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WO2009004164A9 - Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2009004164A9
WO2009004164A9 PCT/FR2008/000731 FR2008000731W WO2009004164A9 WO 2009004164 A9 WO2009004164 A9 WO 2009004164A9 FR 2008000731 W FR2008000731 W FR 2008000731W WO 2009004164 A9 WO2009004164 A9 WO 2009004164A9
Authority
WO
WIPO (PCT)
Prior art keywords
same
pharmaceutical compositions
compositions containing
preparing
diazeniumdiolate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/000731
Other languages
English (en)
Other versions
WO2009004164A3 (fr
WO2009004164A2 (fr
Inventor
Alexis Cordi
Laure Haberkorn
Tony Verbeuren
Christine Courchay
Serge Simonet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of WO2009004164A2 publication Critical patent/WO2009004164A2/fr
Publication of WO2009004164A3 publication Critical patent/WO2009004164A3/fr
Anticipated expiration legal-status Critical
Publication of WO2009004164A9 publication Critical patent/WO2009004164A9/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composés de formule (I) : G-(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 dans laquelle : n vaut 0, 1, 2 ou 3; m vaut 0, 1, 2 ou 3; p vaut 0 ou 1; o vaut 0, 1 ou 2; R1 et R2 représentent chacun un atome d'hydrogène ou un groupement alkyle; un des groupements -CH2- ou -CR1R2- peut également être remplacé par un groupement phénylène, -PhC(O)- ou -PhC(O)O-; A et G sont tels que définis dans la description; R3 représente un groupement (II) ou (III). Médicaments.
PCT/FR2008/000731 2007-05-30 2008-05-29 Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Ceased WO2009004164A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0703815 2007-05-30
FR0703815A FR2916757B1 (fr) 2007-05-30 2007-05-30 Nouveaux derives diazeniumdiolates,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (3)

Publication Number Publication Date
WO2009004164A2 WO2009004164A2 (fr) 2009-01-08
WO2009004164A3 WO2009004164A3 (fr) 2009-04-30
WO2009004164A9 true WO2009004164A9 (fr) 2010-03-18

Family

ID=39004844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000731 Ceased WO2009004164A2 (fr) 2007-05-30 2008-05-29 Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (3)

Country Link
AR (1) AR066776A1 (fr)
FR (1) FR2916757B1 (fr)
WO (1) WO2009004164A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011053519A1 (fr) * 2009-10-29 2011-05-05 Merck Sharp & Dohme Corp. Diurétiques
EP2665701A2 (fr) * 2011-01-19 2013-11-27 Merck Sharp & Dohme Corp. Dérivés de diolate de diazénium
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
CA3028423A1 (fr) * 2016-06-22 2017-12-28 Medchem Partners, Llc. Donneurs d'oxyde nitrique
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US6610660B1 (en) * 1996-09-27 2003-08-26 The United States Of America As Represented By The Department Of Health And Human Services O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates
EP1868653A2 (fr) * 2005-04-12 2007-12-26 PSivida Inc. Combinaisons d'inhibiteurs de hmgcoa reductases et leurs utilisations

Also Published As

Publication number Publication date
AR066776A1 (es) 2009-09-09
WO2009004164A3 (fr) 2009-04-30
WO2009004164A2 (fr) 2009-01-08
FR2916757A1 (fr) 2008-12-05
FR2916757B1 (fr) 2009-07-17

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