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WO2009004465A1 - Inhalateur de poudre sèche et système d'inhalation comprenant un tel inhalateur de poudre sèche - Google Patents

Inhalateur de poudre sèche et système d'inhalation comprenant un tel inhalateur de poudre sèche Download PDF

Info

Publication number
WO2009004465A1
WO2009004465A1 PCT/IB2008/001736 IB2008001736W WO2009004465A1 WO 2009004465 A1 WO2009004465 A1 WO 2009004465A1 IB 2008001736 W IB2008001736 W IB 2008001736W WO 2009004465 A1 WO2009004465 A1 WO 2009004465A1
Authority
WO
WIPO (PCT)
Prior art keywords
slider
container
dry powder
suction tube
support surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/001736
Other languages
English (en)
Inventor
Valerie Diart
Warren Isaacs
Stephen Marsh
John Poley
Lars Kax
Mattias Myrman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Publication of WO2009004465A1 publication Critical patent/WO2009004465A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0038—Cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes

Definitions

  • Dry powder inhaler and inhaling system comprising such dry powder inhaler
  • the invention relates to a dry powder inhaler and to an inhaling system comprising such dry powder inhaler.
  • the invention relates to a dry powder inhaler intended to be used with a container comprising a reservoir provided with dry powder, said dry powder inhaler comprising: a suction tube, - a slider having a support surface adapted to receive the container, said suction tube and said slider being moveable relative to one another along a path from a first to a second position, the support surface of the slider facing the suction tube in at least part of said path, an opener adapted to open the reservoir as the suction tube and the slider are moved relative to one another along said path, so as to allow discharge of the dry powder upon inhalation by a user through the suction tube.
  • An inhaler of the above mentioned type may be used in particular to discharge a metered dose of medication, for example insulin or other, in a fine dry powder form, contained in the reservoir of the container. It is thus essential that the user receives the appropriate dose of medication.
  • a metered dose of medication for example insulin or other
  • a fine dry powder form contained in the reservoir of the container. It is thus essential that the user receives the appropriate dose of medication.
  • the positioning of the reservoir of the container with respect to the opener and the suction tube needs to be accurate for each use of the inhaler.
  • the invention provides for a dry powder inhaler of the above mentioned type, further including an interfering device adapted to prevent the suction tube and the slider from moving relative to one another from the first to the second position if a dry powder container is improperly positioned on said support surface.
  • the user is compelled to properly position the dry powder container in the inhaler in order to use the inhaler, thus contributing to the delivery of a precise dose of dry powder to the user.
  • the slider supports a retaining member which is movable between a supplying position enabling to load the container on said support surface and a locking position in which said retaining member is adapted to retain the container onto the support surface, and said interfering device is adapted to prevent the suction tube and the slider from moving relative to one another from the first to the second position unless the retaining member is in the locking position;
  • the interfering device comprises an abutment element movably mounted on the slider, said abutment element being resiliently biased toward an interfering position wherein said abutment element is adapted to interfere with a portion of the inhaler which is fixed relative to the suction tube so as prevents the suction tube and the slider from moving relative to one another from the first to the second position, and said abutment element being adapted to be moved by a part placed on said support
  • the slider comprises at least one positioning member protruding on said support surface and adapted to engage with the container to ensure a precise positioning thereof;
  • the slider comprises at least two positioning members protruding from the support surface and defining between them a reception space which is adapted to receive said reservoir of the container when said container is loaded on said support surface, the opener being arranged so as to pass between said positioning members as the suction tube and the slider are moved relative to one another;
  • said positioning members are two support walls extending in a direction substantially parallel to the path; the positioning member is made in one piece with the support surface;
  • the slider supports a retaining member which is movable between a supplying position enabling to load the container on said support surface and a locking position in which said retaining member is adapted to retain the container onto the support surface;
  • the retaining member comprises a flap which is pivotally mounted on the slider; the flap comprises a free end adapted to be snap-fitted to the slider in the locking position;
  • the dry powder inhaler further comprises a substantially cylindrical hollow frame
  • Another object of the invention is a dry powder inhaler intended to be used with a container comprising a reservoir provided with dry powder, said dry powder inhaler comprising: a suction tube, a slider having a support surface adapted to receive the container, said suction tube and said slider being moveable relative to one another along a path from a first to a second position, the support surface of the slider facing the suction tube in at least part of said path, an opener adapted to open the reservoir as the suction tube and the slider are moved relative to one another along said path, so as to allow discharge of the dry powder upon inhalation by a user through the suction tube, wherein the slider comprises at least one positioning member protruding on said support surface and adapted to engage with the container to ensure a precise positioning thereof.
  • Still another object of the invention is a dry powder inhaler intended to be used with a container comprising a reservoir provided with dry powder, said dry powder inhaler comprising: - a suction tube, a slider having a support surface adapted to receive the container, said suction tube and said slider being moveable relative to one another along a path from a first to a second position, the support surface of the slider facing the suction tube in at least part of said path, - an opener adapted to open the reservoir as the suction tube and the slider are moved relative to one another along said path, so as to allow discharge of the dry powder upon inhalation by a user through the suction tube, wherein the slider supports a retaining member which is movable between a supplying position enabling to load the container on said support surface and a locking position in which said retaining member retains the container onto the support surface.
  • a further object of the invention is a dry powder inhaler intended to be used with a container comprising a reservoir provided with dry powder, said dry powder inhaler comprising: - a frame, a suction tube removably held on the frame, a slider movably mounted on the frame, said slider having a support surface adapted to receive the container, said suction tube and said slider being moveable relative to one another along a path from a first to a second position, the support surface of the slider facing the suction tube in at least part of said path, an opener adapted to open the reservoir as the suction tube and the slider are moved relative to one another along said path, so as to allow discharge of the dry powder upon inhalation by a user through the suction tube, wherein the frame comprises an annular wall cooperating by fitting engagement with the suction tube, a first element, chosen between said suction tube and said annular wall, comprises two protruding opposite spurs and a second element, chosen between said suction tube and said annular wall, has two grooves in which the spur
  • the invention concerns an inhaling system comprising a dry powder inhaler as defined above and a container comprising a reservoir provided with dry powder, said container further comprising a peripheral flange surrounding the reservoir, said container being adapted to be received on the support surface, and said support surface including at least one protruding positioning member adapted to engage with the container to ensure a precise positioning thereof.
  • the inhaling system may comprise one or several of the following features: the slider comprises at least two positioning members protruding from the support surface and defining between them a reception space which is adapted to receive said reservoir of the container when said container is loaded on said support surface, the opener being arranged so as to pass between said positioning members as the suction tube and the slider are moved relative to one another; said positioning members are adapted to support the peripheral flange of the container on both sides of the reservoir when said container is loaded on said support surface; the slider supports a retaining member which is movable between a supplying position enabling to load the container on said support surface and a locking position in which said retaining member presses on the peripheral flange of the container opposite to the positioning members when said container is loaded on said support surface, to retain the container onto the support surface; the container comprises: - a rigid substrate, a blister supported by said substrate, said blister including a lower foil and an upper foil adapted to be cut open, said reservoir being formed between said lower
  • the retaining member comprises a border surrounding an opening, said border presenting a rear surface having a concavity along the first direction to accommodate the convexity of the lower foil.
  • FIG. 1 is an exploded perspective view of a dry powder inhaler according to an embodiment of the invention
  • FIG. 2 is an enlarged view illustrating a removable suction tube of the inhaler of Figure 1
  • FIG. 3 is a perspective view of a container used in the inhaler of Figure 1 ,
  • Figure 4 is an exploded view on the container of Figure 3,
  • FIGS. 5 and 6 are plan views in longitudinal and transverse cross-sections, respectively, of the container of Figure 3,
  • FIG. 7 is a perspective side view of a slider of the inhaler of Figure 1 , the reservoir of Figure 3 being positioned on a support member of the slider,
  • - Figure 8 is a perspective view of an assembly comprising a retaining member of the slider and the reservoir of Figure 3
  • - Figure 9 is a perspective view of the assembly of Figure 8, in which the reservoir is positioned on the retaining member
  • - Figure 10 is a perspective view of the assembly of Figure 8, pivotally mounted on the slider of Figure 7
  • FIGS 11 and 12 are side views of an interfering device of the inhaler of Figure 1 , said interfering device being illustrated in an interfering position and a remote position, respectively,
  • FIG. 13 is a perspective view of the inhaler of Figure 1 with an outer shell, in a storage position
  • FIG. 14 is a plan view in longitudinal cross-section of the inhaler of Figure 13,
  • Figure 15 is a view similar to that of Figure 13 illustrating a protective front cover partly removed
  • FIG. 16a is a plan view in longitudinal cross-section of the inhaler of Figure 13 at a first step of use of the inhaler
  • FIG. 16b is an enlarged lateral view of the interfering device at said first step
  • FIG. 17a is a plan view in longitudinal cross-section of the inhaler of Figure 13 at a second step of use of the inhaler
  • - Figure 18 is an enlarged lateral view of the interfering device in the interfering position
  • - Figure 19a is a plan view in longitudinal cross-section of the inhaler of Figure 13 at a third step of use of the inhaler
  • FIG. 19b is an enlarged lateral view of the interfering device at said third step
  • - Figure 20 is a plan view in longitudinal cross-section of the inhaler of Figure 13 at a fourth step of use of the inhaler
  • - Figure 21a is a plan view in longitudinal cross-section of the inhaler of Figure 13 at a fifth step of use of the inhaler
  • FIG. 21b is an enlarged lateral view of the interfering device at said fifth step
  • - Figure 22 is a plan view in longitudinal cross-section of the inhaler of Figure 13 with a reservoir retained on the slider, the protective front cover being moved toward the suction tube
  • - Figure 23 is a plan view in longitudinal cross-section of the inhaler of Figure 13 with a reservoir retained on the slider, the protective front cover being placed on the suction tube.
  • Figure 1 represents a dry powder inhaler 1 intended to be used with a container 2 shown in Figures 3 and 4, comprising : a rigid substrate 80, e.g. in the form of a plane plate, and a blister 60, 70 secured to the substrate, said blister forming a reservoir 3 provided with dry powder and a peripheral flange 4 surrounding said reservoir.
  • a rigid substrate 80 e.g. in the form of a plane plate
  • a blister 60, 70 secured to the substrate, said blister forming a reservoir 3 provided with dry powder and a peripheral flange 4 surrounding said reservoir.
  • the dry powder inhaler 1 may be used to discharge a dose of medication, such as insulin or other, in fine dry powder form.
  • the dry powder inhaler 1 shown in Figure 1 comprises:
  • suction tube 5 for instance made out of plastic material, having an inlet end 6 and an outlet end 7 through which the user may inhale,
  • a slider 8 for instance made out of plastic material, having a support surface 9 and adapted to receive the container 2 on said support surface 9, and
  • an opener 10 e.g. a cutting blade.
  • the suction tube 5 and said slider 8 are moveable relative to one another along said path, between a first position (see Figure 19a), in which the support surface 9 of the slider 8 and the inlet end 6 of the suction tube 5 are spaced apart, and a second position (see Figure 21a), in which the support surface 9 of the slider 8 substantially faces the inlet end 6 of the suction tube 5.
  • the opener 10 is fixed relative to the suction tube 5 and is placed in said path, upstream the inlet end 6 of the suction tube 5 with respect to the direction of travel of the slider, so that said opener 10 opens the reservoir 3 as the suction tube 5 and the slider 8 are moved relative to one another from the first to the second position.
  • inhaler 1 in which the slider 8 is moveable in translation along a path substantially parallel to a vertical direction V with respect to the suction tube 5 and the opener 10.
  • the invention is not limited to such embodiment.
  • the suction tube 5 and the opener 10 could be moveable with respect to the slider 8 or both the suction tube 5 and the slider 8 could be moveable with respect to the opener 10.
  • relative movements other than translation could be used, in directions other than vertical.
  • the inhaler may comprise a substantially cylindrical hollow frame 11 , for instance made out of plastic material, of substantially rectangular cross-section for example, extending along a vertical axis A parallel to the vertical direction V.
  • the frame 11 may be formed of two lateral half frames 11a, 11b assembled together along a longitudinal plane (LV) comprising the vertical direction V and a front direction L perpendicular to the vertical direction V.
  • LV longitudinal plane
  • T transverse direction T perpendicular to the vertical and front directions V,
  • the frame 11 may thus comprise front and back walls parallel to a transverse plane (TV), spaced apart along the front direction L and linked with one another by two lateral walls parallel to the longitudinal plane (LV) and spaced apart along transverse direction T.
  • the frame 11 may also comprise a bottom wall parallel to a horizontal plane (LT) and linking one end of the front back and lateral walls.
  • the hollow frame 11 may comprise an upper open end 12, opposite the bottom wall, and a front opening 13 having an axis B parallel to the longitudinal direction L.
  • the above mentioned suction tube 5 and opener 10 may be secured for instance to the frame 11.
  • the suction tube 5 is substantially cylindrical along an axis B which is parallel to the front direction.
  • the suction tube 5 may comprise a central hollow stem 14 defining a conduit, for example of substantially oval cross-section, between the inlet end 6 and the outlet end 7.
  • the suction tube 5 may further comprise an annular mouthpiece 15 attached to the hollow stem 14 close to the outlet end 7.
  • the mouthpiece 15 may have an inner surface of substantially circular cross-section and an outer surface of substantially oval cross-section offset of an angle of 90° with respect to the oval cross-section of the conduit of the hollow stem 14.
  • the inner surface of the mouthpiece 15 is formed by an external ring 16 surrounding the hollow stem 14 and made in one piece with the hollow stem.
  • the outer surface of the mouthpiece 15 is formed with a sleeve 17 secured to an end of the external ring 16, at said outlet end 7 of the suction tube.
  • the suction tube 5 is mounted on the frame 11 so as to extend coaxially through the front opening 13, the inlet end 6 being placed within the frame 11 and the mouthpiece 15 standing outside the frame 11.
  • the suction tube 5 is secured to the frame 11 in a removable manner. In alternative embodiments, it may be permanently attached to the frame.
  • the frame 11 may comprise an annular wall
  • Said annular wall may be of substantially cylindrical form, centered on said axis B.
  • the annular wall 13a is dimensioned to receive the external ring 16 and the hollow stem 14 coaxially to the axis B, and to be surrounded by the sleeve 17 of the mouthpiece 15.
  • the suction tube 5 may comprise two opposite spurs 20 protruding from an outer surface of the external ring 16.
  • the annular wall 13a may be provided with two grooves 21 , symmetrical with respect to the axis B of the front opening 13 and in which the spurs 20 may engage, respectively.
  • each groove 21 may comprise: an axial portion 21a extending from a free end of the annular wall 13a parallel to axis B, and an arched portion 21 b presenting a concavity turned towards said free end.
  • Each arched portion 21b surrounds a perforated central core 21c and has a recess 21 d.
  • a protrusion 21 e extends from the central core 21c in the arched portion 21b behind the recess 21 d with regard to the axial portion 21a.
  • one of the spur 20 is first engaged in the axial portion 21a and then in the arched portion 21b.
  • the perforated central core 21c provides for elasticity to the arched portion 21b so that the arched portion 21 b may deform when urged by the spur 20.
  • Abutment surfaces 21 f may be provided in the perforation of the central core 21c to limit the deformation.
  • the spur 20 slides along the arched portion 21 b until it engages the recess 21 d, the protrusion 21 e preventing the spur to slide further. As the spur 20 engages the recess 21 d, the arched portion is urged toward a rest position where it locks the spur 20.
  • the spurs 20 and the grooves 21 are arranged such that the oval cross- section of the mouthpiece 15 when the spurs 20 are locked in the recesses 21 d extends in the transverse direction T.
  • the above removable connection of the suction tube 5 is of special interest. In particular, this technical solution ensures a precise positioning of the suction tube and avoids accidental removal or displacement of the suction tube, for a reasonable cost.
  • the slider 8 may be engaged in the upper open end 12 of the frame 11 and is mounted on said frame 11 so as to be moveable between the first position, in which the slider 8 protrudes from the frame 11 , and the second position, in which the slider 8 is placed within the frame 11.
  • the slider 8 may be substantially cylindrical, for example with a substantially rectangular cross-section, along an axis parallel to the vertical direction V.
  • the slider 8 may thus comprise a front wall facing the front wall of the frame 11 , a back wall facing the back wall of the frame 11 and two side walls facing the side walls of the frame 11 , respectively.
  • the slider 8 may further comprise a top wall 22 at an upper end of the front, back and side walls. This top wall 22 may be concavely shaped to be used as a pusher by a user of the inhaler 1.
  • the support surface 9 formed on the front wall of the slider 8 bears at least one protruding positioning member 25, here two positioning members 25 defining a reception space 23 between them. As explained later, the positioning members
  • the positioning members 25 are adapted to protrude through the substrate 80 and engage at least part of the lower face of the peripheral flange 4 of the container 2, so as to precisely position and maintain the container 2 and more specifically the reservoir with respect to the support surface. Further, the reception space 23 is adapted to receive the reservoir 3 of the container 2.
  • the positioning members 25 have sloping faces turned one to the other, which define together a V-shaped constraining structure for pressing the reservoir 3 and precisely center the latter in the D2 (lateral) direction. As shown on Figures 1, 7, 10, the positioning members 25 of the slider may be in the form of two support walls 25 protruding from the support surface 9 to a free end 25a.
  • the support walls 25 may be made in one piece with the support surface 9 and extend in a direction substantially parallel to the path, i.e.
  • each support wall 25 may present a convexity adapted to accommodate a curvature of the blister 60, 70 of the container, as explained later, or to conform the blister in a convex shape.
  • the slider 8 further supports a retaining member 26, made out for instance out of plastic material, adapted to retain the container 2 onto the support surface 9.
  • the retaining member may be adapted to be in contact with at least part of an upper surface of the peripheral flange 4 of the container 2 when said container 2 is retained onto the support walls 25.
  • the retaining member may comprise a flap
  • the flap 26 having a front surface, a rear surface and a lower end 27 pivotally mounted on the slider 8 so as to be moveable with respect to said support surface 9 between a supplying position, represented on Figure 10, and a locking position, represented on Figure 1.
  • the flap 26 In the supplying position, the flap 26 is spaced apart from the support surface 9 so as to be able to load a container 2 on the support surface 9.
  • the flap 26 In the locking position, the flap 26 may face the support surface 9 and be fixed to the slider 8, for example by means of a free upper end 28 opposite the lower end 27 adapted to be snap-fitted on the slider 8.
  • the upper end 28 may have resilient legs 28a perpendicular to the rear surface and provided each with a shoulder adapted to engage an opening 29 of the front wall of the slider 8.
  • the flap 26 may comprise an opening 30 and a border 31 surrounding the opening 31.
  • the opening 30 and the border 31 being arranged with respect to the lower end 27 such that, in the locking position, the border 31 faces the support walls 25 and the opening 30 faces the reception space 23.
  • the border 31 may present, on the rear surface, a concavity conformed to the convexity of the free edges 25a of the support walls 25.
  • the dry powder inhaler 1 may further comprise an interfering device adapted to prevent the slider 8 from moving in translation with regard to the suction tube 5 until the flap 26 is in the locking position, or more generally if a dry powder container 2 is improperly positioned on said support surface 9.
  • the interfering device comprises an abutment element 35 pivotally mounted on the slider 8, around an axis of rotation which is perpendicular to the direction of movement of the slider 8, said abutment element 35 being linked to the flap 26.
  • the abutment element 35 may be resiliently urged toward an interfering position, represented on Figure 11 , and be moveable to a remote position, represented on Figure 12, when the flap 26 is in the locking position.
  • the abutment element 35 may comprise a transverse cylindrical pivot pivotally mounted in a transverse cylindrical housing 36 of the slider 8 (see Figure 7), an abutment arm 37 extending downwardly from the cylindrical bar and a control arm 38 extending upwardly from the cylindrical bar.
  • the inhaler 1 may comprise a sliding piece 40 slidingly mounted on the slider, beneath the top wall 22, along the front direction L.
  • the sliding piece 40 presents a lower surface provided with a recess 41 in which a free end of the control arm 38 is engaged.
  • the slider 8 may comprise at least one stopping surface and the frame 11 may comprise at least one abutment surface.
  • the stopping surface and the abutment surface are moveable relative to one another between a stopping position, in which the stopping surface and the abutment surface are in abutment, when the slider 8 is in the second position, and a release position, in which the stopping surface and the abutment surface are spaced apart.
  • the slider 8 may comprise a back plate 56 provided with rear stopping surfaces 52 facing upwardly (see Figure 7 and 10, the plate 56 being omitted on the other Figures).
  • the back plate 56 may be pivotally mounted around pivots 53 on the back wall of the slider 8 and be resiliency urged in the direction of arrow 54 toward the stopping position, where the rear stopping surfaces 52 are in abutment below rear abutment flanges 55 of the frame 11 (see Figure 1).
  • the back plate 56 may be moveable in the release position in a direction opposite to direction 54, in particular by means of a push button 46 slidingly mounted in an opening 47 of the back wall of the frame 11.
  • the slider 8 may be resiliency urged toward the first position, by means of a compression spring 43.
  • the inhaler 1 comprises a guiding device adapted to guide the slider 8 in translation along axis A between the first and second positions.
  • the guiding device may comprise a central rod extending in the vertical direction from the bottom wall of the frame 11 and lateral walls of the frame 11.
  • the slider 8 may have a central bore fitted on the central rod, and the lateral walls of the slider 8 may be moved close to the lateral walls of the frame 11.
  • the guiding device may further comprise a braking system or damper adapted to slow down the translation of the slider 8.
  • the braking system comprises a gear wheel 50 pivotally mounted on the slider 8, beneath the flap 26 and adapted to mesh with a vertical rack 51. Said gear wheel 50 may be turning with flaps enclosed in a receptacle full of viscous liquid, to brake the movement of the wheel and thus of the slider 8.
  • the opener 10 may be secured to the frame 11 close to the inlet end 6 of the suction tube 5.
  • the opener 10 may comprise a blade adapted to form a slit on reservoir 3 and a support to which the blade is secured.
  • the blade is shaped to lift and separate the two cut foil flaps and to create a symmetrical opening for the tube to subsequently suck out the powder.
  • the blade is designed to cut the blister in an even manner, then pealing back the cut foil pieces such that the tube can pass over the powder which is then extracted by patient inspiration.
  • the inhaler 1 may comprise an outer shell 42 formed of two half-shells enclosing the frame 11 and attached thereto.
  • the outer shell 42 comprises an upper opening through which the slider 8 may extend in the first position.
  • the outer shell 42 is so dimensioned that in the second position of the slider 8, the top wall 22 flushes with the surface of the outer shell 42.
  • the outer shell 42 may comprise a protective front cover 44 adapted to be placed in a removable manner on the mouthpiece 15 of the suction tube 5.
  • the protective front cover 44 may have a front abutment surface 44a in abutment against a front stopping surface 44b of the slider 8, when the cover 42 is placed on the mouthpiece 15 and the slider 8 is in the second position.
  • the blister 60, 70 the dry powder container 2 comprises two superposed foils which are secured together at said peripheral flange 4, i.e. a lower, conformed foil 60 and an upper foil 70 adapted to be cut open.
  • Both foils 60, 70 may consist in laminates each comprising for instance at least one metallic layer, such as an aluminum layer, and at least one layer of polymeric material.
  • polymeric material may be for instance PVC and / or PA for the lower foil and for instance Polyester for the upper foil.
  • the lower foil 60 presents an upper face 60a and extends between two boundaries 60b spaced apart along a first direction D1.
  • the upper face 60a of the lower foil 60 presents a convexity along the first direction D1 between said boundaries 60b.
  • the lower foil 60 may be arched between said boundaries 60b, the upper face 60a of the lower foil being convexly curved along the first direction D1 between said boundaries 60b, outside the reservoir 3.
  • the upper face 60a of the lower foil 60 may have a substantially constant radius of curvature in the arched portion.
  • the upper face 60a of the lower foil 60 may present substantially straight cross sections in a second direction D2 perpendicular to the first direction D1 , outside said reservoir 3.
  • a third direction D3 is defined perpendicular to the first D1 and second D2 directions.
  • the lower foil 60 comprises, in said arched portion: a recess 61 which forms an opening 62 into said upper face 60a, and a peripheral border 63 surrounding the opening 62.
  • the recess 61 may be centered between said boundaries 60b and may present a flat bottom, parallel to the first direction D1.
  • the lower foil 60 may have two opposite tongues 64 extending along the first direction D1 , each tongue 64 being linked to the arched portion by a fold line 60b parallel to the second direction D2 and forming one of said boundaries.
  • the upper foil 70 is conformed to the convexity of the upper face 60a of the lower foil 60.
  • the upper foil 70 has a central part which covers the recess 61 , and a peripheral part sealed to the peripheral border 63.
  • the recess 61 of the lower foil 60 and the central part of the upper foil 70 form the reservoir 3, and the peripheral border 63 of the lower foil 60 and the peripheral part of the upper foil 70 form the peripheral flange 4.
  • Provision of the recess 61 and of the peripheral border 63 portion presenting a convexity along a determined direction is particularly suitable for an inhaler of the above disclosed type, where the opener 10 should open the reservoir 3 as the container 2 is moved in translation along said determined translation. Furthermore, the arched portion of the blister provides for a regular upper face 60a without angled portion in the peripheral border so that the container presents an efficient barrier to moisture.
  • the arch shape also enables the blade to cut the foil in an optimum way so that it does not ride over the surface of the lid foil.
  • the substrate 80 may be for example a plastic plate made out of a polymer such as PVC.
  • the substrate 80 may extend substantially in a plane and have a substantially rectangular shape.
  • the substrate 80 presents a width between two opposite large sides 80a and a length between two opposite small sides 80b.
  • the length of the substrate 80 may extend along the first direction D1.
  • the lower foil 60 may be secured to the substrate 80 at the boundaries 60a of the arched portion.
  • the lower foil 60 has a width and a length substantially the same as that of the substrate 80.
  • the tongues 64 of the lower foil 60 may then be glued, thermo sealed or fixed in any other appropriate manner to the substrate 80.
  • the lower foil 60 may have a length smaller than that of the substrate 80, the upper foil 70 having end portions 71 sealed to the tongues 64 and to the substrate 80.
  • the lower foil 60 is spaced apart from the substrate 80 in the third direction D3.
  • the lower foil 60 may thus present an apex P between the fold lines 60b, said apex comprising at least one point located at the maximum distance from the substrate 80.
  • the apex P comprises a line centered with regard to the recess 61.
  • the substrate 80 may comprise two elongated openings 81 extending along the first direction D1 , said openings being arranged in regard to the lower face of the lower foil 60, on both sides of the recess 61.
  • the substrate 80 may have one or several opening 81 of any convenient shape to allow the passage of the positioning member(s) of the slider 8.
  • the dimensions of the container are chosen to impart specific performance in terms of deaggregation of the dry powder and of amount of released dry powder.
  • the fine particle fraction of the dry powder should be over 65%, with a drop of less than 15% when passing from an ambient atmosphere to a humid atmosphere.
  • the emitted dose of dry powder should be over 85%, with a drop of less than 15% when passing from an ambient atmosphere to a humid atmosphere.
  • a suitable container 2 may have the following dimensions:
  • the length of the substrate 80 may be between 25 and 30 mm, - the width of the substrate 80 may be between 13 and 15 mm,
  • a maximum height of the container 2 measured in the third direction D3 from the lower face of the substrate 80 to the upper face of the upper foil 70, is between 4 and 6 mm
  • the radius of curvature of the arched portion of the lower foil 60 is between 8 and 9 mm
  • a length of the recess 61 measured along the first direction D1 is between 9 and 10 mm
  • - a width of the recess 61 measured along the second direction D2 is between 4 and 6 mm
  • the container 2 may be installed directly on the support surface 9 of the slider 8, the openings 81 engaging the support walls 25 so that the free edges 25a of the support walls are in contact with a part of a rear side of the peripheral border 63 of the lower foil 60.
  • the support walls 25 are arranged on each side of the recess 61 , the reception space 23 receiving the recess 61 , and may provide a convenient support and positioning of the lower foil 60 and the recess 61 on the support surface 9.
  • the openings 81 of the substrate 80 provide for a further positioning means of the container 2 with regard to the slider 8.
  • the first direction D1 of the container 2 corresponds to the vertical direction V
  • the second direction D2 of the container 2 corresponds to the transverse direction T
  • the third direction D3 of the container 2 corresponds to the longitudinal direction L.
  • the free edges 25a of the support walls may be convexly curved along the vertical direction V to accommodate the curvature of the arched extent.
  • the flat bottom of the recess 61 is placed at a first distance d1 from the apex P of the lower foil 60.
  • Each support wall 25 present an apex Q, comprising at least one point located at a maximum distance from the support surface 9.
  • the opener 10 is placed at a second distance d2, shown on Figure 14 from the apexes Q of the support walls 25 and said second distance d2 is less than the first distance d1.
  • the flap 26 may then be placed in the locking position, the rear surface of the border 31 being in contact with at least one part of a front side of the peripheral part of the upper foil 70, with the opening 30 facing the central part of said upper foil 70.
  • the rear surface of the border 31 may then be concavely curved along the vertical direction V, in the locking position, to accommodate the curvature of the arched extent.
  • the V-shaped structure formed by the sloping faces of the positioning members 25 engages the lateral curved walls of the reservoir 3, thus precisely centering the reservoir between the members 25.
  • the blister is constrained in three dimensions.
  • FIG. 8 to 10 Another way to install the container 2 on the support surface 9 is shown on Figures 8 to 10.
  • the front side of the peripheral part of the upper foil 70 may be placed against the rear surface of the border 31 of the flap 26 in the supplying position.
  • the flap 26 is moved toward the locking position where the openings 81 of the substrate 80 engages the support walls 25 until the free edges 25a of the support walls 25 are in contact with the rear side of the peripheral border 63 of the lower foil 60, on both sides of the recess 61.
  • the use of the inhaler is now disclosed.
  • the dry powder inhaler 1 is in an unused state where the protective front cover 44 is placed on the mouthpiece 15, the slider 8 is in the second position within the frame 11.
  • the slider 8 is maintained in said second position by the front 44a and rear abutment surfaces of the frame 11 on which the front 44b and rear stopping surfaces of the slider 8 abuts.
  • the back plate As the user pushes the push button 46, the back plate is moved to the release position.
  • the slider 8 under the effect of the spring 43 is urged to the first position.
  • the flap 26 is placed in the supplying position so as to allow a dry powder container 2 provided with dry powder within the reservoir 3 to be installed on the support surface 9.
  • the sliding piece 40 is urged forward so as to protrude from the support surface 9 and to move the abutment arm 37 in the interfering position.
  • the upper end of the flap 26 comes in contact with the sliding piece 40 so as to move said sliding piece backward and to place the abutment arm 37 in the remote position.
  • the flap 26 is in the locking position and the abutment arm 37 is in the remote position.
  • the user places the mouthpiece 15 in his mouth and inhale while exerting a force F on the top surface 22 of the slider 8 to move said slider 8 from the first position to the second position.
  • the speed of the slider 8 and the time to depress the slider are controlled by the damper including the toothed wheel 50.
  • the opener 10 suitably placed in the path of the reservoir 3 as explained above slits the upper foil 70 of the container 2 and space apart lips formed on both sides of the slit thus obtained so as to open the reservoir 3.
  • the reservoir 3 faces the inlet end 6 of the suction tube 5. This corresponds to the final position of the slider where all the powder has been removed from the blister and all relative travel has ceased. At his stage, the user has inhaled the desired amount of fragmented dry powder.
  • the abutment device 35 in the remote position follows the movement of the slider 8 with regard to the frame 11 ( Figure 21 b).
  • the slider 8 is maintained in the second position by the rear stopping surface of the back plate in abutment against the abutment surface of the frame 11.
  • the protective front cover 44 may placed on the mouthpiece 15.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention porte sur un inhalateur de poudre sèche (1) comprenant : un tube d'aspiration (5), un coulisseau (8) comprenant une surface de support (9) apte à recevoir un conteneur (2), ledit tube d'aspiration (5) et ledit coulisseau (8) étant mobiles l'un par rapport à l'autre le long d'un trajet, entre une position d'actionnement et une position de distribution, un dispositif d'ouverture (10) étant placé dans ledit trajet. La surface de support (9) comprend un élément de support (25) et un espace de réception délimité par l'élément de support (25), le coulisseau (8) comprenant un élément de retenue (26) apte à retenir le conteneur (2) sur l'élément de support (25).
PCT/IB2008/001736 2007-07-02 2008-06-26 Inhalateur de poudre sèche et système d'inhalation comprenant un tel inhalateur de poudre sèche Ceased WO2009004465A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94755007P 2007-07-02 2007-07-02
US60/947,550 2007-07-02

Publications (1)

Publication Number Publication Date
WO2009004465A1 true WO2009004465A1 (fr) 2009-01-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001736 Ceased WO2009004465A1 (fr) 2007-07-02 2008-06-26 Inhalateur de poudre sèche et système d'inhalation comprenant un tel inhalateur de poudre sèche

Country Status (1)

Country Link
WO (1) WO2009004465A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2467388A (en) * 2009-01-30 2010-08-04 Vectura Delivery Devices Ltd Inhaler having a pivotally linked housing and blister holder
WO2011110970A1 (fr) * 2010-03-12 2011-09-15 Ranbaxy Laboratories Limited Inhalateur de poudre sèche à dose unique
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
US9289564B2 (en) 2005-04-15 2016-03-22 Vectura Delivery Devices Limited Blister piercing element for dry powder inhaler
US10034989B2 (en) 2013-01-23 2018-07-31 Vectura Delivery Devices Limited Blister piercing element for a dry powder inhaler
EP3283151B1 (fr) * 2015-04-15 2022-07-20 Philip Morris Products S.A. Inhalateur de poudre sèche et procédé d'utilisation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024268A1 (fr) * 2000-09-25 2002-03-28 Microdrug Ag Inhalateur de poudre seche en continu
WO2002024266A1 (fr) * 2000-09-25 2002-03-28 Microdrug Ag Dispositif de decoupe d'opercule
EP1685866A2 (fr) * 1998-06-04 2006-08-02 Nektar Therapeutics Appareil de dispersion de la poudre sèche et son procédé d'utilisation
WO2008051621A2 (fr) * 2006-10-25 2008-05-02 Novartis Ag Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685866A2 (fr) * 1998-06-04 2006-08-02 Nektar Therapeutics Appareil de dispersion de la poudre sèche et son procédé d'utilisation
WO2002024268A1 (fr) * 2000-09-25 2002-03-28 Microdrug Ag Inhalateur de poudre seche en continu
WO2002024266A1 (fr) * 2000-09-25 2002-03-28 Microdrug Ag Dispositif de decoupe d'opercule
WO2008051621A2 (fr) * 2006-10-25 2008-05-02 Novartis Ag Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9289564B2 (en) 2005-04-15 2016-03-22 Vectura Delivery Devices Limited Blister piercing element for dry powder inhaler
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
GB2467388A (en) * 2009-01-30 2010-08-04 Vectura Delivery Devices Ltd Inhaler having a pivotally linked housing and blister holder
US8522776B2 (en) 2009-01-30 2013-09-03 Vectura Delivery Devices Limited Inhaler
GB2467388B (en) * 2009-01-30 2014-01-08 Vectura Delivery Devices Ltd Inhaler
US8739785B2 (en) 2009-01-30 2014-06-03 Vectura Delivery Devices Limited Inhaler
WO2011110970A1 (fr) * 2010-03-12 2011-09-15 Ranbaxy Laboratories Limited Inhalateur de poudre sèche à dose unique
US10034989B2 (en) 2013-01-23 2018-07-31 Vectura Delivery Devices Limited Blister piercing element for a dry powder inhaler
EP3283151B1 (fr) * 2015-04-15 2022-07-20 Philip Morris Products S.A. Inhalateur de poudre sèche et procédé d'utilisation

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