preform for a metal-based antimicrobial patch comprising a metal antimicrobial source layer and a metal substrate, the metal antimicrobial source layer depositing one or more metals on the metal substrate by magnetron sputtering And formed. A metal-based antibacterial patch comprising a metal antibacterial source layer, a metal substrate and an adhesive layer, wherein the metal antibacterial source layer deposits one or more metals on the metal substrate by magnetron sputtering Formed on the upper portion, the adhesive layer is disposed at the bottom of the metal substrate. A metal-based antibacterial patch comprising a metal antibacterial source layer, a metal substrate and an adhesive layer, the metal antibacterial source layer being one or more metal ions, atoms and/or by magnetron sputtering. Or an atomic group is deposited on the upper portion of the metal substrate, and the adhesive layer is disposed on the bottom of the metal substrate.