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WO2009025116A1 - Cdh3ペプチド及びこれを含む薬剤 - Google Patents

Cdh3ペプチド及びこれを含む薬剤 Download PDF

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Publication number
WO2009025116A1
WO2009025116A1 PCT/JP2008/060381 JP2008060381W WO2009025116A1 WO 2009025116 A1 WO2009025116 A1 WO 2009025116A1 JP 2008060381 W JP2008060381 W JP 2008060381W WO 2009025116 A1 WO2009025116 A1 WO 2009025116A1
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Prior art keywords
peptide
same
medicinal agent
amino acid
acid sequence
Prior art date
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Ceased
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PCT/JP2008/060381
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English (en)
French (fr)
Inventor
Yasuharu Nishimura
Katsunori Imai
Takuya Tsunoda
Yusuke Nakamura
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Oncotherapy Science Inc
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Oncotherapy Science Inc
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Publication date
Priority to CA2696591A priority Critical patent/CA2696591C/en
Priority to JP2009528969A priority patent/JP5294271B2/ja
Priority to CN200880112092.5A priority patent/CN101827936B/zh
Priority to AU2008290060A priority patent/AU2008290060B2/en
Priority to BRPI0816236-0A priority patent/BRPI0816236A2/pt
Priority to EP08765194.9A priority patent/EP2192179B9/en
Priority to US12/673,451 priority patent/US8455444B2/en
Priority to ES08765194.9T priority patent/ES2632123T3/es
Priority to NZ583821A priority patent/NZ583821A/en
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Priority to RU2010110545/10A priority patent/RU2483078C2/ru
Priority to MX2010002018A priority patent/MX2010002018A/es
Priority to DK08765194.9T priority patent/DK2192179T3/en
Publication of WO2009025116A1 publication Critical patent/WO2009025116A1/ja
Priority to IL203986A priority patent/IL203986A/en
Anticipated expiration legal-status Critical
Priority to ZA2010/01418A priority patent/ZA201001418B/en
Ceased legal-status Critical Current

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Abstract

 本発明によって、以下の(A)または(B)のペプチドが提供される。 (A)配列番号1または2に記載のアミノ酸配列からなるペプチド。 (B)配列番号1または2に記載のアミノ酸配列において、1個または数個のアミノ酸が置換、欠失、挿入、及び/又は付加されたアミノ酸配列からなり、キラーT細胞の誘導活性を有するペプチド。
PCT/JP2008/060381 2007-08-20 2008-06-05 Cdh3ペプチド及びこれを含む薬剤 Ceased WO2009025116A1 (ja)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NZ583821A NZ583821A (en) 2007-08-20 2008-06-05 Cdh3 peptide and medicinal agent comprising the same
CN200880112092.5A CN101827936B (zh) 2007-08-20 2008-06-05 Cdh3肽以及含有cdh3肽的药剂
AU2008290060A AU2008290060B2 (en) 2007-08-20 2008-06-05 CDH3 peptide and medicinal agent comprising the same
BRPI0816236-0A BRPI0816236A2 (pt) 2007-08-20 2008-06-05 Peptídeo cdh3 e agente medicinal contendo o mesmo
EP08765194.9A EP2192179B9 (en) 2007-08-20 2008-06-05 Cdh3 peptide and medicinal agent comprising the same
US12/673,451 US8455444B2 (en) 2007-08-20 2008-06-05 CDH3 peptide and medicinal agent comprising the same
ES08765194.9T ES2632123T3 (es) 2007-08-20 2008-06-05 Péptido CDH3 y agente medicinal que comprende el mismo
CA2696591A CA2696591C (en) 2007-08-20 2008-06-05 Cdh3 peptide and medicinal agent comprising the same
RU2010110545/10A RU2483078C2 (ru) 2007-08-20 2008-06-05 Cdh3-пептид и включающее его лекарственное средство
JP2009528969A JP5294271B2 (ja) 2007-08-20 2008-06-05 Cdh3ペプチド及びこれを含む薬剤
MX2010002018A MX2010002018A (es) 2007-08-20 2008-06-05 Peptido de cdh3 y agente medicinal que comprende al mismo.
DK08765194.9T DK2192179T3 (en) 2007-08-20 2008-06-05 CDH3 PEPTIDE AND MEDICINE INCLUDING THIS
IL203986A IL203986A (en) 2007-08-20 2010-02-16 3cdh peptide and a drug containing it
ZA2010/01418A ZA201001418B (en) 2007-08-20 2010-02-26 Cdh3 pepetide and medicinal agent comprising the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007213999 2007-08-20
JP2007-213999 2007-08-20

Publications (1)

Publication Number Publication Date
WO2009025116A1 true WO2009025116A1 (ja) 2009-02-26

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PCT/JP2008/060381 Ceased WO2009025116A1 (ja) 2007-08-20 2008-06-05 Cdh3ペプチド及びこれを含む薬剤

Country Status (21)

Country Link
US (1) US8455444B2 (ja)
EP (1) EP2192179B9 (ja)
JP (2) JP5294271B2 (ja)
KR (1) KR101561175B1 (ja)
CN (2) CN101827936B (ja)
AR (1) AR067980A1 (ja)
AU (1) AU2008290060B2 (ja)
BR (1) BRPI0816236A2 (ja)
CA (1) CA2696591C (ja)
CO (1) CO6260151A2 (ja)
DK (1) DK2192179T3 (ja)
ES (1) ES2632123T3 (ja)
IL (1) IL203986A (ja)
MX (1) MX2010002018A (ja)
NZ (1) NZ583821A (ja)
RU (1) RU2483078C2 (ja)
SG (1) SG183718A1 (ja)
TW (1) TWI478941B (ja)
UA (1) UA100127C2 (ja)
WO (1) WO2009025116A1 (ja)
ZA (1) ZA201001418B (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011072231A (ja) * 2009-09-30 2011-04-14 Kumamoto Univ 内胚葉細胞、腸管細胞又は膵細胞の検出方法
US8383590B2 (en) 2007-02-21 2013-02-26 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
EP2565203A1 (en) * 2007-02-21 2013-03-06 Oncotherapy Science, Inc. Peptide vaccines having Seq ID: 344v for cancers expressing tumor-associated antigens
US8435749B2 (en) 2008-06-30 2013-05-07 Oncotherapy Science, Inc. Anti-CDH3 antibodies labeled with radioisotope label and uses thereof
AU2013201338B2 (en) * 2007-02-21 2014-11-27 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
AU2012261725B2 (en) * 2007-02-21 2014-11-27 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
US9597382B2 (en) 2013-03-12 2017-03-21 Oncotherapy Science, Inc. KNTC2 peptides and vaccines containing the same
WO2025109003A1 (en) 2023-11-21 2025-05-30 3B Pharmaceuticals Gmbh P-cadherin ligands

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI526219B (zh) 2008-06-19 2016-03-21 腫瘤療法 科學股份有限公司 Cdca1抗原決定位胜肽及含此胜肽的疫苗
US9884921B2 (en) 2014-07-01 2018-02-06 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
MX394957B (es) * 2015-09-03 2025-03-24 Ono Pharmaceutical Co Agente mejorador de la inmunidad contra el cancer por el antagonista de "allergin-1".
GB201609216D0 (en) 2016-05-25 2016-07-06 Evox Therapeutics And Isis Innovation Ltd Exosomes comprising therapeutic polypeptides

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JPH06317688A (ja) 1993-02-01 1994-11-15 General Electric Co <Ge> 複合核燃料容器およびそれの製造方法
US5545807A (en) 1988-10-12 1996-08-13 The Babraham Institute Production of antibodies from transgenic animals
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
JPH11510507A (ja) 1995-08-03 1999-09-14 リュークスウニベルジテート トゥ ライデン 細胞由来の抗原提示小胞
WO2000059281A1 (en) 1999-03-26 2000-10-05 Ericsson, Inc. Shielding apparatus for electronic devices
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
JP2006500947A (ja) * 2002-09-30 2006-01-12 オンコセラピー・サイエンス株式会社 ヒト膵癌に関連する遺伝子およびポリペプチド

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169071B1 (en) 1996-07-12 2001-01-02 Mcgill University Compounds and methods for modulating cell adhesion
US6800744B1 (en) * 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US5891432A (en) * 1997-07-29 1999-04-06 The Immune Response Corporation Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
WO2001011055A1 (en) * 1999-08-04 2001-02-15 Adelbert Bacher Isoprenoid biosynthesis
WO2002008262A2 (en) 2000-07-26 2002-01-31 Stanford University Bstp-5 proteins and related reagents and methods of use thereof
US7033832B2 (en) * 2000-10-13 2006-04-25 University Of Medicine And Dentistry Of New Jersey Endothelial cell—cell cohesion
US7214786B2 (en) * 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
AU2002309583A1 (en) 2001-04-18 2002-11-05 Protein Desing Labs, Inc. Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
JP2005522982A (ja) 2001-05-31 2005-08-04 カイロン コーポレイション 癌治療のための標的としてのp−カドヘリン
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
WO2004001072A2 (en) 2002-06-19 2003-12-31 Oncotherapy Science, Inc. Method for diagnosis of colorectal tumors
WO2004007770A2 (en) 2002-07-10 2004-01-22 Oncotherapy Science, Inc. Method for diagnosis of intestinal-type gastric tumors
WO2004035732A2 (en) 2002-08-29 2004-04-29 Five Prime Therapeutics, Inc. Human polypeptides encoded by polynucleotides and methods of their use
US20050214836A1 (en) * 2002-08-30 2005-09-29 Oncotherapy Science, Inc. Method of diagnosing ovarian endometriosis
US20050259483A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers
US20050260639A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
TW200413539A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Genes and polypeptides relating to prostate cancers
US20060024692A1 (en) 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
JP2006500946A (ja) 2002-09-30 2006-01-12 オンコセラピー・サイエンス株式会社 精巣精上皮腫の診断方法
WO2004110345A2 (en) 2002-10-29 2004-12-23 Pharmacia Corporation Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
CA2519456A1 (en) * 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
US20070037204A1 (en) 2003-08-08 2007-02-15 Hiroyuki ABURANTAI Gene overexpressed in cancer
WO2005090572A2 (en) 2004-03-24 2005-09-29 Oncotherapy Science, Inc. Compositions and methods for treating pancreatic cancer
WO2006055371A2 (en) * 2004-11-16 2006-05-26 Alexion Pharmaceuticals, Inc. Functional screening of antibody libraries
EP2295601A1 (en) 2005-02-10 2011-03-16 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
US8088976B2 (en) * 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
US7847060B2 (en) 2005-02-25 2010-12-07 Oncotherapy Science, Inc. Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides
NZ562234A (en) 2005-04-26 2009-09-25 Pfizer P-cadherin antibodies
NZ591569A (en) * 2005-07-20 2012-10-26 Agriculture Victoria Serv Pty Modification of flavonoid biosynthesis in plants with transparent testa 2
WO2007013575A2 (en) 2005-07-28 2007-02-01 Oncotherapy Science, Inc. Method for diagnosing and treating renal cell carcinoma
PL1760088T3 (pl) * 2005-09-05 2008-10-31 Immatics Biotechnologies Gmbh Związane z nowotworem peptydy wiążące się w sposób niedyskryminujący z cząsteczkami antygenu ludzkiego leukocytu klasy II (HLA)
JP2007224009A (ja) 2006-01-26 2007-09-06 Takeda Chem Ind Ltd 癌の予防・治療剤
CN101432303A (zh) 2006-02-28 2009-05-13 肿瘤疗法科学股份有限公司 利用抗cdh3抗体的效应物功能来损伤细胞的方法
ES2545457T3 (es) * 2006-10-17 2015-09-11 Oncotherapy Science, Inc. Vacunas de péptidos para cánceres que expresan los polipéptidos DEPDC1
TWI494319B (zh) * 2007-02-21 2015-08-01 Oncotherapy Science Inc 表現腫瘤相關抗原之癌症的胜肽疫苗
TW201008574A (en) * 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5545807A (en) 1988-10-12 1996-08-13 The Babraham Institute Production of antibodies from transgenic animals
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5569825A (en) 1990-08-29 1996-10-29 Genpharm International Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
JPH06317688A (ja) 1993-02-01 1994-11-15 General Electric Co <Ge> 複合核燃料容器およびそれの製造方法
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
JPH11510507A (ja) 1995-08-03 1999-09-14 リュークスウニベルジテート トゥ ライデン 細胞由来の抗原提示小胞
WO2000059281A1 (en) 1999-03-26 2000-10-05 Ericsson, Inc. Shielding apparatus for electronic devices
JP2006500947A (ja) * 2002-09-30 2006-01-12 オンコセラピー・サイエンス株式会社 ヒト膵癌に関連する遺伝子およびポリペプチド

Non-Patent Citations (68)

* Cited by examiner, † Cited by third party
Title
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
"Molecular Cloning: A laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual"
BAUER, R. ET AL., EXP. MOL. PATHOL., vol. 81, 2006, pages 224 - 230
BENMOHAMED L ET AL., HUM. IMMUNOL., vol. 61, no. 8, 2000, pages 764 - 79
BERX G ET AL., GENOMICS, vol. 26, 1995, pages 281 - 289
BETTER; HORWITZ, METHODS ENZYMOL, vol. 178, 1989, pages 476 - 96
BIRD; WALKER, TRENDS BIOTECH, vol. 9, 1991, pages 132 - 7
BOCZKOWSKI D ET AL., J EXP. MED., vol. 184, 1996, pages 465 - 72
BROWNING M. ET AL., IMMUNOL TODAY, vol. 17, 1996, pages 165 - 170
BUTTERFIELD LH ET AL., J. IMMUNOL., vol. 161, 1998, pages 5607 - 13
CO ET AL., J IMMUNOL, vol. 152, 1994, pages 2968 - 76
DALBADIE-MCFARLAND G ET AL., PROC NATL ACAD SCI USA, vol. 79, 1982, pages 6409 - 13
DERES K. ET AL., NATURE, vol. 342, 1989, pages 561 - 4
FRIXEN U H ET AL., J CELL BIOL, vol. 113, 1991, pages 173 - 185
G KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
GLENN, L. ET AL., J CELL BIOL, vol. 139, 1997, pages 1025 - 1032
GOMI S ET AL., J IMMUNOL, vol. 163, 1999, pages 4994 - 5004
HIPP JD ET AL., IN VIVO, vol. 14, 2000, pages 571 - 85
HOOGENBOOM; WINTER, J MOL BIOL, vol. 227, 1992, pages 381 - 8
HUSTON ET AL., PROC NATL ACAD SCI USA, vol. 85, 1998, pages 5879 - 83
INGUNN, M. ET AL., J CLIN ONCOL, vol. 22, 2004, pages 1242 - 1252
J. IMMUNOL., vol. 148, 1992, pages 1438
JOHNSON AG., CLIN. MICROBIOL. REV., vol. 7, 1994, pages 277 - 89
KATSUNORI IMAI ET AL.: "Suigan no men'ki ryoho ni yuyo na shinki gankogen CDH3", DAI 108 KAI ANNUAL CONGRESS OF JAPAN SURGICAL SOCIETY SHOROKUSHU, vol. 109, no. 2 SPECIAL EXTRA ISSUE, 25 April 2008 (2008-04-25), pages 529 *
KATSUNORI IMAI ET AL.: "Suizogan no men'eki ryoho ni yuyo na shinki gankogen CDH3 no dotei", DAI 66 KAI ANNUAL MEETING OF THE JAPAN CANCER ASSOCIATION, vol. 66, 25 August 2007 (2007-08-25), pages 164 *
KITAHARA 0, CANCER RES, vol. 61, 2001, pages 3544 - 3549
KOMORI H ET AL., CLIN CANCER RES, vol. 12, 2006, pages 2689 - 2697
KOMORI H ET AL., CLINICAL CANCER RESEARCH, vol. 12, 2006, pages 2689 - 2697
KOMORI H. ET AL.: "Identification of HLA-A2- or HLA-A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy of hepatocellular carcinoma", CLIN.CANCER RES., vol. 12, no. 9, 2006, pages 2689 - 2697, XP002582946 *
KONDO A ET AL., J.IMMUNOL., vol. 155, 1995, pages 4307 - 12
KUBO RT ET AL., J. IMMUNOL., vol. 152, 1994, pages 3913 - 24
LAMOYI, METHODS ENZYMOL, vol. 121, 1986, pages 652 - 63
MARCK, V. V. ET AL., CANCER RES., vol. 65, 2005, pages 8774 - 8783
MARK DF ET AL., PROC NATLACAD SCI USA, vol. 81, 1984, pages 5662 - 6
MIYOSHI H ET AL., J VIROL, vol. 72, 1998, pages 8150 - 8157
MUZON-GUERRA, M.F. ET AL., CANCER, vol. 103, 2005, pages 960 - 969
NAKAMURA T ET AL., ONCOGENE, vol. 23, 2004, pages 2385 - 2400
NAKAMURA, T. ET AL., ONCOGENE, vol. 23, no. 23, 2004, pages 85 - 2400
NATURE, vol. 344, 1990, pages 873
OBAMA K ET AL., HEPATOLOGY, vol. 41, 2005, pages 1339 - 1348
OBAMA, K. ET AL., HEPATOLOGY, vol. 41, 2005, pages 1339 - 1348
OKAH ET AL., CANCER RES, vol. 53, 1993, pages 1696 - 1701
PALACIOS J ET AL., AM J PATHOL, vol. 146, 1995, pages 605 - 612
PAREDES J ET AL., CLIN CANCER RES 2005, vol. 11, pages 5869 - 5877
PAREDES, J. ET AL., CLIN CANCER RES, vol. 11, 2005, pages 5869 - 5877
PERALTA SOLER A ET AL., CANCER, vol. 86, 1999, pages 1263 - 1272
PLUCKTHUN; SKERRA, METHODS EMZYMOL, vol. 178, 1989, pages 497 - 515
RAMMENSEE HG ET AL., IMMUNOGENETICS, vol. 41, 1995, pages 178 - 228
REEVES ME ET AL., CANCER RES., vol. 56, 1996, pages 5672 - 7
ROSENBERG S A ET AL., NAT MED, vol. 10, 2004, pages 909 - 915
ROUSSEAUX ET AL., METHODS ENZYMOL, vol. 121, 1986, pages 663 - 9
See also references of EP2192179A4
SHATA MT ET AL., MOL. MED. TODAY, vol. 6, 2000, pages 66 - 71
SHEDLOCK DJ; WEINER DB ET AL., J. LEUKOC. BIOL., vol. 68, 2000, pages 793 - 806
SOLER, A. P. ET AL., CANCER, vol. 86, 1999, pages 1263 - 1272
STEFANSSON I M ET AL., J CLIN ONCOL, vol. 22, 2004, pages 1242 - 1252
STOVER CK ET AL., NATURE, vol. 31, 1991, pages 456 - 60
SUYAMA K ET AL., CANCER CELL, vol. 2, 2002, pages 301 - 314
TAHARA-HANAOKA S ET AL., EXP HEMATOL, vol. 30, 2002, pages 11 - 17
TANIUCHI K ET AL., CANCER RES, vol. 65, 2005, pages 3092 - 3099
TANIUCHI K, CANCER RES, vol. 65, 2005, pages 3092 - 3099
TANIUCHI K. ET AL.: "Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases", CANCER RES., vol. 65, no. 8, 2005, pages 3092 - 3099, XP002441363 *
TANIUCHI, K. ET AL., CANCER RES, vol. 65, 2005, pages 3092 - 3099
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 6
YOSHITAKE Y ET AL., CLIN CANCER RES, vol. 10, 2004, pages 6437 - 6448
ZOLLER MJ; SMITH M, NUCLEIC ACIDS RES, vol. 10, 1982, pages 6487 - 500

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US8435749B2 (en) 2008-06-30 2013-05-07 Oncotherapy Science, Inc. Anti-CDH3 antibodies labeled with radioisotope label and uses thereof
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US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
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