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WO2009001904A1 - 抗癌抗体を有効成分とする医薬を投与する患者のスクリーニング方法 - Google Patents

抗癌抗体を有効成分とする医薬を投与する患者のスクリーニング方法 Download PDF

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Publication number
WO2009001904A1
WO2009001904A1 PCT/JP2008/061669 JP2008061669W WO2009001904A1 WO 2009001904 A1 WO2009001904 A1 WO 2009001904A1 JP 2008061669 W JP2008061669 W JP 2008061669W WO 2009001904 A1 WO2009001904 A1 WO 2009001904A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
active ingredient
pharmaceutical agent
cancer antibody
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/061669
Other languages
English (en)
French (fr)
Inventor
Takashi Sato
Naoya Kimoto
Yuji Ohki
Akiko Furuya
Hiroyuki Ishida
Atsushi Ochiai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Cancer Center Japan
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kirin Co Ltd
National Cancer Center Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, National Cancer Center Japan filed Critical Kyowa Hakko Kirin Co Ltd
Priority to EP08777634A priority Critical patent/EP2172218B1/en
Priority to US12/666,716 priority patent/US8642032B2/en
Priority to JP2009520639A priority patent/JP5464698B2/ja
Publication of WO2009001904A1 publication Critical patent/WO2009001904A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　本発明は、抗癌抗体が認識する抗原を発現している患者から試料を採取し、該試料中のカドヘリン機能を測定し、カドヘリン機能が低下または欠損している患者を選択することを特徴とする、抗癌抗体を有効成分とする医薬を投与するための患者のスクリーニング方法、抗癌抗体を有効成分とする医薬の有効率が高い患者のスクリーニング方法、および抗癌抗体を有効成分とする医薬の有効率を高める方法を提供する。
PCT/JP2008/061669 2007-06-26 2008-06-26 抗癌抗体を有効成分とする医薬を投与する患者のスクリーニング方法 Ceased WO2009001904A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08777634A EP2172218B1 (en) 2007-06-26 2008-06-26 Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient
US12/666,716 US8642032B2 (en) 2007-06-26 2008-06-26 Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient
JP2009520639A JP5464698B2 (ja) 2007-06-26 2008-06-26 抗癌抗体を有効成分とする医薬を投与する患者のスクリーニング方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94627807P 2007-06-26 2007-06-26
US60/946,278 2007-06-26

Publications (1)

Publication Number Publication Date
WO2009001904A1 true WO2009001904A1 (ja) 2008-12-31

Family

ID=40185717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061669 Ceased WO2009001904A1 (ja) 2007-06-26 2008-06-26 抗癌抗体を有効成分とする医薬を投与する患者のスクリーニング方法

Country Status (4)

Country Link
US (1) US8642032B2 (ja)
EP (1) EP2172218B1 (ja)
JP (1) JP5464698B2 (ja)
WO (1) WO2009001904A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100223680A1 (en) * 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2875980A1 (en) * 2012-06-06 2013-12-12 Oncomed Pharmaceuticals, Inc. Binding agents that modulate the hippo pathway and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10127283A (ja) * 1996-07-24 1998-05-19 Gsf Forschungszentrum Fuer Umwelt & Gesundheit Gmbh ヒト悪性腫瘍の診断および治療の基礎としてのｅ−カドヘリンの突然変異体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4110405A1 (de) 1991-03-28 1992-10-01 Birchmeier Walter Prof Dr Verfahren zum nachweis der differenzierung und der invasivitaet von karzinomzellen
AU5669494A (en) * 1992-11-17 1994-06-08 Yale University Human homolog of the e-cadherin gene and methods based thereon
JP4915919B2 (ja) * 2004-06-11 2012-04-11 Ｓｂｉバイオテック株式会社 インターフェロン産生細胞の活性調節剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10127283A (ja) * 1996-07-24 1998-05-19 Gsf Forschungszentrum Fuer Umwelt & Gesundheit Gmbh ヒト悪性腫瘍の診断および治療の基礎としてのｅ−カドヘリンの突然変異体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRENCH J.J. ET AL.: "T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?", BRITISH JOURNAL OF CANCER, vol. 87, no. 9, 2002, pages 1034 - 1041, XP002904764 *
OCHIAI A.: "Cadherin to Shikkan", PATHOLOGY AND CLINICAL MEDICINE, vol. 18, no. 4, 2000, pages 320 - 327 *
SLIWKOWSKI M.X. ET AL.: "Nonclinical studies addressing the mechanism of action of Trastuzumab (Herceptin)", SEMINARS IN ONCOLOGY, vol. 26, no. 4, SUPPL. 12, 1999, pages 60 - 70, XP002961545 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100223680A1 (en) * 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation

Also Published As

Publication number Publication date
EP2172218A4 (en) 2010-08-18
EP2172218A1 (en) 2010-04-07
EP2172218B1 (en) 2013-01-09
JPWO2009001904A1 (ja) 2010-08-26
JP5464698B2 (ja) 2014-04-09
US20100189724A1 (en) 2010-07-29
US8642032B2 (en) 2014-02-04

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