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WO2009099590A3 - Psoriatic phenotype mice, cell lines, treatments, and methods - Google Patents

Psoriatic phenotype mice, cell lines, treatments, and methods Download PDF

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Publication number
WO2009099590A3
WO2009099590A3 PCT/US2009/000680 US2009000680W WO2009099590A3 WO 2009099590 A3 WO2009099590 A3 WO 2009099590A3 US 2009000680 W US2009000680 W US 2009000680W WO 2009099590 A3 WO2009099590 A3 WO 2009099590A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
treatments
cell lines
psoriatic phenotype
phenotype mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/000680
Other languages
French (fr)
Other versions
WO2009099590A2 (en
Inventor
Jan Klysik
John Sedivy
Kim Boekelheide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University
Original Assignee
Brown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University filed Critical Brown University
Publication of WO2009099590A2 publication Critical patent/WO2009099590A2/en
Publication of WO2009099590A3 publication Critical patent/WO2009099590A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A genetically-modified, non-human animal, ES cells and methods for diagnosing and identifying agents useful in the treatment of psoriasis, and psoriatic conditions or disorders is provided.
PCT/US2009/000680 2008-01-31 2009-02-02 Psoriatic phenotype mice, cell lines, treatments, and methods Ceased WO2009099590A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6303308P 2008-01-31 2008-01-31
US61/063,033 2008-01-31
US19151808P 2008-09-09 2008-09-09
US61/191,518 2008-09-09

Publications (2)

Publication Number Publication Date
WO2009099590A2 WO2009099590A2 (en) 2009-08-13
WO2009099590A3 true WO2009099590A3 (en) 2010-01-07

Family

ID=40952602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/000680 Ceased WO2009099590A2 (en) 2008-01-31 2009-02-02 Psoriatic phenotype mice, cell lines, treatments, and methods

Country Status (1)

Country Link
WO (1) WO2009099590A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352929B1 (en) * 2009-08-14 2012-01-26 Centro De Investigaciones Energeticas. Medioamb Ientales Y Tecnologicas (Ciemat) HUMANIZED PSORIASIS MODEL
CN107012169A (en) * 2017-04-11 2017-08-04 浙江大学 Farnesyl pyrophosphate synzyme conditionity knocks out model building method and purposes
CN118830517B (en) * 2023-04-12 2025-10-14 中国科学院长春应用化学研究所 A method for establishing a CIA model rat

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050268348A1 (en) * 2004-01-21 2005-12-01 Boehringer Ingelheim International Gmbh Mouse model for psoriasis and psoriatic arthritis
US20060064769A1 (en) * 2004-07-26 2006-03-23 University Of Massachusetts Conditional disruption of Dicer1 in cell lines and non-human mammals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050268348A1 (en) * 2004-01-21 2005-12-01 Boehringer Ingelheim International Gmbh Mouse model for psoriasis and psoriatic arthritis
US20060064769A1 (en) * 2004-07-26 2006-03-23 University Of Massachusetts Conditional disruption of Dicer1 in cell lines and non-human mammals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ERIN PAUL ET AL.: "Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death", MAMM GENOME, vol. 20, 2009, pages 92 - 108 *
PEREIRA ET AL.: "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.", MECHANISMS OF AGEING AND DEVELOPMENT, vol. 128, no. 11-12, 14 September 2007 (2007-09-14), pages 609 - 617 *
WESTERMARCK ET AL.: "The DEHD/H-box RNA helicase RHII/Gu is a cofactor for c-Jun activated transcription.", EMBO JOUMAL, vol. 21, no. 3, 1 February 2002 (2002-02-01), pages 451 - 460 *

Also Published As

Publication number Publication date
WO2009099590A2 (en) 2009-08-13

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