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WO2009008496A1 - 抗HSulf1抗体 - Google Patents

抗HSulf1抗体 Download PDF

Info

Publication number
WO2009008496A1
WO2009008496A1 PCT/JP2008/062547 JP2008062547W WO2009008496A1 WO 2009008496 A1 WO2009008496 A1 WO 2009008496A1 JP 2008062547 W JP2008062547 W JP 2008062547W WO 2009008496 A1 WO2009008496 A1 WO 2009008496A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
cell
hsulf1
atrl
ferm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/062547
Other languages
English (en)
French (fr)
Inventor
Yasuyuki Kaneta
Mitsuru Ono
Toshinori Agatsuma
Keisuke Fukuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of WO2009008496A1 publication Critical patent/WO2009008496A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

【課題】　細胞の癌化及び/又は腫瘍細胞増殖抑制活性を有する抗体等を提供すること。 【解決手段】HSulf1と特異的に結合し、該蛋白質を発現している細胞に対して細胞増殖抑制活性を有する抗体及び、マウスハイブリドーマDS-ATRL-87A3（FERM BP-10835）が産生する抗体によって結合されるエピトープに結合する抗体、マウスハイブリドーマDS-ATRL-87A3（FERM BP-10835）から産生される抗体の相補性決定領域を含む抗体等及びこれらの抗体を含有する医薬。
PCT/JP2008/062547 2007-07-12 2008-07-11 抗HSulf1抗体 Ceased WO2009008496A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-182882 2007-07-12
JP2007182882 2007-07-12

Publications (1)

Publication Number Publication Date
WO2009008496A1 true WO2009008496A1 (ja) 2009-01-15

Family

ID=40228666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/062547 Ceased WO2009008496A1 (ja) 2007-07-12 2008-07-11 抗HSulf1抗体

Country Status (2)

Country Link
TW (1) TW200914044A (ja)
WO (1) WO2009008496A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2570813A4 (en) * 2010-05-13 2013-12-11 Consejo Superior Investigacion METHOD OF DIAGNOSIS / PROGNOSIS OF COLORECTAL CANCER
JPWO2018207931A1 (ja) * 2017-05-12 2020-03-19 三井化学株式会社 組換え微生物、組換え微生物を用いたピリドキサミン又はその塩の製造方法、及び組換え微生物を用いたピリドキサール又はその塩の製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250250360A1 (en) * 2024-02-05 2025-08-07 Ccbiotech Inc. Anti-sulfatase-related antigen specific antibody, detection kit comprising anti-sulfatase-related antigen specific antibody, and method for detecting osteoarthritis and prognostic monitoring of osteoarthritis progression by using anti-sulfatase-related antigen specific antibody

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079390A2 (en) * 2004-02-13 2005-09-01 Boston Biomedical Research Institute Inhibition of fgf signaling
US20060063230A1 (en) * 2000-12-27 2006-03-23 Roman Naworth Sulfatases and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063230A1 (en) * 2000-12-27 2006-03-23 Roman Naworth Sulfatases and methods of use thereof
WO2005079390A2 (en) * 2004-02-13 2005-09-01 Boston Biomedical Research Institute Inhibition of fgf signaling

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AI X. ET AL.: "QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling", THE JOURNAL OF CELL BIOLOGY, vol. 162, no. 2, 2003, pages 341 - 351 *
MORIMOTO-TOMITA M. ET AL.: "Novel extracellular sulfatases: potential roles in cancer", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 15, no. 83, May 2003 (2003-05-01), pages 159 - 164 *
NARITA K. ET AL.: "HSulf-1 inhibits angiogenesis and tumorigenesis in vivo", CANCER RESEARCH, vol. 66, no. 12, 2006, pages 6025 - 6032 *
NARITA K. ET AL.: "Loss of HSulf1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 19, May 2007 (2007-05-01), pages 14413 - 14420 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2570813A4 (en) * 2010-05-13 2013-12-11 Consejo Superior Investigacion METHOD OF DIAGNOSIS / PROGNOSIS OF COLORECTAL CANCER
JPWO2018207931A1 (ja) * 2017-05-12 2020-03-19 三井化学株式会社 組換え微生物、組換え微生物を用いたピリドキサミン又はその塩の製造方法、及び組換え微生物を用いたピリドキサール又はその塩の製造方法

Also Published As

Publication number Publication date
TW200914044A (en) 2009-04-01

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