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WO2009027766A3 - New crystalline solid forms of o-desvenlafaxine base - Google Patents

New crystalline solid forms of o-desvenlafaxine base Download PDF

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Publication number
WO2009027766A3
WO2009027766A3 PCT/IB2007/004654 IB2007004654W WO2009027766A3 WO 2009027766 A3 WO2009027766 A3 WO 2009027766A3 IB 2007004654 W IB2007004654 W IB 2007004654W WO 2009027766 A3 WO2009027766 A3 WO 2009027766A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystalline solid
solid forms
new crystalline
desvenlafaxine base
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/004654
Other languages
French (fr)
Other versions
WO2009027766A2 (en
Inventor
Velez Monica Benito
Iolanda Chamorro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Publication of WO2009027766A2 publication Critical patent/WO2009027766A2/en
Publication of WO2009027766A3 publication Critical patent/WO2009027766A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates generally to crystalline polymorphic forms of O- desmethylvenlafaxine base, designated herein as O-desmethylvenlafaxine base Forms A and B, and methods for preparing and obtaining the same.
PCT/IB2007/004654 2006-12-22 2007-12-21 New crystalline solid forms of o-desvenlafaxine base Ceased WO2009027766A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87658006P 2006-12-22 2006-12-22
US60/876,580 2006-12-22

Publications (2)

Publication Number Publication Date
WO2009027766A2 WO2009027766A2 (en) 2009-03-05
WO2009027766A3 true WO2009027766A3 (en) 2009-04-23

Family

ID=40298639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004654 Ceased WO2009027766A2 (en) 2006-12-22 2007-12-21 New crystalline solid forms of o-desvenlafaxine base

Country Status (2)

Country Link
AR (1) AR064507A1 (en)
WO (1) WO2009027766A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate
CN114478271B (en) * 2021-12-13 2024-05-31 植恩生物技术股份有限公司 Preparation method of desmethylvenlafaxine succinate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045583A1 (en) * 2001-02-12 2003-03-06 American Home Products Corporation Novel succinate salt of O-desmethyl-venlafaxine
US20060058552A1 (en) * 2002-06-10 2006-03-16 Wyeth Novel formate salt of O-desmethyl-venlafaxine
WO2007120925A2 (en) * 2006-04-17 2007-10-25 Teva Pharmeceutical Industries Ltd. Crystal forms of o-desmethylvenlafaxine
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045583A1 (en) * 2001-02-12 2003-03-06 American Home Products Corporation Novel succinate salt of O-desmethyl-venlafaxine
US20060058552A1 (en) * 2002-06-10 2006-03-16 Wyeth Novel formate salt of O-desmethyl-venlafaxine
WO2007120925A2 (en) * 2006-04-17 2007-10-25 Teva Pharmeceutical Industries Ltd. Crystal forms of o-desmethylvenlafaxine
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine

Also Published As

Publication number Publication date
WO2009027766A2 (en) 2009-03-05
AR064507A1 (en) 2009-04-08

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