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WO2009022279A3 - Quinoline as contrast agent in laser induced fluorescence (lif) for lesions - Google Patents

Quinoline as contrast agent in laser induced fluorescence (lif) for lesions Download PDF

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Publication number
WO2009022279A3
WO2009022279A3 PCT/IB2008/053204 IB2008053204W WO2009022279A3 WO 2009022279 A3 WO2009022279 A3 WO 2009022279A3 IB 2008053204 W IB2008053204 W IB 2008053204W WO 2009022279 A3 WO2009022279 A3 WO 2009022279A3
Authority
WO
WIPO (PCT)
Prior art keywords
lesions
contrast agent
quinoline
lif
laser induced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/053204
Other languages
French (fr)
Other versions
WO2009022279A2 (en
Inventor
Chetan Mittal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of WO2009022279A2 publication Critical patent/WO2009022279A2/en
Publication of WO2009022279A3 publication Critical patent/WO2009022279A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The subject of this invention is to provide a compound and a contrast agent comprising a compound for a rapid, non-invasive examination process in the diagnosis of increased vascularity of lesions, especially cancerous lesions. The contrast agents comprising a compound and compounds used for diagnosis of lesions are compounds having a quinoline ring whereas the compounds may emit fluorescence in a range from 300 to 1200 nm. A method of diagnosing lesions is also subject of the present invention.
PCT/IB2008/053204 2007-08-15 2008-08-11 Quinoline as contrast agent in laser induced fluorescence (lif) for lesions Ceased WO2009022279A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114391 2007-08-15
EP07114391.1 2007-08-15

Publications (2)

Publication Number Publication Date
WO2009022279A2 WO2009022279A2 (en) 2009-02-19
WO2009022279A3 true WO2009022279A3 (en) 2009-04-09

Family

ID=40134061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053204 Ceased WO2009022279A2 (en) 2007-08-15 2008-08-11 Quinoline as contrast agent in laser induced fluorescence (lif) for lesions

Country Status (1)

Country Link
WO (1) WO2009022279A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277841B1 (en) * 2000-03-02 2001-08-21 Mallinckrodt Inc. Quinoline ligands and metal complexes for diagnosis and therapy
US6284223B1 (en) * 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
WO2005030254A2 (en) * 2003-09-23 2005-04-07 Light Sciences Corporation Conjugates for photodynamic therapy
WO2006020779A2 (en) * 2004-08-10 2006-02-23 Dow Global Technologies Inc. Targeting chelants and chelates
WO2007067978A1 (en) * 2005-12-09 2007-06-14 Invitrogen Corporation Optical in vivo imaging contrast agents and methods of use
WO2007127958A2 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284223B1 (en) * 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6277841B1 (en) * 2000-03-02 2001-08-21 Mallinckrodt Inc. Quinoline ligands and metal complexes for diagnosis and therapy
WO2005030254A2 (en) * 2003-09-23 2005-04-07 Light Sciences Corporation Conjugates for photodynamic therapy
WO2006020779A2 (en) * 2004-08-10 2006-02-23 Dow Global Technologies Inc. Targeting chelants and chelates
WO2007067978A1 (en) * 2005-12-09 2007-06-14 Invitrogen Corporation Optical in vivo imaging contrast agents and methods of use
WO2007127958A2 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARRIS THOMAS D ET AL: "Structure-activity relationships of In-111- and Tc-99m-labeled quinolin-4-one peptidomimetics as ligands for the vitronectin receptor: Potential tumor imaging agents", BIOCONJUGATE CHEMISTRY, vol. 17, no. 5, September 2006 (2006-09-01), pages 1294 - 1313, XP002510878, ISSN: 1043-1802 *
LAMBRECHT R M ET AL: "DETECTION OF OCULAR MELANOMA WITH IODINE-123 LABELED 4-3 DI METHYLAMINOPROPYLAMINO-7-IODO QUINOLINE", JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 7, 1984, pages 800 - 804, XP002510877, ISSN: 0161-5505 *

Also Published As

Publication number Publication date
WO2009022279A2 (en) 2009-02-19

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