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WO2009008371A1 - ジ（アリールアミノ）アリール化合物 - Google Patents

ジ（アリールアミノ）アリール化合物 Download PDF

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Publication number
WO2009008371A1
WO2009008371A1 PCT/JP2008/062188 JP2008062188W WO2009008371A1 WO 2009008371 A1 WO2009008371 A1 WO 2009008371A1 JP 2008062188 W JP2008062188 W JP 2008062188W WO 2009008371 A1 WO2009008371 A1 WO 2009008371A1
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WO
WIPO (PCT)
Prior art keywords
eml4
alk fusion
egfr variant
cancer
polynucleotide positive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/062188
Other languages
English (en)
French (fr)
Inventor
Yutaka Kondoh
Kazuhiko Iikubo
Sadao Kuromitsu
Nobuaki Shindo
Takatoshi Soga
Takashi Furutani
Itsuro Shimada
Takahiro Matsuya
Kazuo Kurosawa
Akio Kamikawa
Hiroyuki Mano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN2008800236055A priority Critical patent/CN101687822B/zh
Priority to MX2009013625A priority patent/MX2009013625A/es
Priority to EP08777903A priority patent/EP2172461A4/en
Priority to US12/448,759 priority patent/US8318702B2/en
Priority to KR1020097026439A priority patent/KR101323566B1/ko
Priority to BRPI0814809-0A2A priority patent/BRPI0814809A2/pt
Priority to CA 2692611 priority patent/CA2692611A1/en
Priority to JP2009522627A priority patent/JP5233996B2/ja
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Priority to AU2008273426A priority patent/AU2008273426B2/en
Publication of WO2009008371A1 publication Critical patent/WO2009008371A1/ja
Priority to ZA2009/08305A priority patent/ZA200908305B/en
Anticipated expiration legal-status Critical
Priority to US13/618,732 priority patent/US20130096100A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

【課題】EML4-ALK融合タンパク及び変異EGFRタンパクのキナーゼ活性の阻害剤として有用な化合物を提供する。 【解決手段】本発明者らは、EML4-ALK融合タンパク及び変異EGFRタンパクのキナーゼ活性を阻害する作用を有する化合物について鋭意検討した結果、本発明のジ(アリールアミノ)アリール化合物が、EML4-ALK融合タンパク及び変異EGFRタンパクのキナーゼ活性の阻害活性を有することを知見し、本発明を完成させた。本発明化合物は、癌、肺癌、非小細胞肺癌、小細胞肺癌、EML4-ALK融合ポリヌクレオチド陽性及び／若しくは変異EGFRポリヌクレオチド陽性の癌、EML4-ALK融合ポリヌクレオチド陽性及び／若しくは変異EGFRポリヌクレオチド陽性の肺癌、又はEML4-ALK融合ポリヌクレオチド陽性及び／若しくは変異EGFRポリヌクレオチド陽性の非小細胞肺癌等の予防及び／若しくは治療用医薬組成物として使用しうる。
PCT/JP2008/062188 2007-07-06 2008-07-04 ジ（アリールアミノ）アリール化合物 Ceased WO2009008371A1 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA 2692611 CA2692611A1 (en) 2007-07-06 2008-07-04 Di(arylamino)aryl compounds
EP08777903A EP2172461A4 (en) 2007-07-06 2008-07-04 DI (ARYLAMINO) ARYL COMPOUND
US12/448,759 US8318702B2 (en) 2007-07-06 2008-07-04 Di(arylamino)aryl compounds
KR1020097026439A KR101323566B1 (ko) 2007-07-06 2008-07-04 디(아릴아미노)아릴 화합물
BRPI0814809-0A2A BRPI0814809A2 (pt) 2007-07-06 2008-07-04 Compostos di(arilamino)arílicos
CN2008800236055A CN101687822B (zh) 2007-07-06 2008-07-04 二(芳基氨基)芳基化合物
MX2009013625A MX2009013625A (es) 2007-07-06 2008-07-04 Compuestos de di (arilamino) arilo.
JP2009522627A JP5233996B2 (ja) 2007-07-06 2008-07-04 ジ（アリールアミノ）アリール化合物
AU2008273426A AU2008273426B2 (en) 2007-07-06 2008-07-04 Di(arylamino)aryl compounds
ZA2009/08305A ZA200908305B (en) 2007-07-06 2009-11-24 Di(arylamino)aryl compounds
US13/618,732 US20130096100A1 (en) 2007-07-06 2012-09-14 Di(arylamino)aryl compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-178795 2007-07-06
JP2007178795 2007-07-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/618,732 Division US20130096100A1 (en) 2007-07-06 2012-09-14 Di(arylamino)aryl compound

Publications (1)

Publication Number Publication Date
WO2009008371A1 true WO2009008371A1 (ja) 2009-01-15

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ID=40228543

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Application Number Title Priority Date Filing Date
PCT/JP2008/062188 Ceased WO2009008371A1 (ja) 2007-07-06 2008-07-04 ジ（アリールアミノ）アリール化合物

Country Status (13)

Country Link
US (2) US8318702B2 (ja)
EP (1) EP2172461A4 (ja)
JP (1) JP5233996B2 (ja)
KR (1) KR101323566B1 (ja)
CN (1) CN101687822B (ja)
AU (1) AU2008273426B2 (ja)
BR (1) BRPI0814809A2 (ja)
CA (1) CA2692611A1 (ja)
MX (1) MX2009013625A (ja)
RU (1) RU2463299C2 (ja)
TW (1) TWI389893B (ja)
WO (1) WO2009008371A1 (ja)
ZA (1) ZA200908305B (ja)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010128659A1 (ja) 2009-05-08 2010-11-11 アステラス製薬株式会社 ジアミノへテロ環カルボキサミド化合物
WO2010143664A1 (ja) 2009-06-10 2010-12-16 中外製薬株式会社 ４環性化合物
WO2011145548A1 (ja) 2010-05-18 2011-11-24 アステラス製薬株式会社 ジ（アリールアミノ）アリール化合物の結晶
CN102482277A (zh) * 2009-05-05 2012-05-30 达纳-法伯癌症研究所有限公司 表皮生长因子受体抑制剂及治疗障碍的方法
WO2012102393A1 (ja) 2011-01-28 2012-08-02 アステラス製薬株式会社 ジ(アリールアミノ)アリール化合物の製造方法及びその合成中間体
JP2013539795A (ja) * 2010-10-14 2013-10-28 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖の阻害方法
WO2014071832A1 (en) * 2012-11-06 2014-05-15 Shanghai Fochon Pharmaceutical Co Ltd Alk kinase inhibitors
US9714229B2 (en) 2014-04-25 2017-07-25 Chugai Seiyaku Kabushiki Kaisha Crystal of tetracyclic compound
JP2017521436A (ja) * 2014-07-04 2017-08-03 チル ファーマシューティカル カンパニー リミテッド スピロ環アリールリン酸化物及びアリールリン硫化物（ｓｐｉｒｏｃｙｃｌｉｃ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｏｘｉｄｅ ａｎｄ ａｒｙｌ ｐｈｏｓｐｈｏｒｕｓ ｓｕｌｆｉｄｅ）
US10344014B2 (en) 2014-08-08 2019-07-09 Chugai Seiyaku Kabushiki Kaisha Amorphous form of tetracyclic compound
US10350214B2 (en) 2014-04-25 2019-07-16 Chugai Seiyaku Kabushiki Kaisha Preparation containing tetracyclic compound at high dose
US10646468B2 (en) 2010-08-20 2020-05-12 Chugai Seiyaku Kabushiki Kaisha Composition comprising tetracyclic compound
US10668075B2 (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha RET inhibitor
US11077093B2 (en) 2015-01-16 2021-08-03 Chugai Seiyaku Kabushiki Kaisha Combination drug
JP2021521163A (ja) * 2018-04-09 2021-08-26 上海科技大学Ｓｈａｎｇｈａｉ Ｔｅｃｈ Ｕｎｉｖｅｒｓｉｔｙ 標的タンパク質分解化合物、その抗腫瘍応用、その中間体および中間体の応用
RU2526253C9 (ru) * 2009-05-08 2022-08-02 Астеллас Фарма Инк. Диаминогетероциклическое карбоксамидное соединение
US11939322B2 (en) 2018-09-04 2024-03-26 Chugai Seiyaku Kabushiki Kaisha Method for producing tetracyclic compound

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6587781B2 (en) 2000-08-28 2003-07-01 Estimotion, Inc. Method and system for modeling and processing vehicular traffic data and information and applying thereof
US7620402B2 (en) 2004-07-09 2009-11-17 Itis Uk Limited System and method for geographically locating a mobile device
CA2598893C (en) 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
PL2300013T5 (pl) 2008-05-21 2025-04-28 Takeda Pharmaceutical Company Limited Pochodne fosforu jako inhibitor kinazy
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
CN102260263A (zh) * 2010-05-26 2011-11-30 四川大学 一类二苯胺基嘌呤衍生物及制备方法和医药用途
WO2012019132A2 (en) 2010-08-06 2012-02-09 Cell Signaling Technology, Inc. Anaplastic lymphoma kinase in kidney cancer
US9315848B2 (en) 2010-08-18 2016-04-19 Technion Research And Development Foundation Ltd. Volatile organic compounds for detecting cell dysplasia and genetic alterations associated with lung cancer
WO2012135641A2 (en) 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center And Research Institute Aurora kinase inhibitors and methods of making and using thereof
EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
CN102389430B (zh) * 2011-09-07 2013-08-28 苏州大学 一种小分子化合物在制备抗肺癌药物中的应用
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
CN105796562A (zh) * 2012-09-10 2016-07-27 杨子娇 化合物在制备防治青光眼病的药物中的用途
CN105796569A (zh) * 2012-09-10 2016-07-27 杨子娇 化合物在制备防治青光眼病的药物中的用途
HK1211235A1 (en) 2013-02-22 2016-05-20 霍夫曼-拉罗奇有限公司 Methods of treating cancer and preventing drug resistance
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US20170050936A1 (en) 2013-08-23 2017-02-23 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN104458670A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选血管生成素2受体激酶抑制剂高通量筛选方法
CN104458669A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选蛋白激酶a抑制剂高通量筛选方法
CN104458677A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选间变性淋巴瘤激酶抑制剂高通量筛选方法
CN105330698B (zh) * 2014-07-04 2019-05-28 齐鲁制药有限公司 螺环芳基磷氧化物和硫化物
US10106507B2 (en) 2014-08-03 2018-10-23 H. Lee Moffitt Cancer Center and Research Insitute, Inc. Potent dual BRD4-kinase inhibitors as cancer therapeutics
CN106008503B (zh) * 2015-03-31 2020-09-01 齐鲁制药有限公司 螺环芳基砜作为蛋白激酶抑制剂
CN106146478B (zh) * 2015-04-10 2019-07-16 海南轩竹医药科技有限公司 三嗪衍生物类间变性淋巴瘤激酶抑制剂
US10738016B2 (en) 2015-10-13 2020-08-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. BRD4-kinase inhibitors as cancer therapeutics
RU2607371C1 (ru) * 2015-11-19 2017-01-10 Закрытое акционерное общество "Р-Фарм"(ЗАО "Р-Фарм") Замещенные N2-(4-амино-2-метоксифенил)-N4-[2-(диметилфосфорил)-фенил]-5-хлор-пиримидин-2,4-диамины в качестве модуляторов ALK и EGFR, предназначенные для лечения рака
CN106928275B (zh) * 2015-12-29 2020-10-02 齐鲁制药有限公司 螺环胺类芳基磷氧化合物的制备方法及其中间体和晶型
EP3444245B1 (en) 2016-03-31 2022-02-23 Sumitomo Chemical Company, Limited Heterocyclic compound
WO2018035061A1 (en) 2016-08-15 2018-02-22 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN107011266B (zh) * 2017-05-02 2023-04-14 中国人民解放军第二军医大学 苯并吲唑类衍生物的前药及其制备方法、应用
RU2654695C1 (ru) * 2017-07-28 2018-05-22 Акционерное Общество "Р-Фарм" (Ао "Р-Фарм") 8-(1-{ 4-{ (5-Хлор-4-{ (2-(диметилфосфорил)фенил)амино} пиримидин-2-ил)амино)-3-метоксифенил} пиперидин-4-ил)-1-метил-1,8-диазаспиро(4.5)декан-2-он и его фармацевтически приемлемые соли в качестве модулятора ALK и EGER, предназначенные для лечения рака
JP7085242B2 (ja) * 2017-12-21 2022-06-16 深▲チェン▼市塔吉瑞生物医薬有限公司 キナーゼ活性を阻害するためのアリールホスフィンオキシド
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020147702A1 (en) * 2019-01-17 2020-07-23 Betta Pharmaceuticals Co., Ltd Egfr inhibitors, compositions and methods thereof
CN109776513A (zh) * 2019-03-18 2019-05-21 福建省医学科学研究院 一类4-苯基-1,3,5-三嗪-2-胺类抗肿瘤化合物及其制备方法
CN110256429B (zh) * 2019-06-17 2021-06-22 广东药科大学 一种具有螺环结构的氨基嘧啶类化合物及其制备方法和应用
CN114805223B (zh) * 2022-05-30 2023-05-09 自贡市第四人民医院(自贡市急救中心) 一种用于抑制egfr的2，4-二取代喹唑啉类化合物及制备方法及应用
CN116283915A (zh) * 2022-09-08 2023-06-23 中国科学院生物物理研究所 促进致癌融合蛋白EML4-ALK通过泛素化途径降解的小分子化合物dEALK1

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020822A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines as npy receptor antagonist
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
US20040116388A1 (en) * 1999-10-07 2004-06-17 Amgen Inc. Kinase inhibitors
WO2004080980A1 (en) 2003-03-14 2004-09-23 Novartis Ag 2, 4- di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
JP2005522438A (ja) * 2002-02-08 2005-07-28 スミスクライン ビーチャム コーポレーション ピリミジン化合物
WO2007095812A1 (en) 2006-02-27 2007-08-30 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof
EP1914240A1 (en) 2006-10-11 2008-04-23 Astellas Pharma Inc. EML4-ALK fusion gene

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2343148C2 (ru) * 2002-02-01 2009-01-10 Райджел Фармасьютикалз, Инк Соединения 2,4-пиримидиндиаминов и их применение
KR100875362B1 (ko) 2002-02-05 2008-12-22 아스텔라스세이야쿠 가부시키가이샤 2,4,6-트리아미노-1,3,5-트리아진 유도체
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
US7288529B2 (en) * 2003-04-24 2007-10-30 New York University ALK protein tyrosine kinase, cells and methods embodying and using same
DK2287156T3 (da) * 2003-08-15 2013-08-26 Novartis Ag 2,4-Di(phenylamino)-pyrimidiner egnede i behandling af neoplastiske sygdomme, inflammatoriske lidelser og lidelser i immunsystemet
GB0321710D0 (en) * 2003-09-16 2003-10-15 Novartis Ag Organic compounds
JP2007505858A (ja) * 2003-09-18 2007-03-15 ノバルティス アクチエンゲゼルシャフト 増殖性障害の処置に有用な２，４−ジ（フェニルアミノ）ピリミジン
GB0419160D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
GB0419161D0 (en) 2004-08-27 2004-09-29 Novartis Ag Organic compounds
WO2007059300A2 (en) 2005-11-15 2007-05-24 Medimmune, Inc. Anti-alk antagonist and agonist antibodies and uses thereof
US7700339B2 (en) * 2006-04-14 2010-04-20 Cell Signaling Technology, Inc. Gene defects and mutant ALK kinase in human solid tumors
CA2598893C (en) * 2006-10-11 2012-04-10 Astellas Pharma Inc. Eml4-alk fusion gene
AU2007309427B2 (en) 2006-10-23 2013-02-28 Cephalon, Inc. Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
KR101149295B1 (ko) 2006-12-08 2012-07-05 아이알엠 엘엘씨 단백질 키나제 억제제로서의 화합물
JP5562640B2 (ja) 2007-04-13 2014-07-30 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ
CN101827848B (zh) 2007-08-08 2012-11-07 葛兰素史密丝克莱恩有限责任公司 作为IGF-1R抑制剂用于治疗癌症的2-[(2-{苯基氨基}-1H-吡咯并[2,3-d]嘧啶-4-基)氨基]苯甲酰胺衍生物
WO2009032703A1 (en) 2007-08-28 2009-03-12 Irm Llc 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
WO2009054939A2 (en) 2007-10-19 2009-04-30 Cell Signaling Technology, Inc. Cancer classification and methods of use
JP5214799B2 (ja) 2008-04-07 2013-06-19 アイアールエム・リミテッド・ライアビリティ・カンパニー キナーゼ阻害剤としての化合物および組成物
JP5298187B2 (ja) 2008-04-07 2013-09-25 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
PL2300013T5 (pl) 2008-05-21 2025-04-28 Takeda Pharmaceutical Company Limited Pochodne fosforu jako inhibitor kinazy

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020822A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines as npy receptor antagonist
US20040116388A1 (en) * 1999-10-07 2004-06-17 Amgen Inc. Kinase inhibitors
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
JP2005522438A (ja) * 2002-02-08 2005-07-28 スミスクライン ビーチャム コーポレーション ピリミジン化合物
WO2004080980A1 (en) 2003-03-14 2004-09-23 Novartis Ag 2, 4- di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
JP2006520354A (ja) * 2003-03-14 2006-09-07 ノバルティス アクチエンゲゼルシャフト 新生物疾患、炎症および免疫系障害の処置に有用な２，４−ジ（フェニルアミノ）ピリミジン
WO2007095812A1 (en) 2006-02-27 2007-08-30 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof
EP1914240A1 (en) 2006-10-11 2008-04-23 Astellas Pharma Inc. EML4-ALK fusion gene

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
"Clinical Oncology", CANCER AND CHEMOTHERAPY PUBLISHERS INC.
"Molecular Design", vol. 7, 1990, HIROKAWA PUBLISHING, article "Development of Pharmaceuticals", pages: 163 - 198
"Sumilon Celltight Spheroid 96U", SUMITOMO BAKELITE CO., LTD.
CELL, vol. 131, 2007, pages 1190
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999
INTERNATIONAL JOURNAL OF CANCER, vol. 100, 2002, pages 49
LABORATORY INVESTIGATION, vol. 85, 2005, pages 1544
MOLECULAR AND CELLUAR BIOLOGY, vol. 24, 2004, pages 6539 - 6549
NATURE, vol. 448, no. 2, 2007, pages 561
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, vol. 104, no. 1, 2007, pages 270
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, vol. 104, no. 50, 2007, pages 19936
PROG. MED., vol. 5, 1985, pages 2157 - 2161
See also references of EP2172461A4
WHITTEN J.P. ET AL.: "Rapid Microscale Synthesis, a New Method for Lead Optimization Using Robotics and Solution Phase Chemistry: Application to the Synthesis and Optimization of Corticotropin-Releasing Factor Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 22, 1996, pages 4354 - 4357, XP002298972 *

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US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
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EP2440559A4 (en) * 2009-05-05 2012-11-21 Dana Farber Cancer Inst Inc EGFR HEMMER AND METHODS OF DISEASE TREATMENT THEREWITH
RU2526253C2 (ru) * 2009-05-08 2014-08-20 Астеллас Фарма Инк. Диаминогетероциклическое карбоксамидное соединение
EP3009428A1 (en) 2009-05-08 2016-04-20 Astellas Pharma Inc. Diamino heterocyclic carboxamide compound
RU2526253C9 (ru) * 2009-05-08 2022-08-02 Астеллас Фарма Инк. Диаминогетероциклическое карбоксамидное соединение
US9487491B2 (en) 2009-05-08 2016-11-08 Astellas Pharma Inc. Diamino heterocyclic carboxamide compound
WO2010128659A1 (ja) 2009-05-08 2010-11-11 アステラス製薬株式会社 ジアミノへテロ環カルボキサミド化合物
US8969336B2 (en) 2009-05-08 2015-03-03 Astellas Pharma Inc. Diamino heterocyclic carboxamide compound
EP3345903A1 (en) 2009-06-10 2018-07-11 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compounds
US9126931B2 (en) 2009-06-10 2015-09-08 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compound
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