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WO2009087666A3 - An improved process for production of bicalutamide useful in the treatment of prostate cancer - Google Patents

An improved process for production of bicalutamide useful in the treatment of prostate cancer Download PDF

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Publication number
WO2009087666A3
WO2009087666A3 PCT/IN2008/000820 IN2008000820W WO2009087666A3 WO 2009087666 A3 WO2009087666 A3 WO 2009087666A3 IN 2008000820 W IN2008000820 W IN 2008000820W WO 2009087666 A3 WO2009087666 A3 WO 2009087666A3
Authority
WO
WIPO (PCT)
Prior art keywords
bicalutamide
useful
treatment
production
prostate cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000820
Other languages
French (fr)
Other versions
WO2009087666A2 (en
Inventor
Raja Rao Kudaravalli
Muralidhar Rambathri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KEKULE PHARMA
Original Assignee
KEKULE PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KEKULE PHARMA filed Critical KEKULE PHARMA
Publication of WO2009087666A2 publication Critical patent/WO2009087666A2/en
Publication of WO2009087666A3 publication Critical patent/WO2009087666A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to an improved process for production of Bicalutamide useful in the treatment of prostate cancer by oxidizing N[4-Cyano-3-trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl propanamide with Hydrogenperoxide in the presence of ethylacetate as solvent, methanesulfonic acid and sodiumtungstate as catalysts, washing the reaction mixture with sodiumthiosulphate solution or sodium metabisulphite solution, charcolising and evaporating the reaction mixture adding hydrocarbon solvent, cooling to room temperature and filtering.
PCT/IN2008/000820 2008-01-04 2008-12-08 An improved process for production of bicalutamide useful in the treatment of prostate cancer Ceased WO2009087666A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN34/CHE/2008 2008-01-04
IN34CH2008 2008-01-04

Publications (2)

Publication Number Publication Date
WO2009087666A2 WO2009087666A2 (en) 2009-07-16
WO2009087666A3 true WO2009087666A3 (en) 2009-12-30

Family

ID=40853548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000820 Ceased WO2009087666A2 (en) 2008-01-04 2008-12-08 An improved process for production of bicalutamide useful in the treatment of prostate cancer

Country Status (1)

Country Link
WO (1) WO2009087666A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544768A (en) * 2010-09-29 2013-12-19 シルパ メディケア リミテッド Method for preparing bicalutamide
CN109456227B (en) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 Preparation method of bicalutamide epoxy intermediate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5575945A (en) * 1994-09-14 1996-11-19 Brandeis University Chemical treatment system for producing odor and taste-free potable water
US6562994B2 (en) * 2000-09-21 2003-05-13 Bristol-Myers Squibb Co. Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
US6740770B2 (en) * 2001-12-13 2004-05-25 Sumika Fine Chemicals Co., Ltd. Crystal of bicalutamide and production method thereof
US20070149800A1 (en) * 2005-12-27 2007-06-28 Dabur Pharma Limited Process for preparation of bicalutamide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5575945A (en) * 1994-09-14 1996-11-19 Brandeis University Chemical treatment system for producing odor and taste-free potable water
US6562994B2 (en) * 2000-09-21 2003-05-13 Bristol-Myers Squibb Co. Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
US6740770B2 (en) * 2001-12-13 2004-05-25 Sumika Fine Chemicals Co., Ltd. Crystal of bicalutamide and production method thereof
US7132560B2 (en) * 2001-12-13 2006-11-07 Sumitomo Chemical Company, Limited Crystal of bicalutamide and production method thereof
US20070149800A1 (en) * 2005-12-27 2007-06-28 Dabur Pharma Limited Process for preparation of bicalutamide

Also Published As

Publication number Publication date
WO2009087666A2 (en) 2009-07-16

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