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WO2009014342A3 - Markers and kit for diagnosis of alzheimer's disease - Google Patents

Markers and kit for diagnosis of alzheimer's disease Download PDF

Info

Publication number
WO2009014342A3
WO2009014342A3 PCT/KR2008/004181 KR2008004181W WO2009014342A3 WO 2009014342 A3 WO2009014342 A3 WO 2009014342A3 KR 2008004181 W KR2008004181 W KR 2008004181W WO 2009014342 A3 WO2009014342 A3 WO 2009014342A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
alzheimer
diagnosis
kit
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2008/004181
Other languages
French (fr)
Other versions
WO2009014342A2 (en
Inventor
Sang Won Kang
Chul Hee Choi
Jong Bum Kwon
Yong Jeong
Jong Seo Lee
Joong Sik Jang
Jeong Woo Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Young In Frontier Co Ltd
Original Assignee
Young In Frontier Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Young In Frontier Co Ltd filed Critical Young In Frontier Co Ltd
Publication of WO2009014342A2 publication Critical patent/WO2009014342A2/en
Publication of WO2009014342A3 publication Critical patent/WO2009014342A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Disclosed are a protein marker for a diagnosis of Alzheimer's disease, a composition for detecting a diagnostic marker for Alzheimer's disease, comprising an agent for measuring the level of the protein marker, a kit for detecting a diagnostic marker for Alzheimer' s disease, comprising an antibody specific to the protein marker, and a method of diagnosing Alzheimer's disease. Since the diagnostic protein marker exists in blood, there is no pain or side effect in collecting a sample, and sample collection is easy and useful.
PCT/KR2008/004181 2007-07-20 2008-07-17 Markers and kit for diagnosis of alzheimer's disease Ceased WO2009014342A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070072989A KR20090009579A (en) 2007-07-20 2007-07-20 Marker for diagnosis of Alzheimer's disease and diagnostic kit using the same
KR10-2007-0072989 2007-07-20

Publications (2)

Publication Number Publication Date
WO2009014342A2 WO2009014342A2 (en) 2009-01-29
WO2009014342A3 true WO2009014342A3 (en) 2009-03-19

Family

ID=40281960

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/004181 Ceased WO2009014342A2 (en) 2007-07-20 2008-07-17 Markers and kit for diagnosis of alzheimer's disease

Country Status (2)

Country Link
KR (1) KR20090009579A (en)
WO (1) WO2009014342A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101250464B1 (en) * 2010-05-06 2013-04-15 대한민국 A method for the diagnosis of Alzheimer＇s disease from determination of PGCP concentration in human plasma
CA3052636A1 (en) * 2017-02-07 2018-08-16 Bioregency, Inc. S100.beta. and isoforms for detection of neurological conditions
IL298100A (en) * 2020-05-14 2023-01-01 Univ Hong Kong Science & Tech Protein markers for the assessment of Alzheimer's disease
CN113567682A (en) * 2021-07-23 2021-10-29 成都益安博生物技术有限公司 Peripheral blood TCR marker of Alzheimer disease and detection kit and application thereof
CN115078705A (en) * 2022-06-14 2022-09-20 徐州海纳生物科技有限公司 Alzheimer disease biomarker chemiluminescence assay kit
WO2024213092A1 (en) * 2023-04-13 2024-10-17 The Hong Kong University Of Science And Technology Protein markers for mild cognitive impairment and alzheimer's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958684A (en) * 1995-10-02 1999-09-28 Van Leeuwen; Frederik Willem Diagnosis of neurodegenerative disease
KR20040015168A (en) * 2001-04-25 2004-02-18 신 엑스 파마, 인코퍼레이티드 Process for differential diagnosis of alzheimer's dementia and device therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958684A (en) * 1995-10-02 1999-09-28 Van Leeuwen; Frederik Willem Diagnosis of neurodegenerative disease
KR20040015168A (en) * 2001-04-25 2004-02-18 신 엑스 파마, 인코퍼레이티드 Process for differential diagnosis of alzheimer's dementia and device therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A.HYE,ET AL.: "Proteom-based plasma biomarkers for Alzheimer`s disease", BRAIN, vol. 129, 2006, pages 3042 - 3050 *
B.B. MILLER,AND J.W. MANDELL: "Multiplex method for measuring biomarkers of Alzheimer disease in cerebrospinal fluid", CLIN.CHEM., vol. 51, no. 2, 2005, pages 289 - 230 *
K.BLENNOW,ET AL.: "Ubiquitin in cerebrospinal fluid in Alzheimer`s disease and vascular dementia", INT.PSYCHOGERIATR., vol. 6, no. 1, 1994, pages 13 - 22, DISCUSSION 59-60 *
R.E.MRAK AND W.S. GRIFFINBC.: "The role of activated astrocytes and the neurotrophic cytokine S100 beta in the pathogenesis of Alzheimer`s disease", NEUROBIOL.AGING., vol. 22, no. 6, November 2001 (2001-11-01) - December 2001 (2001-12-01), pages 915 - 922 *
R.SULTANA,ET AL.: "Proteomic analysis of the Alzheimer`s disease hippocampal proteome", J.ALZHEIMER`S DIS., vol. 11, no. 2, May 2007 (2007-05-01), pages 153 - 164 *
V.K.SINGH.: "Studies of neuroimmune markers in Alzheimer`s disease", MOL.NEUROBIOL., vol. 9, no. 1-3, August 1994 (1994-08-01) - December 1994 (1994-12-01), pages 73 - 81 *

Also Published As

Publication number Publication date
KR20090009579A (en) 2009-01-23
WO2009014342A2 (en) 2009-01-29

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