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WO2009020119A1 - ＨＩＦ－１αおよびＨＩＦ－２α発現阻害物質含有医薬 - Google Patents

ＨＩＦ－１αおよびＨＩＦ－２α発現阻害物質含有医薬 Download PDF

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Publication number
WO2009020119A1
WO2009020119A1 PCT/JP2008/064038 JP2008064038W WO2009020119A1 WO 2009020119 A1 WO2009020119 A1 WO 2009020119A1 JP 2008064038 W JP2008064038 W JP 2008064038W WO 2009020119 A1 WO2009020119 A1 WO 2009020119A1
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Prior art keywords
hif
alpha
expression
expression inhibitor
pharmaceutical containing
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Ceased
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PCT/JP2008/064038
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English (en)
French (fr)
Inventor
Takeshi Nakajima
Emi Nakajima
Mitsuyoshi Azuma
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Senju Pharmaceutical Co Ltd
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Senju Pharmaceutical Co Ltd
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Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Priority to EP08827097.0A priority Critical patent/EP2186528B1/en
Priority to ES08827097.0T priority patent/ES2462416T3/es
Priority to US12/672,473 priority patent/US8268794B2/en
Priority to CN2008801099708A priority patent/CN101868251B/zh
Priority to JP2009526461A priority patent/JP5241718B2/ja
Publication of WO2009020119A1 publication Critical patent/WO2009020119A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　加齢性黄斑変性症や糖尿病性網膜症などの血管新生を伴う網膜疾患の治療において、より治療効果の高い医薬品を提供する。ＨＩＦ－１αの発現を特異的に阻害する物質およびＨＩＦ－２αの発現を特異的に阻害する物質を含有する、網膜疾患の治療剤。本発明の治療剤中の有効成分である前記阻害物質は、ＨＩＦ－１αおよびＨＩＦ－２αに対するＲＮＡｉ誘導性核酸、アンチセンス核酸もしくはリボザイムまたはそれらの発現ベクターである。
PCT/JP2008/064038 2007-08-06 2008-08-05 ＨＩＦ－１αおよびＨＩＦ－２α発現阻害物質含有医薬 Ceased WO2009020119A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08827097.0A EP2186528B1 (en) 2007-08-06 2008-08-05 Pharmaceutical containing hif-1 alpha and hif-2 alpha expression inhibitor
ES08827097.0T ES2462416T3 (es) 2007-08-06 2008-08-05 Producto farmacéutico que contiene un inhibidor de la expresión de HIF-1 alfa y HIF-2 alfa
US12/672,473 US8268794B2 (en) 2007-08-06 2008-08-05 Pharmaceutical containing HIF-1 alpha and HIF-2 alpha expression inhibitor
CN2008801099708A CN101868251B (zh) 2007-08-06 2008-08-05 含有HIF-1α和HIF-2α表达抑制物质的药物
JP2009526461A JP5241718B2 (ja) 2007-08-06 2008-08-05 ＨＩＦ−１αおよびＨＩＦ−２α発現阻害物質含有医薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007204585 2007-08-06
JP2007-204585 2007-08-06

Publications (1)

Publication Number Publication Date
WO2009020119A1 true WO2009020119A1 (ja) 2009-02-12

Family

ID=40341351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064038 Ceased WO2009020119A1 (ja) 2007-08-06 2008-08-05 ＨＩＦ－１αおよびＨＩＦ－２α発現阻害物質含有医薬

Country Status (6)

Country Link
US (1) US8268794B2 (ja)
EP (1) EP2186528B1 (ja)
JP (1) JP5241718B2 (ja)
CN (1) CN101868251B (ja)
ES (1) ES2462416T3 (ja)
WO (1) WO2009020119A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522410A (ja) * 2011-06-06 2014-09-04 アケビア セラピューティクス インコーポレイテッド がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
EP2961843A2 (en) * 2013-02-28 2016-01-06 Arrowhead Research Corporation Organic compositions to treat epas1-related diseases
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US10246416B2 (en) 2011-06-06 2019-04-02 Akebia Therapeutics, Inc. Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides
KR20190054909A (ko) * 2017-11-13 2019-05-22 서울대학교산학협력단 HIF-2α 활성 억제제를 포함하는 연골육종 치료, 전이 또는 재발 억제용 조성물
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
US11679099B2 (en) 2020-05-13 2023-06-20 Seoul National University R&Db Foundation Use of HIF-2α inhibitors for treating chondrosarcoma, or preventing recurrence and metastasis thereof
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11857543B2 (en) 2013-06-13 2024-01-02 Akebia Therapeutics, Inc. Compositions and methods for treating anemia

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US8796443B2 (en) 2008-09-22 2014-08-05 Rxi Pharmaceuticals Corporation Reduced size self-delivering RNAi compounds
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
WO2011119852A1 (en) 2010-03-24 2011-09-29 Rxi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
CN103200945B (zh) 2010-03-24 2016-07-06 雷克西制药公司 眼部症候中的rna干扰
AU2013100070B4 (en) * 2012-07-03 2013-04-04 Novartis Ag Use of device
CN103993016B (zh) * 2014-04-25 2015-12-30 浙江大学 Hif2a基因突变体及其检测与应用
WO2015168108A2 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic targeting mdm2 or mycn
CN104383557A (zh) * 2014-10-16 2015-03-04 江西农业大学 一种治疗肉鸡腹水征合症的rna干扰药物的制备方法和用途及其药效验证方法
JP7021076B2 (ja) * 2015-05-29 2022-02-16 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法
WO2017053192A1 (en) 2015-09-21 2017-03-30 The Board Of Regents Of The University Of Texas System Biomarkers of response to hif-2-alpha inhibition in cancer and methods for the use thereof
KR20210113273A (ko) 2019-01-09 2021-09-15 애로우헤드 파마슈티컬스 인코포레이티드 HIF-2 알파 (EPAS1)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법
EP4398882A1 (en) * 2021-09-10 2024-07-17 BioNTech SE Lipid-based rna formulations suitable for therapy

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WO2006050734A2 (en) * 2004-11-09 2006-05-18 Santaris Pharma A/S Potent lna oligonucleotides for the inhibition of hif-1a expression
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See also references of EP2186528A4

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10738010B2 (en) 2011-06-06 2020-08-11 Akebia Therapeutics, Inc. Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides
US10246416B2 (en) 2011-06-06 2019-04-02 Akebia Therapeutics, Inc. Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides
JP2014522410A (ja) * 2011-06-06 2014-09-04 アケビア セラピューティクス インコーポレイテッド がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
US11267785B2 (en) 2011-06-06 2022-03-08 Akebia Therapeutics, Inc. Process for preparing [(3-hydroxypyridine-2-carbonyl)amino]alkanoic acids, esters and amides
EP2961843A2 (en) * 2013-02-28 2016-01-06 Arrowhead Research Corporation Organic compositions to treat epas1-related diseases
US11857543B2 (en) 2013-06-13 2024-01-02 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11844756B2 (en) 2015-04-01 2023-12-19 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
KR20190054909A (ko) * 2017-11-13 2019-05-22 서울대학교산학협력단 HIF-2α 활성 억제제를 포함하는 연골육종 치료, 전이 또는 재발 억제용 조성물
KR102122128B1 (ko) * 2017-11-13 2020-06-11 서울대학교산학협력단 HIF-2α 활성 억제제를 포함하는 연골육종 치료, 전이 또는 재발 억제용 조성물
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US12269802B2 (en) 2018-05-09 2025-04-08 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino] acetic acid
US11679099B2 (en) 2020-05-13 2023-06-20 Seoul National University R&Db Foundation Use of HIF-2α inhibitors for treating chondrosarcoma, or preventing recurrence and metastasis thereof

Also Published As

Publication number Publication date
ES2462416T3 (es) 2014-05-22
EP2186528A4 (en) 2012-10-03
CN101868251B (zh) 2012-10-10
JP5241718B2 (ja) 2013-07-17
JPWO2009020119A1 (ja) 2010-11-04
US8268794B2 (en) 2012-09-18
US20110213008A1 (en) 2011-09-01
CN101868251A (zh) 2010-10-20
EP2186528B1 (en) 2014-03-19
EP2186528A1 (en) 2010-05-19

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