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WO2009014372A3 - Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof - Google Patents

Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof Download PDF

Info

Publication number
WO2009014372A3
WO2009014372A3 PCT/KR2008/004298 KR2008004298W WO2009014372A3 WO 2009014372 A3 WO2009014372 A3 WO 2009014372A3 KR 2008004298 W KR2008004298 W KR 2008004298W WO 2009014372 A3 WO2009014372 A3 WO 2009014372A3
Authority
WO
WIPO (PCT)
Prior art keywords
dispersible tablet
drug
containing particles
preparation
coated drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2008/004298
Other languages
French (fr)
Other versions
WO2009014372A2 (en
Inventor
Kwang Hyun Shin
Sung Ah Bin
Kyoung Kook Kim
Joon Ho Bae
Jung Ju Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amorepacific Corp
Original Assignee
Amorepacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Priority to CN2008800253313A priority Critical patent/CN101754754B/en
Publication of WO2009014372A2 publication Critical patent/WO2009014372A2/en
Publication of WO2009014372A3 publication Critical patent/WO2009014372A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a dispersible tablet comprising a plurality of a coated drug-containing particles and a method for preparing said dispersible tablet. The inventive dispersible tablet comprising (a) a plurality of a drug-containing particle having a coating layer on the surface thereof; (b) a binding agent for protecting the coating layer; and (c) a pharmaceutically acceptable excipient, is capable of: maintaining a suitable hardness to prevent from the breakage thereof during the packing, circulating or storing period; enhancing the patient compliance through masking the drug bitterness; and disintegrating and dispersing rapidly enough to be easily administered to young children or old people having difficulty in swallowing a conventional oral formulation.
PCT/KR2008/004298 2007-07-23 2008-07-23 Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof Ceased WO2009014372A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2008800253313A CN101754754B (en) 2007-07-23 2008-07-23 Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2007-0073396 2007-07-23
KR1020070073396A KR101436516B1 (en) 2007-07-23 2007-07-23 Suspensions containing coated pellets and methods for their preparation

Publications (2)

Publication Number Publication Date
WO2009014372A2 WO2009014372A2 (en) 2009-01-29
WO2009014372A3 true WO2009014372A3 (en) 2009-03-19

Family

ID=40281977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/004298 Ceased WO2009014372A2 (en) 2007-07-23 2008-07-23 Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof

Country Status (3)

Country Link
KR (1) KR101436516B1 (en)
CN (1) CN101754754B (en)
WO (1) WO2009014372A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102475689B (en) * 2010-11-30 2015-04-01 杭州赛利药物研究所有限公司 Suspension dispersible tablets and preparation method
CN103040776A (en) * 2012-12-14 2013-04-17 四川美大康药业股份有限公司 Preparation method of azithromycin dispersible tablet granule coating
ITUA20163981A1 (en) * 2016-05-31 2017-12-01 Zambon Spa PHARMACEUTICAL COMPOSITIONS INCLUDING SAFINAMID
CN112076168A (en) * 2020-09-24 2020-12-15 丽珠集团丽珠制药厂 A kind of roxithromycin dispersible tablet and preparation method thereof
CN115501196B (en) * 2022-10-31 2023-04-11 江苏神龙药业有限公司 Preparation method of roxithromycin dispersible tablet

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090827A (en) * 1997-05-28 2000-07-18 Astrazeneca Ab Pharmaceutical formulation of omeprazole
WO2004087112A1 (en) * 2003-03-31 2004-10-14 Korea United Pharm, Inc. Manufacturing method and formulation for bitter taste masked oral dosage form of clarithromycin
US20040241235A1 (en) * 2001-03-09 2004-12-02 Christophe Lebon Granules and granules coated with a masked taste

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3731699A (en) * 1998-05-18 1999-12-06 Takeda Chemical Industries Ltd. Orally disintegrable tablets
CN1543971A (en) * 2003-07-02 2004-11-10 北京博尔达生物技术开发有限公司 Oral disintegrating tablet and its preparation of compound red sage root
CN1274298C (en) * 2003-11-06 2006-09-13 常州市第四制药厂有限公司 Disintegrants for deodoring effectively and their preparation
CN100376258C (en) * 2005-05-27 2008-03-26 北京科信必成医药科技发展有限公司 Orally disintegrating tablet of 'Tianli Bolus' for treating heart disease and its preparation process
CN100448431C (en) * 2005-10-17 2009-01-07 重庆医药工业研究院有限责任公司 Oral disintegrated Anfenmame tablet for treating children's cold and its prepn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090827A (en) * 1997-05-28 2000-07-18 Astrazeneca Ab Pharmaceutical formulation of omeprazole
US20040241235A1 (en) * 2001-03-09 2004-12-02 Christophe Lebon Granules and granules coated with a masked taste
WO2004087112A1 (en) * 2003-03-31 2004-10-14 Korea United Pharm, Inc. Manufacturing method and formulation for bitter taste masked oral dosage form of clarithromycin

Also Published As

Publication number Publication date
WO2009014372A2 (en) 2009-01-29
CN101754754A (en) 2010-06-23
KR20090010352A (en) 2009-01-30
CN101754754B (en) 2013-06-19
KR101436516B1 (en) 2014-09-02

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